Type I ROP16 regulates retinal inflammatory responses during ocular toxoplasmosis

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Type I ROP16 regulates retinal inflammatory responses during ocular toxoplasmosis is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PONE.0214310
P932PMC publication ID6430381
P698PubMed publication ID30901349

P50authorNicolas ArgyQ56384550
Valentin GreigertQ61108953
Alexander W PfaffQ92553963
Alejandra de-la-TorreQ47503954
P2093author name stringJulie Brunet
Ermanno Candolfi
Luc Marcellin
Arnaud Sauer
Marcela Sabou
Elise Rochet
P2860cites workA look at autoimmunity and inflammation in the eyeQ24623065
Selection at a single locus leads to widespread expansion of Toxoplasma gondii lineages that are virulent in miceQ33415462
A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3.Q33591077
Toxoplasma gondii rhoptry kinase ROP16 activates STAT3 and STAT6 resulting in cytokine inhibition and arginase-1-dependent growth controlQ34023014
Unusual abundance of atypical strains associated with human ocular toxoplasmosis.Q52933346
Müller cell activation and photoreceptor depletion in a mice model of congenital ocular toxoplasmosis.Q53840135
IL-10-independent STAT3 activation by Toxoplasma gondii mediates suppression of IL-12 and TNF-alpha in host macrophages.Q53867162
Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii.Q54195040
IFN-gamma overproduction and high level apoptosis are associated with high but not low virulence Toxoplasma gondii infectionQ74147901
[Development of murine models of ocular toxoplasmosis and preliminary results of ocular inflammatory transcriptome]Q84939196
Investigation of tissue cysts in the retina in a mouse model of ocular toxoplasmosis: distribution and interaction with glial cellsQ88956800
Modulation of innate immunity by Toxoplasma gondii virulence effectorsQ34033981
Immune privilege as the result of local tissue barriers and immunosuppressive microenvironmentsQ34352320
Severe South American ocular toxoplasmosis is associated with decreased Ifn-γ/Il-17a and increased Il-6/Il-13 intraocular levelsQ35054186
Ocular immune privilege: the eye takes a dim but practical view of immunity and inflammationQ35186813
Toxoplasma gondii effectors are master regulators of the inflammatory responseQ35434828
Interleukin-6-driven inflammatory response induces retinal pathology in a model of ocular toxoplasmosis reactivationQ35439628
Mechanisms of interferon-induced inhibition of Toxoplasma gondii replication in human retinal pigment epithelial cellsQ35524566
Role of the chemokine receptor CCR5-dependent host defense system in Neospora caninum infectionsQ35684186
Toxoplasma gondii rhoptry 16 kinase promotes host resistance to oral infection and intestinal inflammation only in the context of the dense granule protein GRA15.Q36911407
Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologueQ37087502
Polymorphic secreted kinases are key virulence factors in toxoplasmosisQ37105671
Direct and sensitive detection of a pathogenic protozoan, Toxoplasma gondii, by polymerase chain reaction.Q37178327
New clinical and experimental insights into Old World and neotropical ocular toxoplasmosis.Q38160626
Striking Divergence in Toxoplasma ROP16 Nucleotide Sequences From Human and Meat SamplesQ38871247
An unusually high prevalence of ocular toxoplasmosis in southern BrazilQ41892681
The role of indoleamine 2,3-dioxygenase in retinal pigment epithelial cell-mediated immune modulationQ43175554
Interleukin 17A as an effective target for anti-inflammatory and antiparasitic treatment of toxoplasmic uveitisQ44498184
Respective roles of acquired and congenital infections in presumed ocular toxoplasmosisQ44995831
Ocular toxoplasmosis: a global reassessment. Part I: epidemiology and course of disease.Q46022470
Virulent strains of Toxoplasma gondii comprise a single clonal lineageQ46105888
Murine neonatal infection provides an efficient model for congenital ocular toxoplasmosisQ48459046
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue3
P407language of work or nameEnglishQ1860
P921main subjecttoxoplasmosisQ154878
P304page(s)e0214310
P577publication date2019-03-22
P1433published inPLOS OneQ564954
P1476titleType I ROP16 regulates retinal inflammatory responses during ocular toxoplasmosis
P478volume14

Reverse relations

Q89820516Toxoplasma gondii ROP16I Deletion: The Exacerbated Impact on Adverse Pregnant Outcomes in Micecites workP2860

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