SESN2 protects against doxorubicin-induced cardiomyopathy via rescuing mitophagy and improving mitochondrial function

scientific article published on 12 June 2019

SESN2 protects against doxorubicin-induced cardiomyopathy via rescuing mitophagy and improving mitochondrial function is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.YJMCC.2019.06.005
P698PubMed publication ID31199952

P50authorPei-Qing LiuQ89508083
Jing LuQ45371780
P2093author name stringJunjian Wang
Juan Shen
Qianqian Wang
Zhenzhen Li
Rui Lan
Liying Liang
Panxia Wang
Luping Wang
Kaiteng Guo
Yuehuai Hu
Sidong Cai
Jiyan Xie
P2860cites workSestrin family may play important roles in the regulation of cardiac pathophysiologyQ86225309
Beclin-1-Dependent Autophagy Protects the Heart During SepsisQ88938080
Disease-associated tau impairs mitophagy by inhibiting Parkin translocation to mitochondriaQ90410907
Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1Q24300990
Gene regulation by temperature-sensitive p53 mutants: identification of p53 response genesQ24562795
Mitochondrial biogenesis and dynamics in the developing and diseased heartQ26782031
Mitochondrial dynamism and heart disease: changing shape and shaping changeQ26825299
Mitophagy: mechanisms, pathophysiological roles, and analysisQ26865743
Mechanisms of sudden cardiac death: oxidants and metabolismQ27024176
Mitochondria and mitophagy: the yin and yang of cell death controlQ27028020
Mechanisms of mitophagyQ27310261
Metabolism. AMP-activated protein kinase mediates mitochondrial fission in response to energy stressQ27330478
Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domainsQ28114865
Mitochondrial dynamics--mitochondrial fission and fusion in human diseasesQ28303322
Mitochondrial dynamics and mitochondrial quality controlQ28386855
Bnip3 mediates doxorubicin-induced cardiac myocyte necrosis and mortality through changes in mitochondrial signalingQ28580570
Sestrin as a feedback inhibitor of TOR that prevents age-related pathologiesQ28590387
PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondriaQ28592217
Impaired mitochondrial network excitability in failing guinea-pig cardiomyocytesQ30692654
The targeting of cyclophilin D by RNAi as a novel cardioprotective therapy: evidence from two-photon imagingQ30859470
Upregulation of sestrins protect atriums against oxidative damage and fibrosis in human and experimental atrial fibrillationQ33551782
Cardiomyocyte death in doxorubicin-induced cardiotoxicityQ33604134
Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial functionQ34296896
Identification of the molecular basis of doxorubicin-induced cardiotoxicityQ34308627
Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brainQ34806899
Mitochondrial contagion induced by Parkin deficiency in Drosophila hearts and its containment by suppressing mitofusinQ35359238
Unbreak my heart: targeting mitochondrial autophagy in diabetic cardiomyopathyQ35667361
The effect of monohydroxyethylrutoside on doxorubicin-induced cardiotoxicity in patients treated for metastatic cancer in a phase II studyQ36611388
The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's diseaseQ36611426
Drp1-Dependent Mitochondrial Autophagy Plays a Protective Role Against Pressure Overload-Induced Mitochondrial Dysfunction and Heart Failure.Q36739432
Heme oxygenase-1 regulates mitochondrial quality control in the heart.Q36819774
SESN2/sestrin2 suppresses sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophagesQ37141778
SESN2/sestrin 2 induction-mediated autophagy and inhibitory effect of isorhapontigenin (ISO) on human bladder cancersQ37141782
Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesisQ37526796
Doxorubicin: the good, the bad and the ugly effectQ37528487
The mitochondrial pathways of apoptosis.Q37991635
Doxorubicin-induced cardiomyopathy: from molecular mechanisms to therapeutic strategiesQ37998724
SUMO-regulated mitochondrial function in Parkinson's diseaseQ38757045
Stimulating basal mitochondrial respiration decreases doxorubicin apoptotic signaling in H9c2 cardiomyoblastsQ38872384
Autophagy and mitophagy in the context of doxorubicin-induced cardiotoxicity.Q39264180
Autophagy and Mitophagy in Cardiovascular DiseaseQ39331287
The poly(ADP-ribosyl)ation of FoxO3 mediated by PARP1 participates in isoproterenol-induced cardiac hypertrophy.Q39338239
Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosisQ40002274
Sestrin2 prevents age-related intolerance to ischemia and reperfusion injury by modulating substrate metabolism.Q40168169
Functional modulation of parkin through physical interaction with SUMO-1.Q40235074
Receptor-interacting protein 140 overexpression impairs cardiac mitochondrial function and accelerates the transition to heart failure in chronically infarcted ratsQ40492563
RING finger 1 mutations in Parkin produce altered localization of the proteinQ40629977
ATP depletion is an important factor in DHEA-induced growth inhibition and apoptosis in BV-2 cellsQ40714510
Melatonin protects cardiac microvasculature against ischemia/reperfusion injury via suppression of mitochondrial fission-VDAC1-HK2-mPTP-mitophagy axisQ41066189
PARK2/Parkin becomes critical when DNM1L/Drp1 is absentQ41619777
Sirtuin 3 Deficiency Accelerates Hypertensive Cardiac Remodeling by Impairing AngiogenesisQ41628391
Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagyQ41701419
α-Enolase plays a catalytically independent role in doxorubicin-induced cardiomyocyte apoptosis and mitochondrial dysfunctionQ42178452
The critical role of Sestrin 1 in regulating the proliferation of cardiac fibroblastsQ42450583
Volume density and distribution of mitochondria in myocardial growth and hypertrophyQ44698290
Doxorubicin induces apoptosis in normal and tumor cells via distinctly different mechanisms. intermediacy of H(2)O(2)- and p53-dependent pathwaysQ44822086
Beyond Mitophagy: The Diversity and Complexity of Parkin FunctionQ44935739
Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heartQ45733826
DUSP1 alleviates cardiac ischemia/reperfusion injury by suppressing the Mff-required mitochondrial fission and Bnip3-related mitophagy via the JNK pathwaysQ46129857
Aspalathin Reverts Doxorubicin-Induced Cardiotoxicity through Increased Autophagy and Decreased Expression of p53/mTOR/p62 Signaling.Q46309786
Elimination of dysfunctional mitochondria through mitophagy suppresses benzo[a]pyrene-induced apoptosisQ46315938
Dietary vitamin E decreases doxorubicin-induced oxidative stress without preventing mitochondrial dysfunctionQ46769975
AMPKα2 Protects Against the Development of Heart Failure by Enhancing Mitophagy via PINK1 PhosphorylationQ47248786
Cardiac progenitor cells activated by mitochondrial delivery of resveratrol enhance the survival of a doxorubicin-induced cardiomyopathy mouse model via the mitochondrial activation of a damaged myocardiumQ47394674
Sestrin2 prevents age-related intolerance to post myocardial infarction via AMPK/PGC-1α pathwayQ47554940
Binding of FUN14 Domain Containing 1 With Inositol 1,4,5-Trisphosphate Receptor in Mitochondria-Associated Endoplasmic Reticulum Membranes Maintains Mitochondrial Dynamics and Function in Hearts in VivoQ47753393
SESN2 facilitates mitophagy by helping Parkin translocation through ULK1 mediated Beclin1 phosphorylation.Q49591643
Carbon monoxide protects against hepatic steatosis in mice by inducing sestrin-2 via the PERK-eIF2α-ATF4 pathway.Q50960827
Endogenous Drp1 mediates mitochondrial autophagy and protects the heart against energy stress.Q51313895
PARP1 interacts with STAT3 and retains active phosphorylated-STAT3 in nucleus during pathological myocardial hypertrophy.Q52675853
Distinct multilevel misregulations of Parkin and PINK1 revealed in cell and animal models of TDP-43 proteinopathyQ58712192
The Transcription Factor Function of Parkin: Breaking the DogmaQ61448146
Doxorubicin-induced mitophagy and mitochondrial damage is associated with dysregulation of the PINK1/parkin pathwayQ64137872
Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutationsQ64376689
Roles of transcriptional corepressor RIP140 and coactivator PGC-1α in energy state of chronically infarcted rat hearts and mitochondrial function of cardiomyocytesQ64379237
Mitochondria and cardiovascular diseases-from pathophysiology to treatmentQ64386241
P304page(s)125-137
P577publication date2019-06-12
P1433published inJournal of Molecular and Cellular CardiologyQ2061932
P1476titleSESN2 protects against doxorubicin-induced cardiomyopathy via rescuing mitophagy and improving mitochondrial function
P478volume133