The Transcription Factor Function of Parkin: Breaking the Dogma

scientific article published on 01 January 2018

The Transcription Factor Function of Parkin: Breaking the Dogma is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3389/FNINS.2018.00965
P932PMC publication ID6341214
P698PubMed publication ID30697141

P50authorFrédéric CheclerQ38321085
Cristine Alves da CostaQ40270055
P2093author name stringEric Duplan
Lila Rouland
P2860cites workSUMO-1 modification of the acute promyelocytic leukaemia protein PML: implications for nuclear localisationQ22008651
Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53Q22253350
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligaseQ22254584
Cloning and characterization of LUN, a novel ring finger protein that is highly expressed in lung and specifically binds to a palindromic sequenceQ24291022
PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's diseaseQ24294809
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1Q24297155
Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signalingQ24297849
Parkin ubiquitinates and promotes the degradation of RanBP2Q24298223
Autoregulation of Parkin activity through its ubiquitin-like domainQ24307382
mel-18, a Polycomb group-related mammalian gene, encodes a transcriptional negative regulator with tumor suppressive activityQ24310321
A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2Q24317523
Mdm2 promotes the rapid degradation of p53Q24322597
Parkin differently regulates presenilin-1 and presenilin-2 functions by direct control of their promoter transcription.Q51533923
Transcriptional alterations in skin fibroblasts from Parkinson's disease patients with parkin mutations.Q51765978
SUMOylation, aging and autophagy in neurodegeneration.Q51766687
The Cellular Protein Level of Parkin Is Regulated by Its Ubiquitin-like DomainQ57371863
Recombinant human MDM2 oncoprotein shows sequence composition selectivity for binding to both RNA and DNAQ62599757
Nitrosative and oxidative stress links dysfunctional ubiquitination to Parkinson's diseaseQ81045087
Parkin modulates gene expression in control and ceramide-treated PC12 cellsQ83198040
Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleusQ24532901
Identification and preliminary characterization of a protein motif related to the zinc fingerQ24563322
JASPAR 2016: a major expansion and update of the open-access database of transcription factor binding profilesQ24700982
Ageing and Parkinson's disease: why is advancing age the biggest risk factor?Q27021628
SUMO1 Affects Synaptic Function, Spine Density and MemoryQ27308933
Mechanisms of mitophagyQ27310261
Structure of the human Parkin ligase domain in an autoinhibited stateQ27678455
Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligasesQ27678625
Structure of parkin reveals mechanisms for ubiquitin ligase activationQ27684576
RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.Q27937465
Massively parallel measurements of molecular interaction kinetics on a microfluidic platformQ27938491
Yeast DNA repair proteins Rad6 and Rad18 form a heterodimer that has ubiquitin conjugating, DNA binding, and ATP hydrolytic activitiesQ27938794
S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson's diseaseQ28116512
Molecular cloning and characterization of a novel protein kinase C-interacting protein with structural motifs related to RBCC family proteinsQ28567239
The RING finger protein SNURF is a bifunctional protein possessing DNA binding activityQ28573009
PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondriaQ28592217
TFCat: the curated catalog of mouse and human transcription factorsQ28752619
Genome-wide mapping of in vivo protein-DNA interactionsQ29547162
A census of human transcription factors: function, expression and evolutionQ29622841
Immunodetection of Parkin protein in vertebrate and invertebrate brains: a comparative study using specific antibodiesQ31926278
Loss of Parkin reduces inflammatory arthritis by inhibiting p53 degradationQ33555712
Immunohistochemical and subcellular localization of Parkin protein: absence of protein in autosomal recessive juvenile parkinsonism patientsQ33861614
Presenilins: multifunctional proteins involved in Alzheimer's disease pathologyQ33904253
Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease.Q34189618
Gene regulation and DNA damage in the ageing human brainQ34326236
Electrophoretic mobility shift assay of zinc finger proteins: competition for Zn(2+) bound to Sp1 in protocols including EDTA.Q34778208
Presenilins and γ-secretase: structure, function, and role in Alzheimer DiseaseQ35658184
SUMO1 promotes Aβ production via the modulation of autophagyQ35853044
Functional characterization of Rad18 domains for Rad6, ubiquitin, DNA binding and PCNA modificationQ36082927
The p53 response element and transcriptional repressionQ37693593
Gene-environment interactions in Parkinson's disease and other forms of parkinsonismQ37739520
Determining the specificity of protein–DNA interactionsQ37793836
Methods for Analysis of Transcription Factor DNA-Binding Specificity In VitroQ37873862
To repress or not to repress: this is the guardian's questionQ37878048
Mitophagy and Parkinson's disease: be eaten to stay healthyQ38038443
p53 in neurodegenerative diseases and brain cancersQ38167220
Beyond γ-secretase activity: The multifunctional nature of presenilins in cell signalling pathwaysQ38615871
ER-stress-associated functional link between Parkin and DJ-1 via a transcriptional cascade involving the tumor suppressor p53 and the spliced X-box binding protein XBP-1.Q39187400
Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1.Q39536018
Parkin protects mitochondrial genome integrity and supports mitochondrial DNA repairQ39823278
DNA damage induces nuclear translocation of parkinQ39823990
Identification of ubiquitin ligase activity of RBCK1 and its inhibition by splice variant RBCK2 and protein kinase Cbeta.Q40008621
β-Amyloid Precursor Protein Intracellular Domain Controls Mitochondrial Function by Modulating Phosphatase and Tensin Homolog-Induced Kinase 1 Transcription in Cells and in Alzheimer Mice ModelsQ40170480
Functional modulation of parkin through physical interaction with SUMO-1.Q40235074
A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K-Akt signallingQ40252247
Parkin suppresses the expression of monoamine oxidasesQ40321332
Parkin enhances mitochondrial biogenesis in proliferating cellsQ40322753
Processing of the beta-amyloid precursor protein and its regulation in Alzheimer's diseaseQ40414917
Parkin phosphorylation and modulation of its E3 ubiquitin ligase activityQ40489168
RING finger 1 mutations in Parkin produce altered localization of the proteinQ40629977
Parkin expression in the adult mouse brainQ40836565
Parkin suppresses c-Jun N-terminal kinase-induced cell death via transcriptional regulation in DrosophilaQ43056002
Identification of a novel Zn2+-binding domain in the autosomal recessive juvenile Parkinson-related E3 ligase parkin.Q43123357
Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression.Q47132104
Nuclear p53-mediated repression of autophagy involves PINK1 transcriptional down-regulationQ47850913
Parkin functionally interacts with PGC-1α to preserve mitochondria and protect dopaminergic neuronsQ48005750
Expression of novel DNA-binding protein with zinc finger structure in various tumor cellsQ48248073
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectDNA bindingQ14633858
Parkinson's diseaseQ11085
transcription factorQ407384
regulation of gene expressionQ411391
ubiquitin ligaseQ4274835
P304page(s)965
P577publication date2018-01-01
P1433published inFrontiers in NeuroscienceQ2177807
P1476titleThe Transcription Factor Function of Parkin: Breaking the Dogma
P478volume12

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cites work (P2860)
Q90680494PINK1 Deficiency Ameliorates Cisplatin-Induced Acute Kidney Injury in Rats
Q92752474SESN2 protects against doxorubicin-induced cardiomyopathy via rescuing mitophagy and improving mitochondrial function
Q64118310miR-181a/b downregulation exerts a protective action on mitochondrial disease models

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