International Union of Basic and Clinical Pharmacology. CII: Pharmacological Modulation of H2S Levels: H2S Donors and H2S Biosynthesis Inhibitors

scientific article published in October 2017

International Union of Basic and Clinical Pharmacology. CII: Pharmacological Modulation of H2S Levels: H2S Donors and H2S Biosynthesis Inhibitors is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1124/PR.117.014050
P8608Fatcat IDrelease_asljy32kfbdxdoimqezolf2mle
P932PMC publication ID5629631
P698PubMed publication ID28978633

P2093author name stringAndreas Papapetropoulos
Csaba Szabo
P2860cites workKinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfurationQ22009446
Structure of human cystathionine beta-synthase: a unique pyridoxal 5'-phosphate-dependent heme proteinQ24291509
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteineQ24310423
Human cystathionine beta-synthase is a target for sumoylationQ24312724
Structural basis for the inhibition mechanism of human cystathionine gamma-lyase, an enzyme responsible for the production of H(2)SQ24316078
Crystal structure of Escherichia coli cystathionine gamma-synthase at 1.5 A resolutionQ24533426
Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxationQ24597604
Hydrogen sulfide as a mediator of human corpus cavernosum smooth-muscle relaxationQ24656291
Hydrogen sulfide mediates the vasoactivity of garlicQ24673752
Hydrogen Sulfide and Cellular Redox HomeostasisQ26765798
Nitric oxide: physiology, pathophysiology, and pharmacologyQ26778243
Cysteine and hydrogen sulphide in the regulation of metabolism: insights from genetics and pharmacologyQ26782965
Homocysteine-Induced Endothelial DysfunctionQ26800839
Emergence of hydrogen sulfide as an endogenous gaseous signaling molecule in cardiovascular diseaseQ26823796
A critical review of pharmacological significance of Hydrogen Sulfide in hypertensionQ26824749
The role of gasotransmitters NO, H2S and CO in myocardial ischaemia/reperfusion injury and cardioprotection by preconditioning, postconditioning and remote conditioningQ26825733
The role of H2S bioavailability in endothelial dysfunctionQ26851344
A tale of two gases: NO and H2S, foes or friends for life?Q27002433
Role of homocysteine in the development of cardiovascular diseaseQ27004318
H2S during circulatory shock: some unresolved questionsQ27006240
Signaling molecules: hydrogen sulfide and polysulfideQ27024480
Expression of mutant human cystathionine beta-synthase rescues neonatal lethality but not homocystinuria in a mouse modelQ34131334
Effect of S-adenosyl-L-methionine (SAM), an allosteric activator of cystathionine-β-synthase (CBS) on colorectal cancer cell proliferation and bioenergetics in vitroQ34145385
Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter?Q34157091
The resurgence of covalent drugsQ34174891
Acquired sulfhemoglobinemia. An underreported diagnosis?Q34189973
Structural insight into the molecular mechanism of allosteric activation of human cystathionine β-synthase by S-adenosylmethionineQ34218322
Solubility and permeation of hydrogen sulfide in lipid membranes.Q34235296
Studies on the GABA pathway. I. The inhibition of gamma-aminobutyric acid-alpha-ketoglutaric acid transaminase in vitro and in vivo by U-7524 (amino-oxyacetic acid).Q34249568
NOSH-aspirin (NBS-1120), a novel nitric oxide- and hydrogen sulfide-releasing hybrid is a potent inhibitor of colon cancer cell growth in vitro and in a xenograft mouse modelQ34256975
Failure of aminooxyacetic acid therapy in Huntington diseaseQ34260726
Reactivity of the phosphopyridoxal groups of cystathionaseQ34362228
Sulfide inhibition of and metabolism by cytochrome c oxidase.Q34372858
A novel controllable hydrogen sulfide-releasing molecule protects human skin keratinocytes against methylglyoxal-induced injury and dysfunctionQ34381184
Hydrogen sulfide accounts for the peripheral vascular effects of zofenopril independently of ACE inhibition.Q34402692
Hydrogen sulfide cytoprotective signaling is endothelial nitric oxide synthase-nitric oxide dependentQ34403540
Release of GLP-1 and PYY in response to the activation of G protein-coupled bile acid receptor TGR5 is mediated by Epac/PLC-ε pathway and modulated by endogenous H2S.Q34441486
H2S-releasing drugs: anti-inflammatory, cytoprotective and chemopreventative potentialQ34451352
Correction of disease-causing CBS mutations in yeastQ34468374
Down-regulation of hydrogen sulfide biosynthesis accompanies murine interstitial cells of Cajal dysfunction in partial ileal obstructionQ34469660
AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitroQ34477537
Gaseous mediators in resolution of inflammationQ34481627
MPST but not CSE is the primary regulator of hydrogen sulfide production and function in the coronary artery.Q34500007
Cystathionine β-synthase and cystathionine γ-lyase double gene transfer ameliorate homocysteine-mediated mesangial inflammation through hydrogen sulfide generationQ34501679
Expression profile of hydrogen sulfide and its synthases correlates with tumor stage and grade in urothelial cell carcinoma of bladderQ34512480
Upregulation of cystathionine β-synthetase expression contributes to visceral hyperalgesia induced by heterotypic intermittent stress in ratsQ34535038
cGMP-dependent protein kinase contributes to hydrogen sulfide-stimulated vasorelaxation.Q34535138
Sodium thiosulfate attenuates acute lung injury in miceQ34543931
Evaluation of Amino-Oxyacetic Acid as a Palliative in TinnitusQ34553596
Utilizing hydrogen sulfide as a novel anti-cancer agent by targeting cancer glycolysis and pH imbalanceQ34559610
Cytoprotective effects of hydrogen sulfide-releasing N-methyl-D-aspartate receptor antagonists are mediated by intracellular sulfane sulfurQ34565353
H2S induced hypometabolism in mice is missing in sedated sheepQ34709014
Hydrogen sulfide slows down progression of experimental Alzheimer's disease by targeting multiple pathophysiological mechanisms.Q34751757
Effect of inhaled hydrogen sulfide on metabolic responses in anesthetized, paralyzed, and mechanically ventilated pigletsQ34778474
H2S relaxes isolated human airway smooth muscle cells via the sarcolemmal K(ATP) channelQ37730872
S-propargyl-cysteine, a novel water-soluble modulator of endogenous hydrogen sulfide, promotes angiogenesis through activation of signal transducer and activator of transcription 3.Q37734005
Synthesis and biological effects of hydrogen sulfide (H2S): development of H2S-releasing drugs as pharmaceuticalsQ37749789
Protein modifications involved in neurotransmitter and gasotransmitter signalingQ37789075
Mitochondria and Sulfide: A Very Old Story of Poisoning, Feeding, and Signaling?Q37804386
Hydrogen sulfide and cell signaling.Q37826422
Hydrogen sulfide-mediated myocardial pre- and post-conditioningQ37849578
The therapeutic potential of hydrogen sulfide: separating hype from hopeQ37872122
Emerging role of hydrogen sulfide in health and disease: critical appraisal of biomarkers and pharmacological toolsQ37917815
The CBS domain: a protein module with an emerging prominent role in regulationQ37940566
Hydrogen sulfide and inflammation: the good, the bad, the ugly and the promisingQ37960610
Hydrogen sulfide and the metabolic syndromeQ37960613
Roles of hydrogen sulfide in the pathogenesis of diabetes mellitus and its complicationsQ37965571
Physiological implications of hydrogen sulfide: a whiff exploration that blossomedQ38005671
Evolutionary and comparative aspects of nitric oxide, carbon monoxide and hydrogen sulfideQ38006568
Ventilatory and metabolic effects of exogenous hydrogen sulfideQ38009551
Hydrogen sulphide: biopharmacological roles in the cardiovascular system and pharmaceutical perspectivesQ38017235
Regulation of mercaptopyruvate sulfurtransferase activity via intrasubunit and intersubunit redox-sensing switchesQ38059256
Prodrugs of nonsteroidal anti-inflammatory drugs (NSAIDs), more than meets the eye: a critical reviewQ38068081
Hydrogen sulfide signaling in the gastrointestinal tractQ38098623
Molecular mechanisms for the anti-cancer effects of diallyl disulfideQ38098781
Redox Biology of Hydrogen Sulfide: Implications for Physiology, Pathophysiology, and PharmacologyQ38116513
Physiological role of hydrogen sulfide and polysulfide in the central nervous system.Q38137646
Role of hydrogen sulfide in secondary neuronal injuryQ38163273
Targeting hydrogen sulfide as a promising therapeutic strategy for atherosclerosisQ38184753
Pharmacological tools for hydrogen sulphide research: a brief, introductory guide for beginnersQ38218546
Controversies and conundrums in hydrogen sulfide biologyQ38220160
Hydrogen sulfide: a neuromodulator and neuroprotectant in the central nervous systemQ38250429
Hydrogen sulfide in signaling pathwaysQ38274738
Protective effect of hydrogen sulfide on pancreatic beta-cellsQ38280662
Calorie restriction and methionine restriction in control of endogenous hydrogen sulfide production by the transsulfuration pathway.Q38293712
Role of cGMP in hydrogen sulfide signalingQ38305532
Sodium thiosulfate attenuates glial-mediated neuroinflammation in degenerative neurological diseasesQ38306132
Mechanistic chemical perspective of hydrogen sulfide signaling.Q38366069
GYY4137, a novel water-soluble, H2S-releasing molecule.Q38366070
Hydrogen sulfide signaling: interactions with nitric oxide and reactive oxygen speciesQ38381741
Safety, tolerability and pharmacokinetics of trimebutine 3-thiocarbamoylbenzenesulfonate (GIC-1001) in a randomized phase I integrated design study: single and multiple ascending doses and effect of food in healthy volunteersQ38423641
Hydrogen sulfide increases thermotolerance and lifespan in Caenorhabditis elegans.Q36300148
Dietary HDAC inhibitors: time to rethink weak ligands in cancer chemoprevention?Q36305199
Vasorelaxant Effect of a New Hydrogen Sulfide-Nitric Oxide Conjugated Donor in Isolated Rat Aortic Rings through cGMP PathwayQ36305319
Impaired Hydrogen Sulfide-Mediated Vasodilation Contributes to Microvascular Endothelial Dysfunction in Hypertensive AdultsQ36324582
Hydrogen sulfide and PKG in ischemia-reperfusion injury: sources, signaling, accelerators and brakesQ36341617
Emerging role of hydrogen sulfide in hypertension and related cardiovascular diseasesQ36342111
Sensory and cognitive effects of acute exposure to hydrogen sulfideQ36381300
The hydrogen sulphide-releasing derivative of diclofenac protects against ischaemia-reperfusion injury in the isolated rabbit heart.Q36381503
AP39, A Mitochondrially Targeted Hydrogen Sulfide Donor, Exerts Protective Effects in Renal Epithelial Cells Subjected to Oxidative Stress in Vitro and in Acute Renal Injury in VivoQ36385235
