Synthesis of an Original Oxygenated Taxuspine X Analogue: a Versatile “Non-Natural” Natural Product with Remarkable P-gp Modulating Activity

scientific article published on 01 May 2008

Synthesis of an Original Oxygenated Taxuspine X Analogue: a Versatile “Non-Natural” Natural Product with Remarkable P-gp Modulating Activity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/CMDC.200700337
P698PubMed publication ID18232049

P50authorMarco RadiQ43051752
Maurizio BottaQ87415127
P2093author name stringFederico Corelli
Gianluca Giorgi
Chiara Ghiron
Gianpietro Sgaragli
Elena Galletti
Michela L Renzulli
Stanislava I Avramova
Daniela Alderighi
P2860cites workInitiation, elongation, and termination strategies in polyketide and polypeptide antibiotic biosynthesisQ33744993
Bioactive taxoids from the Japanese yew Taxus cuspidata.Q34587524
Natural product hybrids as new leads for drug discoveryQ35218773
3D QSAR models of interactions between beta-tubulin and microtubule stabilizing antimitotic agents (MSAA): a survey on taxanes and epothilones.Q35644588
Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defenseQ36104162
Multidrug resistance: retrospect and prospects in anti-cancer drug treatment.Q36536479
The functions and structure of ABC transporters: implications for the design of new inhibitors of Pgp and MRP1 to control multidrug resistance (MDR).Q36536579
Paclitaxel and docetaxel resistance: molecular mechanisms and development of new generation taxanesQ36832450
A high-throughput screening microplate test for the interaction of drugs with P-glycoproteinQ40730733
The use of potent inhibitors of alkaline phosphatase to investigate the role of the enzyme in intestinal transport of inorganic phosphateQ42883752
3D QSAR studies for the beta-tubulin binding site of microtubule-stabilizing anticancer agents (MSAAs): a pseudoreceptor model for taxanes based on the experimental structure of tubulinQ47620737
Oxidation of α,β-un saturated aldehydesQ56521223
Trans-selective conversions of gamma-hydroxy-alpha,beta-alkynoic esters to gamma-hydroxy-alpha,beta-alkenoic estersQ80105908
Effects of taxoids from Taxus cuspidata on microtubule depolymerization and vincristine accumulation in MDR cellsQ104909494
Taxuspines X-Z, New Taxoids from Japanese Yew Taxus cuspidata.Q104962993
P433issue5
P921main subjectnatural productQ901227
molecular medicineQ3523816
P304page(s)745-748
P577publication date2008-05-01
P1433published inChemMedChemQ2962252
P1476titleSynthesis of an original oxygenated taxuspine X analogue: a versatile "non-natural" natural product with remarkable P-gp modulating activity
P478volume3