Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers

scientific article published on 04 April 2019

Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1172/JCI.INSIGHT.125019
P932PMC publication ID6483636
P698PubMed publication ID30944259

P50authorJudith CampisiQ19956736
Ok Hee JeonQ88243432
Jordan J GreenQ52663020
P2093author name stringAhmad M Khalil
Kenneth W Witwer
Jennifer H Elisseeff
Laura Santambrogio
Zhenghong Lee
David R Wilson
Cristina C Clement
Christopher Cherry
Sona Rathod
Bonita Powell
P2860cites workA biomarker that identifies senescent human cells in culture and in aging skin in vivoQ24562644
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Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cellsQ27860960
Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespanQ28005547
Extracellular vesicles in the pathogenesis of rheumatoid arthritis and osteoarthritisQ28070177
Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cellsQ28249223
Isolation and characterization of exosomes from cell culture supernatants and biological fluidsQ29615035
Rejuvenation of aged progenitor cells by exposure to a young systemic environmentQ29615250
Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressorQ29615559
Cellular senescence: when bad things happen to good cellsQ29615561
The senescence-associated secretory phenotype: the dark side of tumor suppressionQ29620106
MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responsesQ33588972
Gender-specific differential expression of exosomal miRNA in synovial fluid of patients with osteoarthritis.Q33700665
Exosomes maintain cellular homeostasis by excreting harmful DNA from cellsQ33716401
Serum extracellular vesicle depletion processes affect release and infectivity of HIV-1 in cultureQ33747008
Upregulation of miR-23b enhances the autologous therapeutic potential for degenerative arthritis by targeting PRKACB in synovial fluid-derived mesenchymal stem cells from patients.Q33861686
A novel community driven software for functional enrichment analysis of extracellular vesicles data.Q33893273
IL-17 as a future therapeutic target for rheumatoid arthritisQ34019620
A complex secretory program orchestrated by the inflammasome controls paracrine senescenceQ34037190
The essence of senescenceQ34288983
Standardization of sample collection, isolation and analysis methods in extracellular vesicle researchQ34369038
MicroRNAs Regulate Key Effector Pathways of SenescenceQ35001155
MicroRNA-27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes.Q35114604
Post-traumatic osteoarthritis: the role of accelerated chondrocyte senescence.Q35858168
Osteoarthritis - an untreatable disease?Q36085680
Senescence-associated secretory phenotype favors the emergence of cancer stem-like cells.Q36525196
Protein expression profiles of human lymph and plasma mapped by 2D-DIGE and 1D SDS-PAGE coupled with nanoLC-ESI-MS/MS bottom-up proteomicsQ36781867
Methods for cell sorting of young and senescent cells.Q36883401
DIANA-microT web server v5.0: service integration into miRNA functional analysis workflowsQ36953893
Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrixQ37268683
Senescence-associated exosome release from human prostate cancer cells.Q37352797
Cellular senescence mediated by p16INK4A-coupled miRNA pathwaysQ37574215
MicroRNAs in chondrogenesis, articular cartilage, and osteoarthritis: implications for tissue engineeringQ38016479
Macro view of microRNA function in osteoarthritisQ38034389
Proteomic analysis of human osteoarthritis synovial fluidQ38479729
Toward the promise of microRNAs - Enhancing reproducibility and rigor in microRNA research.Q38958875
Systematic Identification, Characterization and Target Gene Analysis of microRNAs Involved in Osteoarthritis Subchondral Bone PathogenesisQ39947211
Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environmentQ40230478
Exosomes from IL-1β stimulated synovial fibroblasts induce osteoarthritic changes in articular chondrocytesQ42135461
Serum microRNA array analysis identifies miR-140-3p, miR-33b-3p and miR-671-3p as potential osteoarthritis biomarkers involved in metabolic processes.Q47094932
Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice.Q49121379
Integrated bioinformatics analysis of the osteoarthritis‑associated microRNA expression signatureQ50014215
Senescent cells and osteoarthritis: a painful connection.Q52613753
Paracrine cellular senescence exacerbates biliary injury and impairs regeneration.Q52727520
Senescence-associated release of transmembrane proteins involves proteolytic processing by ADAM17 and microvesicle shedding.Q54333956
Publisher Correction: Exosomes maintain cellular homeostasis by excreting harmful DNA from cellsQ57181752
Cell Sorting of Young and Senescent CellsQ60284493
The role of chondrocyte senescence in osteoarthritisQ73711251
Promotion of articular cartilage matrix vesicle mineralization by type I collagenQ81899407
P4510describes a project that usesImageJQ1659584
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectosteoarthritisQ62736
cartilageQ502730
extracellular vesicleQ21097485
P577publication date2019-04-04
P1433published inJCI insightQ27727187
P1476titleSenescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers
P478volume4

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cites work (P2860)
Q92688982A proteomic atlas of senescence-associated secretomes for aging biomarker development
Q96303231Cellular Senescence and Senotherapies in the Kidney: Current Evidence and Future Directions
Q91811482Exploring the Relevance of Senotherapeutics for the Current SARS-CoV-2 Emergency and Similar Future Global Health Threats
Q90271850Senescence in post-mitotic cells: a driver of ageing?
Q90219453Small extracellular vesicles deliver miR-21 and miR-217 as pro-senescence effectors to endothelial cells
Q89532840The ageing epigenome and its rejuvenation

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