Garlic-Derived Organic Polysulfides and Myocardial ProtectionQ36498005
The emerging roles of hydrogen sulfide in the gastrointestinal tract and liverQ36532353
Hydrogen sulfide: both feet on the gas and none on the brake?Q36561890
Upregulation and mitochondrial sequestration of hemoglobins occurs in circulating leukocytes during critical illness, conferring a cytoprotective phenotypeQ36568285
SIRT3 Mediates the Antioxidant Effect of Hydrogen Sulfide in Endothelial Cells.Q36601974
Design, Synthesis, and Cardioprotective Effects of N-Mercapto-Based Hydrogen Sulfide Donors.Q36617377
Hydrogen sulfide inhibits proliferation and release of IL-8 from human airway smooth muscle cellsQ36623483
Betaine supplementation is less effective than methionine restriction in correcting phenotypes of CBS deficient miceQ36668621
Effect of hydrogen sulphide-donating sildenafil (ACS6) on erectile function and oxidative stress in rabbit isolated corpus cavernosum and in hypertensive rats.Q36682260
The effects of therapeutic sulfide on myocardial apoptosis in response to ischemia-reperfusion injuryQ36713900
Hydrogen sulfide modulates chromatin remodeling and inflammatory mediator production in response to endotoxin, but does not play a role in the development of endotoxin tolerance.Q36758450
Hydrogen sulfide (H2S) - the third gas of interest for pharmacologists.Q36766304
D-Penicillamine modulates hydrogen sulfide (H2S) pathway through selective inhibition of cystathionine-γ-lyaseQ36797373
Pyridoxal 5'-phosphate enzymes as targets for therapeutic agentsQ36822863
Thiosulfate Mediates Cytoprotective Effects of Hydrogen Sulfide Against Neuronal IschemiaQ36836222
Improved tag-switch method reveals that thioredoxin acts as depersulfidase and controls the intracellular levels of protein persulfidation.Q36837643
Hydrogen sulfide preconditions the db/db diabetic mouse heart against ischemia-reperfusion injury by activating Nrf2 signaling in an Erk-dependent mannerQ36838022
Hydrogen sulfide attenuates hepatic ischemia-reperfusion injury: role of antioxidant and antiapoptotic signalingQ36844600
Polysulfides as biologically active ingredients of garlicQ36850180
Hydrogen Sulfide Is a Novel Regulator of Bone Formation Implicated in the Bone Loss Induced by Estrogen DeficiencyQ36889262
H₂S protects against pressure overload-induced heart failure via upregulation of endothelial nitric oxide synthaseQ36895184
A case of mistaken identity: are reactive oxygen species actually reactive sulfide species?Q36902539
Molecular targets of cancer chemoprevention by garlic-derived organosulfidesQ36920765
Selectivity of commonly used pharmacological inhibitors for cystathionine β synthase (CBS) and cystathionine γ lyase (CSE).Q36943270
Carbon monoxide, hydrogen sulfide, and nitric oxide as signaling molecules in the gastrointestinal tractQ27026586
Sodium thiosulfate ameliorates oxidative stress and preserves renal function in hyperoxaluric ratsQ27308885
Crystal structures of 1-aminocyclopropane-1-carboxylate (ACC) synthase in complex with aminoethoxyvinylglycine and pyridoxal-5'-phosphate provide new insight into catalytic mechanismsQ27632861
Slow-binding inhibition of Escherichia coli cystathionine beta-lyase by L-aminoethoxyvinylglycine: a kinetic and X-ray studyQ27747982
Relative contributions of cystathionine beta-synthase and gamma-cystathionase to H2S biogenesis via alternative trans-sulfuration reactionsQ27929768
The Role of Hydrogen Sulfide in Renal SystemQ28066719
Persulfides: current knowledge and challenges in chemistry and chemical biologyQ28083376
The Cardioprotective Effects of Hydrogen Sulfide in Heart Diseases: From Molecular Mechanisms to Therapeutic PotentialQ28083965
Inhibition of hydrogen sulfide generation contributes to gastric injury caused by anti-inflammatory nonsteroidal drugsQ28192729
Hydrogen sulfide is an endogenous modulator of leukocyte-mediated inflammationQ28200154
H2S induces a suspended animation-like state in miceQ28246406
Phenazopyridine-induced sulfhemoglobinemiaQ28249837
The role of cystathionine beta-synthase in homocysteine metabolismQ28250320
Reproducibility and sensitivity of oral malodor measurements with a portable sulphide monitorQ28251997
Garlic organosulfur compounds upregulate the expression of the pi class of glutathione S-transferase in rat primary hepatocytesQ28279160
Redox regulation and reaction mechanism of human cystathionine-beta-synthase: a PLP-dependent hemesensor proteinQ28296829
H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyaseQ28298435
The antidotal action of sodium nitrite and sodium thiosulfate against cyanide poisoningQ28305855
Loss of ETHE1, a mitochondrial dioxygenase, causes fatal sulfide toxicity in ethylmalonic encephalopathyQ28306500
The vasorelaxant effect of H(2)S as a novel endogenous gaseous K(ATP) channel openerQ28363080
Selective inhibition of alanine aminotransferase and aspartate aminotransferase in rat hepatocytesQ28366724
Mitochondria as a target in treatmentQ28382780
Hydrogen sulfide-releasing naproxen suppresses colon cancer cell growth and inhibits NF-κB signalingQ28387183
Effects of S-propargyl-cysteine (SPRC) in caerulein-induced acute pancreatitis in miceQ28481347
Gastrointestinal-sparing effects of novel NSAIDs in rats with compromised mucosal defenceQ28482202
Therapeutic effect of hydrogen sulfide-releasing L-Dopa derivative ACS84 on 6-OHDA-induced Parkinson's disease rat modelQ28485947
3-Mercaptopyruvate sulfurtransferase produces hydrogen sulfide and bound sulfane sulfur in the brainQ28513550
Cardioprotective effects of a novel hydrogen sulfide agent-controlled release formulation of S-propargyl-cysteine on heart failure rats and molecular mechanismsQ28534567
Cystathionine beta-synthase (CBS) contributes to advanced ovarian cancer progression and drug resistanceQ28535061
Hydrogen sulfide releasing aspirin, ACS14, attenuates high glucose-induced increased methylglyoxal and oxidative stress in cultured vascular smooth muscle cellsQ28539333
Domain organization, catalysis and regulation of eukaryotic cystathionine beta-synthasesQ28541958
Hydrogen sulfide promotes adipogenesis in 3T3L1 cellsQ28545148
Profound Chemopreventative Effects of a Hydrogen Sulfide-Releasing NSAID in the APCMin/+ Mouse Model of Intestinal TumorigenesisQ28550361
The therapeutic potential of poly(ADP-ribose) polymerase inhibitorsQ34838585
Enhanced synthesis and diminished degradation of hydrogen sulfide in experimental colitis: a site-specific, pro-resolution mechanismQ34938166
Hydrogen sulfide preconditioning protects rat liver against ischemia/reperfusion injury by activating Akt-GSK-3β signaling and inhibiting mitochondrial permeability transitionQ34994670
Physiological and pathophysiological roles of hydrogen sulfide in the gastrointestinal tractQ35004267
The therapeutic potential of cystathionine β-synthetase/hydrogen sulfide inhibition in cancerQ35016080
Role of hydrogen sulphide in haemorrhagic shock in the rat: protective effect of inhibitors of hydrogen sulphide biosynthesisQ35048409
The quantitative significance of the transsulfuration enzymes for H2S production in murine tissuesQ35056200
Structural insights into mutations of cystathionine beta-synthase.Q35103607
Exogenous hydrogen sulfide (H2S) protects alveolar growth in experimental O2-induced neonatal lung injuryQ35113434
Cardioprotective effects of hydrogen sulfideQ35115617
Hydrogen sulfide inhalation decreases early blood-brain barrier permeability and brain edema induced by cardiac arrest and resuscitationQ35143529
The H2S-releasing naproxen derivative, ATB-346, inhibits alveolar bone loss and inflammation in rats with ligature-induced periodontitis.Q35158599
Role of hydrogen sulfide in brain synaptic remodelingQ35166466
Hydrogen sulfide replacement therapy protects the vascular endothelium in hyperglycemia by preserving mitochondrial functionQ35170942
Hydrogen sulfide attenuates high fat diet-induced cardiac dysfunction via the suppression of endoplasmic reticulum stress.Q35181153
Arylthioamides as H2S Donors: l-Cysteine-Activated Releasing Properties and Vascular Effects in Vitro and in VivoQ35181925
Exogenous administration of thiosulfate, a donor of hydrogen sulfide, attenuates angiotensin II-induced hypertensive heart disease in ratsQ35204841
Crucial role of androgen receptor in vascular H2S biosynthesis induced by testosteroneQ35204849
Sodium nitroprusside-induced cyanide intoxication and prevention with sodium thiosulfate prophylaxisQ35224039
PLP-dependent H(2)S biogenesisQ35353935
Hydrogen sulphide and angiogenesis: mechanisms and applications.Q35375963
Cystathionine β-synthase inhibition is a potential therapeutic approach to treatment of ischemic injuryQ35418764
Inhibition of endogenous hydrogen sulfide formation reduces the organ injury caused by endotoxemiaQ35545028
Marine natural products as inhibitors of cystathionine beta-synthase activityQ35558545
Nitric oxide-releasing flurbiprofen reduces formation of proinflammatory hydrogen sulfide in lipopolysaccharide-treated ratQ35566559
Administration of hydrogen sulfide via extracorporeal membrane lung ventilation in sheep with partial cardiopulmonary bypass perfusion: a proof of concept study on metabolic and vasomotor effects.Q35566969
Estrogen Replacement Therapy in Ovariectomized Nonpregnant Ewes Stimulates Uterine Artery Hydrogen Sulfide Biosynthesis by Selectively Up-Regulating Cystathionine β-Synthase ExpressionQ35603320
Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channelsQ35603720
Hydrogen sulfide attenuates cytokine production through the modulation of chromatin remodeling.Q35609926
Effects of hydrogen sulfide synthesis inhibitors on posthypoxic ventilatory behavior in the C57BL/6J mouseQ35613970
Hydrogen Sulfide Donor GYY4137 Protects against Myocardial Fibrosis.Q35640723
Role of hydrogen sulfide in paramyxovirus infectionsQ35641468
Cardioprotection by H2S engages a cGMP-dependent protein kinase G/phospholamban pathway.Q35661834
GYY4137 protects against myocardial ischemia and reperfusion injury by attenuating oxidative stress and apoptosis in ratsQ35666649
Intramitochondrial hydrogen sulfide production by 3-mercaptopyruvate sulfurtransferase maintains mitochondrial electron flow and supports cellular bioenergeticsQ39252442
Differing effects of exogenous and endogenous hydrogen sulphide in carrageenan-induced knee joint synovitis in the rat.Q39291389
H2S dependent and independent anti-inflammatory activity of zofenoprilat in cells of the vascular wall.Q39369158
