Targeting KPNB1 overcomes TRAIL resistance by regulating DR5, Mcl-1 and FLIP in glioblastoma cells

scientific article published on 11 February 2019

Targeting KPNB1 overcomes TRAIL resistance by regulating DR5, Mcl-1 and FLIP in glioblastoma cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41419-019-1383-X
P932PMC publication ID6370806
P698PubMed publication ID30742128

P50authorZhi-Chuan ZhuQ88007971
P2093author name stringCan Yang
Zhi-Qi Xiong
Ming-Jie Li
Ji-Wei Liu
Rong-Jie Wu
P2860cites workTRAF2 Sets a threshold for extrinsic apoptosis by tagging caspase-8 with a ubiquitin shutoff timer.Q50549602
KPNB1 inhibition disrupts proteostasis and triggers unfolded protein response-mediated apoptosis in glioblastoma cells.Q55081473
Silibinin sensitizes human glioma cells to TRAIL-mediated apoptosis via DR5 up-regulation and down-regulation of c-FLIP and survivin.Q55467802
Inhibition of vacuolar ATPase attenuates the TRAIL-induced activation of caspase-8 and modulates the trafficking of TRAIL receptosomesQ24292952
Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptorQ24297204
Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signalingQ24308725
Getting TRAIL back on track for cancer therapyQ27027460
ER stress-induced cell death mechanismsQ27027638
Autophagic flux determines cell death and survival in response to Apo2L/TRAIL (dulanermin).Q30576902
2-Deoxy-D-glucose enhances TRAIL-induced apoptosis in human melanoma cells through XBP-1-mediated up-regulation of TRAIL-R2Q33578562
Dynamics of the STAT3 transcription factor: nuclear import dependent on Ran and importin-β1.Q33916478
mTOR controls FLIPS translation and TRAIL sensitivity in glioblastoma multiforme cellsQ34097241
c-Cbl-mediated degradation of TRAIL receptors is responsible for the development of the early phase of TRAIL resistance.Q34277650
Utilization of the cellular stress response to sensitize cancer cells to TRAIL-mediated apoptosisQ34286028
Translational repression of MCL-1 couples stress-induced eIF2 alpha phosphorylation to mitochondrial apoptosis initiationQ34635166
Carnosic acid sensitized TRAIL-mediated apoptosis through down-regulation of c-FLIP and Bcl-2 expression at the post translational levels and CHOP-dependent up-regulation of DR5, Bim, and PUMA expression in human carcinoma caki cellsQ35176367
Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosisQ35874532
Examination of a second node of translational control in the unfolded protein responseQ37168900
Accumulation of autophagosomes in breast cancer cells induces TRAIL resistance through downregulation of surface expression of death receptors 4 and 5.Q37299291
p62/sequestosome-1 up-regulation promotes ABT-263-induced caspase-8 aggregation/activation on the autophagosomeQ37333720
Translational control of eukaryotic gene expressionQ37551949
Inhibition of eIF2α dephosphorylation enhances TRAIL-induced apoptosis in hepatoma cellsQ37620650
Review: on TRAIL for malignant glioma therapy?Q37681647
TRAIL receptor gene editing unveils TRAIL-R1 as a master player of apoptosis induced by TRAIL and ER stressQ37706093
Proapoptotic DR4 and DR5 signaling in cancer cells: toward clinical translationQ37784920
Integrating stress signals at the endoplasmic reticulum: The BCL-2 protein family rheostat.Q37814626
Translating TRAIL-receptor targeting agents to the clinic.Q38005273
Repression of Mcl-1 and disruption of the Mcl-1/Bak interaction in myeloma cells couple ER stress to mitochondrial apoptosisQ38738359
Glucose Deprivation Induces ATF4-Mediated Apoptosis through TRAIL Death ReceptorsQ38938720
Metformin sensitizes human bladder cancer cells to TRAIL-induced apoptosis through mTOR/S6K1-mediated downregulation of c-FLIP.Q39006307
Monensin, a polyether ionophore antibiotic, overcomes TRAIL resistance in glioma cells via endoplasmic reticulum stress, DR5 upregulation and c-FLIP downregulationQ39161204
ZFX regulates glioma cell proliferation and survival in vitro and in vivoQ39209883
Activation of ATF4 mediates unwanted Mcl-1 accumulation by proteasome inhibitionQ39435523
ER stress sensitizes cells to TRAIL through down-regulation of FLIP and Mcl-1 and PERK-dependent up-regulation of TRAIL-R2.Q39445601
Importin β1 protein-mediated nuclear localization of death receptor 5 (DR5) limits DR5/tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced cell death of human tumor cellsQ39454078
Autophagic degradation of active caspase-8: a crosstalk mechanism between autophagy and apoptosisQ39665408
The JNK pathway modulates expression and phosphorylation of 4E-BP1 in MIN6 pancreatic beta-cells under oxidative stress conditions.Q39686886
A single nucleotide polymorphism determines protein isoform production of the human c-FLIP proteinQ39851972
Proteasome inhibitors enhance TRAIL-induced apoptosis through the intronic regulation of DR5: involvement of NF-kappa B and reactive oxygen species-mediated p53 activationQ39975655
ATF4-mediated induction of 4E-BP1 contributes to pancreatic beta cell survival under endoplasmic reticulum stressQ40006517
DR5 receptor mediates anoikis in human colorectal carcinoma cell lines.Q40017281
Preclinical differentiation between apparently safe and potentially hepatotoxic applications of TRAIL either alone or in combination with chemotherapeutic drugs.Q40287620
Afatinib down-regulates MCL-1 expression through the PERK-eIF2α-ATF4 axis and leads to apoptosis in head and neck squamous cell carcinomaQ40970957
Improvement of Pharmacokinetic Profile of TRAIL via Trimer-Tag Enhances its Antitumor Activity in vivoQ41483641
The ER stress inducer DMC enhances TRAIL-induced apoptosis in glioblastoma.Q42968961
KPNB1, XPO7 and IPO8 mediate the translocation ofNF-κB/p65 into the nucleusQ45049084
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectglioblastomaQ282142
P304page(s)118
P577publication date2019-02-11
P1433published inCell Death and DiseaseQ2197222
P1476titleTargeting KPNB1 overcomes TRAIL resistance by regulating DR5, Mcl-1 and FLIP in glioblastoma cells
P478volume10

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cites work (P2860)
Q101166773KPNB1-mediated nuclear translocation of PD-L1 promotes non-small cell lung cancer cell proliferation via the Gas6/MerTK signaling pathway
Q64253207Natural Product Mediated Regulation of Death Receptors and Intracellular Machinery: Fresh from the Pipeline about TRAIL-Mediated Signaling and Natural TRAIL Sensitizers

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