The importance of neuritic plaques and tangles to the development and evolution of AD

scientific article

The importance of neuritic plaques and tangles to the development and evolution of AD is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1212/01.WNL.0000129697.01779.0A
P3181OpenCitations bibliographic resource ID3845862
P698PubMed publication ID15184601

P50authorJody Corey-BloomQ50848575
Leon J. ThalQ56839882
P2093author name stringL. A. Hansen
L A Hansen
P Tiraboschi
P. Tiraboschi
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)1984-1989
1984-9
P577publication date2004-06-07
2004-06-08
P1433published inNeurologyQ1161692
P1476titleThe importance of neuritic plaques and tangles to the development and evolution of AD
P478volume62

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cites work (P2860)
Q35208143"End-stage" neurofibrillary tangle pathology in preclinical Alzheimer's disease: fact or fiction?
Q28828212A chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibition
Q38862070A myristoylated cell-penetrating peptide bearing a transferrin receptor-targeting sequence for neuro-targeted siRNA delivery
Q36385926A novel inhibitor of amyloid β (Aβ) peptide aggregation: from high throughput screening to efficacy in an animal model of Alzheimer disease
Q35005568A review of creatine supplementation in age-related diseases: more than a supplement for athletes
Q35106666A systematic review of single chinese herbs for Alzheimer's disease treatment
Q30455082APP transgenic mice for modelling behavioural and psychological symptoms of dementia (BPSD).
Q38073067Advances in microfluidics-based experimental methods for neuroscience research
Q57792155Age dependency of cerebral P-glycoprotein function in wild-type and APPPS1 mice measured with PET
Q37700238Age-related changes of protein SUMOylation balance in the AβPP Tg2576 mouse model of Alzheimer's disease
Q92874248Aggregation States of Aβ1-40, Aβ1-42 and Aβp3-42 Amyloid Beta Peptides: A SANS Study
Q47094454Alzheimer disease neuropathology: understanding autonomic dysfunction
Q36713885Alzheimer's disease protein Abeta1-42 does not disrupt isolated synaptic vesicles
Q37785311Alzheimer's secretases regulate voltage-gated sodium channels
Q27009411Amyloid PET in clinical practice: Its place in the multidimensional space of Alzheimer's disease
Q37698159Amyloid deposition is linked to aberrant entorhinal activity among cognitively normal older adults
Q33775494Amyloid load in nondemented brains correlates with APOE e4.
Q60530541Amyloid, tau, pathogen infection and antimicrobial protection in Alzheimer's disease -conformist, nonconformist, and realistic prospects for AD pathogenesis
Q34070840An efficient approach for differentiating Alzheimer's disease from normal elderly based on multicenter MRI using gray-level invariant features
Q33536493Analysis of microdissected human neurons by a sensitive ELISA reveals a correlation between elevated intracellular concentrations of Abeta42 and Alzheimer's disease neuropathology
Q34007682Analysis of microdissected neurons by 18O mass spectrometry reveals altered protein expression in Alzheimer's disease
Q53333346Apolipoprotein E genotype and neurological disease onset in Niemann-Pick disease, type C1.
Q58609478Association between normal tension glaucoma and the risk of Alzheimer's disease: a nationwide population-based cohort study in Taiwan
Q38247994Autophagy and neurodegenerative disorders
Q48884122Beta-amyloid induced changes in A-type K⁺ current can alter hippocampo-septal network dynamics.
Q34310255Beta-amyloid oligomers activate apoptotic BAK pore for cytochrome c release.
Q50928336Betaine attenuates Alzheimer-like pathological changes and memory deficits induced by homocysteine.
