Recent Advances in Anti-virulence Therapeutic Strategies With a Focus on Dismantling Bacterial Membrane Microdomains, Toxin Neutralization, Quorum-Sensing Interference and Biofilm Inhibition

scientific article published on 02 April 2019

Recent Advances in Anti-virulence Therapeutic Strategies With a Focus on Dismantling Bacterial Membrane Microdomains, Toxin Neutralization, Quorum-Sensing Interference and Biofilm Inhibition is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.3389/FCIMB.2019.00074
P932PMC publication ID6454102
P698PubMed publication ID31001485

P50authorSuzana Meira RibeiroQ95948222
Octávio Luiz FrancoQ55807541
Marlon Henrique CardosoQ56013894
P2093author name stringOsmel Fleitas Martínez
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Flotillin scaffold activity contributes to type VII secretion system assembly in Staphylococcus aureusQ47139134
Statins: antimicrobial resistance breakers or makers?Q47140385
Neutralizing α-toxin accelerates healing of Staphylococcus aureus-infected wounds in normal and diabetic mice.Q47193259
Combination Therapy Strategy of Quorum Quenching Enzyme and Quorum Sensing Inhibitor in Suppressing Multiple Quorum Sensing Pathways of P. aeruginosa.Q47559168
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Castanea sativa (European Chestnut) Leaf Extracts Rich in Ursene and Oleanene Derivatives Block Staphylococcus aureus Virulence and Pathogenesis without Detectable ResistanceQ21089631
Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agentQ24613185
Mechanism of action and inhibition of dehydrosqualene synthaseQ24628816
Dispersing biofilms with engineered enzymatic bacteriophageQ24684087
Beyond killing: Can we find new ways to manage infection?Q26750724
Targeting Staphylococcus aureus Toxins: A Potential form of Anti-Virulence TherapyQ26752975
PqsBC, a Condensing Enzyme in the Biosynthesis of thePseudomonas aeruginosaQuinolone SignalQ27312117
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Crystal structure of a statin bound to a class II hydroxymethylglutaryl-CoA reductaseQ27640636
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensingQ27654037
The SaeRS Two-Component System of  Staphylococcus aureusQ28073824
Antimicrobial peptides of multicellular organismsQ28131811
Poring over pores: alpha-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumoniaQ28260215
Quorum sensing inhibition selects for virulence and cooperation in Pseudomonas aeruginosaQ28473858
The Campylobacter jejuni Cj0268c protein is required for adhesion and invasion in vitroQ28484956
Structure-Based Design and Biological Evaluation of Triphenyl Scaffold-Based Hybrid Compounds as Hydrolytically Stable Modulators of a LuxR-Type Quorum Sensing ReceptorQ36454100
The role of 2,4-dihydroxyquinoline (DHQ) in Pseudomonas aeruginosa pathogenicityQ36469527
A novel bacteriophage cocktail reduces and disperses Pseudomonas aeruginosa biofilms under static and flow conditionsQ36483482
Auto Poisoning of the Respiratory Chain by a Quorum-Sensing-Regulated Molecule Favors Biofilm Formation and Antibiotic ToleranceQ36510450
Exploration of Modulated Genetic Circuits Governing Virulence Determinants in Staphylococcus aureusQ36510788
The quorum quenching antibody RS2-1G9 protects macrophages from the cytotoxic effects of the Pseudomonas aeruginosa quorum sensing signalling molecule N-3-oxo-dodecanoyl-homoserine lactoneQ36608383
Exploiting quorum sensing to confuse bacterial pathogensQ36667376
Targeting virulence: a new paradigm for antimicrobial therapyQ36914994
Bacterial strategies of resistance to antimicrobial peptides.Q36920921
Host-pathogen interactions in sepsisQ37026360
Efficacy of AiiM, an N-acylhomoserine lactonase, against Pseudomonas aeruginosa in a mouse model of acute pneumoniaQ37036592
What's on the Outside Matters: The Role of the Extracellular Polymeric Substance of Gram-negative Biofilms in Evading Host Immunity and as a Target for Therapeutic InterventionQ37066508
Highly Stable, Amide-Bridged Autoinducing Peptide Analogues that Strongly Inhibit the AgrC Quorum Sensing Receptor in Staphylococcus aureusQ37149488
Is Quorum Sensing Interference a Viable Alternative to Treat Pseudomonas aeruginosa Infections?Q37254245
Critical Role of Alpha-Toxin and Protective Effects of Its Neutralization by a Human Antibody in Acute Bacterial Skin and Skin Structure InfectionsQ37287845
Quorum sensing signal-response systems in Gram-negative bacteriaQ37324474
