Characterization of the HIV-1 transcription profile after romidepsin administration in ART-suppressed individuals

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Characterization of the HIV-1 transcription profile after romidepsin administration in ART-suppressed individuals is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1097/QAD.0000000000002083
P932PMC publication ID6374101
P698PubMed publication ID30531314

P50authorMartin TolstrupQ38325043
Ole Schmeltz SøgaardQ56984920
P2093author name stringPeggy Kim
Joseph K Wong
Steven A Yukl
Sara Moron-Lopez
P2860cites workPanobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trialQ38958099
Histone deacetylase inhibitors (HDACis) that release the positive transcription elongation factor b (P-TEFb) from its inhibitory complex also activate HIV transcriptionQ39173861
Combined effect of Vacc-4x, recombinant human granulocyte macrophage colony-stimulating factor vaccination, and romidepsin on the HIV-1 reservoir (REDUC): a single-arm, phase 1B/2A trialQ39361321
A5 Peripheral blood cells contribute to HIV-1 viremia induced by romidepsinQ40068696
Sequential Vacc-4x and romidepsin during combination antiretroviral therapy (cART): Immune responses to Vacc-4x regions on p24 and changes in HIV reservoirs.Q41936227
What do we measure when we measure cell-associated HIV RNA.Q47548192
HIV latency in isolated patient CD4+ T cells may be due to blocks in HIV transcriptional elongation, completion, and splicing.Q52680785
Genetic characterization of the HIV-1 reservoir after Vacc-4x and romidepsin therapy in HIV-1-infected individualsQ57201701
Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapyQ28253761
Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapyQ28544949
Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapyQ29615993
Recovery of replication-competent HIV despite prolonged suppression of plasma viremiaQ29615995
Romidepsin-induced HIV-1 viremia during effective ART contains identical viral sequences with few deleterious mutationsQ30490742
HIV-1 expression within resting CD4+ T cells after multiple doses of vorinostatQ34106191
Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapyQ34290545
HIV-1 DNA predicts disease progression and post-treatment virological controlQ34350410
Comparative analysis of measures of viral reservoirs in HIV-1 eradication studiesQ34607763
The Depsipeptide Romidepsin Reverses HIV-1 Latency In VivoQ35778783
Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivationQ36409885
Digital detection of endonuclease mediated gene disruption in the HIV provirus.Q36528328
The size of the expressed HIV reservoir predicts timing of viral rebound after treatment interruptionQ36824388
HIV rebounds from latently infected cells, rather than from continuing low-level replicationQ36954950
New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo.Q37695001
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)425-431
P577publication date2019-03-01
P1433published inAIDSQ4651863
P1476titleCharacterization of the HIV-1 transcription profile after romidepsin administration in ART-suppressed individuals
P478volume33

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cites work (P2860)
Q89836084Antiretroviral therapy alone versus antiretroviral therapy with a kick and kill approach, on measures of the HIV reservoir in participants with recent HIV infection (the RIVER trial): a phase 2, randomised trial
Q64083383Cat and Mouse: HIV Transcription in Latency, Immune Evasion and Cure/Remission Strategies
Q89875340Cell-associated HIV-1 RNA predicts viral rebound and disease progression after discontinuation of temporary early ART
Q93062057Chromatin maturation of the HIV-1 provirus in primary resting CD4+ T cells
Q89620873Current Status of Latency Reversing Agents Facing the Heterogeneity of HIV-1 Cellular and Tissue Reservoirs
Q89685622Integrated assessment of viral transcription, antigen presentation, and CD8+ T cell function reveal multiple limitations of class I selective HDACi during HIV-1 latency reversal

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