Q37915439Casting a net on dendritic spines: the extracellular matrix and its receptors
Q92638553Changes in visual function and retinal structure in the progression of Alzheimer's disease
Q37035800Characterization of Japanese-American men with a single neocortical AD lesion type
Q33670849Characterizing amyloid‐beta protein misfolding from molecular dynamics simulations with explicit water
Q48558378Clearing the fog: patenting trends for the treatment of Alzheimer's disease
Q34554590Clinicopathologic correlations in a large Alzheimer disease center autopsy cohort: neuritic plaques and neurofibrillary tangles "do count" when staging disease severity
Q36691131Co-localization of amyloid beta and tau pathology in Alzheimer's disease synaptosomes
Q37180132Coexisting cholinergic and parahippocampal degeneration: a key to memory loss in dementia and a challenge for transgenic models?
Q34061233Cognition, glucose metabolism and amyloid burden in Alzheimer's disease
Q36575903Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature
Q33389200Criteria for the neuropathological diagnosis of dementing disorders: routes out of the swamp?
Q38199058Cytoplasmic dynein: a key player in neurodegenerative and neurodevelopmental diseases
Q38807264DYRK1A inhibition as potential treatment for Alzheimer's disease.
Q36787352Dementia syndromes: evaluation and treatment
Q38109214Developmental neuroplasticity and the origin of neurodegenerative diseases
Q36380210Differential regulation of inhibitors of apoptosis proteins in Alzheimer's disease brains
Q47555988Differentiating between Alzheimer Disease Patients and Controls with Phase-difference-enhanced Imaging at 3T: A Feasibility Study
Q43427045Dihydromyricetin ameliorates behavioral deficits and reverses neuropathology of transgenic mouse models of Alzheimer's disease
Q47260966Disrupted functional connectivity between perirhinal and parahippocampal cortices with hippocampal subfields in patients with mild cognitive impairment and Alzheimer's disease
Q33993507Effect size of reference memory deficits in the Morris water maze in Tg2576 mice
Q90477691Elucidating Critical Proteinopathic Mechanisms and Potential Drug Targets in Neurodegeneration
Q64263723Epigenetic Modifications in Alzheimer's Neuropathology and Therapeutics
Q34543638Expression of α-subunit of α-glucosidase II in adult mouse brain regions and selected organs
Q64121571GeneAnalytics Pathways and Profiling of Shared Autism and Cancer Genes
Q35686013Genetic association of TNF-α-308 G/A and -863 C/A polymorphisms with late onset Alzheimer's disease in Azeri Turk population of Iran
Q41960357Heavy metals and neurodegenerative diseases: an observational study
Q35855414Heterogeneity of Regional Brain Atrophy Patterns Associated with Distinct Progression Rates in Alzheimer's Disease
Q48416807Hippocampal neuron loss is correlated with cognitive deficits in SAMP8 mice
Q64244115Identification and Analysis of Alzheimer's Candidate Genes by an Amplitude Deviation Algorithm
Q47665108Identification of a small set of plasma signalling proteins using neural network for prediction of Alzheimer's disease
Q51911405Imaging dementing illnesses.
Q48326005Impact of Alzheimer's pathology on cognitive trajectories in nondemented elderly
Q64080477Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis
Q47556778Impact of social relationships on Alzheimer's memory impairment: mechanistic studies
Q36967181In vitro and in vivo study of effects of fermented soybean product (chungkookjang) on NGF secretion ability and NGF receptor signaling pathway
Q64988218Inhibition of Phosphodiesterase-4 Reverses Aβ-Induced Memory Impairment by Regulation of HPA Axis Related cAMP Signaling.
Q37813015Interleukin-1β with learning and memory
Q64054840Interpretable classification of Alzheimer’s disease pathologies with a convolutional neural network pipeline
Q34776816Is there a neuropathology difference between mild cognitive impairment and dementia?
Q30366183Lead discovery for Alzheimer's disease related target protein RbAp48 from traditional Chinese medicine.
Q92543632Linking the low-density lipoprotein receptor-binding segment enables the therapeutic 5-YHEDA peptide to cross the blood-brain barrier and scavenge excess iron and radicals in the brain of senescent mice
Q36958569MRI measures of temporoparietal regions show differential rates of atrophy during prodromal AD.