Enhanced detection of hydrogen sulfide generated in cell culture using an agar trap methodQ39406950
Hydrogen sulfide-releasing NSAIDs inhibit the growth of human cancer cells: a general property and evidence of a tissue type-independent effectQ39416914
H2S releasing aspirin protects amyloid beta induced cell toxicity in BV-2 microglial cellsQ39501848
Thioredoxin and dihydrolipoic acid are required for 3-mercaptopyruvate sulfurtransferase to produce hydrogen sulfideQ39511939
Hydrogen sulfide contributes to hypoxic inhibition of airway transepithelial sodium absorptionQ39578261
S-Propargyl-cysteine (SPRC) attenuated lipopolysaccharide-induced inflammatory response in H9c2 cells involved in a hydrogen sulfide-dependent mechanism.Q39595060
Quantitative Persulfide Site Identification (qPerS-SID) Reveals Protein Targets of H2S Releasing Donors in Mammalian CellsQ39605149
Pharmacological postconditioning against myocardial infarction with a slow-releasing hydrogen sulfide donor, GYY4137.Q39631796
GYY4137, a novel hydrogen sulfide-releasing molecule, protects against endotoxic shock in the rat.Q39859585
Markedly reduced toxicity of a hydrogen sulphide-releasing derivative of naproxen (ATB-346).Q39884340
Hydrogen sulfide depletion contributes to microvascular remodeling in obesityQ39906675
Perspective on recent developments on sulfur-containing agents and hydrogen sulfide signalingQ40035000
Surviving blood loss using hydrogen sulfideQ40077365
Preconditioning of H2S inhalation protects against cerebral ischemia/reperfusion injury by induction of HSP70 through PI3K/Akt/Nrf2 pathwayQ40102686
Menadione effect on l-cysteine desulfuration in U373 cells.Q40129178
NOSH-aspirin (NBS-1120), a novel nitric oxide- and hydrogen sulfide-releasing hybrid has enhanced chemo-preventive properties compared to aspirin, is gastrointestinal safe with all the classic therapeutic indicationsQ40138226
Hydrogen Sulfide in Exhaled Gases From Ventilated Septic Neonates and Children: A Preliminary ReportQ40169637
S-allyl cysteine alleviates nonsteroidal anti-inflammatory drug-induced gastric mucosal damages by increasing cyclooxygenase-2 inhibition, heme oxygenase-1 induction, and histone deacetylation inhibitionQ40177294
Recombinant adeno-associated virus mediated gene transfer in a mouse model for homocystinuriaQ40187095
Cytoprotective and antioxidant role of diallyl tetrasulfide on cadmium induced renal injury: an in vivo and in vitro studyQ40204626
Hydrogen sulfide inhibits nitric oxide production and nuclear factor-kappaB via heme oxygenase-1 expression in RAW264.7 macrophages stimulated with lipopolysaccharideQ40266368
Hydrogen sulfide protects HT22 neuronal cells from oxidative stressQ40283312
Protective effects of garlic sulfur compounds against DNA damage induced by direct- and indirect-acting genotoxic agents in HepG2 cellsQ40295924
Toxicology of thiono-sulfur compoundsQ40331713
Anethole dithiolethione: biochemical considerationsQ40369484
Hydrogen Sulfide Is an Antiviral and Antiinflammatory Endogenous Gasotransmitter in the Airways. Role in Respiratory Syncytial Virus Infection.Q40476846
Hydrogen sulfide-induced relaxation of resistance mesenteric artery beds of ratsQ40504398
Mitochondrially targeted compounds and their impact on cellular bioenergeticsQ40513041
The novel neuromodulator hydrogen sulfide: an endogenous peroxynitrite 'scavenger'?Q40535164
GYY4137 attenuates remodeling, preserves cardiac function and modulates the natriuretic peptide response to ischemiaQ40646334
Dapsone intoxication: two case reportsQ40677801
The effect of a hydrogen sulfide releasing molecule (Na2S) on the cold storage of livers from cardiac dead donor rats. A study in an ex vivo model.Q40818312
Hydrogen sulfide improves resuscitation via non-hibernatory mechanisms in a porcine shock modelQ40959455
Detection of exhaled hydrogen sulphide gas in healthy human volunteers during intravenous administration of sodium sulphideQ40985662
Effect of CCl4 and blocking H2S biosynthesis on oesophageal mucosa rats: model of nonerosive oesophagitisQ41043660
Active cystathionine beta-synthase can be expressed in heme-free systems in the presence of metal-substituted porphyrins or a chemical chaperoneQ41177625
Hydrogen sulfide mediates the cardioprotective effects of gene therapy with PKG-Iα.Q41189484
Cystathionine γ-lyase is expressed in human atherosclerotic plaque microvessels and is involved in micro-angiogenesisQ41344125
Fragment-based de novo design of a cystathionine γ-lyase selective inhibitor blocking hydrogen sulfide productionQ41344548
NOSH-aspirin (NBS-1120), a dual nitric oxide and hydrogen sulfide-releasing hybrid, reduces inflammatory painQ41360072
Hydrogen sulfide poisoning: an antidotal role for sodium nitrite?Q41484614
Modulation of angiogenesis by dithiolethione-modified NSAIDs and valproic acid.Q41556578
A distal ligand mutes the interaction of hydrogen sulfide with human neuroglobinQ41598860
A Novel H2S-releasing Amino-Bisphosphonate which combines bone anti-catabolic and anabolic functions.Q41696640
Hydrogen sulfide-releasing cyclooxygenase inhibitor ATB-346 enhances motor function and reduces cortical lesion volume following traumatic brain injury in mice.Q41729974
Hydrogen sulfide decreases adenosine triphosphate levels in aortic rings and leads to vasorelaxation via metabolic inhibitionQ41906351
Organelle-Targeted H2S Probes Enable Visualization of the Subcellular Distribution of H2S DonorsQ41980247
Detection of exhaled hydrogen sulphide gas in rats exposed to intravenous sodium sulphideQ41990618
Inhaled hydrogen sulfide protects against lipopolysaccharide-induced acute lung injury in miceQ41994150
Cysteine-activated hydrogen sulfide (H2S) donors.Q42005921
Complementary roles of gasotransmitters CO and H2S in sleep apneaQ42064248
Hydrogen sulfide poisoning treated with hyperbaric oxygenQ42087523
Anethole dithiolethione lowers the homocysteine and raises the glutathione levels in solid tissues and plasma of rats: a novel non-vitamin homocysteine-lowering agent.Q42120299
Characterization of the enzymic capacity for cysteine desulphhydration in liver and kidney of the ratQ42122753
Interdependency of cystathione γ-lyase and cystathione β-synthase in hydrogen sulfide-induced blood pressure regulation in ratsQ35671857
Regulation of Vascular Tone, Angiogenesis and Cellular Bioenergetics by the 3-Mercaptopyruvate Sulfurtransferase/H2S Pathway: Functional Impairment by Hyperglycemia and Restoration by DL-α-Lipoic Acid.Q35707083
Cystathionine beta-synthase: structure, function, regulation, and location of homocystinuria-causing mutationsQ35747052
Protective effects of hydrogen sulfide inhalation on oxidative stress in rats with cotton smoke inhalation-induced lung injuryQ35803214
Effect of the Inhibition of Hydrogen Sulfide Synthesis on Ischemic Injury and Oxidative Stress Biomarkers in a Transient Model of Focal Cerebral Ischemia in Rats.Q35811498
Cinaciguat, a novel activator of soluble guanylate cyclase, protects against ischemia/reperfusion injury: role of hydrogen sulfide.Q35850118
Folding and activity of mutant cystathionine β-synthase depends on the position and nature of the purification tag: characterization of the R266K CBS mutantQ35869955
Detrimental effects for colonocytes of an increased exposure to luminal hydrogen sulfide: The adaptive responseQ35916188
Hydrogen Sulfide--Mechanisms of Toxicity and Development of an AntidoteQ35923856
A practical look at the chemistry and biology of hydrogen sulfideQ35929034
Inhaled hydrogen sulfide prevents endotoxin-induced systemic inflammation and improves survival by altering sulfide metabolism in mice.Q35929055
Hydrogen sulfide in biochemistry and medicineQ35929408
Homocystinuria: a study with low-methionine diet in three patientsQ35934134
NOSH-sulindac (AVT-18A) is a novel nitric oxide- and hydrogen sulfide-releasing hybrid that is gastrointestinal safe and has potent anti-inflammatory, analgesic, antipyretic, anti-platelet, and anti-cancer properties.Q36017220
Hydrogen sulphide-releasing diclofenac derivatives inhibit breast cancer-induced osteoclastogenesis in vitro and prevent osteolysis ex vivoQ36025402
The polysulfide diallyl trisulfide protects the ischemic myocardium by preservation of endogenous hydrogen sulfide and increasing nitric oxide bioavailabilityQ36042694
Enhanced activity of a hydrogen sulphide-releasing derivative of mesalamine (ATB-429) in a mouse model of colitisQ36052635
Regulation of vascular nitric oxide in vitro and in vivo; a new role for endogenous hydrogen sulphide?Q36054349
Dietary treatment of homocystinuriaQ36061315
Polymorphic Variants of Human Rhodanese Exhibit Differences in Thermal Stability and Sulfur Transfer KineticsQ36093046
Mechanistic basis of enzyme-targeted drugsQ36094899
Capsaicin-Sensitive Sensory Nerves Mediate the Cellular and Microvascular Effects of H2S via TRPA1 Receptor Activation and Neuropeptide Release.Q36104085
Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitorsQ36111918
Increased endogenous H2S generation by CBS, CSE, and 3MST gene therapy improves ex vivo renovascular relaxation in hyperhomocysteinemiaQ36114692
Synthesis and anti-cancer potential of the positional isomers of NOSH-aspirin (NBS-1120) a dual nitric oxide and hydrogen sulfide releasing hybridQ36119481
Biological thiols-triggered hydrogen sulfide releasing microfibers for tissue engineering applications.Q36173769
NOSH-Aspirin: A Novel Nitric Oxide-Hydrogen Sulfide-Releasing Hybrid: A New Class of Anti-inflammatory PharmaceuticalsQ36176425
Cardioprotective effects and pharmacokinetic properties of a controlled release formulation of a novel hydrogen sulfide donor in rats with acute myocardial infarctionQ36185207
Nitric Oxide and Hydrogen Sulfide Interact When Modulating Gastric Physiological Functions in Rodents.Q36198431
Toxicology of Hydrogen SulfideQ36213459
Molecular mechanisms underlying histological and biochemical changes induced by nitrate in rat liver and the efficacy of S-Allylcysteine.Q36222560
H2S, a novel gasotransmitter, involves in gastric accommodationQ36245777
Evidence that d-cysteine protects mice from gastric damage via hydrogen sulfide produced by d-amino acid oxidaseQ36264264
S-Propargyl-Cysteine, a Novel Hydrogen Sulfide Donor, Inhibits Inflammatory Hepcidin and Relieves Anemia of Inflammation by Inhibiting IL-6/STAT3 PathwayQ28554256
Thioredoxin-dependent enzymatic activation of mercaptopyruvate sulfurtransferase. An intersubunit disulfide bond serves as a redox switch for activationQ28567305
Hydrogen sulfide-mediated stimulation of mitochondrial electron transport involves inhibition of the mitochondrial phosphodiesterase 2A, elevation of cAMP and activation of protein kinase AQ28574416
