Identification, pathophysiology, and clinical implications of primary insulin hypersecretion in nondiabetic adults and adolescents

Identification, pathophysiology, and clinical implications of primary insulin hypersecretion in nondiabetic adults and adolescents is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1172/JCI.INSIGHT.124912
P932PMC publication ID6338316
P698PubMed publication ID30568042

P50authorAndrea NataliQ37380762
Eleuterio FerranniniQ59193801
Domenico TricòQ61089444
P2093author name stringAndrea Mari
Silva Arslanian
P2860cites workalpha-hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic populationQ21136353
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Chronic primary hyperinsulinaemia is associated with altered insulin receptor mRNA splicing in muscle of patients with insulinomaQ38362229
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Plasma HDL-cholesterol and triglycerides, but not LDL-cholesterol, are associated with insulin secretion in non-diabetic subjectsQ38912695
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The glucose-alanine cycleQ39921733
Production of insulin resistance by hyperinsulinaemia in man.Q41485467
Antiobesity effect of diazoxide in obese Zucker ratsQ42516151
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Impaired beta cell glucose sensitivity rather than inadequate compensation for insulin resistance is the dominant defect in glucose intoleranceQ43131881
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Increased insulin resistance and insulin secretion in nondiabetic African-Americans and Hispanics compared with non-Hispanic whites. The Insulin Resistance Atherosclerosis StudyQ43584210
Hyperinsulinemia in african-american children: decreased insulin clearance and increased insulin secretion and its relationship to insulin sensitivityQ44155534
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beta-Cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysisQ45105931
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Polymorphisms in the adiponutrin gene are associated with increased insulin secretion and obesityQ46410689
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Early and longer term effects of gastric bypass surgery on tissue-specific insulin sensitivity and beta cell function in morbidly obese patients with and without type 2 diabetesQ59297363
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Effects of insulin on hemodynamics and metabolism in human forearmQ68499375
Splanchnic and renal metabolism of insulin in human subjects: a dose-response studyQ70261209
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Differences in the in vivo insulin secretion and sensitivity of healthy black versus white adolescentsQ71524947
Neural control of insulin secretion: interaction of norepinephrine and acetylcholineQ72552288
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Beneficial effect of diazoxide in obese hyperinsulinemic adultsQ74645788
The Science and Translation of Lactate Shuttle TheoryQ88264743
Effects of Diazoxide-Mediated Insulin Suppression on Glucose and Lipid Metabolism in Nondiabetic Obese MenQ88265698
Triglyceride-rich very low-density lipoproteins (VLDL) are independently associated with insulin secretion in a multiethnic cohort of adolescentsQ90021948
P433issue24
P407language of work or nameEnglishQ1860
P921main subjectpathophysiologyQ1135939
preproinsulinQ7240673
P577publication date2018-12-20
P1433published inJCI insightQ27727187
P1476titleIdentification, pathophysiology, and clinical implications of primary insulin hypersecretion in nondiabetic adults and adolescents
P478volume3

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cites work (P2860)
Q97682145Brain substrate metabolism and ß-cell function in humans: A positron emission tomography study
Q92152159Different physiological mechanisms underlie an adverse cardiovascular disease risk profile in men and women
Q92784035Fructose Consumption Contributes to Hyperinsulinemia in Adolescents With Obesity Through a GLP-1-Mediated Mechanism
Q99248451Hyperinsulinaemia in cancer
Q90139193Hyperinsulinemia: An Early Indicator of Metabolic Dysfunction
Q90458264Influence of adiposity, insulin resistance and intrahepatic triglyceride content on insulin kinetics
Q91621152Maternal Western-style diet affects offspring islet composition and function in a non-human primate model of maternal over-nutrition
Q93138049Mechanisms of hyperinsulinaemia in apparently healthy non-obese young adults: role of insulin secretion, clearance and action and associations with plasma amino acids
Q89638479Metabolic phenotype in Darier disease: a cross-sectional clinical study
Q92197404What role do fat cells play in pancreatic tissue?

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