Hydrogen Sulfide Biochemistry and Interplay with Other Gaseous Mediators in Mammalian Physiology

scientific article published on 27 June 2018

Hydrogen Sulfide Biochemistry and Interplay with Other Gaseous Mediators in Mammalian Physiology is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1155/2018/6290931
P932PMC publication ID6040266
P698PubMed publication ID30050658

P50authorJoão B. VicenteQ42326259
Alessandro GiuffrèQ42615379
P2860cites workStructure of human cystathionine beta-synthase: a unique pyridoxal 5'-phosphate-dependent heme proteinQ24291509
Human sulfide:quinone oxidoreductase catalyzes the first step in hydrogen sulfide metabolism and produces a sulfane sulfur metaboliteQ24294580
Human cystathionine β-synthase (CBS) contains two classes of binding sites for S-adenosylmethionine (SAM): complex regulation of CBS activity and stability by SAMQ24298897
H2S-Induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress responseQ24299859
Hydrogen sulfide-linked sulfhydration of NF-κB mediates its antiapoptotic actionsQ24301813
Human cystathionine beta-synthase is a target for sumoylationQ24312724
Structural basis for the inhibition mechanism of human cystathionine gamma-lyase, an enzyme responsible for the production of H(2)SQ24316078
Nitrite reductase activity and inhibition of H₂S biogenesis by human cystathionine ß-synthaseQ24319814
NO* binds human cystathionine β-synthase quickly and tightlyQ24336765
Ethylmalonic encephalopathy is caused by mutations in ETHE1, a gene encoding a mitochondrial matrix protein.Q24533166
De morbis artificum diatriba [diseases of workers]. 1713Q24544098
Dynamics of carbon monoxide binding to cystathionine beta-synthaseQ24652874
NH2-terminal sequence truncation decreases the stability of bovine rhodanese, minimally perturbs its crystal structure, and enhances interaction with GroEL under native conditionsQ27618135
Structural and functional insights into sulfide:quinone oxidoreductaseQ27655458
The structure of Aquifex aeolicus sulfide:quinone oxidoreductase, a basis to understand sulfide detoxification and respirationQ27655708
Crystal structure of sulfide:quinone oxidoreductase from Acidithiobacillus ferrooxidans: insights into sulfidotrophic respiration and detoxificationQ27660291
Structural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine  -synthaseQ27665916
Structure and Kinetic Analysis of H2S Production by Human Mercaptopyruvate SulfurtransferaseQ27678264
Structure-activity characterization of sulfide:quinone oxidoreductase variantsQ27678787
Structural basis of regulation and oligomerization of human cystathionine  -synthase, the central enzyme of transsulfurationQ27679976
Three-dimensional structure of cyanomet-sulfmyoglobin CQ27731410
Relative contributions of cystathionine beta-synthase and gamma-cystathionase to H2S biogenesis via alternative trans-sulfuration reactionsQ27929768
Inhibition of the catalytic activity of rhodanese by S-nitrosylation using nitric oxide donorsQ28205694
Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathwayQ28235964
H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyaseQ28298435
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factorQ28299224
Loss of ETHE1, a mitochondrial dioxygenase, causes fatal sulfide toxicity in ethylmalonic encephalopathyQ28306500
H2S signals through protein S-sulfhydrationQ28511531
3-Mercaptopyruvate sulfurtransferase produces hydrogen sulfide and bound sulfane sulfur in the brainQ28513550
Tissue and subcellular distribution of mercaptopyruvate sulfurtransferase in the rat: confocal laser fluorescence and immunoelectron microscopic studies combined with biochemical analysisQ28569061
Biogenesis of reactive sulfur species for signaling by hydrogen sulfide oxidation pathwaysQ28601441
