Overview on the Effects of -Acetylcysteine in Neurodegenerative Diseases

scientific article published on 13 December 2018

Overview on the Effects of -Acetylcysteine in Neurodegenerative Diseases is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3390/MOLECULES23123305
P932PMC publication ID6320789
P698PubMed publication ID30551603

P50authorEmanuela MazzonQ56849438
Giuseppe TardioloQ90515081
P2093author name stringPlacido Bramanti
P2860cites workThe New Cholinesterase Inhibitors for Alzheimer's Disease, Part 2: Illustrating Their Mechanisms of ActionQ22241109
The importance of neuritic plaques and tangles to the development and evolution of ADQ22241659
Gabapentin for chronic neuropathic pain and fibromyalgia in adultsQ24194998
Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signalingQ24313304
N-acetylcysteine (NAC) in neurological disorders: mechanisms of action and therapeutic opportunitiesQ24568289
Recommendations for the pharmacological management of neuropathic pain: an overview and literature updateQ24616897
The influence of N-acetyl-L-cystein infusion on cytokine levels and gastric intramucosal pH during severe sepsisQ24800533
The glutamate receptor ion channelsQ28137916
The systemic availability of oral glutathioneQ28184603
Distinct nuclear factor-kappaB/Rel proteins have opposing modulatory effects in glutamate-induced cell death in HT22 cellsQ28192145
Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell deathQ28217736
Glutathione precursor, N-acetyl-cysteine, improves mismatch negativity in schizophrenia patientsQ28257370
The promise of N-acetylcysteine in neuropsychiatryQ28284644
In vitro studies of amyloid beta-protein fibril assembly and toxicity provide clues to the aetiology of Flemish variant (Ala692-->Gly) Alzheimer's diseaseQ28363291
Mitochondria and apoptosisQ29547905
Pharmacology and functions of metabotropic glutamate receptorsQ29619150
Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystandersQ29619537
N-Acetyl Cysteine May Support Dopamine Neurons in Parkinson's Disease: Preliminary Clinical and Cell Line DataQ30000089
N-methyl-d-aspartate (NMDA) receptor dysfunction or dysregulation: the final common pathway on the road to schizophrenia?Q30474021
Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adductQ31029246
Administration of N-acetylcysteine after focal cerebral ischemia protects brain and reduces inflammation in a rat model of experimental strokeQ44870573
Glutathione depletion resulting in selective mitochondrial complex I inhibition in dopaminergic cells is via an NO-mediated pathway not involving peroxynitrite: implications for Parkinson's diseaseQ45269246
Tissue-specific changes of mitochondrial functions in aged rats: effect of a long-term dietary treatment with N-acetylcysteineQ45275305
Role of nuclear transcription factor kappa B (NF-kappaB) for MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahyropyridine)-induced apoptosis in nigral neurons of miceQ46232854
Different protection of K252a and N-acetyl-L-cysteine against amyloid-beta peptide-induced cortical neuron apoptosis involving inhibition of MLK3-MKK7-JNK3 signal cascadesQ46296648
Quinone and oxyradical scavenging properties of N-acetylcysteine prevent dopamine mediated inhibition of Na+, K+-ATPase and mitochondrial electron transport chain activity in rat brain: implications in the neuroprotective therapy of Parkinson's diseQ46527836
N-acetylcysteine prevents beta-amyloid toxicity by a stimulatory effect on p35/cyclin-dependent kinase 5 activity in cultured cortical neuronsQ46567564
Role of oxidative stress in pathophysiology of peripheral neuropathy and modulation by N-acetyl-L-cysteine in ratsQ46743652
The effect of ethyl pyruvate and N-acetylcysteine on ischemia-reperfusion injury in an experimental model of ischemic strokeQ47818081
Genetic and environmental risk factors in Parkinson's diseaseQ47938136
Evaluation of the Neuroprotective Potential of N-Acetylcysteine for Prevention and Treatment of Cognitive Aging and DementiaQ47946531
N-acetylcysteine elicited increase in cytochrome c oxidase activity in mice synaptic mitochondria.Q48087819
Repeated-Dose Oral N-Acetylcysteine in Parkinson's Disease: Pharmacokinetics and Effect on Brain Glutathione and Oxidative StressQ48100438
In vivo modulation of rodent glutathione and its role in peroxynitrite-induced neocortical synaptosomal membrane protein damageQ48249285
