| review article | Q7318358 |
| scholarly article | Q13442814 |
| P50 | author | David J Topham | Q57294998 |
| Marta L DeDiego | Q61471846 | ||
| Luis Martinez-Sobrido | Q55189492 | ||
| Aitor Nogales | Q56528198 | ||
| P2860 | cites work | Influenza A and B viruses expressing altered NS1 proteins: A vaccine approach | Q33895154 |
| Innate immunity to influenza virus infection | Q33923354 | ||
| Quantitative proteomic analysis of the influenza A virus nonstructural proteins NS1 and NS2 during natural cell infection identifies PACT as an NS1 target protein and antiviral host factor | Q34059267 | ||
| Lethal H5N1 influenza viruses escape host anti-viral cytokine responses | Q34146021 | ||
| Molecular pathways in virus-induced cytokine production | Q34174972 | ||
| RNA binding by the novel helical domain of the influenza virus NS1 protein requires its dimer structure and a small number of specific basic amino acids | Q34361738 | ||
| Glycine 184 in nonstructural protein NS1 determines the virulence of influenza A virus strain PR8 without affecting the host interferon response | Q34416678 | ||
| Species-specific inhibition of RIG-I ubiquitination and IFN induction by the influenza A virus NS1 protein | Q34499411 | ||
| The cold adapted and temperature sensitive influenza A/Ann Arbor/6/60 virus, the master donor virus for live attenuated influenza vaccines, has multiple defects in replication at the restrictive temperature | Q34596703 | ||
| The primary function of RNA binding by the influenza A virus NS1 protein in infected cells: Inhibiting the 2'-5' oligo (A) synthetase/RNase L pathway | Q34598589 | ||
| Type I IFN triggers RIG-I/TLR3/NLRP3-dependent inflammasome activation in influenza A virus infected cells | Q34671862 | ||
| Geographic dependence, surveillance, and origins of the 2009 influenza A (H1N1) virus | Q34983373 | ||
| Strong interferon-inducing capacity of a highly virulent variant of influenza A virus strain PR8 with deletions in the NS1 gene | Q35000926 | ||
| Type I and type III interferons drive redundant amplification loops to induce a transcriptional signature in influenza-infected airway epithelia | Q35053045 | ||
| The virulence of 1997 H5N1 influenza viruses in the mouse model is increased by correcting a defect in their NS1 proteins | Q35077820 | ||
| Influenza virus non-structural protein NS1: interferon antagonism and beyond. | Q35237056 | ||
| Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B. | Q35566028 | ||
| Influenza A Virus NS1 Protein Inhibits the NLRP3 Inflammasome | Q35610815 | ||
| Influenza virus targets the mRNA export machinery and the nuclear pore complex | Q35629429 | ||
| PA-X decreases the pathogenicity of highly pathogenic H5N1 influenza A virus in avian species by inhibiting virus replication and host response | Q35640905 | ||
| IκB kinase epsilon (IKK(epsilon)) regulates the balance between type I and type II interferon responses | Q35641446 | ||
| Influenza A virus NS1 protein activates the PI3K/Akt pathway to mediate antiapoptotic signaling responses | Q35785139 | ||
| Enhanced virus resistance of transgenic mice expressing the human MxA protein. | Q35842115 | ||
| A20 Deficiency in Lung Epithelial Cells Protects against Influenza A Virus Infection | Q35905711 | ||
| Selective Degradation of Host RNA Polymerase II Transcripts by Influenza A Virus PA-X Host Shutoff Protein. | Q35915706 | ||
| The RNA binding domain of influenza A virus NS1 protein affects secretion of tumor necrosis factor alpha, interleukin-6, and interferon in primary murine tracheal epithelial cells | Q35947867 | ||
| Regulation of a nuclear export signal by an adjacent inhibitory sequence: the effector domain of the influenza virus NS1 protein | Q36058189 | ||
| Spotlight on the NLRP3 inflammasome pathway | Q57069855 | ||
| Functional Evolution of the 2009 Pandemic H1N1 Influenza Virus NS1 and PA in Humans | Q57093666 | ||
| The continual threat of influenza virus infections at the human-animal interface: What is new from a one health perspective? | Q57093697 | ||
| Inhibition of cell-free protein synthesis by pppA2′ p5′ A2′ p5′ A: a novel oligonucleotide synthesized by interferon-treated L cell extracts | Q58667075 | ||
| Host Shutoff in Influenza A Virus: Many Means to an End | Q58762417 | ||
| Novel Flu Viruses in Bats and Cattle: "Pushing the Envelope" of Influenza Infection | Q58798213 | ||
| The Discovery of the Antiviral Resistance Gene Mx: A Story of Great Ideas, Great Failures, and Some Success | Q59357902 | ||