Hormonal regulation of cystathionine beta-synthase expression in liverQ28581820
Broad-Range Antiviral Activity of Hydrogen Sulfide Against Highly Pathogenic RNA VirusesQ28582806
S-Propargyl-cysteine, a novel hydrogen sulfide-modulated agent, attenuates lipopolysaccharide-induced spatial learning and memory impairment: Involvement of TNF signaling and NF-κB pathway in ratsQ28583198
Biogenesis of reactive sulfur species for signaling by hydrogen sulfide oxidation pathwaysQ28601441
Discovery and Mechanistic Characterization of Selective Inhibitors of H2S-producing Enzyme: 3-Mercaptopyruvate Sulfurtransferase (3MST) Targeting Active-site Cysteine PersulfideQ28817472
Self-Immolative Thiocarbamates Provide Access to Triggered H2S Donors and Analyte Replacement Fluorescent ProbesQ28829960
Synthesis of Amino-ADT Provides Access to Hydrolytically Stable Amide-Coupled Hydrogen Sulfide Releasing Drug TargetsQ28831055
Pyridoxal phosphate enzymes: mechanistic, structural, and evolutionary considerationsQ29620045
Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics.Q30355313
H2S-releasing nanoemulsions: a new formulation to inhibit tumor cells proliferation and improve tissue repair.Q30358087
Working with "H2S": facts and apparent artifacts.Q30363652
Human polycomb 2 protein is a SUMO E3 ligase and alleviates substrate-induced inhibition of cystathionine beta-synthase sumoylationQ30440592
Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial functionQ30480176
Hydrogen sulfide improves survival after cardiac arrest and cardiopulmonary resuscitation via a nitric oxide synthase 3-dependent mechanism in mice.Q30491252
Using a functional enzyme model to understand the chemistry behind hydrogen sulfide induced hibernation.Q30492583
Hydrogen sulfide is an endogenous stimulator of angiogenesis.Q30492603
Redox biochemistry of hydrogen sulfideQ30495475
Hydrogen sulfide (H2S) metabolism in mitochondria and its regulatory role in energy productionQ30505673
Is hydrogen sulfide-induced suspended animation general anesthesia?Q30514252
Urinary sulfur metabolites associate with a favorable cardiovascular risk profile and survival benefit in renal transplant recipientsQ30578815
A Long-Term and Slow-Releasing Hydrogen Sulfide Donor Protects against Myocardial Ischemia/Reperfusion InjuryQ30855744
AP39, a Mitochondria-Targeted Hydrogen Sulfide Donor, Supports Cellular Bioenergetics and Protects against Alzheimer's Disease by Preserving Mitochondrial Function in APP/PS1 Mice and NeuronsQ31071777
Sustained-Release Delivery System of a Slow Hydrogen Sulfide Donor, GYY 4137, for Potential Application in GlaucomaQ31155331
The cystine/cysteine cycle: a redox cycle regulating susceptibility versus resistance to cell deathQ33298076
Gene expression changes following acute hydrogen sulfide (H2S)-induced nasal respiratory epithelial injuryQ33333240
New method for quantification of gasotransmitter hydrogen sulfide in biological matrices by LC-MS/MS.Q33559882
Preclinical assessment of the distribution, metabolism, and excretion of S-propargyl-cysteine, a novel H2S donor, in Sprague-Dawley ratsQ33567488
Differential mechanisms underlying neuroprotection of hydrogen sulfide donors against oxidative stressQ33692977
Inhaled hydrogen sulfide: a rapidly reversible inhibitor of cardiac and metabolic function in the mouseQ33726946
Is pharmacological, H₂S-induced 'suspended animation' feasible in the ICU?Q33764969
Interactions of the major metabolite of the cancer chemopreventive drug oltipraz with cytochrome c: a novel pathway for cancer chemopreventionQ33815474
Ammonium tetrathiomolybdate following ischemia/reperfusion injury: Chemistry, pharmacology, and impact of a new class of sulfide donor in preclinical injury models.Q33873758
Positional isomerism markedly affects the growth inhibition of colon cancer cells by NOSH-aspirin: COX inhibition and modeling.Q38839698
Hydrogen sulfide inhalation ameliorates allergen induced airway hypereactivity by modulating mast cell activationQ38846453
Hydrogen Sulfide Treatment Mitigates Renal Allograft Ischemia-Reperfusion Injury during Cold Storage and Improves Early Transplant Kidney Function and Survival Following Allogeneic Renal TransplantationQ38846635
L-Cysteine/D,L-homocysteine-regulated ileum motility via system L and B°(,+) transporter: Modification by inhibitors of hydrogen sulfide synthesis and dietary treatmentsQ38850455
Discovery of New H2S Releasing Phosphordithioates and 2,3-Dihydro-2-phenyl-2-sulfanylenebenzo[d][1,3,2]oxazaphospholes with Improved Antiproliferative Activity.Q38856414
Diallyl trisulfide protects against high glucose-induced cardiac apoptosis by stimulating the production of cystathionine gamma-lyase-derived hydrogen sulfideQ38865887
The protective effects of endogenous hydrogen sulfide modulator, S-propargyl-cysteine, on high glucose-induced apoptosis in cardiomyocytes: A novel mechanism mediated by the activation of Nrf2.Q38874251
Diallyl trisufide protects against oxygen glucose deprivation -induced apoptosis by scavenging free radicals via the PI3K/Akt -mediated Nrf2/HO-1 signaling pathway in B35 neural cellsQ38884095
Garlic-derived natural polysulfanes as hydrogen sulfide donors: Friend or foe?Q38901220
Oxidation of H2S in mammalian cells and mitochondria.Q38905194
Use of phosphorodithioate-based compounds as hydrogen sulfide donorsQ38905197
Glutathione-garlic sulfur conjugates: slow hydrogen sulfide releasing agents for therapeutic applications.Q38917841
Sirtuin 6 is essential for sodium sulfide-mediated cytoprotective effect in ischemia/reperfusion-stimulated brain endothelial cellsQ38925091
Regulation and role of endogenously produced hydrogen sulfide in angiogenesisQ38939480
Evaluating the anti-neuroinflammatory capacity of raw and steamed garlic as well as five organosulfur compounds.Q38943205
Hydrogen sulfide alleviates hypertensive kidney dysfunction through an epigenetic mechanismQ38954601
Role of the cystathionine γ lyase/hydrogen sulfide pathway in human melanoma progression.Q38957953
Biological chemistry of hydrogen sulfide and persulfides.Q38971040
Hydrogen sulfide, an enhancer of vascular nitric oxide signaling: mechanisms and implicationsQ38991916
Metabolic, Cardiac, and Renal Effects of the Slow Hydrogen Sulfide-Releasing Molecule GYY4137 During Resuscitated Septic Shock in Swine with Pre-Existing Coronary Artery DiseaseQ39010015
GYY4137, a hydrogen sulfide (H₂S) donor, shows potent anti-hepatocellular carcinoma activity through blocking the STAT3 pathwayQ39023096
Functional and Molecular Insights of Hydrogen Sulfide Signaling and Protein SulfhydrationQ39053014
Hydrogen Sulfide as a "Double-Faced" Compound: One with Pro- and Antioxidant EffectQ39068763
Boiling enriches the linear polysulfides and the hydrogen sulfide-releasing activity of garlicQ39097705
Vascular biology of hydrogen sulfideQ39113984
NOSH-aspirin (NBS-1120), a novel nitric oxide and hydrogen sulfide releasing hybrid, attenuates neuroinflammation induced by microglial and astrocytic activation: a new candidate for treatment of neurodegenerative disordersQ39114886
Dysregulation of cystathionine γ-lyase (CSE)/hydrogen sulfide pathway contributes to ox-LDL-induced inflammation in macrophageQ39122959
S-Transnitrosation reactions of hydrogen sulfide (H2S/HS-/S2-) with S-nitrosated cysteinyl thiols in phosphate buffer of pH 7.4: Results and review of the literatureQ39129878
Oxidative stress suppresses the cellular bioenergetic effect of the 3-mercaptopyruvate sulfurtransferase/hydrogen sulfide pathwayQ39174189
The gasotransmitter hydrogen sulfide induces nrf2-target genes by inactivating the keap1 ubiquitin ligase substrate adaptor through formation of a disulfide bond between cys-226 and cys-613.Q39245992
Synthesis and biological activity of NOSH-naproxen (AVT-219) and NOSH-sulindac (AVT-18A) as potent anti-inflammatory agents with chemotherapeutic potentialQ42159113
Light-induced hydrogen sulfide release from "caged" gem-dithiols.Q42160193
Hydrogen Sulfide Oxidation by Myoglobin.Q42212484
Esterase-Sensitive Prodrugs with Tunable Release Rates and Direct Generation of Hydrogen Sulfide.Q42252277
Downregulation of cystathionine β-synthase and cystathionine γ-lyase expression stimulates inflammation in kidney ischemia-reperfusion injuryQ42252740
Characterization of zofenoprilat as an inducer of functional angiogenesis through increased H2 S availability.Q42268714
Hydrogen Sulfide Prevents Formation of Reactive Oxygen Species through PI3K/Akt Signaling and Limits Ventilator-Induced Lung InjuryQ42321800
The Effect of Garlic Derivatives (S-Allylmercaptocysteine, Diallyl Disulfide, and S-Allylcysteine) on Gentamicin Induced Ototoxicity: An Experimental Study.Q42366049
Heme-dependent Metabolite Switching Regulates H2S Synthesis in Response to Endoplasmic Reticulum (ER) Stress.Q42380152
Therapeutic Delivery of H2S via COS: Small Molecule and Polymeric Donors with Benign Byproducts.Q42381107
Controlled release hydrogen sulfide delivery system based on mesoporous silica nanoparticles protects graft endothelium from ischemia-reperfusion injuryQ42407985
A monobromobimane-based assay to measure the pharmacokinetic profile of reactive sulphide species in bloodQ42429578
Cytotoxic effects of hydrogen sulfide on pulmonary alveolar macrophages in ratsQ42476413
Mechanism of vasorelaxation and role of endogenous hydrogen sulfide production in mouse aorta.Q42484213
S-Sulfhydration of ATP synthase by hydrogen sulfide stimulates mitochondrial bioenergeticsQ42498020
Sildenafil effect on the human bladder involves the L-cysteine/hydrogen sulfide pathway: a novel mechanism of action of phosphodiesterase type 5 inhibitorsQ42510309
Iminothioethers as Hydrogen Sulfide Donors: From the Gasotransmitter Release to the Vascular Effects.Q42513564
Protective and Detrimental Effects of Sodium Sulfide and Hydrogen Sulfide in Murine Ventilator-induced Lung InjuryQ42567549
Characterization and interaction studies of two isoforms of the dual localized 3-mercaptopyruvate sulfurtransferase TUM1 from humansQ42580601
Gaseotransmitters: New Frontiers for Translational ScienceQ42600835
In vitro-controlled release delivery system for hydrogen sulfide donorQ42752973
Inhaled Hydrogen Sulfide Prevents Neurodegeneration and Movement Disorder in a Mouse Model of Parkinson's DiseaseQ42764683
The hypothesis of the main role of H2S in coupled sulphide-nitroso signalling pathwayQ42778920
Pharmacological profile of a novel H(2)S-releasing aspirinQ42804885
