A PDZ Protein MDA-9/Syntenin: As a Target for Cancer Therapy

A PDZ Protein MDA-9/Syntenin: As a Target for Cancer Therapy is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CSBJ.2019.01.002
P932PMC publication ID6360254
P698PubMed publication ID30766662

P2093author name stringKai Wang
Yongsheng Yu
Xiaoping Wan
Shuangdi Li
P2860cites workThe neural cell recognition molecule neurofascin interacts with syntenin-1 but not with syntenin-2, both of which reveal self-associating activityQ24290724
Characterization of syntenin, a syndecan-binding PDZ protein, as a component of cell adhesion sites and microfilamentsQ24290826
Syntenin is overexpressed and promotes cell migration in metastatic human breast and gastric cancer cell linesQ24298538
A novel eIF5A complex functions as a regulator of p53 and p53-dependent apoptosisQ24304245
The postsynaptic density 95/disc-large/zona occludens protein syntenin directly interacts with frizzled 7 and supports noncanonical Wnt signalingQ24311477
Syntenin, a PDZ protein that binds syndecan cytoplasmic domainsQ24311619
Syndecan-syntenin-ALIX regulates the biogenesis of exosomesQ24337195
Extensions of PSD-95/discs large/ZO-1 (PDZ) domains influence lipid binding and membrane targeting of syntenin-1Q24337436
PDZ tandem of human syntenin: crystal structure and functional propertiesQ27640904
Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensionsQ27644225
Crystal structure of a PDZ domainQ27733300
PDZ domains: structural modules for protein complex assemblyQ28210680
The role of synaptic GTPase-activating protein in neuronal development and synaptic plasticityQ28211165
Interleukin-10 and related cytokines and receptorsQ28251518
Targeted Covalent Inhibition of Grb2-Sos1 Interaction through Proximity-Induced Conjugation in Breast Cancer CellsQ30008796
Expression analysis and genomic characterization of human melanoma differentiation associated gene-5, mda-5: a novel type I interferon-responsive apoptosis-inducing gene.Q30336430
The binding of the PDZ tandem of syntenin to target proteins.Q30439757
Melanoma differentiation associated gene-9, mda-9, is a human gamma interferon responsive geneQ32086811
Elevated expression of syntenin in breast cancer is correlated with lymph node metastasis and poor patient survivalQ33739518
Differentiation therapy in acute myelogenous leukemia (non-APL).Q33864593
Src kinase activation is mandatory for MDA-9/syntenin-mediated activation of nuclear factor-kappaB.Q33884626
Syntenin-syndecan binding requires syndecan-synteny and the co-operation of both PDZ domains of synteninQ33898645
In vitro selection of unnatural cyclic peptide libraries via mRNA displayQ34077317
Mda-9/syntenin is expressed in uveal melanoma and correlates with metastatic progressionQ34135637
mda-9/syntenin: recent insights into a novel cell signaling and metastasis-associated geneQ34363845
Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progressionQ34369804
Syndecan binding protein (SDCBP) is overexpressed in estrogen receptor negative breast cancers, and is a potential promoter for tumor proliferationQ34638020
MDA-9/Syntenin regulates differentiation and angiogenesis programs in head and neck squamous cell carcinomaQ34781101
MDA-9/syntenin is essential for factor VIIa-induced signaling, migration, and metastasis in melanoma cellsQ35055504
Rigidified clicked dimeric ligands for studying the dynamics of the PDZ1-2 supramodule of PSD-95.Q35434851
MDA-9/syntenin and IGFBP-2 promote angiogenesis in human melanomaQ36545071
MDA-9/Syntenin-Slug transcriptional complex promote epithelial-mesenchymal transition and invasion/metastasis in lung adenocarcinoma.Q36729428
Syntenin, a syndecan adaptor and an Arf6 phosphatidylinositol 4,5-bisphosphate effector, is essential for epiboly and gastrulation cell movements in zebrafishQ36851334
mda-9/Syntenin promotes metastasis in human melanoma cells by activating c-SrcQ36949152
Selected approaches for rational drug design and high throughput screening to identify anti-cancer moleculesQ37149641
mda-9/Syntenin: more than just a simple adapter protein when it comes to cancer metastasisQ37152452