| Influenza A mutant viruses with altered NS1 protein function provoke caspase-1 activation in primary human macrophages, resulting in fast apoptosis and release of high levels of interleukins 1beta and 18 | Q81158144 | ||
| The multifunctional NS1 protein of influenza A viruses | Q28294201 | ||
| Influenza A virus attenuation by codon deoptimization of the NS gene for vaccine development | Q28395006 | ||
| Cellular antiviral responses against influenza A virus are countered at the posttranscriptional level by the viral NS1A protein via its binding to a cellular protein required for the 3' end processing of cellular pre-mRNAS | Q28609773 | ||
| A recombinant influenza A virus expressing an RNA-binding-defective NS1 protein induces high levels of beta interferon and is attenuated in mice | Q28609778 | ||
| Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3'end formation of cellular pre-mRNAs | Q28609836 | ||
| Influenza A Virus Lacking the NS1 Gene Replicates in Interferon-Deficient Systems | Q29039793 | ||
| Mortality associated with influenza and respiratory syncytial virus in the United States | Q29615578 | ||
| Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans | Q29619059 | ||
| Regulation of influenza A virus induced CXCL-10 gene expression requires PI3K/Akt pathway and IRF3 transcription factor | Q30155582 | ||
| Mechanism of influenza A virus NS1 protein interaction with the p85beta, but not the p85alpha, subunit of phosphatidylinositol 3-kinase (PI3K) and up-regulation of PI3K activity | Q30157667 | ||
| SH3 binding motif 1 in influenza A virus NS1 protein is essential for PI3K/Akt signaling pathway activation | Q30157758 | ||
| Standing on three legs: antiviral activities of RIG-I against influenza viruses | Q30244017 | ||
| A review of vaccine research and development: human acute respiratory infections. | Q30351377 | ||
| Multiple anti-interferon actions of the influenza A virus NS1 protein | Q30361157 | ||
| Infection and pathogenesis of canine, equine, and human influenza viruses in canine tracheas | Q30363291 | ||
| Functional genomic and serological analysis of the protective immune response resulting from vaccination of macaques with an NS1-truncated influenza virus. | Q30363578 | ||
| The contribution of PA-X to the virulence of pandemic 2009 H1N1 and highly pathogenic H5N1 avian influenza viruses. | Q30371441 | ||
| Influenza A Virus Protein PA-X Contributes to Viral Growth and Suppression of the Host Antiviral and Immune Responses | Q30373511 | ||
| Twenty amino acids at the C-terminus of PA-X are associated with increased influenza A virus replication and pathogenicity. | Q30373730 | ||
| Transmission of influenza virus in a mammalian host is increased by PB2 amino acids 627K or 627E/701N. | Q30374182 | ||
| PA-X is a virulence factor in avian H9N2 influenza virus. | Q30378192 | ||
| The RNA- and TRIM25-Binding Domains of Influenza Virus NS1 Protein Are Essential for Suppression of NLRP3 Inflammasome-Mediated Interleukin-1β Secretion | Q30384313 | ||
| Mutations in the NS1 C-terminal tail do not enhance replication or virulence of the 2009 pandemic H1N1 influenza A virus. | Q30386800 | ||
| Inefficient control of host gene expression by the 2009 pandemic H1N1 influenza A virus NS1 protein | Q30388846 | ||
| NS-based live attenuated H1N1 pandemic vaccines protect mice and ferrets | Q30394706 | ||
| Impacts of different expressions of PA-X protein on 2009 pandemic H1N1 virus replication, pathogenicity and host immune responses. | Q30398067 | ||
| An overview of the epidemiology and emergence of influenza A infection in humans over time | Q30400433 | ||
| Influenza A viruses: new research developments | Q30404670 | ||
| Effects of the C-terminal truncation in NS1 protein of the 2009 pandemic H1N1 influenza virus on host gene expression | Q30408557 | ||
| Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis | Q30408691 | ||
| Viral phosphodiesterases that antagonize double-stranded RNA signaling to RNase L by degrading 2-5A | Q33714369 | ||
| Activation of interferon regulatory factor 3 is inhibited by the influenza A virus NS1 protein | Q33810694 | ||
| Attenuation of equine influenza viruses through truncations of the NS1 protein | Q33843410 | ||
| Influenza A viruses with truncated NS1 as modified live virus vaccines: pilot studies of safety and efficacy in horses | Q33886927 | ||
