A Review of Hydrogen Sulfide Synthesis, Metabolism, and Measurement: Is Modulation of Hydrogen Sulfide a Novel Therapeutic for Cancer?

scientific article published on 29 June 2018

A Review of Hydrogen Sulfide Synthesis, Metabolism, and Measurement: Is Modulation of Hydrogen Sulfide a Novel Therapeutic for Cancer? is …
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scholarly articleQ13442814

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P356DOI10.1089/ARS.2017.7058
P932PMC publication ID6551999
P698PubMed publication ID29790379

P50authorJinsong BianQ73151602
P2093author name stringYong Yang
Lei Ding
Xu Cao
Matthew Whiteman
Philip K Moore
Zhi-Zhong Xie
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Hydrogen sulfide mediates the vasoactivity of garlicQ24673752
Hydrogen Sulfide and Cellular Redox HomeostasisQ26765798
Interaction of Hydrogen Sulfide with Nitric Oxide in the Cardiovascular SystemQ26774063
Emergence of hydrogen sulfide as an endogenous gaseous signaling molecule in cardiovascular diseaseQ26823796
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Anti-cancer activity of new designer hydrogen sulfide-donating hybridsQ26825705
Structure and Kinetic Analysis of H2S Production by Human Mercaptopyruvate SulfurtransferaseQ27678264
Relative contributions of cystathionine beta-synthase and gamma-cystathionase to H2S biogenesis via alternative trans-sulfuration reactionsQ27929768
The Role of Hydrogen Sulfide in Renal SystemQ28066719
Aberrant rel/nfkb genes and activity in human cancerQ28140722
Proliferation, cell cycle and apoptosis in cancerQ28189476
Hydrogen sulfide is an endogenous modulator of leukocyte-mediated inflammationQ28200154
Tumor hypoxia: definitions and current clinical, biologic, and molecular aspectsQ28200181
The role of cystathionine beta-synthase in homocysteine metabolismQ28250320
H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyaseQ28298435
Hydrogen sulfide protects the retina from light-induced degeneration by the modulation of Ca2+ influxQ35604374
Hydrogen Sulfide Donor GYY4137 Protects against Myocardial Fibrosis.Q35640723
An Anticancer Role of Hydrogen Sulfide in Human Gastric Cancer Cells.Q35640793
GYY4137 protects against myocardial ischemia and reperfusion injury by attenuating oxidative stress and apoptosis in ratsQ35666649
Hydrogen Sulfide Promotes Tet1- and Tet2-Mediated Foxp3 Demethylation to Drive Regulatory T Cell Differentiation and Maintain Immune HomeostasisQ35746822
Hydrogen sulfide is an endogenous potentiator of T cell activationQ35763228
Endogenous production of hydrogen sulfide in mammalsQ35819602
Hydrogen sulfide protects colon cancer cells from chemopreventative agent beta-phenylethyl isothiocyanate induced apoptosisQ35851111
Hydrogen sulfide is a signaling molecule and a cytoprotectantQ35929049
Hydrogen sulfide in biochemistry and medicineQ35929408
Identification of Additional Anti-Persister Activity against Borrelia burgdorferi from an FDA Drug LibraryQ35973174
Shared signaling pathways among gasotransmittersQ36061562
NOSH-Aspirin: A Novel Nitric Oxide-Hydrogen Sulfide-Releasing Hybrid: A New Class of Anti-inflammatory PharmaceuticalsQ36176425
Toxicology of Hydrogen SulfideQ36213459
Hydrogen Sulfide and CancerQ36336507
Hydrogen sulfide stimulates ischemic vascular remodeling through nitric oxide synthase and nitrite reduction activity regulating hypoxia-inducible factor-1α and vascular endothelial growth factor-dependent angiogenesis.Q36522675
A novel persulfide detection method reveals protein persulfide- and polysulfide-reducing functions of thioredoxin and glutathione systems.Q36532821
Heme oxygenase-1 in macrophages controls prostate cancer progressionQ36545252
Role of cystathionine beta synthase in lipid metabolism in ovarian cancerQ36545745
Measurement of plasma hydrogen sulfide in vivo and in vitroQ36702598
Improved tag-switch method reveals that thioredoxin acts as depersulfidase and controls the intracellular levels of protein persulfidation.Q36837643
"Zipped Synthesis" by Cross-Metathesis Provides a Cystathionine β-Synthase Inhibitor that Attenuates Cellular H2S Levels and Reduces Neuronal Infarction in a Rat Ischemic Stroke ModelQ36850630
Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.Q36850905
Hypoxia: a key regulator of angiogenesis in cancerQ36866153