Ultrastructural characteristics of tau filaments in tauopathies: immuno-electron microscopic demonstration of tau filaments in tauopathiesQ48380434
Oxidative stress precedes fibrillar deposition of Alzheimer's disease amyloid beta-peptide (1-42) in a transgenic Caenorhabditis elegans modelQ48381823
Antioxidants attenuate multiple phases of formalin-induced nociceptive response in mice.Q48443158
Protective effect of N-acetyl-L-cysteine on amyloid beta-peptide-induced learning and memory deficits in miceQ48461244
Aggregated amyloid-beta protein induces cortical neuronal apoptosis and concomitant "apoptotic" pattern of gene induction.Q48620994
Oxidized glutathione modulates N-methyl-D-aspartate- and depolarization-induced increases in intracellular Ca2+ in cultured rat forebrain neuronsQ48622602
N-acetylcysteine protects against age-related increase in oxidized proteins in mouse synaptic mitochondriaQ48658513
Normobaric Hyperoxia Extends Neuro- and Vaso-Protection of N-Acetylcysteine in Transient Focal IschemiaQ48737963
Limb remote postconditioning alleviates cerebral reperfusion injury through reactive oxygen species-mediated inhibition of delta protein kinase C in ratsQ48933902
Age-related increase in oxidized proteins in mouse synaptic mitochondriaQ48939604
N-acetylcysteine treatment attenuates the cognitive impairment and synaptic plasticity loss induced by streptozotocin.Q50438231
Maintenance of Cognitive Performance and Mood for Individuals with Alzheimer's Disease Following Consumption of a Nutraceutical Formulation: A One-Year, Open-Label Study.Q50663391
A Phase II Randomized Clinical Trial of a Nutritional Formulation for Cognition and Mood in Alzheimer's Disease.Q50758347
Reactive oxygen species enhance excitatory synaptic transmission in rat spinal dorsal horn neurons by activating TRPA1 and TRPV1 channels.Q50960514
N-acetyl-cysteine attenuates neuropathic pain by suppressing matrix metalloproteinases.Q51532696
N-Acetylcysteine delays age-associated memory impairment in mice: role in synaptic mitochondria.Q52029587
Diabetes enhances oxidative stress-induced TRPM2 channel activity and its control by N-acetylcysteine in rat dorsal root ganglion and brain.Q52145830
Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability.Q53248798
N-Acetylcysteine for the Treatment of Psychiatric Disorders: A Review of Current EvidenceQ58698161
Neuropathic painQ59510177
N -Acetylcysteine Enhances Hippocampal Neuronal Survival After Transient Forebrain Ischemia in RatsQ60153477
Effect of N-acetylcysteine on the spinal-cord glutathione system and nitric-oxide metabolites in rats with neuropathic painQ61182724
N-acetylcysteine elicited increase in complex I activity in synaptic mitochondria from aged mice: implications for treatment of Parkinson's diseaseQ64787845
Regulation of gamma-glutamyl-cysteine synthetase by nonallosteric feedback inhibition by glutathioneQ66909758
Prevention of dopamine-induced cell death by thiol antioxidants: possible implications for treatment of Parkinson's disease.Q67228281
Dose dependent pharmacokinetics of N-acetylcysteine after oral dosing to manQ68758976
Metabolism of N-acetyl-L-cysteine. Some structural requirements for the deacetylation and consequences for the oral bioavailabilityQ69403184
Immunomodulatory and protective effects of N-acetylcysteine in mitogen-activated murine splenocytes in vitroQ73040013
In-vivo glutathione elevation protects against hydroxyl free radical-induced protein oxidation in rat brainQ73453586
N-acetylcysteine suppresses TNF-induced NF-kappaB activation through inhibition of IkappaB kinasesQ73731634
N-acetyl cysteine inhibits induction of no production by endotoxin or cytokine stimulated rat peritoneal macrophages, C6 glial cells and astrocytesQ74069333
Prevention of PC12 cell death by N-acetylcysteine requires activation of the Ras pathwayQ74562743
Alzheimer's disease results from the cerebral accumulation and cytotoxicity of amyloid beta-proteinQ74736370
Parkinsonism in Ontario: increased mortality compared with controls in a large cohort studyQ77387951
Sulfasalazine attenuates ACL transection and medial menisectomy-induced cartilage destruction by inhibition of cystine/glutamate antiporterQ86487669
Intake of vitamin E, vitamin C, and carotenoids and the risk of Parkinson's disease: a meta-analysisQ33215518
Hypothesis: can N-acetylcysteine be beneficial in Parkinson's disease?Q33607640
Oral N-Acetyl-Cysteine Attenuates Loss of Dopaminergic Terminals in α-Synuclein Overexpressing MiceQ33680232