| Conformational plasticity of the influenza A virus NS1 protein | Q38220184 | ||
| IFITM-Family Proteins: The Cell's First Line of Antiviral Defense | Q38323041 | ||
| Timing Is Everything: Coordinated Control of Host Shutoff by Influenza A Virus NS1 and PA-X Proteins | Q38422972 | ||
| Phase I/II trial of a replication-deficient trivalent influenza virus vaccine lacking NS1. | Q38442047 | ||
| Inhibition of the OAS/RNase L pathway by viruses | Q38558607 | ||
| Influenza A Virus Virulence Depends on Two Amino Acids in the N-Terminal Domain of Its NS1 Protein To Facilitate Inhibition of the RNA-Dependent Protein Kinase PKR. | Q38714315 | ||
| Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes | Q38739966 | ||
| G45R on nonstructural protein 1 of influenza A virus contributes to virulence by increasing the expression of proinflammatory cytokines in mice | Q38744046 | ||
| Directed selection of influenza virus produces antigenic variants that match circulating human virus isolates and escape from vaccine-mediated immune protection | Q38795680 | ||
| Influenza A virus-encoded NS1 virulence factor protein inhibits innate immune response by targeting IKK. | Q39297691 | ||
| Eukaryotic translation initiation factor 4GI is a cellular target for NS1 protein, a translational activator of influenza virus | Q39454971 | ||
| Phosphatidylinositol-3-kinase (PI3K) is activated by influenza virus vRNA via the pathogen pattern receptor Rig-I to promote efficient type I interferon production | Q39478013 | ||
| Influenza A virus NS1 protein prevents activation of NF-kappaB and induction of alpha/beta interferon | Q39593618 | ||
| Influenza A virus strains that circulate in humans differ in the ability of their NS1 proteins to block the activation of IRF3 and interferon-β transcription | Q39646325 | ||
| The influenza A virus NS1 protein inhibits activation of Jun N-terminal kinase and AP-1 transcription factors | Q39685168 | ||
| Splicing of influenza A virus NS1 mRNA is independent of the viral NS1 protein | Q39697237 | ||
| The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA. | Q39861713 | ||
| Prevention and Control of Seasonal Influenza with Vaccines: Recommendations of the Advisory Committee on Immunization Practices - United States, 2017-18 Influenza Season | Q40070473 | ||
| The K186E Amino Acid Substitution in the Canine Influenza Virus H3N8 NS1 Protein Restores Its Ability To Inhibit Host Gene Expression. | Q40072930 | ||
| Synthetic Toll-Like Receptor 4 (TLR4) and TLR7 Ligands Work Additively via MyD88 To Induce Protective Antiviral Immunity in Mice | Q40116011 | ||
| Properties of H7N7 influenza A virus strain SC35M lacking interferon antagonist NS1 in mice and chickens | Q40148649 | ||
| Functional Evolution of Influenza Virus NS1 Protein in Currently Circulating Human 2009 Pandemic H1N1 Viruses. | Q40150645 | ||
| Interplay of PA-X and NS1 Proteins in Replication and Pathogenesis of a Temperature-Sensitive 2009 Pandemic H1N1 Influenza A Virus | Q40150668 | ||
| A site on the influenza A virus NS1 protein mediates both inhibition of PKR activation and temporal regulation of viral RNA synthesis | Q40167332 | ||
| Small self-RNA generated by RNase L amplifies antiviral innate immunity | Q40180990 | ||
| IFNbeta induction by influenza A virus is mediated by RIG-I which is regulated by the viral NS1 protein | Q40202119 | ||
| Binding of the influenza A virus NS1 protein to PKR mediates the inhibition of its activation by either PACT or double-stranded RNA. | Q40319046 | ||
| NS1 Protein Amino Acid Changes D189N and V194I Affect Interferon Responses, Thermosensitivity, and Virulence of Circulating H3N2 Human Influenza A Viruses | Q40399903 | ||
| Influenza a virus NS1 protein induced A20 contributes to viral replication by suppressing interferon-induced antiviral response | Q40443239 | ||
| Canine influenza viruses with modified NS1 proteins for the development of live-attenuated vaccines | Q40503815 | ||
| Nuclear MxA proteins form a complex with influenza virus NP and inhibit the transcription of the engineered influenza virus genome | Q40695371 | ||
| PA-X-associated early alleviation of the acute lung injury contributes to the attenuation of a highly pathogenic H5N1 avian influenza virus in mice | Q40706208 | ||
| Essential role for the dsRNA-dependent protein kinase PKR in innate immunity to viral infection | Q40863327 | ||