Q39153824Main Plant Extracts' Active Properties Effective on Scopolamine-Induced Memory Loss
Q38870841Matrix metalloproteinases in the brain and blood-brain barrier: Versatile breakers and makers
Q38151704Matrix metalloproteinases, new insights into the understanding of neurodegenerative disorders
Q38187044Mercury toxicity and neurodegenerative effects
Q35349339Mining disease genes using integrated protein-protein interaction and gene-gene co-regulation information
Q33828911Modeling the association between 43 different clinical and pathological variables and the severity of cognitive impairment in a large autopsy cohort of elderly persons
Q26783344Molecular and biochemical trajectories from diabetes to Alzheimer's disease: A critical appraisal
Q35228880Monodisperse carboxyl-functionalized poly(ethylene glycol)-coated magnetic poly(glycidyl methacrylate) microspheres: application to the immunocapture of β-amyloid peptides
Q37559812Multi-Target-Directed Ligands and other Therapeutic Strategies in the Search of a Real Solution for Alzheimer's Disease
Q26825619N-methyl D-aspartate (NMDA) receptor antagonists and memantine treatment for Alzheimer's disease, vascular dementia and Parkinson's disease
Q40867620NSAID-based γ-secretase modulators do not bind to the amyloid-β polypeptide
Q38388660Neuritic and Diffuse Plaque Associations with Memory in Non-Cognitively Impaired Elderly
Q33288482Neuropathological findings processed by artificial neural networks (ANNs) can perfectly distinguish Alzheimer's patients from controls in the Nun Study
Q36496131Neuropathological quantification of dtg APP/PS1: neuroimaging, stereology, and biochemistry
Q37218110Neuropathology and cognitive impairment in Alzheimer disease: a complex but coherent relationship
Q61449183Neuropeptides Exert Neuroprotective Effects in Alzheimer's Disease
Q58130251New genetic players in late-onset Alzheimer's disease: Findings of genome-wide association studies
Q38170010New insight into neurodegeneration: the role of proteomics
Q46979323Nicotinamide treatment reduces the levels of oxidative stress, apoptosis, and PARP-1 activity in Aβ(1-42)-induced rat model of Alzheimer's disease.
Q35993835Ocular manifestations of Alzheimer's disease in animal models.
Q30572288Origins of Alzheimer's disease: reconciling cerebrospinal fluid biomarker and neuropathology data regarding the temporal sequence of amyloid-beta and tau involvement
Q60957194Overview on the Effects of -Acetylcysteine in Neurodegenerative Diseases
Q37421024Oxidative stress and neurodegenerative disorders
Q33783748Pathways for small molecule delivery to the central nervous system across the blood-brain barrier
Q90215258Peripheral Biomarkers for Early Detection of Alzheimer's and Parkinson's Diseases
Q36576018Pharmacokinetics of cotinine in rats: a potential therapeutic agent for disorders of cognitive function
Q36962319Potential role of PCTAIRE-2, PCTAIRE-3 and P-Histone H4 in amyloid precursor protein-dependent Alzheimer pathology
Q36298571Prediction and classification of Alzheimer disease based on quantification of MRI deformation
Q60960925Prediction of Autopsy Verified Neuropathological Change of Alzheimer's Disease Using Machine Learning and MRI
Q34354478Probable Early-Onset Alzheimer’s Disease in an Apolipoprotein E2 Homozygote
Q35223610Profiles of SUMO and ubiquitin conjugation in an Alzheimer's disease model
Q37644772Protective effect of APOE epsilon 2 on intrinsic functional connectivity of the entorhinal cortex is associated with better episodic memory in elderly individuals with risk factors for Alzheimer's disease
Q38468247Protein Drug Targets of Lavandula angustifolia on treatment of Rat Alzheimer's Disease
Q37553976Protein SUMOylation in neuropathological conditions.
