Functional Evolution of the 2009 Pandemic H1N1 Influenza Virus NS1 and PA in Humans

scholarly article by Aitor Nogales published in October 2018

Functional Evolution of the 2009 Pandemic H1N1 Influenza Virus NS1 and PA in Humans is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.01206-18
P932PMC publication ID6146824
P698PubMed publication ID30021892

P50authorAitor NogalesQ56528198
David J TophamQ57294998
P2093author name stringLuis Martinez-Sobrido
Marta L DeDiego
Kevin Chiem
P2860cites workInhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virusQ24311228
Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-IQ24312113
Influenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 3'-end processing machineryQ24534097
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
Structural basis for suppression of a host antiviral response by influenza A virusQ27651800
Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease?Q28217338
Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemiaQ28262914
NS1 protein of influenza A virus inhibits the function of intracytoplasmic pathogen sensor, RIG-IQ28269604
The multifunctional NS1 protein of influenza A virusesQ28294201
Replication-competent fluorescent-expressing influenza B virusQ28387786
Cellular antiviral responses against influenza A virus are countered at the posttranscriptional level by the viral NS1A protein via its binding to a cellular protein required for the 3' end processing of cellular pre-mRNASQ28609773
A recombinant influenza A virus expressing an RNA-binding-defective NS1 protein induces high levels of beta interferon and is attenuated in miceQ28609778
Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3'end formation of cellular pre-mRNAsQ28609836
Influenza A Virus Lacking the NS1 Gene Replicates in Interferon-Deficient SystemsQ29039793
Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humansQ29619059
In vitro and in vivo characterization of new swine-origin H1N1 influenza virusesQ29619174
A review of vaccine research and development: human acute respiratory infections.Q30351377
PA-X-associated early alleviation of the acute lung injury contributes to the attenuation of a highly pathogenic H5N1 avian influenza virus in miceQ40706208
Mapping of a Region of the PA-X Protein of Influenza A Virus That Is Important for Its Shutoff Activity.Q40871573
The novel influenza A virus protein PA-X and its naturally deleted variant show different enzymatic properties in comparison to the viral endonuclease PA.Q41347441
A single amino acid substitution in the novel H7N9 influenza A virus NS1 protein increases CPSF30 binding and virulence.Q42202713
Antigenicity of the 2015-2016 seasonal H1N1 human influenza virus HA and NA proteinsQ45324745
Immunomodulatory Nonstructural Proteins of Influenza A VirusesQ47548714
The CPSF30 binding site on the NS1A protein of influenza A virus is a potential antiviral target.Q30353557
Naturally occurring mutations in the PA gene are key contributors to increased virulence of pandemic H1N1/09 influenza virus in mice.Q30358923
Multiple anti-interferon actions of the influenza A virus NS1 proteinQ30361157
The contribution of PA-X to the virulence of pandemic 2009 H1N1 and highly pathogenic H5N1 avian influenza viruses.Q30371441
Influenza A Virus Protein PA-X Contributes to Viral Growth and Suppression of the Host Antiviral and Immune ResponsesQ30373511
Twenty amino acids at the C-terminus of PA-X are associated with increased influenza A virus replication and pathogenicity.Q30373730
PA-X is a virulence factor in avian H9N2 influenza virus.Q30378192
Inefficient control of host gene expression by the 2009 pandemic H1N1 influenza A virus NS1 proteinQ30388846
T cell-mediated protection against lethal 2009 pandemic H1N1 influenza virus infection in a mouse modelQ30395346
2009 pandemic H1N1 influenza virus causes disease and upregulation of genes related to inflammatory and immune responses, cell death, and lipid metabolism in pigsQ30406831