| Mapping of a Region of the PA-X Protein of Influenza A Virus That Is Important for Its Shutoff Activity. | Q40871573 | ||
| The novel influenza A virus protein PA-X and its naturally deleted variant show different enzymatic properties in comparison to the viral endonuclease PA. | Q41347441 | ||
| Live-Attenuated Influenza Vaccine Effectiveness in Children From 2009 to 2015-2016: A Systematic Review and Meta-Analysis | Q41510419 | ||
| Emergence of a C-terminal seven-amino-acid elongation of NS1 in around 1950 conferred a minor growth advantage to former seasonal influenza A viruses. | Q42018577 | ||
| Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity | Q42153057 | ||
| Structure of influenza A polymerase bound to the viral RNA promoter | Q42181164 | ||
| A single amino acid substitution in the novel H7N9 influenza A virus NS1 protein increases CPSF30 binding and virulence. | Q42202713 | ||
| Mx protein: constitutive expression in 3T3 cells transformed with cloned Mx cDNA confers selective resistance to influenza virus | Q42812948 | ||
| Antigenicity of the 2015-2016 seasonal H1N1 human influenza virus HA and NA proteins | Q45324745 | ||
| Natural and directed antigenic drift of the H1 influenza virus hemagglutinin stalk domain | Q45325357 | ||
| Pathogenesis of Hong Kong H5N1 influenza virus NS gene reassortants in mice: the role of cytokines and B- and T-cell responses | Q45492687 | ||
| Sequence of interrupted and uninterrupted mRNAs and cloned DNA coding for the two overlapping nonstructural proteins of influenza virus | Q45791146 | ||
| Effectiveness of inactivated influenza vaccines varied substantially with antigenic match from the 2004-2005 season to the 2006-2007 season | Q46159620 | ||
| Mammalian adaptation of an avian influenza A virus involves stepwise changes in NS1. | Q46241877 | ||
| Host Cell Restriction Factors that Limit Influenza A Infection. | Q47097744 | ||
| NS1 protein of 2009 pandemic influenza A virus inhibits porcine NLRP3 inflammasome-mediated interleukin-1 beta production by suppressing ASC ubiquitination | Q47547478 | ||
| Immunomodulatory Nonstructural Proteins of Influenza A Viruses | Q47548714 | ||
| Influenza Virus: Dealing with a Drifting and Shifting Pathogen | Q47548723 | ||
| Genome-wide identification of interferon-sensitive mutations enables influenza vaccine design | Q47551693 | ||
| Specific mutations in the PB2 protein of influenza A virus compensate for the lack of efficient IFN antagonism of the NS1 protein of bat influenza A-like viruses | Q47555896 | ||
| Differential expression of NLRP3 among hematopoietic cells. | Q50528108 | ||
| Identification of novel amino acid residues of influenza virus PA-X that are important for PA-X shutoff activity by using yeast. | Q52716990 | ||
| Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition. | Q54217744 | ||
| Major contribution of the RNA-binding domain of NS1 in the pathogenicity and replication potential of an avian H7N1 influenza virus in chickens. | Q55009858 | ||
| Live attenuated versus inactivated influenza vaccine in infants and young children. | Q55043222 | ||
| PA-X: a key regulator of influenza A virus pathogenicity and host immune responses | Q56563872 | ||
| A revision of the system of nomenclature for influenza viruses: a WHO memorandum | Q56941030 | ||
| New world bats harbor diverse influenza A viruses | Q21090482 | ||
| THE ORIGINS OF NEW PANDEMIC VIRUSES: The Acquisition of New Host Ranges by Canine Parvovirus and Influenza A Viruses | Q22255612 | ||
| Influenza A virus NS1 protein binds p85beta and activates phosphatidylinositol-3-kinase signaling | Q24302191 | ||
| The inflammasomes | Q24304087 | ||
| Suppression of the antiviral response by an influenza histone mimic | Q24307599 | ||
| Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virus | Q24311228 | ||
| Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I | Q24312113 | ||
| PACT, a protein activator of the interferon-induced protein kinase, PKR. | Q24319677 | ||
| Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection | Q24336824 | ||
| Influenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 3'-end processing machinery | Q24534097 | ||
| Influenza: the once and future pandemic | Q24630177 | ||
| The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus | Q24645420 | ||
| Live attenuated influenza viruses containing NS1 truncations as vaccine candidates against H5N1 highly pathogenic avian influenza | Q24652088 | ||