The end of an old hypothesis: the pseudomonas signaling molecules 4-hydroxy-2-alkylquinolines derive from fatty acids, not 3-ketofatty acidsQ37424462
Retrocyclins neutralize bacterial toxins by potentiating their unfoldingQ37545884
Effect of Quorum Quenching Lactonase in Clinical Isolates of Pseudomonas aeruginosa and Comparison with Quorum Sensing Inhibitors.Q37639329
Anti-virulence strategies to combat bacteria-mediated diseaseQ37676924
The biofilm formation defect of a Bacillus subtilis flotillin-defective mutant involves the protease FtsH.Q37705575
Mechanisms and synthetic modulators of AHL-dependent gene regulationQ37818125
Current status of multiple antigen-presenting peptide vaccine systems: Application of organic and inorganic nanoparticlesQ37921384
Microevolution of Pseudomonas aeruginosa to a chronic pathogen of the cystic fibrosis lungQ37981915
Lipopolysaccharide neutralization by antimicrobial peptides: a gambit in the innate host defense strategy.Q37996318
Isoprenoid biosynthesis in bacterial pathogensQ37998851
AI-2-mediated signalling in bacteriaQ38019983
Metabolic plasticity for isoprenoid biosynthesis in bacteriaQ38101378
The increasingly complex mechanism of HMG-CoA reductase.Q38125222
Quorum quenching enzymes.Q38249028
Pseudomonas aeruginosa Diversification during Infection Development in Cystic Fibrosis Lungs-A Review.Q38273318
Investigational therapies targeting quorum-sensing for the treatment of Staphylococcus aureus infections.Q38364049
Defensive remodeling: How bacterial surface properties and biofilm formation promote resistance to antimicrobial peptidesQ38519180
Pseudomonas aeruginosa Biofilm Infections: Community Structure, Antimicrobial Tolerance and Immune ResponseQ38576398
Quorum quenching: role in nature and applied developmentsQ38598251
Potential Emergence of Multi-quorum Sensing Inhibitor Resistant (MQSIR) BacteriaQ38722412
Dracorhodin Perochlorate attenuates Staphylococcus aureus USA300 virulence by decreasing α-toxin expressionQ38728314
Molecular mechanisms of biofilm-based antibiotic resistance and tolerance in pathogenic bacteriaQ38736102
New frontiers for anti-biofilm drug developmentQ38741798
Anti-virulence Strategies to Target Bacterial InfectionsQ38760476
Pseudomonas aeruginosa LasR·DNA Binding Is Directly Inhibited by Quorum Sensing Antagonists.Q38771960
Inhibition of quorum sensing-controlled biofilm formation in Pseudomonas aeruginosa by quorum-sensing inhibitors.Q47939062
Protein-mediated anti-adhesion surface against oral bacteria.Q48161585
Quorum-Sensing Systems as Targets for Antivirulence TherapyQ49046920
Hygrocin C from marine-derived Streptomyces sp. SCSGAA 0027 inhibits biofilm formation in Bacillus amyloliquefaciens SCSGAB0082 isolated from South China Sea gorgonianQ49490835
Synthesis, quorum sensing inhibition and docking studies of 1,5-dihydropyrrol-2-ones.Q50278615
Structural and thermodynamic analyses of the interaction between melittin and lipopolysaccharide.Q50676762
Head-to-Head Prenyl Synthases in Pathogenic Bacteria.Q50946882
Discovery of potent inhibitors targeting Vibrio harveyi LuxR through shape and e-pharmacophore based virtual screening and its biological evaluation.Q51274904
Molecular Docking, Molecular Dynamics Simulations, Computational Screening to Design Quorum Sensing Inhibitors Targeting LuxP of Vibrio harveyi and Its Biological Evaluation.Q51565431
Eriodictyol protects against Staphylococcus aureus-induced lung cell injury by inhibiting alpha-hemolysin expression.Q52578765
A Biofilm Matrix-Associated Protease Inhibitor Protects Pseudomonas aeruginosa from Proteolytic Attack.Q52595428
Exploring the impact of parthenolide as anti-quorum sensing and anti-biofilm agent against Pseudomonas aeruginosa.Q52663191
Linear peptidomimetics as potent antagonists of Staphylococcus aureus agr quorum sensing.Q52687686
Release of Staphylococcus aureus extracellular vesicles and their application as a vaccine platform.Q52719970
5-Benzylidene-4-oxazolidinones potently inhibit biofilm formation in Methicillin-resistant Staphylococcus aureus.Q53272194
Coumarins reduce biofilm formation and the virulence of Escherichia coli O157:H7.Q53549286
Development of molecularly imprinted polymers to block quorum sensing and inhibit bacterial biofilm formation.Q53681307
PvdQ Quorum Quenching Acylase Attenuates Pseudomonas aeruginosa Virulence in a Mouse Model of Pulmonary Infection.Q54213053
Quorum Sensing-Regulated Phenol-Soluble Modulins Limit Persister Cell Populations in Staphylococcus aureus.Q54260303