Discovery and Mechanistic Characterization of Selective Inhibitors of H2S-producing Enzyme: 3-Mercaptopyruvate Sulfurtransferase (3MST) Targeting Active-site Cysteine PersulfideQ28817472
Nitric oxide and the immune responseQ29617591
Heme regulation of human cystathionine beta-synthase activity: insights from fluorescence and Raman spectroscopyQ37351627
Modulation of the heme electronic structure and cystathionine beta-synthase activity by second coordination sphere ligands: The role of heme ligand switching in redox regulation.Q37409372
Inactivation of cystathionine beta-synthase with peroxynitrite.Q37437761
Nitrosopersulfide (SSNO(-)) accounts for sustained NO bioactivity of S-nitrosothiols following reaction with sulfideQ37541011
Enzymology of H2S biogenesis, decay and signalingQ37543232
Hydrogen sulfide upregulates heme oxygenase-1 expression in rats with volume overload-induced heart failureQ37565539
Evidence that the heme regulatory motifs in heme oxygenase-2 serve as a thiol/disulfide redox switch regulating heme bindingQ37642980
A new structure-based classification of sulfide:quinone oxidoreductases.Q37676135
Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part I. Biochemical and physiological mechanismsQ37686284
Hydrogen sulfide activation in hemeproteins: the sulfheme scenarioQ37691508
Catalase as a sulfide-sulfur oxido-reductase: An ancient (and modern?) regulator of reactive sulfur species (RSS).Q37700190
H2S biosynthesis and catabolism: new insights from molecular studiesQ37709987
A Clinically Relevant Variant of the Human Hydrogen Sulfide-Synthesizing Enzyme Cystathionine β-Synthase: Increased CO Reactivity as a Novel Molecular Mechanism of Pathogenicity?Q37738145
Mitochondria and Sulfide: A Very Old Story of Poisoning, Feeding, and Signaling?Q37804386
Cytochrome c oxidase and nitric oxide in action: molecular mechanisms and pathophysiological implications.Q37937094
Chemical foundations of hydrogen sulfide biologyQ38121347
On the chemical biology of the nitrite/sulfide interaction.Q38300806
Mechanistic chemical perspective of hydrogen sulfide signaling.Q38366069
H2S: A Novel Gasotransmitter that Signals by SulfhydrationQ38600019
CO-CBS-H2 S Axis: From Vascular Mediator to Cancer RegulatorQ38625414
The Role of Hydrogen Sulfide in Evolution and the Evolution of Hydrogen Sulfide in Metabolism and SignalingQ38671099
The Reactive Species Interactome: Evolutionary Emergence, Biological Significance, and Opportunities for Redox Metabolomics and Personalized Medicine.Q38732036
Inorganic sulfur-nitrogen compounds: from gunpowder chemistry to the forefront of biological signalingQ38742866
Targeting Cystathionine Beta-Synthase Misfolding in Homocystinuria by Small Ligands: State of the Art and Future DirectionsQ38756682
H2S oxidation by nanodisc-embedded human sulfide quinone oxidoreductaseQ38781930
Bioenergetic relevance of hydrogen sulfide and the interplay between gasotransmitters at human cystathionine β-synthase.Q38796590
Reaction of Hydrogen Sulfide with Disulfide and Sulfenic Acid to Form the Strongly Nucleophilic Persulfide.Q38844064
Nitrosopersulfide (SSNO-) decomposes in the presence of sulfide, cyanide or glutathione to give HSNO/SNO-: consequences for the assumed role in cell signallingQ38851306
Protein sulfhydrationQ38902747
Oxidation of H2S in mammalian cells and mitochondria.Q38905194
Hydrogen polysulfide (H2S n ) signaling along with hydrogen sulfide (H2S) and nitric oxide (NO).Q38916218
Biological chemistry of hydrogen sulfide and persulfides.Q38971040
Sulfide-inhibition of mitochondrial respiration at very low oxygen concentrationsQ38981422
Tat-glyoxalase protein inhibits against ischemic neuronal cell damage and ameliorates ischemic injuryQ39061362