Selectivity of commonly used pharmacological inhibitors for cystathionine β synthase (CBS) and cystathionine γ lyase (CSE).Q36943270
Thrombospondin-1 is a CD47-dependent endogenous inhibitor of hydrogen sulfide signaling in T cell activationQ36997217
A H 2 S Donor GYY4137 Exacerbates Cisplatin-Induced Nephrotoxicity in Mice.Q37000218
Tumor-derived hydrogen sulfide, produced by cystathionine-β-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancerQ37049363
Putative biological roles of hydrogen sulfide in health and disease: a breath of not so fresh air?Q37052295
Oxygen-sensitive mitochondrial accumulation of cystathionine β-synthase mediated by Lon proteaseQ37068583
Garlic oil polysulfides: H2S- and O2-independent prooxidants in buffer and antioxidants in cellsQ37071845
Cisplatin nephrotoxicity: mechanisms and renoprotective strategiesQ37084089
Interplay between heme oxygenase-1 and miR-378 affects non-small cell lung carcinoma growth, vascularization, and metastasisQ37087420
The endogenous production of hydrogen sulphide in intrauterine tissuesQ37097518
Discovery and saturation analysis of cancer genes across 21 tumour typesQ28305204
High performance liquid chromatographic determination of bound sulfide and sulfite and thiosulfate at their low levels in human serum by pre-column fluorescence derivatization with monobromobimaneQ28317998
The vasorelaxant effect of H(2)S as a novel endogenous gaseous K(ATP) channel openerQ28363080
Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disordersQ28384232
Reactive oxygen species, cellular redox systems, and apoptosisQ28393669
Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κBQ28508403
H2S signals through protein S-sulfhydrationQ28511531
3-Mercaptopyruvate sulfurtransferase produces hydrogen sulfide and bound sulfane sulfur in the brainQ28513550
Cystathionine beta-synthase (CBS) contributes to advanced ovarian cancer progression and drug resistanceQ28535061
Tissue and subcellular distribution of mercaptopyruvate sulfurtransferase in the rat: confocal laser fluorescence and immunoelectron microscopic studies combined with biochemical analysisQ28569061
Hydrogen sulfide protects neurons against hypoxic injury via stimulation of ATP-sensitive potassium channel/protein kinase C/extracellular signal-regulated kinase/heat shock protein 90 pathwayQ28572649
Hydrogen sulfide-mediated stimulation of mitochondrial electron transport involves inhibition of the mitochondrial phosphodiesterase 2A, elevation of cAMP and activation of protein kinase AQ28574416
Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1Q28576810
Purification and characterization of cysteine aminotransferase from rat liver cytosolQ28576872
S-Propargyl-cysteine, a novel hydrogen sulfide-modulated agent, attenuates lipopolysaccharide-induced spatial learning and memory impairment: Involvement of TNF signaling and NF-κB pathway in ratsQ28583198
Molecular mechanisms and clinical applications of angiogenesisQ29547314
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesisQ29614217
Drug resistance and the solid tumor microenvironmentQ29614403
An essential role for NF-kappaB in preventing TNF-alpha-induced cell deathQ29614707
Cell cycle control and cancerQ29617536
The impact of O2 availability on human cancerQ29619884
Human polycomb 2 protein is a SUMO E3 ligase and alleviates substrate-induced inhibition of cystathionine beta-synthase sumoylationQ30440592
H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemiaQ30487095
Hydrogen sulfide is an endogenous stimulator of angiogenesis.Q30492603
Redox biochemistry of hydrogen sulfideQ30495475
Hydrogen sulfide (H2S) metabolism in mitochondria and its regulatory role in energy productionQ30505673
Key bioactive reaction products of the NO/H2S interaction are S/N-hybrid species, polysulfides, and nitroxyl.Q30662956
Mutations in the regulatory domain of cystathionine beta synthase can functionally suppress patient-derived mutations in cis.Q32069456
Nrf2: friend or foe for chemoprevention?Q33575690
Hypoxic pulmonary vasodilation: a paradigm shift with a hydrogen sulfide mechanismQ33589523
Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signalingQ33694685
Novel insights into hydrogen sulfide--mediated cytoprotection.Q33830124
Detoxification of hydrogen sulfide and methanethiol in the cecal mucosaQ33859570