A comparative study on the anti-inflammatory effects of single oral doses of naproxen and its hydrogen sulfide (H2S)-releasing derivative ATB-346 in rats with carrageenan-induced synovitis.Q42861082
Thiol-activated gem-dithiols: a new class of controllable hydrogen sulfide donors.Q42865592
Activity of a new hydrogen sulfide-releasing aspirin (ACS14) on pathological cardiovascular alterations induced by glutathione depletion in rats.Q42913506
Crosstalk between hydrogen sulfide and nitric oxide in endothelial cellsQ42914546
Hydrogen sulfide is an endogenous inhibitor of phosphodiesterase activity.Q42969013
Systemic peripheral artery relaxation by KCNQ channel openers and hydrogen sulfideQ43006034
Adiposity is a major determinant of plasma levels of the novel vasodilator hydrogen sulphideQ43087876
Hydrogen sulfide improves neutrophil migration and survival in sepsis via K+ATP channel activationQ43118261
Modulation of thiol homeostasis induced by H2S-releasing aspirinQ43156037
L-cysteine stimulates hydrogen sulfide synthesis in myocardium associated with attenuation of ischemia-reperfusion injury.Q43172655
Cardiac and metabolic effects of hypothermia and inhaled hydrogen sulfide in anesthetized and ventilated miceQ43186198
Effect of hydrogen sulfide on myocardial protection in the setting of cardioplegia and cardiopulmonary bypassQ43201845
Protective effects of cysteine analogues on acute myocardial ischemia: novel modulators of endogenous H(2)S production.Q43258277
ACS67, a hydrogen sulfide-releasing derivative of latanoprost acid, attenuates retinal ischemia and oxidative stress to RGC-5 cells in cultureQ43285272
Biochemical and cytologic alterations in the respiratory tract of rats exposed for 4 hours to hydrogen sulfideQ43567625
Effects of organosulfur compounds from garlic oil on the antioxidation system in rat liver and red blood cellsQ43603072
Urinary sulfur compounds in Down syndrome.Q43684805
Role of cystathionine β-synthase in human breast CancerQ43800252
The role of hydrogen sulphide in the control of breathing in hypoxic zebrafish (Danio rerio).Q43803750
The effect of hydrogen sulfide donors on lipopolysaccharide-induced formation of inflammatory mediators in macrophagesQ33875055
H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO-TRPA1-CGRP signalling pathwayQ33924111
Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness.Q33924974
The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivoQ33942063
H2S donor, S-propargyl-cysteine, increases CSE in SGC-7901 and cancer-induced mice: evidence for a novel anti-cancer effect of endogenous H2S?Q33954567
S-diclofenac protects against doxorubicin-induced cardiomyopathy in mice via ameliorating cardiac gap junction remodelingQ34062431
Inhaled hydrogen sulfide induces suspended animation, but does not alter the inflammatory response after blunt chest traumaQ34076127
Brain phenotype of transgenic mice overexpressing cystathionine β-synthaseQ34130338
H2S Synthesizing Enzymes: Biochemistry and Molecular Aspects.Q38545008
Hydrogen Sulfide and Urogenital Tract.Q38545017
H2S and Inflammation: An OverviewQ38545022
Hydrogen Sulfide and NeuroinflammationQ38545023
H2S and Pain: A Novel Aspect for Processing of Somatic, Visceral and Neuropathic Pain SignalsQ38545028
H2S: A New Approach to Lifespan Enhancement and Healthy Ageing?Q38545032
The Pharmacological Effects of S-Propargyl-Cysteine, a Novel Endogenous H2S-Producing CompoundQ38545035
Phosphinodithioate and Phosphoramidodithioate Hydrogen Sulfide DonorsQ38545038
One- and two-electron oxidation of thiols: mechanisms, kinetics and biological fatesQ38578487
A critical review of the literature on hydrogen sulfide toxicityQ38583535
Nitric Oxide and Hydrogen Sulfide Regulation of Ischemic Vascular Remodeling.Q38588632
Effects of inhibitors of hydrogen sulphide synthesis on rat colonic motility.Q38649892
The Role of Hydrogen Sulfide in Evolution and the Evolution of Hydrogen Sulfide in Metabolism and SignalingQ38671099
The Effects of Oltipraz on Tissue Regeneration in the Process of Wound Healing: A Stereological Study.Q38679798
The role of hydrogen sulfide in burnsQ38704225
Hydrogen sulfide in hypertensionQ38710992
Discovery of medium ring thiophosphorus based heterocycles as antiproliferative agentsQ38721596
Ammonium tetrathiomolybdate as a water-soluble and slow-release hydrogen sulfide donor.Q38730945
Hydrogen Sulfide-Releasing Therapeutics: Translation to the ClinicQ38733463
Synthesis and biological evaluation of novel hydrogen sulfide releasing nicotinic acid derivativesQ38746792
GYY4137 ameliorates intestinal barrier injury in a mouse model of endotoxemiaQ38750577
Targeting Cystathionine Beta-Synthase Misfolding in Homocystinuria by Small Ligands: State of the Art and Future DirectionsQ38756682
Cardioprotection by H2S Donors: Nitric Oxide-Dependent and ‑Independent MechanismsQ38762356
H2S-Donating Doxorubicins May Overcome Cardiotoxicity and Multidrug ResistanceQ38775062
Diallyl trisulfide protects against ethanol-induced oxidative stress and apoptosis via a hydrogen sulfide-mediated mechanism.Q38776072
Hydrogen sulfide protects H9c2 cardiac cells against doxorubicin-induced cytotoxicity through the PI3K/Akt/FoxO3a pathwayQ38778052
The cytotoxicity of garlic-related disulphides and thiosulfonates in WHCO1 oesophageal cancer cells is dependent on S-thiolation and not production of ROS.Q38779872
Synthesis and antitumor activity of ATB-429 derivatives containing a nitric oxide-releasing moietyQ38784805
Synthesis and biological evaluation of novel hydrogen sulfide releasing glycyrrhetic acid derivativesQ38792152
Maternal melatonin or N-acetylcysteine therapy regulates hydrogen sulfide-generating pathway and renal transcriptome to prevent prenatal NG-Nitro-L-arginine-methyl ester (L-NAME)-induced fetal programming of hypertension in adult male offspring.Q38803978
Hydrogen Sulfide Donors Activated by Reactive Oxygen SpeciesQ38806800
A novel slow-releasing hydrogen sulfide donor, FW1256, exerts anti-inflammatory effects in mouse macrophages and in vivo.Q38809420
Macromolecular Hydrogen Sulfide Donors Trigger Spatiotemporally Confined Changes in Cell Signaling.Q38812934
Hydrogen sulfide augments neutrophil migration through enhancement of adhesion molecule expression and prevention of CXCR2 internalization: role of ATP-sensitive potassium channelsQ43909191
Management of acute sulfide poisoning. Effects of oxygen, thiosulfate, and nitriteQ43962352
A randomized phase IIb trial of anethole dithiolethione in smokers with bronchial dysplasiaQ44049327
Correction of endothelial dysfunction after selective homocysteine lowering gene therapy reduces arterial thrombogenicity but has no effect on atherogenesis.Q44088074
Polysulfides are possible H2S-derived signaling molecules in rat brain.Q44122492
A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cellsQ44131370
Hydrogen sulphide triggers VEGF-induced intracellular Ca²⁺ signals in human endothelial cells but not in their immature progenitors.Q44169318
S-propargyl-cysteine (ZYZ-802), a sulphur-containing amino acid, attenuates beta-amyloid-induced cognitive deficits and pro-inflammatory response: involvement of ERK1/2 and NF-κB pathway in ratsQ44301714
A novel orally administered trimebutine compound (GIC-1001) is anti-nociceptive and features peripheral opioid agonistic activity and Hydrogen Sulphide-releasing capacity in mice.Q44333395
Hydrogen sulfide prevents ethanol-induced gastric damage in mice: role of ATP-sensitive potassium channels and capsaicin-sensitive primary afferent neurons.Q44572022
Modulation of endogenous production of H2S in rat tissuesQ44653708
The possible role of hydrogen sulfide on the pathogenesis of spontaneous hypertension in ratsQ44691266
Anti-inflammatory and gastrointestinal effects of a novel diclofenac derivativeQ44706021
Hydrogen sulfide induces calcium waves in astrocytes.Q44735803
The interaction of estrogen and CSE/H2S pathway in the development of atherosclerosisQ44868846
Hydrogen sulfide protects neurons from oxidative stressQ44904699
Thiosulfate: a readily accessible source of hydrogen sulfide in oxygen sensingQ44933023
L-Cysteine promotes the proliferation and differentiation of neural stem cells via the CBS/H₂S pathwayQ45005785
Peptide-based hydrogen sulphide-releasing gels.Q45016507
Acetylenic enzyme inactivators. Inactivation of gamma-cystathionase, in vitro and in vivo, by propargylglycineQ45307357
Systemic hydrogen sulfide administration partially restores normal alveolarization in an experimental animal model of bronchopulmonary dysplasiaQ45743135
Physiological effects of hydrogen sulfide inhalation during exercise in healthy menQ45782129
Cystathionine-beta-synthase gene transfer and 3-deazaadenosine ameliorate inflammatory response in endothelial cellsQ45871031
Novel Angiogenic Activity and Molecular Mechanisms of ZYZ-803, a Slow-Releasing Hydrogen Sulfide-Nitric Oxide Hybrid Molecule.Q45885946
Effect of hydrogen sulfide in a porcine model of myocardial ischemia-reperfusion: comparison of different administration regimens and characterization of the cellular mechanisms of protection.Q45924442
S-propargyl-cysteine protects both adult rat hearts and neonatal cardiomyocytes from ischemia/hypoxia injury: the contribution of the hydrogen sulfide-mediated pathway.Q45957950
Hydrogen sulfide-releasing NSAIDs attenuate neuroinflammation induced by microglial and astrocytic activation.Q45959353
Inhibitory effect of novel diallyldisulfide analogs on HMG-CoA reductase expression in hypercholesterolemic rats: CREB as a potential upstream target.Q45970576
Downregulation of the renal and hepatic hydrogen sulfide (H2S)-producing enzymes and capacity in chronic kidney disease.Q45986959
Role of paraoxonase-1 in the protection of hydrogen sulfide-donating sildenafil (ACS6) against homocysteine-induced neurotoxicityQ46041979
Endogenous and exogenous hydrogen sulfide promotes resolution of colitis in ratsQ46046531
Pancreatic islet overproduction of H2S and suppressed insulin release in Zucker diabetic ratsQ46252508
Role of hydrogen sulfide in the development of atherosclerotic lesions in apolipoprotein E knockout miceQ46260974
Regulatory effect of hydrogen sulfide on vascular collagen content in spontaneously hypertensive ratsQ46275634
Whole tissue hydrogen sulfide concentrations are orders of magnitude lower than presently accepted valuesQ46361411
Inhibitory effect of copper on cystathionine beta-synthase activity: protective effect of an analog of the human albumin N-terminusQ46389605
Endogenous hydrogen sulfide regulates inflammatory response by activating the ERK pathway in polymicrobial sepsisQ46392031
