Activation of mTOR signaling pathway associated with adverse prognostic factors of epithelial ovarian cancer

scientific article published on 26 January 2011

Activation of mTOR signaling pathway associated with adverse prognostic factors of epithelial ovarian cancer is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.YGYNO.2010.12.364
P698PubMed publication ID21276607

P50authorJae Hong NoQ55089375
P2093author name stringJae Yong Han
Jeong Mook Lim
Jae Weon Kim
Noh-Hyun Park
Yong-Sang Song
Soon-Beom Kang
In-Ae Park
Yong-Beom Kim
Yong-Tark Jeon
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eIF4E--from translation to transformationQ35750110
mTOR, translation initiation and cancerQ36623679
Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function.Q37037473
Biomarkers of response to epidermal growth factor receptor inhibitors in Non-Small-Cell Lung Cancer Working Group: standardization for use in the clinical trial setting.Q37087122
Beyond chemotherapy: targeted therapies in ovarian cancerQ37399899
Expression of an activated mammalian target of rapamycin in adenocarcinoma of the cervix: A potential biomarker and molecular target therapyQ40040127
Bevacizumab and rapamycin inhibit tumor growth in peritoneal model of human ovarian cancerQ40048139
Dissecting the Akt/mammalian target of rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative.Q40177512
Activated mammalian target of rapamycin is an adverse prognostic factor in patients with biliary tract adenocarcinomaQ40183375
4E-binding protein 1, a cell signaling hallmark in breast cancer that correlates with pathologic grade and prognosisQ40187965
A nuclear transport signal in mammalian target of rapamycin is critical for its cytoplasmic signaling to S6 kinase 1.Q40331048
Activated eIF4E-binding Protein Slows G1 Progression and Blocks Transformation by c-myc without Inhibiting Cell GrowthQ40618406
AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growthQ42463490
HER-2 overexpression is an independent marker of poor prognosis of advanced primary ovarian carcinoma: a multicenter study of the GINECO groupQ44695868
RAD001 (Everolimus) delays tumor onset and progression in a transgenic mouse model of ovarian cancer.Q51761211
Phosphorylated 4E binding protein 1: a hallmark of cell signaling that correlates with survival in ovarian cancerQ80287572
Characterization of active mitogen-activated protein kinase in ovarian serous carcinomasQ80843829
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectovarian cancerQ172341
P304page(s)8-12
P577publication date2011-01-26
P1433published inGynecologic OncologyQ5625182
P1476titleActivation of mTOR signaling pathway associated with adverse prognostic factors of epithelial ovarian cancer
P478volume121

Reverse relations

cites work (P2860)
Q37225342AKT/mTOR substrate P70S6K is frequently phosphorylated in gallbladder cancer tissue and cell lines
Q35058443EIF4EBP1 overexpression is associated with poor survival and disease progression in patients with hepatocellular carcinoma
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Q37190310Everolimus exhibits anti-tumorigenic activity in obesity-induced ovarian cancer
Q64240609Expression of total and phospho 4EBP1 in metastatic and non-metastatic renal cell carcinoma
Q35087191Growth differentiation factor 15 stimulates rapamycin-sensitive ovarian cancer cell growth and invasion
Q37616060Loss of LKB1 and PTEN tumor suppressor genes in the ovarian surface epithelium induces papillary serous ovarian cancer.
Q34294000Mechanisms of GOLPH3 associated with the progression of gastric cancer: a preliminary study
Q49515435Meta-analysis of the prognostic value of p-4EBP1 in human malignancies
Q33890763Metformin against cancer stem cells through the modulation of energy metabolism: special considerations on ovarian cancer
Q36962391MicroRNAs 125a and 125b inhibit ovarian cancer cells through post-transcriptional inactivation of EIF4EBP1
Q34586019Multiple genetic alterations within the PI3K pathway are responsible for AKT activation in patients with ovarian carcinoma
Q98612773Nanotechnology-Based Targeting of mTOR Signaling in Cancer
Q35837949Optimizing molecular-targeted therapies in ovarian cancer: the renewed surge of interest in ovarian cancer biomarkers and cell signaling pathways
Q37420213Pathway modulations and epigenetic alterations in ovarian tumorbiogenesis
Q33698105Phosphorylation of mTOR and S6RP predicts the efficacy of everolimus in patients with metastatic renal cell carcinoma
Q92565739Rapamycin enhanced the antitumor effects of doxorubicin in myelogenous leukemia K562 cells by downregulating the mTOR/p70S6K pathway
Q64269604The Prognostic Role of Ribosomal Protein S6 Kinase 1 Pathway in Patients With Solid Tumors: A Meta-Analysis
Q36242802The association of PI3 kinase signaling and chemoresistance in advanced ovarian cancer.
Q55225058The effect of the type of dietary protein on the development of ovarian cancer.
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Q35005636The mTORC2 component rictor contributes to cisplatin resistance in human ovarian cancer cells
Q36403652Unfolded protein response to autophagy as a promising druggable target for anticancer therapy
Q37406873mTOR downstream effectors, 4EBP1 and eIF4E, are overexpressed and associated with HPV status in precancerous lesions and carcinomas of the uterine cervix
Q48252712miR-130a upregulates mTOR pathway by targeting TSC1 and is transactivated by NF-κB in high-grade serous ovarian carcinoma

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