The effect of hydrogen sulfide donors on lipopolysaccharide-induced formation of inflammatory mediators in macrophagesQ33875055
Carbon monoxide: an emerging regulator of ion channelsQ33882424
Hydrogen sulfide acts as a double-edged sword in human hepatocellular carcinoma cells through EGFR/ERK/MMP-2 and PTEN/AKT signaling pathwaysQ33895006
Hydrogen sulfide-releasing aspirin inhibits the growth of leukemic Jurkat cells and modulates β-catenin expressionQ37161280
Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: studies with sulforaphane and garlic organosulfur compoundsQ37240767
A novel hydrogen sulfide prodrug, SG1002, promotes hydrogen sulfide and nitric oxide bioavailability in heart failure patientsQ37279303
The inhibition of mitochondrial cytochrome oxidase by the gases carbon monoxide, nitric oxide, hydrogen cyanide and hydrogen sulfide: chemical mechanism and physiological significanceQ37288616
The complex effects of the slow-releasing hydrogen sulfide donor GYY4137 in a model of acute joint inflammation and in human cartilage cells.Q37295023
Beyond DNA Repair: Additional Functions of PARP-1 in CancerQ37346306
Carbon monoxide expedites metabolic exhaustion to inhibit tumor growthQ37365107
Novel dithiolethione-modified nonsteroidal anti-inflammatory drugs in human hepatoma HepG2 and colon LS180 cells.Q37371516
No facilitator required for membrane transport of hydrogen sulfideQ37377256
Modulation of the heme electronic structure and cystathionine beta-synthase activity by second coordination sphere ligands: The role of heme ligand switching in redox regulation.Q37409372
Is hydrogen sulfide a circulating "gasotransmitter" in vertebrate blood?Q37441330
Bench-to-bedside review: Hydrogen sulfide--the third gaseous transmitter: applications for critical careQ37516593
Apoptosis and cancer: the genesis of a research fieldQ37529250
5-FU targets rpL3 to induce mitochondrial apoptosis via cystathionine-β-synthase in colon cancer cells lacking p53.Q37580393
Making and working with hydrogen sulfide: The chemistry and generation of hydrogen sulfide in vitro and its measurement in vivo: a reviewQ37601063
Hydrogen sulfide: from brain to gut.Q37608291
Gasotransmitters in cancer: from pathophysiology to experimental therapyQ37656625
Regulation of cardiovascular cell function by hydrogen sulfide (H(2)S).Q37682138
Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part I. Biochemical and physiological mechanismsQ37686284
Catalase as a sulfide-sulfur oxido-reductase: An ancient (and modern?) regulator of reactive sulfur species (RSS).Q37700190
Hydrogen sulfide: its production, release and functionsQ37700262
Enhancement of tumor cell death by combining cisplatin with an oncolytic adenovirus carrying MDA-7/IL-24Q37727955
Hydrogen sulfide and cell signaling.Q37826422
Chemical properties and mechanisms determining the anti-cancer action of garlic-derived organic sulfur compounds.Q37832516
Hydrogen sulfide gas has cell growth regulatory roleQ37837123
Hydrogen sulfide and inflammation: the good, the bad, the ugly and the promisingQ37960610
Hydrogen sulfide in the mammalian cardiovascular system.Q37981269
Differentiating among incretin therapies: a multiple-target approach to type 2 diabetesQ37995760
Combining immunotherapy and targeted therapies in cancer treatmentQ37995939
Physiological implications of hydrogen sulfide: a whiff exploration that blossomedQ38005671
Biology and therapeutic potential of hydrogen sulfide and hydrogen sulfide-releasing chimerasQ38056004
Regulation of mercaptopyruvate sulfurtransferase activity via intrasubunit and intersubunit redox-sensing switchesQ38059256
How cancer metabolism is tuned for proliferation and vulnerable to disruptionQ38059777
Prodrugs of nonsteroidal anti-inflammatory drugs (NSAIDs), more than meets the eye: a critical reviewQ38068081
Chemical aspects of hydrogen sulfide measurements in physiological samplesQ38114680
Hydrogen sulfide-releasing aspirin suppresses NF-κB signaling in estrogen receptor negative breast cancer cells in vitro and in vivoQ39419473
Hydrogen sulfide mediates the anti-survival effect of sulforaphane on human prostate cancer cellsQ39456872
Molecular basis underlying the biological effects elicited by extremely low-frequency magnetic field (ELF-MF) on neuroblastoma cells.Q39492971