Attenuation of equine influenza viruses through truncations of the NS1 proteinQ33843410
Innate immunity to influenza virus infectionQ33923354
Evasion of innate and adaptive immune responses by influenza A virusQ33965443
Geographic dependence, surveillance, and origins of the 2009 influenza A (H1N1) virusQ34983373
Replication-competent influenza A viruses expressing a red fluorescent proteinQ35071285
PA-X decreases the pathogenicity of highly pathogenic H5N1 influenza A virus in avian species by inhibiting virus replication and host responseQ35640905
Selective Degradation of Host RNA Polymerase II Transcripts by Influenza A Virus PA-X Host Shutoff Protein.Q35915706
NS1-truncated live attenuated virus vaccine provides robust protection to aged mice from viral challengeQ36276683
An overlapping protein-coding region in influenza A virus segment 3 modulates the host responseQ36554219
Identification of the N-terminal domain of the influenza virus PA responsible for the suppression of host protein synthesis.Q36668024
Protection against lethal influenza with a viral mimicQ37036766
Rearrangement of Influenza Virus Spliced Segments for the Development of Live-Attenuated Vaccines.Q37073339
Suppression of the induction of alpha, beta, and lambda interferons by the NS1 and NS2 proteins of human respiratory syncytial virus in human epithelial cells and macrophages [corrected]Q37093418
Critical Role of the PA-X C-Terminal Domain of Influenza A Virus in Its Subcellular Localization and Shutoff ActivityQ37174404
NS1 Protein Mutation I64T Affects Interferon Responses and Virulence of Circulating H3N2 Human Influenza A Viruses.Q37347309
Pathogen recognition by innate immunity and its signalingQ37444445
The influenza virus RNA synthesis machine: advances in its structure and functionQ37847896
Molecular mechanisms enhancing the proteome of influenza A viruses: an overview of recently discovered proteins.Q38199917
Timing Is Everything: Coordinated Control of Host Shutoff by Influenza A Virus NS1 and PA-X ProteinsQ38422972
Comparing the functions of equine and canine influenza H3N8 virus PA-X proteins: Suppression of reporter gene expression and modulation of global host gene expressionQ38763878
The inflammatory response triggered by Influenza virus: a two edged sword.Q38981754
Generation of Recombinant Influenza Virus from Plasmid DNAQ39664696
Functional Evolution of Influenza Virus NS1 Protein in Currently Circulating Human 2009 Pandemic H1N1 Viruses.Q40150645
Interplay of PA-X and NS1 Proteins in Replication and Pathogenesis of a Temperature-Sensitive 2009 Pandemic H1N1 Influenza A VirusQ40150668
IFNbeta induction by influenza A virus is mediated by RIG-I which is regulated by the viral NS1 proteinQ40202119
NS1 Protein Amino Acid Changes D189N and V194I Affect Interferon Responses, Thermosensitivity, and Virulence of Circulating H3N2 Human Influenza A VirusesQ40399903
Canine influenza viruses with modified NS1 proteins for the development of live-attenuated vaccinesQ40503815
P4510describes a project that usesImageJQ1659584
P433issue19
P407language of work or nameEnglishQ1860
P921main subjectvirologyQ7215
immunologyQ101929
pandemicQ12184
P577publication date2018-10-01
P1433published inJournal of VirologyQ1251128
P1476titleFunctional Evolution of the 2009 Pandemic H1N1 Influenza Virus NS1 and PA in Humans
P478volume92

Reverse relations

cites work (P2860)
Q92538061Functional Characterization and Direct Comparison of Influenza A, B, C, and D NS1 Proteins in vitro and in vivo
Q58762417Host Shutoff in Influenza A Virus: Many Means to an End
Q89511393Increasing the Safety Profile of the Master Donor Live Attenuated Influenza Vaccine
Q60959439Modulation of Innate Immune Responses by the Influenza A NS1 and PA-X Proteins
Q64116962Novel Approaches for The Development of Live Attenuated Influenza Vaccines
Q64107548The Influenza A Virus Endoribonuclease PA-X Usurps Host mRNA Processing Machinery to Limit Host Gene Expression

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