Q41869540Protein kinase C-regulated aβ production and clearance
Q38746607Quantum dot-mediated delivery of siRNA to inhibit sphingomyelinase activities in brain-derived cells
Q91771264RNA Granules and Their Role in Neurodegenerative Diseases
Q64243648Random forest prediction of Alzheimer's disease using pairwise selection from time series data
Q38061634Recent advances in the design, synthesis, and biological evaluation of selective DYRK1A inhibitors: a new avenue for a disease modifying treatment of Alzheimer's?
Q39613391Regional dynamics of amyloid-β deposition in healthy elderly, mild cognitive impairment and Alzheimer's disease: a voxelwise PiB-PET longitudinal study
Q38435275Registering eye movements during reading in Alzheimer's disease: difficulties in predicting upcoming words
Q34438729Resting-state network disruption and APOE genotype in Alzheimer's disease: a lagged functional connectivity study
Q35581060Review of 'the potential role of arterial stiffness in the pathogenesis of Alzheimer's disease'.
Q36418108Role of ABC transporters in the pathogenesis of Alzheimer's disease
Q38659590Role of Apolipoproteins and α-Synuclein in Parkinson's Disease.
Q37922607Role of metal ions in aggregation of intrinsically disordered proteins in neurodegenerative diseases
Q87404860Role of pH in structural changes for Pin1 protein: an insight from molecular dynamics study
Q26783370SUMOylation: Novel Neuroprotective Approach for Alzheimer's Disease?
Q49096980Sex Dimorphism Profile of Alzheimer's Disease-Type Pathologies in an APP/PS1 Mouse Model
Q36115392Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid β production and clearance
Q48248565Social interaction rescues memory deficit in an animal model of Alzheimer's disease by increasing BDNF-dependent hippocampal neurogenesis.
Q47799714Sumoylation: Implications for Neurodegenerative Diseases
Q37783348Synthesis and transport of creatine in the CNS: importance for cerebral functions
Q38812439T-type Ca(2+) channels: New players in the aging brain
Q90450363The effect of ApoE ε 4 on clinical and structural MRI markers in prodromal Alzheimer's disease
Q37544199The effect of the top 20 Alzheimer disease risk genes on gray-matter density and FDG PET brain metabolism
Q34159126The emerging role of guanine nucleotide exchange factors in ALS and other neurodegenerative diseases.
Q38527233The epigenetics of aging and neurodegeneration.
Q38563230The impact of base excision DNA repair in age-related neurodegenerative diseases
Q33652461The importance of hydrogen bonding between the glutamine side chains to the formation of amyloid VQIVYK parallel beta-sheets: an ONIOM DFT/AM1 study
Q30441452The involvement of secondary neuronal damage in the development of neuropsychiatric disorders following brain insults
Q37038726The role of DNA repair in brain related disease pathology
Q35551001The role of environmental exposures in neurodegeneration and neurodegenerative diseases
Q33943520Thinking outside the box: Alzheimer-type neuropathology that does not map directly onto current consensus recommendations
Q28082768Three dimensions of the amyloid hypothesis: time, space and 'wingmen'
Q48485666Tomoregulin-2 is found extensively in plaques in Alzheimer's disease brain
Q35861900Tract-based analysis of white matter degeneration in Alzheimer's disease.
Q37253034Transdermal delivery of treatment for Alzheimer's disease: development, clinical performance and future prospects
Q37352964Transglutaminase activation in neurodegenerative diseases.
Q38874015Ubiquitin-dependent and independent roles of SUMO in proteostasis
Q38039079Understanding complexity in neurodegenerative diseases: in silico reconstruction of emergence
Q34418781Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models
Q99240291Vaccination Prevented Short-Term Memory Loss, but Deteriorated Long-Term Spatial Memory in Alzheimer's Disease Mice, Independent of Amyloid-β Pathology
Q89766852β-Arrestin2 oligomers impair the clearance of pathological tau and increase tau aggregates
Q60191481„Default-mode“-Netzwerk des Gehirns

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