HNO suppresses LPS-induced inflammation in BV-2 microglial cells via inhibition of NF-κB and p38 MAPK pathwaysQ39506027
Antitumoral activity of allicin in murine lymphoma L5178Y.Q39613045
Allicin purified from fresh garlic cloves induces apoptosis in colon cancer cells via Nrf2.Q39647808
Oxidation of hydrogen sulfide remains a priority in mammalian cells and causes reverse electron transfer in colonocytes.Q39714012
Hydrogen sulfide induces human colon cancer cell proliferation: role of Akt, ERK and p21.Q39735129
Growth of desulfovibrio in lactate or ethanol media low in sulfate in association with H2-utilizing methanogenic bacteriaQ39812639
GYY4137, a novel hydrogen sulfide-releasing molecule, protects against endotoxic shock in the rat.Q39859585
1,4-Naphthoquinone is a potent inhibitor of human cancer cell growth and angiogenesisQ39891048
Hydrogen sulfide induces direct radical-associated DNA damage.Q40138015
Tangeretin and nobiletin induce G1 cell cycle arrest but not apoptosis in human breast and colon cancer cellsQ40188424
Hydrogen sulfide inhibits nitric oxide production and nuclear factor-kappaB via heme oxygenase-1 expression in RAW264.7 macrophages stimulated with lipopolysaccharideQ40266368
L-cysteine inhibits insulin release from the pancreatic beta-cell: possible involvement of metabolic production of hydrogen sulfide, a novel gasotransmitterQ40286540
Hydrogen sulphide: a novel inhibitor of hypochlorous acid-mediated oxidative damage in the brain?Q40479415
The novel neuromodulator hydrogen sulfide: an endogenous peroxynitrite 'scavenger'?Q40535164
Hydrogen sulfide induces serum-independent cell cycle entry in nontransformed rat intestinal epithelial cells.Q40648929
Nephrotoxicity and hydration management for cisplatin, carboplatin, and ormaplatinQ40848346
Cisplatin and DNA repair in cancer chemotherapyQ40930064
Kinetic and thermodynamic studies on the disulfide-bond reducing potential of hydrogen sulfideQ41685113
Detection of protein S-sulfhydration by a tag-switch technique.Q41806978
A fluorescent probe for fast and quantitative detection of hydrogen sulfide in blood.Q41885434
Detection of exhaled hydrogen sulphide gas in rats exposed to intravenous sodium sulphideQ41990618
Hydrogen Sulfide Oxidation by Myoglobin.Q42212484
A monobromobimane-based assay to measure the pharmacokinetic profile of reactive sulphide species in bloodQ42429578
A source of hydrogen sulfide and a mechanism of its release in the brainQ42440890
The coordination of S-sulfhydration, S-nitrosylation, and phosphorylation of endothelial nitric oxide synthase by hydrogen sulfideQ42465332
Stimulation of cystine uptake by nitric oxide: regulation of endothelial cell glutathione levelsQ42470465
S-Sulfhydration of ATP synthase by hydrogen sulfide stimulates mitochondrial bioenergeticsQ42498020
Carbon monoxide stimulates global protein methylation via its inhibitory action on cystathionine β-synthase.Q42573621
Cisplatin as an anti-tumor drug: cellular mechanisms of activity, drug resistance and induced side effectsQ42575787
Rat cystathionine beta-synthase. Gene organization and alternative splicingQ42611353
Endogenously produced hydrogen sulfide supports tumor cell growth and proliferationQ42770490
Hypoxia-Inducible Factor-1.ALPHA. Is Involved in the Pro-angiogenic Effect of Hydrogen Sulfide under Hypoxic StressQ42914634
Hydrogen sulfide interacts with nitric oxide in the heart: possible involvement of nitroxylQ42957349
Hypoxia in the renal medulla: implications for hydrogen sulfide signaling.Q43081728
Hydrogen sulfide ameliorates the kidney dysfunction and damage in cisplatin-induced nephrotoxicity in rat.Q43085121
Modulation of thiol homeostasis induced by H2S-releasing aspirinQ43156037
Hydrogen sulfide regulates intracellular pH in rat primary cultured glia cellsQ43264328
Role of cystathionine β-synthase in human breast CancerQ43800252
Exhaled hydrogen sulfide in patients with chronic obstructive pulmonary disease and its correlation with exhaled nitric oxideQ43819468
Characterization of NO binding to human cystathionine beta-synthase: possible implications of the effects of CO and NO binding to the human enzymeQ43823323
Rat cystathionine beta-synthase: expression of four alternatively spliced isoforms in transfected cultured cellsQ43914547
Polysulfides are possible H2S-derived signaling molecules in rat brain.Q44122492