Chaperone therapy for homocystinuria: the rescue of CBS mutations by heme arginate.Q51746265
Hydrogen Sulfide Abrogates Hemoglobin-Lipid Interaction in Atherosclerotic Lesion.Q52645873
H2S confers colonoprotection against TNBS-induced colitis by HO-1 upregulation in rats.Q53128579
Mitochondrial responses to carbon monoxide toxicity.Q53724427
Sulfheme proteins. I. Optical and magnetic properties of sulfmyoglobin and its derivatives.Q53754181
Sulfide, the first inorganic substrate for human cellsQ56611319
Insights into the mechanism of the reaction between hydrogen sulfide and peroxynitriteQ56971548
Beyond H2S and NO Interplay: Hydrogen Sulfide and Nitroprusside React Directly to Give Nitroxyl (HNO). A New Pharmacological Source of HNOQ56971558
Kinetic stability of cystathionine beta-synthase can be modulated by structural analogs of S-adenosylmethionine: Potential approach to pharmacological chaperone therapy for homocystinuriaQ57578364
Evidence for the formation of a novel nitrosothiol from the gaseous mediators nitric oxide and hydrogen sulphideQ57931896
Nitric Oxide and Cytochrome c Oxidase: Mechanisms of Inhibition and NO DegradationQ58070426
Small aminothiol compounds improve the function of Arg to Cys variant proteins: effect on the human cystathionine β-synthase p.R336CQ59504337
Insights into the Regulatory Domain of Cystathionine Beta-Synthase: Characterization of Six Variant ProteinsQ59504344
Evidence of hydrogen sulfide involvement in amyotrophic lateral sclerosisQ61051661
Role of 3-mercaptopyruvate sulfurtransferase in the formation of the iron-sulfur chromophore of adrenal ferredoxinQ68698559
Detoxication of sodium 35S-sulphide in the ratQ69403818
Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radicalQ69908799
HS-:O2 oxidoreductase activity of Cu,Zn superoxide dismutaseQ71607313
Interaction of Cu,Zn superoxide dismutase with hydrogen sulfideQ72200013
Tissue and subcellular distribution of bound and acid-labile sulfur, and the enzymic capacity for sulfide production in the ratQ72203903
On the mechanism of sulfide inactivation by methemoglobinQ72807312
Oxidation of sulphide by cytochrome aa3Q72910989
Sulphide as an inhibitor and electron donor for the cytochrome c oxidase systemQ72949661
Characterization of the heme and pyridoxal phosphate cofactors of human cystathionine beta-synthase reveals nonequivalent active sitesQ77828273
Direct inhibition of endothelial nitric oxide synthase by hydrogen sulfide: contribution to dual modulation of vascular tensionQ79717151
Hydrogen Sulfide Oxidation Is Coupled to Oxidative Phosphorylation in Mitochondria of Solemya reidiQ81145356
Reactivity of hydrogen sulfide with peroxynitrite and other oxidants of biological interestQ82231964
Detoxification of H(2)S by differentiated colonic epithelial cells: implication of the sulfide oxidizing unit and of the cell respiratory capacityQ83520918
Addition and redox reactivity of hydrogen sulfides (H2S/HS⁻) with nitroprusside: new chemistry of nitrososulfide ligandsQ83612656
The reaction products of sulfide and S-nitrosoglutathione are potent vasorelaxantsQ86367671
Role of human sulfide: quinone oxidoreductase in H2S metabolismQ86844399
The chemical biology of the persulfide (RSSH)/perthiyl (RSS·) redox couple and possible role in biological redox signalingQ45278298
Reduced response of Cystathionine Beta-Synthase (CBS) to S-Adenosylmethionine (SAM): Identification and functional analysis of CBS gene mutations in Homocystinuria patientsQ45730250
Cystathionine beta-synthase as a carbon monoxide-sensitive regulator of bile excretionQ46196479
Metabolism of hydrogen sulfide (H2S) and Production of Reactive Sulfur Species (RSS) by superoxide dismutaseQ46245169
Mechanisms of myeloperoxidase catalyzed oxidation of H2S by H2O2 or O2 to produce potent protein Cys-polysulfide-inducing species.Q46269857