| The H5N1 influenza virus NS genes selected after 1998 enhance virus replication in mammalian cells | Q24676166 | ||
| Modulating the Innate Immune Response to Influenza A Virus: Potential Therapeutic Use of Anti-Inflammatory Drugs | Q26800158 | ||
| Induction and function of type I and III interferon in response to viral infection | Q27010065 | ||
| Interferon-λ in the context of viral infections: production, response and therapeutic implications | Q27013848 | ||
| Activation of the NLRP3 inflammasome by IAV virulence protein PB1-F2 contributes to severe pathophysiology and disease | Q27334659 | ||
| Structural basis for suppression of a host antiviral response by influenza A virus | Q27651800 | ||
| A novel RNA-binding motif in influenza A virus non-structural protein 1 | Q27747001 | ||
| Crystal structure of the unique RNA-binding domain of the influenza virus NS1 protein | Q27747036 | ||
| RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates | Q27861007 | ||
| Nuclear and nucleolar targeting of influenza A virus NS1 protein: striking differences between different virus subtypes | Q27865187 | ||
| Reverse Genetics Approaches for the Development of Influenza Vaccines | Q28076140 | ||
| Interferons and viruses: an evolutionary arms race of molecular interactions | Q28083788 | ||
| NS1 protein of influenza A virus inhibits the function of intracytoplasmic pathogen sensor, RIG-I | Q28269604 | ||
| Influenza virus activates inflammasomes via its intracellular M2 ion channel | Q28279385 | ||
| Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity | Q28290992 | ||
| FluBlok, a recombinant hemagglutinin influenza vaccine | Q36251189 | ||
| NS1-truncated live attenuated virus vaccine provides robust protection to aged mice from viral challenge | Q36276683 | ||
| Evolutionary conservation of the PA-X open reading frame in segment 3 of influenza A virus | Q36363892 | ||
| Ribosomal frameshifting used in influenza A virus expression occurs within the sequence UCC_UUU_CGU and is in the +1 direction | Q36401203 | ||
| An overlapping protein-coding region in influenza A virus segment 3 modulates the host response | Q36554219 | ||
| Identification of the N-terminal domain of the influenza virus PA responsible for the suppression of host protein synthesis. | Q36668024 | ||
| A new influenza virus virulence determinant: the NS1 protein four C-terminal residues modulate pathogenicity | Q36670254 | ||
| JAK-STAT signaling: from interferons to cytokines | Q36821751 | ||
| Inhibition of influenza viral mRNA synthesis in cells expressing the interferon-induced Mx gene product. | Q36851167 | ||
| Two nuclear location signals in the influenza virus NS1 nonstructural protein | Q36879352 | ||
| Phylodynamics of H1N1/2009 influenza reveals the transition from host adaptation to immune-driven selection | Q37031869 | ||
| Traditional and new influenza vaccines | Q37035833 | ||
| Critical Role of the PA-X C-Terminal Domain of Influenza A Virus in Its Subcellular Localization and Shutoff Activity | Q37174404 | ||
| NS1 Protein Mutation I64T Affects Interferon Responses and Virulence of Circulating H3N2 Human Influenza A Viruses. | Q37347309 | ||
| Influenza viruses control the vertebrate type I interferon system: factors, mechanisms, and consequences | Q37587170 | ||
| Pre-mRNA 3'-end processing complex assembly and function | Q37693565 | ||
| The influenza virus RNA synthesis machine: advances in its structure and function | Q37847896 | ||
| Quadrivalent Ann Arbor strain live-attenuated influenza vaccine | Q38059737 | ||
| The broad-spectrum antiviral functions of IFIT and IFITM proteins | Q38067210 | ||
| P275 | copyright license | Creative Commons Attribution | Q6905323 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 12 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | virus | Q808 |
| transcription factor | Q407384 | ||
| innate immune response | Q428253 | ||
| host-pathogen interaction | Q5909198 | ||
| influenza A virus | Q834390 | ||
| viral protein | Q952587 | ||
| DNA-binding protein | Q2252764 | ||
| viral nonstructural proteins | Q4354558 | ||
| repressor proteins | Q66764508 | ||
| host microbial interaction | Q68260314 | ||
| P304 | page(s) | 708 | |
| P577 | publication date | 2018-12-12 | |
| P1433 | published in | Viruses | Q7935305 |
| P1476 | title | Modulation of Innate Immune Responses by the Influenza A NS1 and PA-X Proteins | |
| P478 | volume | 10 |
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