A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cellsQ44131370
Comparative effects of mono-, di-, tri-, and tetrasulfides derived from plants of the Allium family: redox cycling in vitro and hemolytic activity and Phase 2 enzyme induction in vivoQ44410814
Changes in arterial hydrogen sulfide (H(2)S) content during septic shock and endotoxin shock in ratsQ44512617
Modulation of endogenous production of H2S in rat tissuesQ44653708
H2S generated by heart in rat and its effects on cardiac functionQ44698472
Anti-inflammatory and gastrointestinal effects of a novel diclofenac derivativeQ44706021
Thiosulfate: a readily accessible source of hydrogen sulfide in oxygen sensingQ44933023
H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO-TRPA1-CGRP signalling pathwayQ33924111
The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivoQ33942063
Hydrogen sulfide represses androgen receptor transactivation by targeting at the second zinc finger moduleQ33947136
H2S donor, S-propargyl-cysteine, increases CSE in SGC-7901 and cancer-induced mice: evidence for a novel anti-cancer effect of endogenous H2S?Q33954567
The use of transformed IMR90 cell model to identify the potential extra-telomeric effects of hTERT in cell migration and DNA damage responseQ34021399
Sequence of cDNA for rat cystathionine gamma-lyase and comparison of deduced amino acid sequence with related Escherichia coli enzymesQ34052124
Hypoxic regulation of the cerebral microcirculation is mediated by a carbon monoxide-sensitive hydrogen sulfide pathway.Q34122686
Effect of S-adenosyl-L-methionine (SAM), an allosteric activator of cystathionine-β-synthase (CBS) on colorectal cancer cell proliferation and bioenergetics in vitroQ34145385
Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter?Q34157091
NOSH-aspirin (NBS-1120), a novel nitric oxide- and hydrogen sulfide-releasing hybrid is a potent inhibitor of colon cancer cell growth in vitro and in a xenograft mouse modelQ34256975
H₂S signalling through protein sulfhydration and beyondQ34287129
Hydrogen sulfide lowers proliferation and induces protective autophagy in colon epithelial cells.Q34297044
Sulfur amino acid metabolism: pathways for production and removal of homocysteine and cysteineQ34326009
Protective effect of hydrogen sulphide against 6‐OHDA‐induced cell injury in SH‐SY5Y cells involves PKC/PI3K/Akt pathwayQ34339802
PI3K-Akt pathway: its functions and alterations in human cancerQ34362034
Hydrogen sulfide cytoprotective signaling is endothelial nitric oxide synthase-nitric oxide dependentQ34403540
NF-kappa B: a crucial transcription factor for glial and neuronal cell functionQ34428983
Organization of the human mitochondrial hydrogen sulfide oxidation pathwayQ34467414
Carbon monoxide: endogenous production, physiological functions, and pharmacological applicationsQ34480319
Expression profile of hydrogen sulfide and its synthases correlates with tumor stage and grade in urothelial cell carcinoma of bladderQ34512480
Utilizing hydrogen sulfide as a novel anti-cancer agent by targeting cancer glycolysis and pH imbalanceQ34559610
Nephrotoxicity induced by cancer chemotherapy with special emphasis on cisplatin toxicityQ34690068
The association between the 844ins68 polymorphism in the CBS gene and breast cancerQ34974355
Actions and interactions of nitric oxide, carbon monoxide and hydrogen sulphide in the cardiovascular system and in inflammation--a tale of three gases!Q34984278
Vascular endothelium expresses 3-mercaptopyruvate sulfurtransferase and produces hydrogen sulfide.Q34992435
S-glutathionylation enhances human cystathionine β-synthase activity under oxidative stress conditions.Q35015674
The therapeutic potential of cystathionine β-synthetase/hydrogen sulfide inhibition in cancerQ35016080
Role of hydrogen sulphide in haemorrhagic shock in the rat: protective effect of inhibitors of hydrogen sulphide biosynthesisQ35048409
Hydrogen sulfide accelerates cell cycle progression in oral squamous cell carcinoma cell linesQ35109557
Interactions of hydrogen sulfide with myeloperoxidaseQ35204852
Reversible heme-dependent regulation of human cystathionine β-synthase by a flavoprotein oxidoreductase.Q35243063
Hydrogen sulphide and angiogenesis: mechanisms and applications.Q35375963
Marine natural products as inhibitors of cystathionine beta-synthase activityQ35558545