Role of the cystathionine β-synthase/H2S system in liver cancer cells and the inhibitory effect of quinolone-indolone conjugate QIC2 on the systemQ46377236
Engineering and Characterization of an Enzyme Replacement Therapy for Classical HomocystinuriaQ46379059
Structural and Mechanistic Insights into Hemoglobin-catalyzed Hydrogen Sulfide Oxidation and the Fate of Polysulfide Products.Q46416014
Adaptative metabolic response of human colonic epithelial cells to the adverse effects of the luminal compound sulfide.Q46582653
Three enzymatic activities catalyze the oxidation of sulfide to thiosulfate in mammalian and invertebrate mitochondria.Q46583629
Dioxygen reactivity and heme redox potential of truncated human cystathionine beta-synthaseQ46751069
Ferrous human cystathionine beta-synthase loses activity during enzyme assay due to a ligand switch processQ46935677
Hydrogen sulfide inhibits activity of three isoforms of recombinant nitric oxide synthaseQ46987231
Chemical Biology of H2S Signaling through PersulfidationQ47430972
Enzyme replacement prevents neonatal death, liver damage, and osteoporosis in murine homocystinuriaQ47933258
Hydrogen sulfide induces heme oxygenase-1 in human kidney cells.Q48009046
Biogenesis of Hydrogen Sulfide and Thioethers by Cystathionine Beta-SynthaseQ48032377
Heme interaction of the intrinsically disordered N-terminal peptide segment of human cystathionine-β-synthaseQ48095729
Use of Tissue Metabolite Analysis and Enzyme Kinetics To Discriminate between Alternate Pathways for Hydrogen Sulfide Metabolism.Q48328467
Cystathionine-β-Synthase Gene Transfer Into Rostral Ventrolateral Medulla Exacerbates Hypertension via Nitric Oxide in Spontaneously Hypertensive RatsQ48356680
Expression of 3-Mercaptopyruvate Sulfurtransferase in the Mouse.Q48395944
Solving the 170-Year-Old Mystery About Red-Violet and Blue Transient Intermediates in the Gmelin ReactionQ50209230
The effect of sulphide on cytochrome aa3. Isosteric and allosteric shifts of the reduced alpha-peak.Q50959838
Transsulfuration in mammals. Microassays and tissue distributions of three enzymes of the pathway.Q51246583
Nitrosopersulfide (SSNO-) targets the Keap-1/Nrf2 redox system.Q51469018
Positive feedback during sulfide oxidation fine-tunes cellular affinity for oxygen.Q51528739
Hydrogen Sulfide Induces Keap1 S-sulfhydration and Suppresses Diabetes-Accelerated Atherosclerosis via Nrf2 Activation.Q51687105
Oxidation of hydrogen sulfide by human liver mitochondria.Q51717053
The quantitative significance of the transsulfuration enzymes for H2S production in murine tissuesQ35056200
Nitric oxide and cytochrome oxidase: reaction mechanisms from the enzyme to the cellQ35076882
Interactions of hydrogen sulfide with myeloperoxidaseQ35204852
Metabolic integration during the evolutionary origin of mitochondriaQ35219213
Sulfide oxidation by a noncanonical pathway in red blood cells generates thiosulfate and polysulfidesQ35221567
Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channelsQ35603720
Nitric oxide and mitochondrial complex IV.Q35622940
Control of cytochrome c oxidase activity by nitric oxideQ35752188
Detrimental effects for colonocytes of an increased exposure to luminal hydrogen sulfide: The adaptive responseQ35916188
Regulation of vascular nitric oxide in vitro and in vivo; a new role for endogenous hydrogen sulphide?Q36054349
Chemical chaperone rescue of mutant human cystathionine beta-synthaseQ36088268
Identification of H2S3 and H2S produced by 3-mercaptopyruvate sulfurtransferase in the brainQ36123398
Transient Kinetic Analysis of Hydrogen Sulfide Oxidation Catalyzed by Human Sulfide Quinone OxidoreductaseQ36139912