Involvements of the lipid peroxidation product, HNE, in the pathogenesis and progression of Alzheimer's diseaseQ33915362
The origin and neuronal function of in vivo nonsynaptic glutamate.Q34155228
Stroke intervention pathways: NMDA receptors and beyondQ34163807
System xc⁻ cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS.Q34184493
The chemistry and biological activities of N-acetylcysteineQ34341263
Glutathione is an endogenous ligand of rat brain N-methyl-D-aspartate (NMDA) and 2-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptorsQ34434863
Synaptic plasticity impairment and hypofunction of NMDA receptors induced by glutathione deficit: relevance to schizophreniaQ34473140
Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic reviewQ34475761
Cystine/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seekingQ34480486
N-acetylcysteine in the treatment of psychiatric disorders: current status and future prospects.Q34543171
Role of membrane transport in metabolism and function of glutathione in mammalsQ34558675
NMDA receptor subunits: function and pharmacology.Q34579640
From revolution to evolution: the glutamate hypothesis of schizophrenia and its implication for treatmentQ34632695
Lipid peroxidation and protein oxidation in Alzheimer's disease brain: potential causes and consequences involving amyloid beta-peptide-associated free radical oxidative stressQ34657995
Pharmacologic management of neuropathic pain: evidence-based recommendationsQ34699259
Metabotropic glutamate receptor involvement in models of acute and persistent pain: prospects for the development of novel analgesicsQ35137409
Role of distinct NMDA receptor subtypes at central synapsesQ35923174
Rationale for the development of cholinesterase inhibitors as anti-Alzheimer agents.Q35950157
The role of glutathione in radiation and drug induced cytotoxicity.Q36290861
Tumor necrosis factor alpha-induced apoptosis in human neuronal cells: protection by the antioxidant N-acetylcysteine and the genes bcl-2 and crmAQ36550693
Oxidative damage in mild cognitive impairment and early Alzheimer's diseaseQ36825753
Mitochondrial dysfunction in aging and Alzheimer's disease: strategies to protect neuronsQ36909218
N-acetylcysteine and neurodegenerative diseases: basic and clinical pharmacologyQ36939735
Acetylcholine esterase activity in mild cognitive impairment and Alzheimer's diseaseQ37057317
Inflammatory aspects of Alzheimer disease and other neurodegenerative disordersQ37167095
Lipopolysaccharide-induced peroxisomal dysfunction exacerbates cerebral white matter injury: attenuation by N-acetyl cysteineQ37170694
Molecular mechanisms of L-DOPA-induced dyskinesiaQ37247578
Metabotropic receptors for glutamate and GABA in pain.Q37369271
Contribution of cystine-glutamate antiporters to the psychotomimetic effects of phencyclidineQ37533087
The glutamate homeostasis hypothesis of addictionQ37538517
???Q64767196
Activated astroglia during chronic inflammation in Alzheimer's disease--do they neglect their neurosupportive roles?Q37596067
N-Acetylcysteine boosts brain and blood glutathione in Gaucher and Parkinson diseases.Q37603362
Hypoxia-inducible factor 1 contributes to N-acetylcysteine's protection in strokeQ37619972
The functional neurophysiology of the amyloid precursor protein (APP) processing pathwayQ37694798
Clinical pharmacokinetics of N-acetylcysteineQ37713718
Antioxidant approaches for the treatment of Alzheimer's diseaseQ37768449
Molecular basis of NMDA receptor functional diversity.Q37852112
Glutamatergic medications for the treatment of drug and behavioral addictionsQ37871133
Nutritional approaches to modulate oxidative stress in Alzheimer's diseaseQ37878523
Molecular mechanisms of l-DOPA-induced dyskinesia.Q37930022
What Future Role Might N-Acetyl-Cysteine Have in the Treatment of Obsessive Compulsive and Grooming Disorders?: A Systematic Review.Q38656700
2016 Alzheimer's disease facts and figuresQ39444315
Role of glutathione and other endogenous thiols in radiation protectionQ39546805
Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: insights into the development of Alzheimer's diseaseQ40352054
1 Glutathione metabolismQ40468949
The protection conferred against ischemia-reperfusion injury in the diabetic brain by N-acetylcysteine is associated with decreased dicarbonyl stressQ40797864
Are dopaminergic neurons selectively vulnerable to Parkinson's disease?Q40868945