Sulfide, the first inorganic substrate for human cellsQ56611319
Evidence for the formation of a novel nitrosothiol from the gaseous mediators nitric oxide and hydrogen sulphideQ57931896
Selective fluorescent probes for live-cell monitoring of sulphideQ61198325
Extractive alkylation and gas chromatographic analysis of sulfideQ68293344
Determination of sulfide in brain tissue and rumen fluid by ion-interaction reversed-phase high-performance liquid chromatographyQ68834764
Pharmacokinetics of cis-diamminedichloroplatinum(II) after administration in hypertonic salineQ69614900
Monoamine oxidase inhibition as a sequel of hydrogen sulfide intoxication: increases in brain catecholamine and 5-hydroxytryptamine levelsQ69625532
Determination of sulfide in brain tissue by gas dialysis/ion chromatography: postmortem studies and two case reportsQ69631168
The oxidation of L- and D-cysteine to inorganic sulfate and taurine in the ratQ70968282
Oxidation of sodium sulphide by rat liver, lungs and kidneyQ71350765
Thiol S-methyltransferase: suggested role in detoxication of intestinal hydrogen sulfideQ71391175
Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervixQ71545581
Reactions catalysed by serine sulfhydrase from chicken liverQ72360091
Monobromobimane: a substrate for the fluorimetric assay of glutathione transferaseQ72558041
Oxidation of hydrogen sulfide and methanethiol to thiosulfate by rat tissues: a specialized function of the colonic mucosaQ73965302
Sulfur reduction by human erythrocytesQ77356166
Cisplatin nephrotoxicityQ78761584
Hydrogen sulfide mediates vasoactivity in an O2-dependent mannerQ79609011
Hydrogen sulphide regulates intracellular pH in vascular smooth muscle cellsQ80389174
The novel proangiogenic effect of hydrogen sulfide is dependent on Akt phosphorylationQ80613445
Hydrogen sulfide enhances ulcer healing in ratsQ80624339
Reappraisal of H2S/sulfide concentration in vertebrate blood and its potential significance in ischemic preconditioning and vascular signalingQ81098816
Polarographic measurement of hydrogen sulfide production and consumption by mammalian tissuesQ81706798
Reactivity of hydrogen sulfide with peroxynitrite and other oxidants of biological interestQ82231964
Passive loss of hydrogen sulfide in biological experimentsQ82362478
Hydrogen sulfide as a new endogenous gaseous transmitter in the cardiovascular systemQ82528556
Polydimethylsiloxane permeability-based method for the continuous and specific detection of hydrogen sulfideQ84334809
Hydrogen sulfide promotes calcium signals and migration in tumor-derived endothelial cellsQ84850837
Rapid reaction of hydrogen sulfide with the neutrophil oxidant hypochlorous acid to generate polysulfidesQ85038733
Hydrogen sulfide is produced by cystathionine γ-lyase at the steady-state low intracellular Ca(2+) concentrationsQ85892282
[Correlation of methylation of CpG island in cystathionine beta synthase promoter and clinicopathological features in colorectal cancer]Q85959630
Identification of cystathionine β-synthase inhibitors using a hydrogen sulfide selective probeQ86434332
Role of human sulfide: quinone oxidoreductase in H2S metabolismQ86844399
The anti-thrombotic effect of hydrogen sulfide is partly mediated by an upregulation of nitric oxide synthasesQ87203045
Expression of cystathionine beta-synthase is downregulated in hepatocellular carcinoma and associated with poor prognosisQ95822068
Thioredoxin and Cancer: A Role for Thioredoxin in all States of Tumor OxygenationQ38166568
Controversies and conundrums in hydrogen sulfide biologyQ38220160
Fluorescence chemosensors for hydrogen sulfide detection in biological systemsQ38295883
Study on the inhibitory effect of allicin on human gastric cancer cell line SGC-7901 and its mechanismQ38312453
Mechanistic chemical perspective of hydrogen sulfide signaling.Q38366069
Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitterQ38409371
Hydrogen sulfide in cancer: Friend or foe?Q38571666
A critical review of the literature on hydrogen sulfide toxicityQ38583535
CO-CBS-H2 S Axis: From Vascular Mediator to Cancer RegulatorQ38625414
Nitroxyl (HNO): A Possible Strategy for Fighting Cancer.Q38731725
Hydrogen sulfide: A novel nephroprotectant against cisplatin-induced renal toxicityQ38812510
A practical guide to working with H2S at the interface of chemistry and biology.Q38831885