Structural and Mechanistic Insights into Hemoglobin-catalyzed Hydrogen Sulfide Oxidation and the Fate of Polysulfide Products.Q46416014
Effect of S-diclofenac, a novel hydrogen sulfide releasing derivative inhibit rat vascular smooth muscle cell proliferationQ46445452
Generation of endogenous hydrogen sulfide by cystathionine gamma-lyase limits renal ischemia/reperfusion injury and dysfunctionQ46446506
Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouseQ46465914
Serum free sulfhydryl status is associated with patient and graft survival in renal transplant recipients.Q46473896
The novel H2S-donor 4-carboxyphenyl isothiocyanate promotes cardioprotective effects against ischemia/reperfusion injury through activation of mitoKATP channels and reduction of oxidative stressQ46475883
Protective effects of diallyl sulfide, a garlic constituent, on the warm hepatic ischemia-reperfusion injury in a rat model.Q46484123
Mitochondria-Targeted Agents: Mitochondriotropics, Mitochondriotoxics, and MitocansQ46494088
Synthesis of a photocontrollable hydrogen sulfide donor using ketoprofenate photocagesQ46508139
Dual role of hydrogen sulfide in mechanical inflammatory hypernociceptionQ46514150
Hydrogen sulphide is involved in testosterone vascular effect.Q46568548
Hydrogen sulfide regulates lung tissue-oxidized glutathione and total antioxidant capacity in hypoxic pulmonary hypertensive ratsQ46577544
Hydrogen sulfide protects rat lung from ischemia-reperfusion injuryQ46593773
The possible role of hydrogen sulfide as an endogenous neuromodulator.Q46606180
Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfideQ46621665
Changes of the new gaseous transmitter H2S in patients with coronary heart diseaseQ46658029
Direct stimulation of K(ATP) channels by exogenous and endogenous hydrogen sulfide in vascular smooth muscle cellsQ46693585
High-throughput tandem-microwell assay identifies inhibitors of the hydrogen sulfide signaling pathwayQ46699363
Plasma hydrogen sulfide and homocysteine levels in hypertensive patients with different blood pressure levels and complicationsQ46701305
Hydrogen sulfide accelerates the recovery of kidney tubules after renal ischemia/reperfusion injuryQ46705377
Exogenous Hydrogen Sulfide Attenuates Cardiac Fibrosis Through Reactive Oxygen Species Signal Pathways in Experimental Diabetes Mellitus ModelsQ46713047
Do garlic-derived allyl sulfides scavenge peroxyl radicals?Q46713306
Hemodynamic and metabolic effects of hydrogen sulfide during porcine ischemia/reperfusion injury.Q46715911
Mitochondria-targeted hydrogen sulfide donor AP39 improves neurological outcomes after cardiac arrest in mice.Q46730611
The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide.Q46738154
H2S: a universal defense against antibiotics in bacteriaQ46754342
Different patterns of H2S/NO activity and cross-talk in the control of the coronary vascular bed under normotensive or hypertensive conditionsQ46755862
Calcium polysulfide overdose: a report of two casesQ46797896
Hydrogen sulphide in the hypothalamus causes an ATP-sensitive K+ channel-dependent decrease in blood pressure in freely moving rats.Q46803560
Endogenous hydrogen sulfide contributes to the cardioprotection by metabolic inhibition preconditioning in the rat ventricular myocytesQ46833532
Hydrogen sulfide releasing capacity of natural isothiocyanates: is it a reliable explanation for the multiple biological effects of Brassicaceae?Q46874690
Aspirin augments the concentration of endogenous hydrogen sulfide in mouse brain and liver.Q46882152
Changes in intracellular pH play a secondary role in hydrogen sulfide-induced nasal cytotoxicityQ46884546
Role of hydrogen sulfide in cecal ligation and puncture-induced sepsis in the mouseQ46905143
Hydrogen sulphide-induced hypothermia attenuates stress-related ulceration in ratsQ46946123
Hydrogen sulfide facilitates carotid sinus baroreflex in anesthetized ratsQ46953703
Possible role for the novel gasotransmitter hydrogen sulphide in erectile dysfunction--a pilot studyQ46983043
Role of KATP channels and TRPV1 receptors in hydrogen sulfide-enhanced gastric emptying of liquid in awake miceQ47275682
Hydrogen Sulfide Protects Renal Grafts Against Prolonged Cold Ischemia-Reperfusion Injury via Specific Mitochondrial ActionsQ47663417
All in the timing: a comparison between the cardioprotection induced by H2S preconditioning and post-infarction treatmentQ47690370
In situ depot comprising phase-change materials that can sustainably release a gasotransmitter H2S to treat diabetic woundsQ47751620
A timeline of hydrogen sulfide (H2S) research: From environmental toxin to biological mediatorQ47762321
Trypsin cleavage of human cystathionine beta-synthase into an evolutionarily conserved active core: structural and functional consequencesQ47800302
Inhibition of Mitochondrial Bioenergetics by Esterase-Triggered COS/H2S Donors.Q47863298
A hydrogen sulfide-releasing cyclooxygenase inhibitor markedly accelerates recovery from experimental spinal cord injuryQ47894844
Respiratory tract toxicity of inhaled hydrogen sulfide in Fischer-344 rats, Sprague-Dawley rats, and B6C3F1 mice following subchronic (90-day) exposureQ47966448
Neuroprotective effects of lentivirus-mediated cystathionine-beta-synthase overexpression against 6-OHDA-induced parkinson's disease ratsQ48003246
Hydrogen sulfide induces heme oxygenase-1 in human kidney cells.Q48009046
Nucleoside monophosphorothioates as the new hydrogen sulfide precursors with unique properties.Q48022089
AP39, a mitochondria-targeting hydrogen sulfide (H2 S) donor, protects against myocardial reperfusion injury independently of salvage kinase signallingQ48024405
Biogenesis of Hydrogen Sulfide and Thioethers by Cystathionine Beta-SynthaseQ48032377
Pharmacological characterization of the vascular effects of aryl isothiocyanates: is hydrogen sulfide the real player?Q48034814
Hydrogen sulfide intoxicationQ48070542
Hydrogen Sulfide Inhalation Improves Neurological Outcome via NF-κB-Mediated Inflammatory Pathway in a Rat Model of Cardiac Arrest and ResuscitationQ48087988
Experimental beta-alaninuria induced by (aminooxy)acetateQ48252645
Cystathionine-β-Synthase Gene Transfer Into Rostral Ventrolateral Medulla Exacerbates Hypertension via Nitric Oxide in Spontaneously Hypertensive RatsQ48356680
Bio-orthogonal "click-and-release" donation of caged carbonyl sulfide (COS) and hydrogen sulfide (H2S).Q48364614
N-Acetylcysteine ethyl ester (NACET): a novel lipophilic cell-permeable cysteine derivative with an unusual pharmacokinetic feature and remarkable antioxidant potential.Q48366429
Expression of 3-Mercaptopyruvate Sulfurtransferase in the Mouse.Q48395944
Is development of high-grade gliomas sulfur-dependent?Q48403130
A functional transsulfuration pathway in the brain links to glutathione homeostasisQ48411596
Cystathionase activity in rat tissues during developmentQ48508782
Effects of hydrogen sulfide on a rat model of sepsis-associated encephalopathyQ48805640
Hydrogen Sulfide Regulates the [Ca2+]i Level in the Primary Medullary NeuronsQ37389882
Gp130-mediated STAT3 activation by S-propargyl-cysteine, an endogenous hydrogen sulfide initiator, prevents doxorubicin-induced cardiotoxicity.Q37412473
The novel mitochondria-targeted hydrogen sulfide (H2S) donors AP123 and AP39 protect against hyperglycemic injury in microvascular endothelial cells in vitroQ37420836
Effect of endotoxemia in mice genetically deficient in cystathionine-γ-lyase, cystathionine-β-synthase or 3-mercaptopyruvate sulfurtransferase.Q37426673
Potential applications of hydrogen sulfide-induced suspended animationQ37438086
Is hydrogen sulfide a circulating "gasotransmitter" in vertebrate blood?Q37441330
Inhibition of cystathionine β-synthetase suppresses sodium channel activities of dorsal root ganglion neurons of rats with lumbar disc herniationQ37459943
Cystathionine γ-lyase deficiency protects mice from galactosamine/lipopolysaccharide-induced acute liver failureQ37460255
Beneficial effect of a hydrogen sulphide donor (sodium sulphide) in an ovine model of burn- and smoke-induced acute lung injuryQ37481192
Bench-to-bedside review: Hydrogen sulfide--the third gaseous transmitter: applications for critical careQ37516593
Keap1 cysteine 288 as a potential target for diallyl trisulfide-induced Nrf2 activationQ37525077
The Effects of Different Garlic-Derived Allyl Sulfides on Anaerobic Sulfur Metabolism in the Mouse KidneyQ37533626
Enzymology of H2S biogenesis, decay and signalingQ37543232
Production and physiological effects of hydrogen sulfide.Q37544124
Coenzyme Q deficiency causes impairment of the sulfide oxidation pathway.Q37555498
CoQ deficiency causes disruption of mitochondrial sulfide oxidation, a new pathomechanism associated with this syndrome.Q37555654
Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growthQ37568665
YAP and 14-3-3γ are involved in HS-OA-induced growth inhibition of hepatocellular carcinoma cells: A novel mechanism for hydrogen sulfide releasing oleanolic acidQ37588424
The New Synthetic H2S-Releasing SDSS Protects MC3T3-E1 Osteoblasts against H2O2-Induced Apoptosis by Suppressing Oxidative Stress, Inhibiting MAPKs, and Activating the PI3K/Akt PathwayQ37595201
Making and working with hydrogen sulfide: The chemistry and generation of hydrogen sulfide in vitro and its measurement in vivo: a reviewQ37601063
Hydrogen sulfide's involvement in modulating nociception.Q37604899
Provisional Advisory Levels (PALs) for hydrogen sulfide (H2S).Q37614541
Correction of cystathionine β-synthase deficiency in mice by treatment with proteasome inhibitorsQ37615678
S-sulfhydration as a cellular redox regulationQ37626815
Gases in the mitochondriaQ37652506
Gasotransmitters in cancer: from pathophysiology to experimental therapyQ37656625
Ammonium tetrathiomolybdate treatment targets the copper transporter ATP7A and enhances sensitivity of breast cancer to cisplatinQ37686235
Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part I. Biochemical and physiological mechanismsQ37686284
Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part II. Pathophysiological and therapeutic aspectsQ37686288
Mechanisms of angiogenesis: role of hydrogen sulphideQ37690808
Catalase as a sulfide-sulfur oxido-reductase: An ancient (and modern?) regulator of reactive sulfur species (RSS).Q37700190
H2S biosynthesis and catabolism: new insights from molecular studiesQ37709987
Cardiovascular disease and resuscitated septic shock lead to the downregulation of the H2S-producing enzyme cystathionine-γ-lyase in the porcine coronary arteryQ37712551