Allosteric communication between the pyridoxal 5'-phosphate (PLP) and heme sites in the H2S generator human cystathionine β-synthaseQ36368169
Cystathionine β-synthase regulates endothelial function via protein S-sulfhydrationQ36385381
S-Adenosyl-l-methionine Modulates CO and NO• Binding to the Human H2S-generating Enzyme Cystathionine β-SynthaseQ36442325
Quantitative H2S-mediated protein sulfhydration reveals metabolic reprogramming during the integrated stress responseQ36520868
A novel persulfide detection method reveals protein persulfide- and polysulfide-reducing functions of thioredoxin and glutathione systems.Q36532821
Effect of the disease-causing R266K mutation on the heme and PLP environments of human cystathionine β-synthaseQ36600625
Biosynthesis and Reactivity of Cysteine Persulfides in SignalingQ36695581
Nitric oxide regulation of mitochondrial oxygen consumption II: Molecular mechanism and tissue physiologyQ36747857
Kinetics of Nitrite Reduction and Peroxynitrite Formation by Ferrous Heme in Human Cystathionine β-SynthaseQ36778803
Tumor-derived hydrogen sulfide, produced by cystathionine-β-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancerQ37049363
Oxygen-sensitive mitochondrial accumulation of cystathionine β-synthase mediated by Lon proteaseQ37068583
Kinetics of reversible reductive carbonylation of heme in human cystathionine β-synthase.Q37089366
Novel method for measuring S-nitrosothiols using hydrogen sulfide.Q37191422
Potential biological chemistry of hydrogen sulfide (H2S) with the nitrogen oxidesQ37233345
The inhibition of mitochondrial cytochrome oxidase by the gases carbon monoxide, nitric oxide, hydrogen cyanide and hydrogen sulfide: chemical mechanism and physiological significanceQ37288616
Heme regulatory motifs in heme oxygenase-2 form a thiol/disulfide redox switch that responds to the cellular redox state.Q37343966
Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, AnemiaQ30275352
Introduction: What we do and do not know regarding redox processes of thiols in signaling pathwaysQ30372489
H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemiaQ30487095
Redox biochemistry of hydrogen sulfideQ30495475
Hydrogen sulfide (H2S) metabolism in mitochondria and its regulatory role in energy productionQ30505673
Key bioactive reaction products of the NO/H2S interaction are S/N-hybrid species, polysulfides, and nitroxyl.Q30662956
Does perthionitrite (SSNO(-)) account for sustained bioactivity of NO? A (bio)chemical characterizationQ30976747
Identification and tissue distribution of human cystathionine beta-synthase mRNA isoformsQ32121425
Heme oxygenase 2: endothelial and neuronal localization and role in endothelium-dependent relaxationQ33580047
Protective effect of hydrogen sulphide against myocardial hypertrophy in miceQ33618317
Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signalingQ33694685
Small molecule signaling agents: the integrated chemistry and biochemistry of nitrogen oxides, oxides of carbon, dioxygen, hydrogen sulfide, and their derived speciesQ33771832
Rescue of cystathionine beta-synthase (CBS) mutants with chemical chaperones: purification and characterization of eight CBS mutant enzymesQ33855124
The effect of hydrogen sulfide donors on lipopolysaccharide-induced formation of inflammatory mediators in macrophagesQ33875055
Chemical characterization of the smallest S-nitrosothiol, HSNO; cellular cross-talk of H2S and S-nitrosothiolsQ34032571
Pathways and regulation of homocysteine metabolism in mammalsQ34049280
Interactions of multiple gas-transducing systems: hallmarks and uncertainties of CO, NO, and H2S gas biologyQ34078151
Elucidating the Catalytic Mechanism of Sulfite Oxidizing Enzymes Using Structural, Spectroscopic, and Kinetic AnalysesQ34082032
Hypoxic regulation of the cerebral microcirculation is mediated by a carbon monoxide-sensitive hydrogen sulfide pathway.Q34122686
Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter?Q34157091
Structural insight into the molecular mechanism of allosteric activation of human cystathionine β-synthase by S-adenosylmethionineQ34218322
Nitric oxide inhibition of respiration involves both competitive (heme) and noncompetitive (copper) binding to cytochrome c oxidaseQ34270791
H₂S signalling through protein sulfhydration and beyondQ34287129
Extracellular transsulfuration generates hydrogen sulfide from homocysteine and protects endothelium from redox stressQ34357822
Sulfide inhibition of and metabolism by cytochrome c oxidase.Q34372858
Crystal structure of human persulfide dioxygenase: structural basis of ethylmalonic encephalopathy.Q34458551
Organization of the human mitochondrial hydrogen sulfide oxidation pathwayQ34467414
AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitroQ34477537
Carbon monoxide: endogenous production, physiological functions, and pharmacological applicationsQ34480319
Nitric oxide and cytochrome oxidase: substrate, inhibitor or effector?Q34498075
S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacityQ34597732
Redox chemistry and chemical biology of H2S, hydropersulfides, and derived species: implications of their possible biological activity and utilityQ34646825
Inter-domain communication of human cystathionine β-synthase: structural basis of S-adenosyl-L-methionine activationQ34774516
Hydrogen sulfide and hemeproteins: knowledge and mysteriesQ35055729
Diallyl-disulfide, an organosulfur compound of garlic, attenuates airway inflammation via activation of the Nrf-2/HO-1 pathway and NF-kappaB suppressionQ39094006
Comparison between the effects of diallyl tetrasulfide on human retina pigment epithelial cells (ARPE-19) and HCT116 cells.Q39109939
The activation of HO-1/Nrf-2 contributes to the protective effects of diallyl disulfide (DADS) against ethanol-induced oxidative stressQ39132177
Catalytic promiscuity and heme-dependent redox regulation of H2S synthesisQ39173063
Intramitochondrial hydrogen sulfide production by 3-mercaptopyruvate sulfurtransferase maintains mitochondrial electron flow and supports cellular bioenergeticsQ39252442
Temperature and cell-type dependency of sulfide effects on mitochondrial respirationQ39317479
Reactions between nitrosopersulfide and heme proteinsQ39409105
Quantitative Persulfide Site Identification (qPerS-SID) Reveals Protein Targets of H2S Releasing Donors in Mammalian CellsQ39605149
Oxidation of hydrogen sulfide remains a priority in mammalian cells and causes reverse electron transfer in colonocytes.Q39714012
Enzyme replacement with PEGylated cystathionine β-synthase ameliorates homocystinuria in murine model.Q39763307
H(2)S and HS(-) donor NaHS releases nitric oxide from nitrosothiols, metal nitrosyl complex, brain homogenate and murine L1210 leukaemia cells.Q39985068
Ligand-induced spectral changes in cytochrome c oxidase and their possible significanceQ40025756
The effect of inhibitors on the oxygen kinetics of cytochrome c oxidaseQ40063626
H2S regulation of nitric oxide metabolismQ40064447
Thioethers as markers of hydrogen sulfide production in homocystinurias.Q40082628
Hydrogen sulfide inhibits nitric oxide production and nuclear factor-kappaB via heme oxygenase-1 expression in RAW264.7 macrophages stimulated with lipopolysaccharideQ40266368
Regulation of the Heme Oxygenase-1/carbon monoxide system by hydrogen sulfide in murine coxsackievirus B3-induced myocarditis.Q41195448
The chemical biology of protein hydropersulfides: Studies of a possible protective function of biological hydropersulfide generation.Q41246905
Overproduction of nitric oxide by endothelial cells and macrophages contributes to mitochondrial oxidative stress in adrenocortical cells and adrenal insufficiency during endotoxemiaQ41285332
