MicroRNA-125b-5p regulates IL-1β induced inflammatory genes via targeting TRAF6-mediated MAPKs and NF-κB signaling in human osteoarthritic chondrocytes

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MicroRNA-125b-5p regulates IL-1β induced inflammatory genes via targeting TRAF6-mediated MAPKs and NF-κB signaling in human osteoarthritic chondrocytes is …
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scholarly articleQ13442814

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P356DOI10.1038/S41598-019-42601-3
P932PMC publication ID6499837
P698PubMed publication ID31053727

P50authorZafar RasheedQ46706100
P2093author name stringNaila Rasheed
Muhammad Ismail Khan
Waleed Al Abdulmonem
P2860cites workChondrocyte cytokine and growth factor expression in murine osteoarthritis.Q50903388
MiR-125b Inhibits LPS-Induced Inflammatory Injury via Targeting MIP-1α in Chondrogenic Cell ATDC5.Q52650382
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Advanced glycation end products induce the expression of interleukin-6 and interleukin-8 by receptor for advanced glycation end product-mediated activation of mitogen-activated protein kinases and nuclear factor-κB in human osteoarthritis chondrocytQ34802374
MicroRNA-27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes.Q35114604
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Epigallocatechin-3-gallate suppresses the global interleukin-1beta-induced inflammatory response in human chondrocytes.Q35557911
Endoplasmic reticulum stress induces the expression of COX-2 through activation of eIF2α, p38-MAPK and NF-κB in advanced glycation end products stimulated human chondrocytes.Q35875201
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MicroRNA-125b regulates the expression of aggrecanase-1 (ADAMTS-4) in human osteoarthritic chondrocytesQ36903284
Role of Chondrocytes in Cartilage Formation, Progression of Osteoarthritis and Cartilage RegenerationQ37027619
Green tea polyphenol epigallocatechin-3-gallate inhibits advanced glycation end product-induced expression of tumor necrosis factor-alpha and matrix metalloproteinase-13 in human chondrocytesQ37270775
Signaling by p38 MAPK stimulates nuclear localization of the microprocessor component p68 for processing of selected primary microRNAsQ37288961
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Epigallocatechin-3-O-gallate up-regulates microRNA-199a-3p expression by down-regulating the expression of cyclooxygenase-2 in stimulated human osteoarthritis chondrocytesQ37466796
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MicroRNA-125b-5p modulates the inflammatory state of macrophages via targeting B7-H4.Q38654483
MicroRNA-125b targeted STAT3 to inhibit laryngeal squamous cell carcinoma cell growth and motilityQ38660108
Lactoferrin from Camelus dromedarius Inhibits Nuclear Transcription Factor-kappa B Activation, Cyclooxygenase-2 Expression and Prostaglandin E2 Production in Stimulated Human ChondrocytesQ38806224
Epigallocatechin-3-O-gallate modulates global microRNA expression in interleukin-1β-stimulated human osteoarthritis chondrocytes: potential role of EGCG on negative co-regulation of microRNA-140-3p and ADAMTS5.Q39007281
Do MicroRNAs have a key epigenetic role in osteoarthritis and in mechanotransduction?Q39082472
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Bioavailable constituents/metabolites of pomegranate (Punica granatum L) preferentially inhibit COX2 activity ex vivo and IL-1beta-induced PGE2 production in human chondrocytes in vitro.Q39520696
miR-125b inhibits keratinocyte proliferation and promotes keratinocyte apoptosis in oral lichen planus by targeting MMP-2 expression through PI3K/Akt/mTOR pathwayQ39806178
Polyphenol-rich pomegranate fruit extract (POMx) suppresses PMACI-induced expression of pro-inflammatory cytokines by inhibiting the activation of MAP Kinases and NF-kappaB in human KU812 cellsQ39897321
Growth factors in the treatment of early osteoarthritisQ41867435
Activation of interleukin-1 signaling cascades in normal and osteoarthritic articular cartilageQ42096174
RNA-Seq Identifies Circulating miR-125a-5p, miR-125b-5p, and miR-143-3p as Potential Biomarkers for Acute Ischemic StrokeQ42777136
P38 MAP kinase inhibitors as potential therapeutics for the treatment of joint degeneration and pain associated with osteoarthritisQ43214803
High-efficiency transfection of nucleic acids by the modified calcium phosphate precipitation method in chondrocytesQ45879695
New insights on the MMP-13 regulatory network in the pathogenesis of early osteoarthritisQ47104080
Circulating miR-125b but not miR-125a correlates with acute exacerbations of chronic obstructive pulmonary disease and the expressions of inflammatory cytokinesQ47640362
miR-125b-5p and miR-99a-5p downregulate human γδ T-cell activation and cytotoxicity.Q50074487
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P2507corrigendum / erratumAuthor Correction: MicroRNA-125b-5p regulates IL-1β induced inflammatory genes via targeting TRAF6-mediated MAPKs and NF-κB signaling in human osteoarthritic chondrocytesQ90598317
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectosteoarthritisQ62736
NF-κBQ411114
P304page(s)6882
P577publication date2019-05-03
P1433published inScientific ReportsQ2261792
P1476titleMicroRNA-125b-5p regulates IL-1β induced inflammatory genes via targeting TRAF6-mediated MAPKs and NF-κB signaling in human osteoarthritic chondrocytes
P478volume9

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cites work (P2860)
Q92844854Correlation of microRNA-125a/b with acute respiratory distress syndrome risk and prognosis in sepsis patients
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Q92953495Effect of bacillus bacterial extracts on the expression of major histocompatibility complex Class I and Class II receptors on MDA-MB 231 breast cancer cells
Q90079293Non-Coding RNAs in Cartilage Development: An Updated Review
Q92257889Quercetin, Epigallocatechin Gallate, Curcumin, and Resveratrol: From Dietary Sources to Human MicroRNA Modulation
Q89623393miR-125b and miR-223 Contribute to Inflammation by Targeting the Key Molecules of NFκB Pathway