Glutathione depletion in PC12 results in selective inhibition of mitochondrial complex I activity. Implications for Parkinson's disease.Q41740537
N-Acetyl-cysteine causes analgesia by reinforcing the endogenous activation of type-2 metabotropic glutamate receptors.Q41843975
Determining the critical nucleus and mechanism of fibril elongation of the Alzheimer's Abeta(1-40) peptide.Q42059881
N-acetylcysteine downregulates phosphorylated p-38 expression but does not reverse the increased superoxide anion levels in the spinal cord of rats with neuropathic painQ42317396
Reduced intravenous glutathione in the treatment of early Parkinson's diseaseQ42644977
Effects of N-acetylcysteine on spinal cord oxidative stress biomarkers in rats with neuropathic painQ42664517
Maintenance of glutathione content is isolated hepatocyctesQ42932952
Potential in vivo amelioration by N-acetyl-L-cysteine of oxidative stress in brain in human double mutant APP/PS-1 knock-in mice: toward therapeutic modulation of mild cognitive impairmentQ42963006
Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseasesQ43130235
Effect of oral N-acetylcysteine treatment on plasma inflammatory and oxidative stress markers in peritoneal dialysis patients: a placebo-controlled studyQ43147200
Integrated regulation of signal coding and plasticity by NMDA receptors at a central synapse.Q43182255
Transcriptional regulation of type-2 metabotropic glutamate receptors: an epigenetic path to novel treatments for chronic painQ43197524
Pyruvate released by astrocytes protects neurons from copper-catalyzed cysteine neurotoxicity.Q43594208
Therapeutic potential of N-acetylcysteine in age-related mitochondrial neurodegenerative diseasesQ43599271
Glutathione elevation and its protective role in acrolein-induced protein damage in synaptosomal membranes: relevance to brain lipid peroxidation in neurodegenerative diseaseQ43641383
The glial glutamate transporter, GLT-1, is oxidatively modified by 4-hydroxy-2-nonenal in the Alzheimer's disease brain: the role of Abeta1-42.Q43681037
Therapeutic efficacy of aortic administration of N-acetylcysteine as a chemoprotectant against bone marrow toxicity after intracarotid administration of alkylators, with or without glutathione depletion in a rat model.Q43787467
N-Acetyl-L-Cystein downregulates beta-amyloid precursor protein gene transcription in human neuroblastoma cellsQ43799400
N-acetyl-L-cysteine inhibits 26S proteasome function: implications for effects on NF-kappaB activationQ43962734
3-nitropropionic acid-induced changes in bilayer fluidity in synaptosomal membranes: implications for Huntington's diseaseQ44116936
Antioxidants inhibit the human cortical neuron apoptosis induced by hydrogen peroxide, tumor necrosis factor alpha, dopamine and beta-amyloid peptide 1-42.Q44319953
The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 miceQ44326540
N-Acetyl cysteine protects against injury in a rat model of focal cerebral ischemiaQ44401022
Neuroadaptations in cystine-glutamate exchange underlie cocaine relapseQ44460612
Nigral glutathione deficiency is not specific for idiopathic Parkinson's disease.Q44591949
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectamino acidQ8066
neurodegenerationQ1755122
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)3305
P577publication date2018-12-13
P1433published inMoleculesQ151332
P1476titleOverview on the Effects of N-Acetylcysteine in Neurodegenerative Diseases
P478volume23

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cites work (P2860)
Q90385275Antinociceptive and anti-inflammatory effects of N-acetylcysteine and verapamil in Wistar rats
Q90522821Antioxidants Reduce Muscular Dystrophy in the dy2J/dy2J Mouse Model of Laminin α2 Chain-Deficient Muscular Dystrophy
Q89599040Exposure of CuO Nanoparticles Contributes to Cellular Apoptosis, Redox Stress, and Alzheimer's Aβ Amyloidosis
Q91611173Medical and Dietary Uses of N-Acetylcysteine
Q92167765Oxidative stress-induced angiogenesis is mediated by miR-205-5p
Q91738703Protective potentials of Annona muricata fruit pulp on etoposide-induced gastrointestinal toxicity in Wistar rats
Q98224443Spotlight on Ferroptosis: Iron-Dependent Cell Death in Alzheimer's Disease
Q64891767The Role of N-Methyl-D-Aspartate Receptor Neurotransmission and Precision Medicine in Behavioral and Psychological Symptoms of Dementia.

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