3-Mercaptopyruvate sulfurtransferase produces potential redox regulators cysteine- and glutathione-persulfide (Cys-SSH and GSSH) together with signaling molecules H2S2, H2S3 and H2S.Q41620501
Detection of protein S-sulfhydration by a tag-switch technique.Q41806978
Interactions of sulphide and other ligands with cytochrome c oxidase. An electron-paramagnetic-resonance studyQ41830573
Restoring assembly and activity of cystathionine β-synthase mutants by ligands and chemical chaperonesQ41995821
Heme-dependent Metabolite Switching Regulates H2S Synthesis in Response to Endoplasmic Reticulum (ER) Stress.Q42380152
Cysteine perthiosulfenic acid (Cys-SSOH): A novel intermediate in thiol-based redox signaling?Q42380231
S-Sulfhydration of ATP synthase by hydrogen sulfide stimulates mitochondrial bioenergeticsQ42498020
The formation and properties of sulphmyoglobin and sulphcatalaseQ42553332
Characterization and interaction studies of two isoforms of the dual localized 3-mercaptopyruvate sulfurtransferase TUM1 from humansQ42580601
Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics.Q42587502
Sulfide oxidation coupled to ATP synthesis in chicken liver mitochondriaQ43597813
Characterization of NO binding to human cystathionine beta-synthase: possible implications of the effects of CO and NO binding to the human enzymeQ43823323
A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cellsQ44131370
Mechanism of sulfide-quinone reductase investigated using site-directed mutagenesis and sulfur analysisQ44148057
Deletion mutagenesis of human cystathionine beta-synthase. Impact on activity, oligomeric status, and S-adenosylmethionine regulationQ44179264
Single eubacterial origin of eukaryotic sulfide:quinone oxidoreductase, a mitochondrial enzyme conserved from the early evolution of eukaryotes during anoxic and sulfidic timesQ44495539
Control of respiration by nitric oxide in Keilin-Hartree particles, mitochondria and SH-SY5Y neuroblastoma cells.Q44593010
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P921main subjectmammalQ7377
P304page(s)6290931
P577publication date2018-06-27
P1433published inOxidative medicine and cellular longevityQ26840015
P1476titleHydrogen Sulfide Biochemistry and Interplay with Other Gaseous Mediators in Mammalian Physiology
P478volume2018

Reverse relations

cites work (P2860)
Q97885848Cysteine as a Carbon Source, a Hot Spot in Cancer Cells Survival
Q102323905Cysteine metabolic circuitries: druggable targets in cancer
Q90043601Hydrogen Sulfide Metabolism and Signaling in the Tumor Microenvironment
Q64242163Hydrogen Sulfide Oxidation: Adaptive Changes in Mitochondria of SW480 Colorectal Cancer Cells upon Exposure to Hypoxia
Q93012032Hydrogen sulfide stimulates Mycobacterium tuberculosis respiration, growth and pathogenesis
Q92309718Imbalance of Homocysteine and H2S: Significance, Mechanisms, and Therapeutic Promise in Vascular Injury
Q64069917Inorganic Polysulfides and Related Reactive Sulfur–Selenium Species from the Perspective of Chemistry
Q90043554Metabolic Remodeling as a Way of Adapting to Tumor Microenvironment (TME), a Job of Several Holders
Q92423074N-Acetylcysteine Serves as Substrate of 3-Mercaptopyruvate Sulfurtransferase and Stimulates Sulfide Metabolism in Colon Cancer Cells
Q57065957Role of Hydrogen Sulfide in NRF2- and Sirtuin-Dependent Maintenance of Cellular Redox Balance
Q61444242Screening Pyridine Derivatives against Human Hydrogen Sulfide-synthesizing Enzymes by Orthogonal Methods
Q90397401Synergisms, Discrepancies and Interactions between Hydrogen Sulfide and Carbon Monoxide in the Gastrointestinal and Digestive System Physiology, Pathophysiology and Pharmacology

Search more.