L-methionine-dl-sulfoxide metabolism and toxicity in freshly isolated mouse hepatocytes: gender differences and inhibition with aminooxyacetic acidQ36952093
S-Propargyl-cysteine Exerts a Novel Protective Effect on Methionine and Choline Deficient Diet-Induced Fatty Liver via Akt/Nrf2/HO-1 PathwayQ36969802
Hydrogen sulphide and its therapeutic potentialQ36975742
Biosynthesis of H2S is impaired in non-obese diabetic (NOD) mice.Q36977469
Role of garlic in the prevention of ischemia-reperfusion injury.Q36983870
Hydrogen Sulfide Contributes to Retinal Neovascularization in Ischemia-Induced RetinopathyQ36997322
A H 2 S Donor GYY4137 Exacerbates Cisplatin-Induced Nephrotoxicity in Mice.Q37000218
H2S-donating sildenafil (ACS6) inhibits superoxide formation and gp91phox expression in arterial endothelial cells: role of protein kinases A and GQ37002373
Production of hydrogen sulfide from d-cysteine and its therapeutic potential.Q37016283
Tumor-derived hydrogen sulfide, produced by cystathionine-β-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancerQ37049363
Primary hepatocytes from mice lacking cysteine dioxygenase show increased cysteine concentrations and higher rates of metabolism of cysteine to hydrogen sulfide and thiosulfateQ37059694
Prodrugs: design and clinical applications.Q37064858
Oxygen-sensitive mitochondrial accumulation of cystathionine β-synthase mediated by Lon proteaseQ37068583
Garlic oil polysulfides: H2S- and O2-independent prooxidants in buffer and antioxidants in cellsQ37071845
Controllable hydrogen sulfide donors and their activity against myocardial ischemia-reperfusion injuryQ37097747
The hydrogen sulfide donor, GYY4137, exhibits anti-atherosclerotic activity in high fat fed apolipoprotein E(-/-) miceQ37122696
Effect of Hydrogen Sulfide Donors on Intraocular Pressure in RabbitsQ37125134
Hydrogen sulfide triggers late-phase preconditioning in postischemic small intestine by an NO- and p38 MAPK-dependent mechanismQ37138975
Inhibition of cystine uptake disrupts the growth of primary brain tumorsQ37189377
Synthesis and evaluation of phosphorodithioate-based hydrogen sulfide donors.Q37213154
The cysteine dioxgenase knockout mouse: altered cysteine metabolism in nonhepatic tissues leads to excess H2S/HS(-) production and evidence of pancreatic and lung toxicityQ37216462
Zofenopril Protects Against Myocardial Ischemia-Reperfusion Injury by Increasing Nitric Oxide and Hydrogen Sulfide BioavailabilityQ37240724
A novel hydrogen sulfide prodrug, SG1002, promotes hydrogen sulfide and nitric oxide bioavailability in heart failure patientsQ37279303
Pro-inflammatory effects of hydrogen sulphide on substance P in caerulein-induced acute pancreatitisQ37293868
Inducible hydrogen sulfide synthesis in chondrocytes and mesenchymal progenitor cells: is H2S a novel cytoprotective mediator in the inflamed joint?Q37294661
The complex effects of the slow-releasing hydrogen sulfide donor GYY4137 in a model of acute joint inflammation and in human cartilage cells.Q37295023
Hydrogen sulfide mediates cardioprotection through Nrf2 signalingQ37328256
Polysulfides link H2S to protein thiol oxidation.Q37334548
S-propargyl-cysteine attenuates inflammatory response in rheumatoid arthritis by modulating the Nrf2-ARE signaling pathwayQ37343152
Cystathionine-beta-synthase inhibition for colon cancer: Enhancement of the efficacy of aminooxyacetic acid via the prodrug approach.Q37353949
Hydrogen Sulfide Regulates Krüppel-Like Factor 5 Transcription Activity via Specificity Protein 1 S-Sulfhydration at Cys664 to Prevent Myocardial Hypertrophy.Q37364524
The hydrogen sulfide donor, Lawesson's reagent, prevents alendronate-induced gastric damage in rats.Q37371504
Novel dithiolethione-modified nonsteroidal anti-inflammatory drugs in human hepatoma HepG2 and colon LS180 cells.Q37371516
Hydrogen sulfide therapy attenuates the inflammatory response in a porcine model of myocardial ischemia/reperfusion injury.Q37379431
Exogenous and Endogenous Hydrogen Sulfide Protects Gastric Mucosa against the Formation and Time-Dependent Development of Ischemia/Reperfusion-Induced Acute Lesions Progressing into Deeper Ulcerations.Q50185789
Hydrogen Sulfide Attenuates Tissue Plasminogen Activator-Induced Cerebral Hemorrhage Following Experimental StrokeQ50203349
Development of photo-controllable hydrogen sulfide donor applicable in live cellsQ50219423
Hydrogen sulfide protects blood-brain barrier integrity following cerebral ischemiaQ50224206
Potential role of the gaseous mediator hydrogen sulphide (H2S) in inhibition of human colonic contractilityQ50452581
The hydrogen sulfide releasing compounds ATB-346 and diallyl trisulfide attenuate streptozotocin-induced cognitive impairment, neuroinflammation, and oxidative stress in rats: involvement of asymmetric dimethylarginine.Q50519678
Sulfhemoglobinemia after dermal application of DMSO.Q50524694
Effects of acetylsalicylic acid on the levels of sulfane sulfur and non-protein sulfhydryl groups in mouse tissues.Q50749737
Lipoic Acid as a Possible Pharmacological Source of Hydrogen Sulfide/Sulfane Sulfur.Q50863448
Colorimetric detection of endogenous hydrogen sulfide production in living cells.Q50924344
Delayed sulfhemoglobinemia after acute dapsone intoxication.Q50934967
Exercise Increases Cystathionine-γ-lyase Expression and Decreases the Status of Oxidative Stress in Myocardium of Ovariectomized Rats.Q50950978
Dysregulation of hydrogen sulfide producing enzyme cystathionine γ-lyase contributes to maternal hypertension and placental abnormalities in preeclampsia.Q50963577
Effects of 10-ppm hydrogen sulfide inhalation in exercising men and women. Cardiovascular, metabolic, and biochemical responses.Q50971574
Effects of 5 ppm hydrogen sulfide inhalation on biochemical properties of skeletal muscle in exercising men and women.Q51032144
Correlation between levels of exhaled hydrogen sulfide and airway inflammatory phenotype in patients with chronic persistent asthma.Q51047167
Effect of the hydrogen sulfide donor GYY4137 on platelet activation and microvascular thrombus formation in mice.Q51068380
Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases.Q51116354
Hydrogen sulfide and its possible roles in myocardial ischemia in experimental rats.Q51119493
Novel H2S Releasing Nano-fibrous Coating for In Vivo Dermal Wound Regeneration.Q51209959
Lung inflation with hydrogen sulfide during the warm ischemia phase ameliorates injury in rat donor lungs via metabolic inhibition after cardiac death.Q51252388
Relevant variations and neuroprotecive effect of hydrogen sulfide in a rat glaucoma model.Q51301277
Protective effects of exogenous and endogenous hydrogen sulfide in mast cell-mediated pruritus and cutaneous acute inflammation in mice.Q51329487
ATB-346, a novel hydrogen sulfide-releasing anti-inflammatory drug, induces apoptosis of human melanoma cells and inhibits melanoma development in vivo.Q51365513
Both the H2S biosynthesis inhibitor aminooxyacetic acid and the mitochondrially targeted H2S donor AP39 exert protective effects in a mouse model of burn injury.Q51495600
Whatever happened to ….Q51500537
S-allyl-L-cysteine and isoliquiritigenin improve mitochondrial function in cellular models of oxidative and nitrosative stress.Q51583169
Sodium thiosulfate protects brain in rat model of adenine induced vascular calcification.Q51595850
Potentiation of Hypoxic Pulmonary Vasoconstriction by Hydrogen Sulfide Precursors 3-Mercaptopyruvate and D-Cysteine Is Blocked by the Cystathionine γ Lyase Inhibitor Propargylglycine.Q51601346
Homocystinuria--the effects of betaine in the treatment of patients not responsive to pyridoxine.Q51646110
Hydrogen Sulfide Induces Keap1 S-sulfhydration and Suppresses Diabetes-Accelerated Atherosclerosis via Nrf2 Activation.Q51687105
Exhaled Hydrogen Sulfide Predicts Airway Inflammation Phenotype in COPD.Q51689166
Neuroprotective effect of S-allyl-l-cysteine derivatives against endoplasmic reticulum stress-induced cytotoxicity is independent of calpain inhibition.Q52142904
Diallyl Trisulfide Is a Fast H2S Donor, but Diallyl Disulfide Is a Slow One: The Reaction Pathways and Intermediates of Glutathione with Polysulfides.Q52815584
[Regulation of hydrogen sulfide on transporter protein Bsep and Mdr2 in acute liver failure].Q52887221
The effects of hydrogen sulfide on platelet-leukocyte aggregation and microvascular thrombolysis.Q52968284
Hydrogen sulfide improves colonic barrier integrity in DSS-induced inflammation in Caco-2 cells and mice.Q53059481
Novel hydrogen sulfide-releasing compound, S-propargyl-cysteine, prevents STZ-induced diabetic nephropathy.Q53127535
Hydrogen sulfide producing enzymes in pregnancy and preeclampsia.Q53181366
Organosulfide profile and hydrogen sulfide-releasing capacity of stinky bean (Parkia speciosa) oil: Effects of pH and extraction methods.Q53204969
Hydrogen sulfide ameliorates acute lung injury induced by infrarenal aortic cross-clamping by inhibiting inflammation and angiopoietin 2 release.Q53205137
Myocardial and lung injuries induced by hydrogen sulfide and the effectiveness of oxygen therapy in rats.Q53253915
Applications of Synthetic Organic Tetrasulfides as H2S Donors.Q53335172
Reversal of endothelial dysfunction in aorta of streptozotocin-nicotinamide-induced type-2 diabetic rats by S-Allylcysteine.Q53465500
Hydrogen sulfide releasing naproxen offers better anti-inflammatory and chondroprotective effect relative to naproxen in a rat model of zymosan induced arthritis.Q53508791
Effect of S-diclofenac, a novel hydrogen sulfide releasing derivative, on carrageenan-induced hindpaw oedema formation in the rat.Q53548199
Taurine Supplementation Lowers Blood Pressure and Improves Vascular Function in Prehypertension: Randomized, Double-Blind, Placebo-Controlled Study.Q53640921
Effects of AP39, a novel triphenylphosphonium derivatised anethole dithiolethione hydrogen sulfide donor, on rat haemodynamic parameters and chloride and calcium Cav3 and RyR2 channels.Q53647294
Sodium thiosulfate attenuates angiotensin II-induced hypertension, proteinuria and renal damage.Q54182308
Synthesis and Pharmacological Evaluation of Novel Adenine-Hydrogen Sulfide Slow Release Hybrids Designed as Multitarget Cardioprotective Agents.Q54186047
Protein kinase G Iα oxidation paradoxically underlies blood pressure lowering by the reductant hydrogen sulfide.Q54318607
Oltipraz upregulates the nuclear factor (erythroid-derived 2)-like 2 [corrected](NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice.Q54397165
New biologically active hydrogen sulfide donors.Q54782602
