Experimental Metabolic Syndrome Model Associated with Mechanical and Structural Degenerative Changes of the Aortic Valve

scientific article published in Scientific Reports

Experimental Metabolic Syndrome Model Associated with Mechanical and Structural Degenerative Changes of the Aortic Valve is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1110453112
P356DOI10.1038/S41598-018-36388-Y
P932PMC publication ID6292876
P698PubMed publication ID30546028

P50authorJason L GoQ61799248
Mohammed A Al-HijjiQ61799251
Lilach O. LermanQ77286570
Amir LermanQ77286771
P2093author name stringQing Qin
Christopher Noble
Komal Prem
Melissa D Young
P2860cites workFiji: an open-source platform for biological-image analysisQ27860912
Investigating the Metabolic Syndrome: Contributions of Swine ModelsQ28069653
RAGE influences the development of aortic valve stenosis in mice on a high fat dietQ30317445
Aortic calcified particles modulate valvular endothelial and interstitial cells.Q50788088
OxLDL-derived lysophosphatidic acid promotes the progression of aortic valve stenosis through a LPAR1-RhoA-NF-κB pathway.Q51020305
Dynamic and reversible changes of interstitial cell phenotype during remodeling of cardiac valves.Q51601913
In Vitro Model of a Fibrosa Layer of a Heart Valve.Q51799846
Increased Calcific Aortic Valve Disease in response to a diabetogenic, procalcific diet in the LDLr-/-ApoB100/100 mouse model.Q52655804
Autophagy Portends the Level of Cardiac Hypertrophy in Experimental Hypertensive Swine Model.Q52949067
Lp-PLA2 is associated with structural valve degeneration of bioprostheses.Q53656544
Decellularization of pericardial tissue and its impact on tensile viscoelasticity and glycosaminoglycan contentQ59644733
Type I and type III collagen synthesis and composition in the valve matrix in aortic valve stenosisQ82233765
Correlation between plasma osteopontin levels and aortic valve calcification: potential insights into the pathogenesis of aortic valve calcification and stenosisQ84169959
Evaluation of a porcine model of early aortic valve sclerosisQ88224294
Calcific aortic stenosisQ89216879
The extracellular matrix in development and morphogenesis: a dynamic viewQ30432483
Calcific aortic valve stenosis: methods, models, and mechanismsQ30503246
Design of Bioprosthetic Aortic Valves using biaxial test dataQ31035378
The extracellular matrix at a glanceQ34152843
Role of circulating osteogenic progenitor cells in calcific aortic stenosisQ34424461
Lipoprotein-associated phospholipase A2: a target directed at the atherosclerotic plaqueQ34837405
Adipose tissue remodeling in a novel domestic porcine model of diet-induced obesityQ35030636
Animal models of calcific aortic valve diseaseQ35147157
Analysis of osteopontin levels for the identification of asymptomatic patients with calcific aortic valve diseaseQ35716232
Valvular interstitial cells suppress calcification of valvular endothelial cellsQ35988417
Lipoprotein-associated phospholipase A2 as a target of therapyQ36180406
Lipoprotein-associated phospholipase A2: a novel marker of cardiovascular risk and potential therapeutic targetQ36187055
Osteocalcin positive CD133+/CD34-/KDR+ progenitor cells as an independent marker for unstable atherosclerosisQ36438740
Early atherosclerosis aggravates renal microvascular loss and fibrosis in swine renal artery stenosisQ36791992
The emerging role of valve interstitial cell phenotypes in regulating heart valve pathobiologyQ36933045
Osteocalcin expression by circulating endothelial progenitor cells in patients with coronary atherosclerosisQ37035270
Consensus panel recommendation for incorporating lipoprotein-associated phospholipase A2 testing into cardiovascular disease risk assessment guidelinesQ37189899
Statins block calcific nodule formation of valvular interstitial cells by inhibiting alpha-smooth muscle actin expressionQ37397533
Tenascins and their implications in diseases and tissue mechanicsQ37473590
Manipulation of valve composition to elucidate the role of collagen in aortic valve calcificationQ37623938
Human degenerative valve disease is associated with up-regulation of low-density lipoprotein receptor-related protein 5 receptor-mediated bone formationQ37633944
Calcific aortic stenosis: a disease of the valve and the myocardiumQ38051804
Quantification and comparison of the mechanical properties of four human cardiac valvesQ38740727
Comparison of calcification potential of valvular interstitial cells isolated from individual aortic valve cuspsQ39999479
Recellularization of a novel off-the-shelf valve following xenogenic implantation into the right ventricular outflow tract.Q41200397
Can valvular interstitial cells become true osteoblasts? A side-by-side comparison.Q41486764
Human Aortic Valve Calcification Is Associated With an Osteoblast PhenotypeQ41950206
Supercritical carbon dioxide-based sterilization of decellularized heart valvesQ42315226
Metabolic syndrome negatively influences disease progression and prognosis in aortic stenosisQ42687231
Elevated expression of lipoprotein-associated phospholipase A2 in calcific aortic valve disease: implications for valve mineralizationQ44621087
New therapeutic targets for calcific aortic valve stenosis: the lipoprotein(a)-lipoprotein-associated phospholipase A2-oxidized phospholipid axisQ44760819
Pioglitazone attenuates progression of aortic valve calcification via down-regulating receptor for advanced glycation end productsQ45721093
The metabolic syndrome induces early changes in the swine renal medullary mitochondriaQ46392965
Different patterns of extracellular matrix protein expression in the convexity and the concavity of the dilated aorta with bicuspid aortic valve: preliminary resultsQ47753194
Mitoprotection attenuates myocardial vascular impairment in porcine metabolic syndromeQ49356498
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectmetabolic syndromeQ657193
P304page(s)17835
P577publication date2018-12-13
P1433published inScientific ReportsQ2261792
P1476titleExperimental Metabolic Syndrome Model Associated with Mechanical and Structural Degenerative Changes of the Aortic Valve
P478volume8

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Q92081738Diet-Induced Rabbit Models for the Study of Metabolic Syndromecites workP2860

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