MDA-9/syntenin is a key regulator of glioma pathogenesisQ37409706
Novel role of MDA-9/syntenin in regulating urothelial cell proliferation by modulating EGFR signaling.Q37412627
Critical research gaps and translational priorities for the successful prevention and treatment of breast cancerQ37533025
Inhibition of radiation-induced glioblastoma invasion by genetic and pharmacological targeting of MDA-9/SynteninQ37589930
Raf kinase inhibitor RKIP inhibits MDA-9/syntenin-mediated metastasis in melanomaQ37611006
Syntenin increases the invasiveness of small cell lung cancer cells by activating p38, AKT, focal adhesion kinase and SP1.Q37679452
Novel function of MDA-9/Syntenin (SDCBP) as a regulator of survival and stemness in glioma stem cellsQ37688017
MDA-9/Syntenin (SDCBP) modulates small GTPases RhoA and Cdc42 via transforming growth factor β1 to enhance epithelial-mesenchymal transition in breast cancerQ37696985
MDA-9/syntenin: a positive gatekeeper of melanoma metastasis.Q37971509
In vivo modeling of malignant glioma: the road to effective therapyQ38216989
SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.Q38281136
Syntenin and syndecan in the biogenesis of exosomesQ38511561
PDZ-Reactive Peptide Activates Ephrin-B Reverse Signaling and Inhibits Neuronal Chemotaxis.Q38822961
Mda-9/syntenin promotes human brain glioma migration through focal adhesion kinase (FAK)-JNK and FAK-AKT signaling.Q39287553
Endocytosis of the neuronal glycine transporter GLYT2: role of membrane rafts and protein kinase C-dependent ubiquitination.Q39475468
The tandem PDZ domains of syntenin promote cell invasionQ40142496
JAK kinases control IL-5 receptor ubiquitination, degradation, and internalization.Q40182524
Differentiation, differentiation/gene therapy and cancerQ41334613
Melanoma-Derived iPCCs Show Differential Tumorigenicity and Therapy ResponseQ42038580
Activation of the integrin effector kinase focal adhesion kinase in cancer cells is regulated by crosstalk between protein kinase Calpha and the PDZ adapter protein mda-9/SynteninQ42467088
The ins and outs of syntenin, a multifunctional intracellular adaptor proteinQ46055534
Syntenin is involved in the developmental regulation of neuronal membrane architectureQ46410469
CRISPR/Cas9 knockouts reveal genetic interaction between strain-transcendent erythrocyte determinants of Plasmodium falciparum invasionQ48014614
The melanoma differentiation-associated gene mda-6, which encodes the cyclin-dependent kinase inhibitor p21, is differentially expressed during growth, differentiation and progression in human melanoma cellsQ48073787
Myc suppresses tumor invasion and cell migration by inhibiting JNK signalingQ48371923
The MDA-9/Syntenin/IGF-1R/STAT3 axis directs prostate cancer invasion.Q52430984
Syntenin-targeted peptide blocker inhibits progression of cancer cells.Q54977384
MDA-9/Syntenin regulates protective autophagy in anoikis-resistant glioma stem cells.Q55457100
Nanotechnology for treatment of glioblastoma multiformeQ58695662
Regulation of protective autophagy in anoikis-resistant glioma stem cells by SDCBP/MDA-9/SynteninQ62746678
mda-9/Syntenin: a positive regulator of melanoma metastasisQ64378235
Lung Cancer Therapy Targeting Histone Methylation: Opportunities and ChallengesQ90013973
Biophysics of Tumor Microenvironment and Cancer Metastasis - A Mini ReviewQ91051911
P407language of work or nameEnglishQ1860
P921main subjectPDZ domainQ24721050
P304page(s)136-141
P577publication date2019-01-01
P1433published inComputational and Structural Biotechnology JournalQ19865804
P1476titleA PDZ Protein MDA-9/Syntenin: As a Target for Cancer Therapy
P478volume17

Reverse relations

cites work (P2860)
Q89728843MDA-9/Syntenin (SDCBP): Novel gene and therapeutic target for cancer metastasis
Q97419455Mimicking the Endometrial Cancer Tumor Microenvironment to Reprogram Tumor-Associated Macrophages in Disintegrable Supramolecular Gelatin Hydrogel
Q92905820Syntenin: PDZ Protein Regulating Signaling Pathways and Cellular Functions
Q92880008Targeted Therapy of Uveal Melanoma: Recent Failures and New Perspectives