Hydrogen Sulfide Donor GYY4137 Protects against Myocardial Fibrosis.

scientific article published on 11 May 2015

Hydrogen Sulfide Donor GYY4137 Protects against Myocardial Fibrosis. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1155/2015/691070
P932PMC publication ID4442292
P698PubMed publication ID26078813
P5875ResearchGate publication ID277343811

P50authorAlbert FerroQ37843366
P2093author name stringRui Wang
Yu Chen
Liping Xie
Xin Tang
Yong Ji
Yuqing Zhang
Zhengrong Huang
Yongfeng Shao
Philip K Moore
Guoliang Meng
Yujiao Xiao
Jinbiao Zhu
P2860cites workMolecular imaging of the cardiac extracellular matrixQ27687824
H2S ameliorates oxidative and proteolytic stresses and protects the heart against adverse remodeling in chronic heart failureQ33655952
Hydrogen sulfide inhibits the renal fibrosis of obstructive nephropathyQ33696105
Hydrogen sulfide attenuates carbon tetrachloride-induced hepatotoxicity, liver cirrhosis and portal hypertension in ratsQ34055831
Hydrogen sulphide suppresses human atrial fibroblast proliferation and transformation to myofibroblastsQ34154740
Hydrogen sulfide protects HUVECs against hydrogen peroxide induced mitochondrial dysfunction and oxidative stressQ34580841
Metformin inhibits angiotensin II-induced differentiation of cardiac fibroblasts into myofibroblastsQ34983872
H(2)S inhibits hyperglycemia-induced intrarenal renin-angiotensin system activation via attenuation of reactive oxygen species generationQ34994649
Hydrogen sulfide alleviates myocardial collagen remodeling in association with inhibition of TGF-β/Smad signaling pathway in spontaneously hypertensive ratsQ35192817
The neuroprotection of hydrogen sulfide against MPTP-induced dopaminergic neuron degeneration involves uncoupling protein 2 rather than ATP-sensitive potassium channels.Q36084474
H₂S is an endothelium-derived hyperpolarizing factor.Q51272873
Inhibition of invasion and epithelial-mesenchymal transition of human breast cancer cells by hydrogen sulfide through decreased phospho-p38 expression.Q53056135
Diallyl sulfide induces cell cycle arrest and apoptosis in HeLa human cervical cancer cells through the p53, caspase- and mitochondria-dependent pathways.Q53259981
Hydrogen sulfide-induces DNA damage and changes in apoptotic gene expression in human lung fibroblast cells.Q53587374
The regulatory effect of hydrogen sulfide on hypoxic pulmonary hypertension in rats.Q53956045
Collagen phenotypes during development and regression of myocardial hypertrophy in spontaneously hypertensive ratsQ68433121
Characterisation of left ventricular collagen in the ratQ72784519
Chronic sodium hydrosulfide treatment decreases medial thickening of intramyocardial coronary arterioles, interstitial fibrosis, and ROS production in spontaneously hypertensive ratsQ80609679
Protective effect of hydrogen sulfide on gentamicin-induced renal injuryQ87548519
Emerging role of hydrogen sulfide in hypertension and related cardiovascular diseasesQ36342111
Hydrogen sulfide preconditions the db/db diabetic mouse heart against ischemia-reperfusion injury by activating Nrf2 signaling in an Erk-dependent mannerQ36838022
The pathogenesis of cardiac fibrosis.Q37161329
Hydrogen sulfide mediates cardioprotection through Nrf2 signalingQ37328256
Aging, exercise, and extracellular matrix in the heartQ37332371
Tempol attenuates renal fibrosis in mice with unilateral ureteral obstruction: the role of PI3K-Akt-FoxO3a signalingQ37583050
The role of alpha-smooth muscle actin in myogenic differentiation of human glandular stem cells and their potential for smooth muscle cell replacement therapiesQ37724366
Signaling pathways for the vascular effects of hydrogen sulfideQ37837422
Biomarkers of myocardial fibrosisQ37855500
Physiological implications of hydrogen sulfide: a whiff exploration that blossomedQ38005671
Stem cell transplantation as a therapy for cardiac fibrosis.Q38046544
Myofibroblast-mediated mechanisms of pathological remodelling of the heartQ38064729
Hydrogen sulfide and the pathogenesis of atherosclerosisQ38098634
The therapeutic potential of miRNAs in cardiac fibrosis: where do we stand?Q38118947
Understanding the origin, activation and regulation of matrix-producing myofibroblasts for treatment of fibrotic disease.Q38134341
Investigational drugs targeting cardiac fibrosisQ38161896
Dynamic changes in myocardial matrix and relevance to disease: translational perspectivesQ38191847
Hydrogen sulfide: physiological properties and therapeutic potential in ischaemia.Q38236845
Decreased expression of p38 MAPK mediates protective effects of hydrogen sulfide on hepatic fibrosisQ39173217
Determination of hydroxyprolineQ39967323
Hydrogen sulfide attenuates cardiac hypertrophy and fibrosis induced by abdominal aortic coarctation in ratsQ41349390
Hydrogen sulfide alleviates diabetic nephropathy in a streptozotocin-induced diabetic rat modelQ41856390
Diallylsulfide attenuates excessive collagen production and apoptosis in a rat model of bleomycin induced pulmonary fibrosis through the involvement of protease activated receptor-2.Q42711443
Inhibition of NADPH oxidase 4-related signaling by sodium hydrosulfide attenuates myocardial fibrotic response.Q44773974
Plasma profiles of matrix metalloproteinases and tissue inhibitors of the metalloproteinases predict recurrence of atrial fibrillation following cardioversionQ45840647
Hydrogen sulfide protects against cellular senescence via S-sulfhydration of Keap1 and activation of Nrf2.Q45947130
Synergistic attenuation of myocardial fibrosis in spontaneously hypertensive rats by joint treatment with benazepril and candesartan.Q45986994
Role of hydrogen sulfide in the development of atherosclerotic lesions in apolipoprotein E knockout miceQ46260974
Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfideQ46621665
Hydrogen sulfide protects endothelial nitric oxide function under conditions of acute oxidative stress in vitro.Q46658810
Animal models of cardiac fibrosisQ46676482
Diallyl trisufide (DATS) suppresses high glucose-induced cardiomyocyte apoptosis by inhibiting JNK/NFκB signaling via attenuating ROS generationQ46976904
Posterior diaphragm agenesis: when liver simulates lungs.Q47823576
Exogenous hydrogen sulfide protects H9c2 cardiac cells against high glucose-induced injury by inhibiting the activities of the p38 MAPK and ERK1/2 pathways.Q47864828
Involvement of hydrogen sulfide and homocysteine transsulfuration pathway in the progression of kidney fibrosis after ureteral obstructionQ48024039
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P304page(s)691070
P577publication date2015-05-11
P1433published inOxidative medicine and cellular longevityQ26840015
P1476titleHydrogen Sulfide Donor GYY4137 Protects against Myocardial Fibrosis
P478volume2015