Nrf2-heme oxygenase-1 axis in mucoepidermoid carcinoma of the lung: Antitumoral effects associated with down-regulation of matrix metalloproteinasesQ38833582
Discovery of New H2S Releasing Phosphordithioates and 2,3-Dihydro-2-phenyl-2-sulfanylenebenzo[d][1,3,2]oxazaphospholes with Improved Antiproliferative Activity.Q38856414
Garlic-derived natural polysulfanes as hydrogen sulfide donors: Friend or foe?Q38901220
Role of the cystathionine γ lyase/hydrogen sulfide pathway in human melanoma progression.Q38957953
Wnt/β-catenin signaling induces the transcription of cystathionine-γ-lyase, a stimulator of tumor in colon cancerQ38959405
Major pathogenic mechanisms in vascular dementia: Roles of cellular stress response and hormesis in neuroprotectionQ38962899
Decreased expression of cystathionine β-synthase promotes glioma tumorigenesisQ38978111
Hydrogen sulfide reduces RAGE toxicity through inhibition of its dimer formationQ39009131
GYY4137, a hydrogen sulfide (H₂S) donor, shows potent anti-hepatocellular carcinoma activity through blocking the STAT3 pathwayQ39023096
GYY4137, a novel hydrogen sulfide-releasing molecule, likely protects against high glucose-induced cytotoxicity by activation of the AMPK/mTOR signal pathway in H9c2 cells.Q39038826
Differential susceptibility to hydrogen sulfide-induced apoptosis between PHLDA1-overexpressing oral cancer cell lines and oral keratinocytes: role of PHLDA1 as an apoptosis suppressorQ39056593
NOSH-aspirin (NBS-1120), a novel nitric oxide and hydrogen sulfide releasing hybrid, attenuates neuroinflammation induced by microglial and astrocytic activation: a new candidate for treatment of neurodegenerative disordersQ39114886
Regulation of cystathionine γ-lyase in mammalian cells by hypoxiaQ39126123
Intramitochondrial hydrogen sulfide production by 3-mercaptopyruvate sulfurtransferase maintains mitochondrial electron flow and supports cellular bioenergeticsQ39252442
A New Hope for a Devastating Disease: Hydrogen Sulfide in Parkinson's Disease.Q39325806
Signaling by sulfur-containing molecules. Quantitative aspectsQ39349439
Sp1 is involved in regulation of cystathionine γ-lyase gene expression and biological function by PI3K/Akt pathway in human hepatocellular carcinoma cell linesQ39391366
Characterization of hydrogen sulfide and its synthases, cystathionine β-synthase and cystathionine γ-lyase, in human prostatic tissue and cellsQ39400649
Hydrogen sulfide-releasing NSAIDs inhibit the growth of human cancer cells: a general property and evidence of a tissue type-independent effectQ39416914
Hydrogen sulfide and L-cysteine increase phosphatidylinositol 3,4,5-trisphosphate (PIP3) and glucose utilization by inhibiting phosphatase and tensin homolog (PTEN) protein and activating phosphoinositide 3-kinase (PI3K)/serine/threonine protein kinQ35562685
Exogenous hydrogen sulfide exerts proliferation/anti-apoptosis/angiogenesis/migration effects via amplifying the activation of NF-κB pathway in PLC/PRF/5 hepatoma cellsQ35571393
Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channelsQ35603720
Specificity and some other properties of liver serine sulphhydrase: Evidence for its identity with cystathionine β-synthaseQ44954650
Hydrogen sulfide-induced apoptosis of human aorta smooth muscle cells via the activation of mitogen-activated protein kinases and caspase-3.Q45061684
Reaction-based fluorescent probes for selective imaging of hydrogen sulfide in living cellsQ45232759
Dysregulated pH: a perfect storm for cancer progression.Q45255109
Anti-apoptotic action of hydrogen sulfide is associated with early JNK inhibition.Q45925801
Hydrogen sulfide protects against cellular senescence via S-sulfhydration of Keap1 and activation of Nrf2.Q45947130
S-propargyl-cysteine protects both adult rat hearts and neonatal cardiomyocytes from ischemia/hypoxia injury: the contribution of the hydrogen sulfide-mediated pathway.Q45957950
Hydrogen sulfide from adipose tissue is a novel insulin resistance regulatorQ46149486
Cystathionine beta-synthase as a carbon monoxide-sensitive regulator of bile excretionQ46196479
Whole tissue hydrogen sulfide concentrations are orders of magnitude lower than presently accepted valuesQ46361411
Hydrogen sulfide increases nitric oxide production with calcium-dependent activation of endothelial nitric oxide synthase in endothelial cellsQ46364517
