A Phase I/II Placebo-Controlled Randomized Pilot Clinical Trial of Recombinant Deoxyribonuclease (DNase) Eye Drops Use in Patients With Dry Eye Disease

A Phase I/II Placebo-Controlled Randomized Pilot Clinical Trial of Recombinant Deoxyribonuclease (DNase) Eye Drops Use in Patients With Dry Eye Disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1167/TVST.8.3.10
P932PMC publication ID6504128
P698PubMed publication ID31110911

P2093author name stringDamiano Rondelli
Ilangovan Raju
Anna Ahn
Sandeep Jain
Sapna Tibrewal
Ji-Eun Kwon
Yi-Fan Chen
Shilpa Gulati
Bayasgalan Surenkhuu
Anubhav Pradeep
Christine Mun
Seungwon An
Morgan Buwick
Nour Atassi
P2860cites workReliability and validity of the Ocular Surface Disease IndexQ73801624
Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88Q74342588
New insight into dry eye inflammationQ85715473
Enhanced formation and impaired degradation of neutrophil extracellular traps in dermatomyositis and polymyositis: a potential contributor to interstitial lung disease complicationsQ87417489
n-3 Fatty Acid Supplementation for the Treatment of Dry Eye DiseaseQ88350776
Dornase alfa for cystic fibrosisQ24185927
Extracellular DNA traps in allergic, infectious, and autoimmune diseasesQ26825623
NETs and CF Lung Disease: Current Status and Future ProspectsQ26864316
Neutrophil extracellular traps kill bacteriaQ27860996
Cathelicidin LL-37: an antimicrobial peptide with a role in inflammatory skin diseaseQ28266421
Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptideQ29619485
Extracellular histones are major mediators of death in sepsisQ34019901
Neutrophil extracellular traps directly induce epithelial and endothelial cell death: a predominant role of histonesQ34184548
Topical interleukin 1 receptor antagonist for treatment of dry eye disease: a randomized clinical trial.Q34206399
Hyperosmolar stress induces neutrophil extracellular trap formation: implications for dry eye diseaseQ34677680
Neutrophil extracellular traps: double-edged swords of innate immunityQ36226113
Trashing the genome: the role of nucleases during apoptosisQ36231781
Ocular surface extracellular DNA and nuclease activity imbalance: a new paradigm for inflammation in dry eye diseaseQ36474926
The origin and properties of extracellular DNA: from PAMP to DAMP.Q37047827
Tear fluid extracellular DNA: diagnostic and therapeutic implications in dry eye diseaseQ37386334
Minimal clinically important difference for the ocular surface disease indexQ37672025
Structural modification of DNA--a therapeutic option in SLE?Q37947116
Comparative biochemical properties of vertebrate deoxyribonuclease I.Q38033968
Dornase alfa (Pulmozyme).Q38044650
Neutrophil extracellular traps as a new paradigm in innate immunity: friend or foe?Q38127783
Role of hyperosmolarity in the pathogenesis and management of dry eye disease: proceedings of the OCEAN group meetingQ38151227
Effects of elastase inhibitor on the epithelial cell apoptosis in bleomycin-induced pulmonary fibrosisQ38490506
TFOS DEWS II pathophysiology reportQ38652987
TFOS DEWS II Definition and Classification Report.Q38665717
The development of validated bulbar redness grading scales.Q39824014
Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes.Q40948258
Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6.Q42227558
Inhibition of deoxyribonuclease I by actin is to protect cells from premature cell deathQ42828776
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivs 4.0 InternationalQ24082749
P6216copyright statuscopyrightedQ50423863
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectclinical trialQ30612
placeboQ269829
eye diseaseQ3041498
phase I clinical trialQ5452194
NetsQ28838095
P304page(s)10
P577publication date2019-05-01
P1433published inTranslational vision science & technologyQ27724547
P1476titleA Phase I/II Placebo-Controlled Randomized Pilot Clinical Trial of Recombinant Deoxyribonuclease (DNase) Eye Drops Use in Patients With Dry Eye Disease
P478volume8

Reverse relations

cites work (P2860)
Q92959380Neutrophil Extracellular Traps: Current Perspectives in the Eye
Q90403233Optical Molecular Imaging of Inflammatory Cells in Interventional Medicine-An Emerging Strategy

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