Reverse relations

cites work (P2860)
Q62381232A Review of Hydrogen Sulfide Synthesis, Metabolism, and Measurement: Is Modulation of Hydrogen Sulfide a Novel Therapeutic for Cancer?
Q60952208Exogenous Hydrogen Sulfide Supplement Attenuates Isoproterenol-Induced Myocardial Hypertrophy in a Sirtuin 3-Dependent Manner
Q46581242Exogenous hydrogen sulphide ameliorates diabetic cardiomyopathy in rats by reversing disordered calcium-handling system in sarcoplasmic reticulum
Q94562632GYY4137 a H2S donor, attenuates ipsilateral epididymis injury in experimentally varicocele-induced rats via activation of the PI3K/Akt pathway
Q57300054Hydrogen Sulfide (HS)-Releasing Compounds: Therapeutic Potential in Cardiovascular Diseases
Q64991647Hydrogen Sulfide Ameliorates Homocysteine-Induced Cardiac Remodeling and Dysfunction.
Q89736835Hydrogen Sulfide as a Potential Alternative for the Treatment of Myocardial Fibrosis
Q39906675Hydrogen sulfide depletion contributes to microvascular remodeling in obesity
Q47914860International Union of Basic and Clinical Pharmacology. CII: Pharmacological Modulation of H2S Levels: H2S Donors and H2S Biosynthesis Inhibitors
Q64234079Modulation of miR-10a-mediated TGF-β1/Smads signaling affects atrial fibrillation-induced cardiac fibrosis and cardiac fibroblast proliferation
Q39240558Nitric oxide and hydrogen sulfide: the gasotransmitter paradigm of the vascular system
Q36085536Oxymatrine inhibits aldosterone-induced rat cardiac fibroblast proliferation and differentiation by attenuating smad-2,-3 and-4 expression: an in vitro study
Q61818125Protective Smell of Hydrogen Sulfide and Polysulfide in Cisplatin-Induced Nephrotoxicity
Q33618317Protective effect of hydrogen sulphide against myocardial hypertrophy in mice
Q38692090Protein S-sulfhydration by hydrogen sulfide in cardiovascular system
Q28066719The Role of Hydrogen Sulfide in Renal System
Q47284733Transient receptor potential vanilloid-3 (TRPV3) activation plays a central role in cardiac fibrosis induced by pressure overload in rats via TGF-β1 pathway

Search more.