Generation of endogenous hydrogen sulfide by cystathionine gamma-lyase limits renal ischemia/reperfusion injury and dysfunctionQ46446506
Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouseQ46465914
Streptozotocin-induced diabetes in the rat is associated with enhanced tissue hydrogen sulfide biosynthesisQ46557223
Hydrogen sulfide protects rat lung from ischemia-reperfusion injuryQ46593773
The possible role of hydrogen sulfide as an endogenous neuromodulator.Q46606180
Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfideQ46621665
Direct stimulation of K(ATP) channels by exogenous and endogenous hydrogen sulfide in vascular smooth muscle cellsQ46693585
High-throughput tandem-microwell assay identifies inhibitors of the hydrogen sulfide signaling pathwayQ46699363
Evidence that hydrogen sulfide exerts antinociceptive effects in the gastrointestinal tract by activating KATP channelsQ46726610
The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide.Q46738154
H2S: a universal defense against antibiotics in bacteriaQ46754342
Exogenous hydrogen sulfide (H2S) protects against regional myocardial ischemia-reperfusion injury--Evidence for a role of K ATP channelsQ46835777
Hydrogen sulfide contributes to cardioprotection during ischemia-reperfusion injury by opening K ATP channelsQ46861147
Renal protective effect of hydrogen sulfide in cisplatin-induced nephrotoxicityQ47216689
The role of hydrogen sulfide in cyclic nucleotide signaling.Q47381905
Chemical Biology of H2S Signaling through PersulfidationQ47430972
Hydrogen sulfide attenuates neuronal injury induced by vascular dementia via inhibiting apoptosis in ratsQ47673598
Inhibition of respiratory and bioenergetic mechanisms by hydrogen sulfide in mammalian brainQ47854783
H2S-induced S-sulfhydration of lactate dehydrogenase a (LDHA) stimulates cellular bioenergetics in HCT116 colon cancer cellsQ47921367
Exogenous hydrogen sulfide protects against global cerebral ischemia/reperfusion injury via its anti-oxidative, anti-inflammatory and anti-apoptotic effects in ratsQ48309111
Is development of high-grade gliomas sulfur-dependent?Q48403130
Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancerQ49057404
Free and Acid-Labile Hydrogen Sulfide Concentrations in Mouse Tissues: Anomalously High Free Hydrogen Sulfide in Aortic TissueQ49057479
Renal protective effect of polysulfide in cisplatin-induced nephrotoxicity.Q50136697
Garlic-derived S-allylmercaptocysteine is a novel in vivo antimetastatic agent for androgen-independent prostate cancer.Q50693362
Dysregulation of hydrogen sulfide producing enzyme cystathionine γ-lyase contributes to maternal hypertension and placental abnormalities in preeclampsia.Q50963577
Hydrogen sulfide and its possible roles in myocardial ischemia in experimental rats.Q51119493
Spontaneous and Selective Formation of HSNO, a Crucial Intermediate Linking H2S and Nitroso Chemistries.Q51192616
Atorvastatin affects the tissue concentration of hydrogen sulfide in mouse kidneys and other organs.Q51486220
Colorectal cancer risk, chronic illnesses, operations, and medications: case control results from the Melbourne Colorectal Cancer Study.Q52426535
Hydrogen sulfide (H2S)/cystathionine γ-lyase (CSE) pathway contributes to the proliferation of hepatoma cells.Q52648729
HORMESIS: A Fundamental Concept with Widespread Biological and Biomedical Applications.Q52665131
The multifaceted roles of nitric oxide in cancer.Q53433015
Hydrogen sulfide improves glucose metabolism and prevents hypertrophy in cardiomyocytes.Q53664011
Hydrogen sulfide promotes nitric oxide production in corpus cavernosum by enhancing expression of endothelial nitric oxide synthase.Q54282706
The expression and activity of cystathionine-γ-lyase and 3-mercaptopyruvate sulfurtransferase in human neoplastic cell lines.Q54429511
Effects of nonsteroidal anti-inflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway.Q55066553
P433issue1
P304page(s)1-38
P577publication date2018-06-29
P1433published inAntioxidants & Redox SignalingQ4775078
P1476titleA Review of Hydrogen Sulfide Synthesis, Metabolism, and Measurement: Is Modulation of Hydrogen Sulfide a Novel Therapeutic for Cancer?
P478volume31

Reverse relations

cites work (P2860)
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