Opening the Blood-Brain Barrier and Improving the Efficacy of Temozolomide Treatments of Glioblastoma Using Pulsed, Focused Ultrasound with a Microbubble Contrast Agent

scientific article published on 11 November 2018

Opening the Blood-Brain Barrier and Improving the Efficacy of Temozolomide Treatments of Glioblastoma Using Pulsed, Focused Ultrasound with a Microbubble Contrast Agent is …
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scholarly articleQ13442814

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P356DOI10.1155/2018/6501508
P932PMC publication ID6252217
P698PubMed publication ID30534564

P50authorQiongzhen DengQ90387898
P2093author name stringLin He
Qian Dong
Linbo Chen
P2860cites workProspective evaluation of serum glial fibrillary acidic protein (GFAP) as a diagnostic marker for glioblastoma.Q52147346
High-performance liquid chromatographic determination and stability of 5-(3-methyltriazen-1-yl)-imidazo-4-carboximide, the biologically active product of the antitumor agent temozolomide, in human plasma.Q52900369
Prognosis of glioma patients by combined immunostaining for survivin, Ki-67 and epidermal growth factor receptorQ82208970
[The blood-brain barrier and drug delivery in the central nervous system]Q84580567
SOX-18 controls endothelial-specific claudin-5 gene expression and barrier functionQ24302370
Treating malignant glioma in Chinese patients: update on temozolomideQ26863755
Asymmetric Distribution of GFAP in Glioma Multipotent CellsQ27318047
Focused ultrasound-induced blood-brain barrier opening to enhance temozolomide delivery for glioblastoma treatment: a preclinical studyQ27334453
A bioinformatics analysis of memory consolidation reveals involvement of the transcription factor c-relQ28257961
Microbubbles coupled to methotrexate-loaded liposomes for ultrasound-mediated delivery of methotrexate across the blood-brain barrierQ30427348
Blood-brain barrier disruption and vascular damage induced by ultrasound bursts combined with microbubbles can be influenced by choice of anesthesia protocolQ30465348
Ultrasound-enhanced thrombolysis using Definity as a cavitation nucleation agent.Q30479478
Ultrasound for drug and gene delivery to the brainQ30488675
Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruptionQ30500905
High-performance liquid chromatographic analysis and stability of anti-tumor agent temozolomide in human plasmaQ31994979
Local delivery of temozolomide by biodegradable polymers is superior to oral administration in a rodent glioma modelQ33374014
Ultrasound, microbubbles and the blood-brain barrierQ33999309
The organization of tight junctions in epithelia: implications for mammary gland biology and breast tumorigenesisQ34103481
Rat brain tumor models in experimental neuro-oncology: the C6, 9L, T9, RG2, F98, BT4C, RT-2 and CNS-1 gliomasQ37452837
Looking at the blood–brain barrier: Molecular anatomy and possible investigation approachesQ37777780
Glioblastoma and other malignant gliomas: a clinical review.Q38160159
An overview of the influence of therapeutic ultrasound exposures on the vasculature: high intensity ultrasound and microbubble-mediated bioeffectsQ38365342
Hypoxia disrupts the barrier function of neural blood vessels through changes in the expression of claudin-5 in endothelial cellsQ40153022
Serum GFAP is a diagnostic marker for glioblastoma multiformeQ40155072
Transporting therapeutics across the blood-brain barrierQ41105360
GLUT1 expression in tissue and (18)F-FDG uptake.Q44924412
Disposition and pharmacokinetics of temozolomide in rat.Q45061495
Characterization of 9L glioma model of the Wistar rat.Q48277149
Noninvasive, transcranial and localized opening of the blood-brain barrier using focused ultrasound in miceQ48327685
Diagnostic and prognostic value of preoperative combined GFAP, IGFBP-2, and YKL-40 plasma levels in patients with glioblastomaQ48595349
Targeted disruption of the blood-brain barrier with focused ultrasound: association with cavitation activityQ48655725
Association between contrast‐enhanced MR images and blood–brain barrier disruption following transcranial focused ultrasoundQ50246872
Quantitative evaluation of the use of microbubbles with transcranial focused ultrasound on blood-brain-barrier disruption.Q50248965
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesmicrobubbleQ6839290
ImageJQ1659584
P407language of work or nameEnglishQ1860
P921main subjectblood–brain barrierQ221694
microbubbleQ6839290
contrast agentQ6849688
glioblastomaQ282142
temozolomideQ425088
P304page(s)6501508
P577publication date2018-11-11
P1433published inBioMed Research InternationalQ17509958
P1476titleOpening the Blood-Brain Barrier and Improving the Efficacy of Temozolomide Treatments of Glioblastoma Using Pulsed, Focused Ultrasound with a Microbubble Contrast Agent
P478volume2018