Insights into the mechanism of the reaction between hydrogen sulfide and peroxynitriteQ56971548
Deciphering the pathogenesis of NSAID enteropathy using proton pump inhibitors and a hydrogen sulfide-releasing NSAIDQ57144376
Hydrogen sulfide compensates nitric oxide deficiency in murine corpus cavernosumQ57718561
Hydrogen sulfide is involved in dexamethasone-induced hypertension in ratQ57718569
Maternal N-acetylcysteine therapy regulates hydrogen sulfide-generating pathway and prevents programmed hypertension in male offspring exposed to prenatal dexamethasone and postnatal high-fat dietQ57845133
Evidence for the formation of a novel nitrosothiol from the gaseous mediators nitric oxide and hydrogen sulphideQ57931896
Why Can Hydrogen Sulfide Permeate Cell Membranes?Q58987030
Thioglycine and l-thiovaline: Biologically active H2S-donorsQ60695399
Gastrointestinal Safety and Anti-Inflammatory Effects of a Hydrogen Sulfide–Releasing Diclofenac Derivative in the RatQ60695408
5-Amino-2-hydroxybenzoic Acid 4-(5-Thioxo-5H-[1,2]dithiol-3yl)-phenyl Ester (ATB-429), a Hydrogen Sulfide-Releasing Derivative of Mesalamine, Exerts Antinociceptive Effects in a Model of Postinflammatory HypersensitivityQ60695409
Screening of a composite library of clinically used drugs and well-characterized pharmacological compounds for cystathionine β-synthase inhibition identifies benserazide as a drug potentially suitable for repurposing for the experimental therapy ofQ63965443
Pharmacological activation and genetic manipulation of cystathionine beta-synthase alter circulating levels of homocysteine and hydrogen sulfide in miceQ64374785
Modifiers of mercaptopyruvate sulfurtransferase catalyzed conversion of cyanide to thiocyanate in vitroQ67559562
Effects of hydrogen sulfide exposure on lung mitochondrial respiratory chain enzymes in ratsQ68459824
The treatment of hydrogen sulfide intoxication: oxygen versus nitritesQ70258969
The effect of three alpha-keto acids on 3-mercaptopyruvate sulfurtransferase activityQ71528980
Effects of 10-ppm hydrogen sulfide inhalation on pulmonary function in healthy men and womenQ71741533
Specificity studies of 3-Mercaptopyruvate sulfurtransferaseQ71814547
Early diagnosis and treatment of homocystinuriaQ72875786
Sulphide as an inhibitor and electron donor for the cytochrome c oxidase systemQ72949661
An adolescent case of sulfhemoglobinemia associated with high-dose metoclopramide and N-acetylcysteineQ73026111
Domain architecture of the heme-independent yeast cystathionine beta-synthase provides insights into mechanisms of catalysis and regulationQ74217092
Effects of aminooxyacetate on glutamate compartmentation and TCA cycle kinetics in rat heartsQ74255333
The activity of 3-mercaptopyruvate sulfurtransferase in erythrocytes from patients with polycythemia veraQ74538449
The glutathione dependence of inorganic sulfate formation from L- or D-cysteine in isolated rat hepatocytesQ74605312
A crystalline enzyme that cleaves homoserine and cystathionine. II. Prosthetic groupQ77071638
Evidence for heme-mediated redox regulation of human cystathionine beta-synthase activityQ77300083
Anethole dithiolethione, a putative neuroprotectant, increases intracellular and extracellular glutathione levels during starvation of cultured astroglial cellsQ77763649
Endogenous hydrogen sulfide overproduction in Down syndromeQ78720991
Hydrogen sulfide acts as an inflammatory mediator in cecal ligation and puncture-induced sepsis in mice by upregulating the production of cytokines and chemokines via NF-kappaBQ79512390
[Plasma level of endogenous hydrogen sulfide in patients with acute asthma]Q79642051
The production of hydrogen sulfide limits myocardial ischemia and reperfusion injury and contributes to the cardioprotective effects of preconditioning with endotoxin, but not ischemia in the ratQ80027203
Suspended animation-like state protects mice from lethal hypoxiaQ80111384
Hydrogen sulphide regulates intracellular pH in vascular smooth muscle cellsQ80389174
Endogenous hydrogen sulfide regulates leukocyte trafficking in cecal ligation and puncture-induced sepsisQ80545026
Treatment with H2S-releasing diclofenac protects mice against acute pancreatitis-associated lung injuryQ80590460
The novel proangiogenic effect of hydrogen sulfide is dependent on Akt phosphorylationQ80613445
Hydrogen sulfide enhances ulcer healing in ratsQ80624339
Cardioprotection induced by hydrogen sulfide preconditioning involves activation of ERK and PI3K/Akt pathwaysQ80732265
Protective effect of hydrogen sulfide in a murine model of acute lung injury induced by combined burn and smoke inhalationQ80809383
A point mutation in a silencer module reduces the promoter activity for the human mercaptopyruvate sulfurtransferaseQ80912932
S-allylcysteine mediates cardioprotection in an acute myocardial infarction rat model via a hydrogen sulfide-mediated pathwayQ80980892
Reappraisal of H2S/sulfide concentration in vertebrate blood and its potential significance in ischemic preconditioning and vascular signalingQ81098816
Use of Lawesson's reagent in organic synthesesQ81293632
Medicine. Nothing rotten about hydrogen sulfide's medical promiseQ81358069
Regulatory effects of hydrogen sulfide on IL-6, IL-8 and IL-10 levels in the plasma and pulmonary tissue of rats with acute lung injuryQ81411464
Prevention of hydrogen sulfide (H2S)-induced mouse lethality and cytotoxicity by hydroxocobalamin (vitamin B(12a))Q81538824
Polarographic measurement of hydrogen sulfide production and consumption by mammalian tissuesQ81706798
Passive loss of hydrogen sulfide in biological experimentsQ82362478
The effects of garlic-derived sulfur compounds on cell proliferation, caspase 3 activity, thiol levels and anaerobic sulfur metabolism in human hepatoblastoma HepG2 cellsQ82563538
Determination of S-propargyl-cysteine in rat plasma by mixed-mode reversed-phase and cation-exchange HPLC-MS/MS method and its application to pharmacokinetic studiesQ82878851
S-propargyl-cysteine, a novel hydrogen sulfide-modulated agent, attenuated tumor necrosis factor-α-induced inflammatory signaling and dysfunction in endothelial cellsQ83222411
ACS84, a novel hydrogen sulfide-releasing compound, protects against amyloid β-induced cell cytotoxicityQ83385623
Calcium sulfide (CaS), a donor of hydrogen sulfide (H(2)S): a new antihypertensive drug?Q83746870
Inhaled hydrogen sulfide protects against ventilator-induced lung injuryQ84468122
Effects of intravenous sulfide during porcine aortic occlusion-induced kidney ischemia/reperfusion injuryQ84596416
Synthesis of a Fe(II)SH complex stabilized by an intramolecular N-H···S hydrogen bond, which acts as a H2S donorQ84945958
Hydrogen sulfide contributes to hypoxia-induced radioresistance on hepatoma cellsQ84999681
Effects of conventional and hydrogen sulfide-releasing non-steroidal anti-inflammatory drugs in rats with stress-induced and epinephrine-induced gastric damageQ85341704
The effect of CSE gene deletion in caerulein-induced acute pancreatitis in the mouseQ85641160
Hydrogen sulfide is produced by cystathionine γ-lyase at the steady-state low intracellular Ca(2+) concentrationsQ85892282
Physicochemical characteristics and gastrointestinal absorption behaviors of S-propargyl-cysteine, a potential new drug candidate for cardiovascular protection and antitumor treatmentQ85914710
Potential role of hydrogen sulfide in the pathogenesis of vascular dysfunction in septic shockQ86420474
Identification of cystathionine β-synthase inhibitors using a hydrogen sulfide selective probeQ86434332
Estrogens increase cystathionine-γ-lyase expression and decrease inflammation and oxidative stress in the myocardium of ovariectomized ratsQ86567066
Anti-inflammatory and cytoprotective properties of hydrogen sulfideQ86881583
S-aroylthiooximes: a facile route to hydrogen sulfide releasing compounds with structure-dependent release kineticsQ87370467
Hydrogen sulfide-releasing aspirin derivative ACS14 exerts strong antithrombotic effects in vitro and in vivoQ87397480
Hydrogen sulfide inhibits human platelet aggregation in vitro in part by interfering gap junction channels: effects of ACS14, a hydrogen sulfide-releasing aspirinQ87421006
Outcome after hydrogen sulphide intoxicationQ87502766
Cystathionine-gamma-lyase deficient mice are protected against the development of multiorgan failure and exhibit reduced inflammatory response during burnQ87610780
The cystathionine γ-lyase/hydrogen sulfide system maintains cellular glutathione statusQ87627634
Enhanced chemopreventive effects of a hydrogen sulfide-releasing anti-inflammatory drug (ATB-346) in experimental colorectal cancerQ87713329
Effect of processing conditions on the organosulfides of shallot (Allium cepa L. Aggregatum group)Q87905365
Design and synthesis of polymeric hydrogen sulfide donorsQ88106978
Design, synthesis and biological evaluation of hydrogen sulfide releasing derivatives of 3-n-butylphthalide as potential antiplatelet and antithrombotic agentsQ88204611
Garlic-inspired trisulfide linkers for thiol-stimulated H2S releaseQ88436528
Esterase Activated Carbonyl Sulfide/Hydrogen Sulfide (H2S) DonorsQ89022568
Discovery of a ring-opened derivative of 3-n-butylphthalide bearing NO/H2S-donating moieties as a potential anti-ischemic stroke agentQ89092897
Hydrogen sulfide modulates sub-cellular susceptibility to oxidative stress induced by myocardial ischemic reperfusion injuryQ89112299
Synthesis and biological evaluation of nitric oxide (NO)-hydrogen sulfide (H2S) releasing derivatives of (S)-3-n-butylphthalide as potential antiplatelet agentsQ89415079
pH-Controlled Hydrogen Sulfide Release for Myocardial Ischemia-Reperfusion InjuryQ89422157
Discovery of selective cystathionine β-synthase inhibitors by high-throughput screening with a fluorescent thiol probeQ90949122
P433issue4
P921main subjectpharmacologyQ128406
P304page(s)497-564
P577publication date2017-10-01
P1433published inPharmacological ReviewsQ2085079
P1476titleInternational Union of Basic and Clinical Pharmacology. CII: Pharmacological Modulation of H2S Levels: H2S Donors and H2S Biosynthesis Inhibitors
P478volume69

Reverse relations

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Q57477623AP39, a modulator of mitochondrial bioenergetics, reduces anti-angiogenic response and oxidative stress in hypoxia-exposed trophoblasts: relevance for preeclampsia pathogenesis
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Q90481348Aminooxyacetic acid (AOAA) sensitizes colon cancer cells to oxaliplatin via exaggerating apoptosis induced by ROS
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