Growth/differentiation factor 15 causes TGFβ-activated kinase 1-dependent muscle atrophy in pulmonary arterial hypertension

scientific article published on 15 December 2018

Growth/differentiation factor 15 causes TGFβ-activated kinase 1-dependent muscle atrophy in pulmonary arterial hypertension is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1136/THORAXJNL-2017-211440
P932PMC publication ID6467240
P698PubMed publication ID30554141

P50authorStephen J SawiakQ47503896
Paul R KempQ47714009
Cai ReadQ56432879
Peiran YangQ56432881
Nicholas W MorrellQ60960702
Mark L OrmistonQ63922266
P2093author name stringStephen Moore
Michael I Polkey
Richard Paul
Alexi Crosby
Carl Harries
Lisa Parfitt
Martin Rice
Dongmin Shao
Stephen John Wort
Benjamin E Garfield
P2860cites workMuscle function in COPD: a complex interplayQ26865732
Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) "cachexia-anorexia in chronic wasting diseases" and "nutrition in geriatrics"Q28269804
A phase I/IItrial of MYO-029 in adult subjects with muscular dystrophyQ28272415
Identification, expression and functional characterization of the GRAL geneQ28591475
Exercise training and rehabilitation in pulmonary arterial hypertension: rationale and current data evaluationQ30662612
GDF-15 is abundantly expressed in plexiform lesions in patients with pulmonary arterial hypertension and affects proliferation and apoptosis of pulmonary endothelial cellsQ33891553
Macrophage inhibitory cytokine-1 (MIC-1/GDF15): a new marker of all-cause mortalityQ34072831
Divergent molecular mechanisms underlying the pleiotropic functions of macrophage inhibitory cytokine-1 in cancerQ34099900
ATS StatementQ34136219
Increased expression of GDF-15 may mediate ICU-acquired weakness by down-regulating muscle microRNAsQ35135414
Dexamethasone induces apoptosis in pulmonary arterial smooth muscle cellsQ35779717
FHL1 activates myostatin signalling in skeletal muscle and promotes atrophyQ36076177
TAK1 inhibition prevents the development of autoimmune diabetes in NOD miceQ36149886
Protection from cerebral ischemia by inhibition of TGFβ-activated kinaseQ36162153
Quadriceps strength predicts mortality in patients with moderate to severe chronic obstructive pulmonary diseaseQ36203206
TAK1 modulates satellite stem cell homeostasis and skeletal muscle repairQ36379442
MAP3K11/GDF15 axis is a critical driver of cancer cachexiaQ36892019
Growth differentiation factor-15 is associated with muscle mass in chronic obstructive pulmonary disease and promotes muscle wasting in vivo.Q36893044
Prolonged NF-κB Activation by a Macrophage Inhibitory Cytokine 1-Linked Signal in Enteropathogenic Escherichia coli-Infected Epithelial CellsQ36911360
TAK1, more than just innate immunityQ38040025
The transforming growth factor-β-bone morphogenetic protein type signalling pathway in pulmonary vascular homeostasis and diseaseQ38104321
Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1.Q40056643
Regulation of GDF-8 signaling by the p38 MAPK.Q40487518
Heart failure increases atrogin-1 and MuRF1 gene expression in skeletal muscle with fiber type-specific atrophyQ43116137
A novel murine model of severe pulmonary arterial hypertensionQ43409467
Growth differentiation factor-15 in idiopathic pulmonary arterial hypertensionQ44226730
Sustained elevation of circulating growth and differentiation factor-15 and a dynamic imbalance in mediators of muscle homeostasis are associated with the development of acute muscle wasting following cardiac surgeryQ44678534
Altered bone morphogenetic protein and transforming growth factor-beta signaling in rat models of pulmonary hypertension: potential for activin receptor-like kinase-5 inhibition in prevention and progression of diseaseQ46157334
Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.Q46582776
Skeletal Muscle Dysfunction in Idiopathic Pulmonary Arterial HypertensionQ47715759
Changing demographics, epidemiology, and survival of incident pulmonary arterial hypertension: results from the pulmonary hypertension registry of the United Kingdom and Ireland.Q51343750
Physical activity in patients with COPD.Q53124508
Apoptosis of skeletal muscle myofibers and interstitial cells in experimental heart failureQ54106864
Signaling pathways underlying skeletal muscle wasting in experimental pulmonary arterial hypertensionQ58229904
Ultrasound measurement of rectus femoris cross-sectional area and the relationship with quadriceps strength in COPDQ60441819
An Official American Thoracic Society/European Respiratory Society Statement: Key Concepts and Advances in Pulmonary RehabilitationQ60473179
Human skeletal muscle function: description of tests and normal valuesQ67555754
Randomized phase 2 trial of anti-tumor necrosis factor therapy for cachexia in patients with early rheumatoid arthritisQ79422083
Peripheral muscle dysfunction in idiopathic pulmonary arterial hypertensionQ84499295
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectprimary pulmonary hypertensionQ18554794
P304page(s)164-176
P577publication date2018-12-15
P1433published inThoraxQ7796158
P1476titleGrowth/differentiation factor 15 causes TGFβ-activated kinase 1-dependent muscle atrophy in pulmonary arterial hypertension
P478volume74

Reverse relations

Q89911643Utility of Plasma GDF-15 for Diagnosis and Prognosis Assessment of ICU-Acquired Weakness in Mechanically Ventilated Patients: Prospective Observational Studycites workP2860

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