Designer cells programming quorum-sensing interference with microbes.Q54936236
Terrein is an inhibitor of quorum sensing and c-di-GMP in Pseudomonas aeruginosa: a connection between quorum sensing and c-di-GMP.Q55265092
A Small Molecule-Screening Pipeline to Evaluate the Therapeutic Potential of 2-Aminoimidazole Molecules Against Clostridium difficile.Q55333418
Characterization of AiiK, an AHL lactonase, from Kurthia huakui LAM0618T and its application in quorum quenching on Pseudomonas aeruginosa PAO1.Q55354038
In Vitro and In Vivo Activity of Peptidomimetic Compounds That Target the Periodontal Pathogen Porphyromonas gingivalis.Q55426263
Small-molecule AgrA inhibitors F12 and F19 act as antivirulence agents against Gram-positive pathogensQ57062562
2-Aminobenzimidazoles as antibiofilm agents against serovar TyphimuriumQ57136045
Catechin-mediated restructuring of a bacterial toxin inhibits activityQ57813110
Targeting the quinolone signal quorum sensing system for the discovery of novel anti-infective pathoblockersQ58560779
Propolis potentiates the effect of cranberry (Vaccinium macrocarpon) in reducing the motility and the biofilm formation of uropathogenic Escherichia coliQ58715270
Coumarin Reduces Virulence and Biofilm Formation in by Affecting Quorum Sensing, Type III Secretion and C-di-GMP LevelsQ58729430
Identification of a Small Molecule Anti-biofilm Agent AgainstQ59791673
Lactam hybrid analogues of solonamide B and autoinducing peptides as potent S. aureus AgrC antagonistsQ62368197
Application of an agr-Specific Antivirulence Compound as Therapy for Staphylococcus aureus-Induced Inflammatory Skin DiseaseQ62368248
Inhibition of Lipopolysaccharide- and Lipoprotein-Induced Inflammation by Antitoxin Peptide Pep19-2.5.Q64965279
Impact of the regulatory loci agr, sarA and sae of Staphylococcus aureus on the induction of alpha-toxin during device-related infection resolved by direct quantitative transcript analysisQ74153291
Nosocomial outbreak of carbapenem-resistant Enterobacter cloacae highlighting the interspecies transferability of the blaOXA-48 gene in the gut floraQ83186450
Specific inhibitions of annonaceous acetogenins on class II 3-hydroxy-3-methylglutaryl coenzyme A reductase from Streptococcus pneumoniaeQ84059475
Benzamidobenzoic acids as potent PqsD inhibitors for the treatment of Pseudomonas aeruginosa infectionsQ87398209
Receptor-Based Peptides for Inhibition of Leukotoxin ActivityQ88615459
Oral Biofilm Formation on Different Materials for Dental ImplantsQ89472195
α-Toxin Induces Platelet Aggregation and Liver Injury during Staphylococcus aureus SepsisQ90392500
Impact of endotracheal tube biofilm and respiratory secretions on airway resistance and mechanics of breathing in a neonatal lung modelQ90495264
Structural and Biochemical Characterization of AaL, a Quorum Quenching Lactonase with Unusual Kinetic PropertiesQ90523757
Subinhibitory concentrations of resveratrol reduce alpha-hemolysin production in Staphylococcus aureus isolates by downregulating saeRSQ90672889
Subinhibitory Concentrations of Prim-O-Glucosylcimifugin Decrease the Expression of Alpha-Hemolysin in Staphylococcus aureus (USA300)Q90930842
Repurposing metformin as a quorum sensing inhibitor in Pseudomonas aeruginosa.Q45970428
Staphylococcus aureus and Atopic Dermatitis: A Complex and Evolving Relationship.Q46242750
An Update on the Sociomicrobiology of Quorum Sensing in Gram-Negative Biofilm DevelopmentQ46275919
Mechanistic understanding of Phenyllactic acid mediated inhibition of quorum sensing and biofilm development in Pseudomonas aeruginosaQ46293335
Flavonoids Suppress Pseudomonas aeruginosa Virulence through Allosteric Inhibition of Quorum-sensing Receptors.Q46428179
Quorum-Quenching and Matrix-Degrading Enzymes in Multilayer Coatings Synergistically Prevent Bacterial Biofilm Formation on Urinary CathetersQ46635815
NMR structures and interactions of temporin-1Tl and temporin-1Tb with lipopolysaccharide micelles: mechanistic insights into outer membrane permeabilization and synergistic activityQ35085167
Cultivation-independent examination of horizontal transfer and host range of an IncP-1 plasmid among gram-positive and gram-negative bacteria indigenous to the barley rhizosphereQ35091869
Impact of Campylobacter jejuni cj0268c knockout mutation on intestinal colonization, translocation, and induction of immunopathology in gnotobiotic IL-10 deficient miceQ35108746
Differential expression and roles of Staphylococcus aureus virulence determinants during colonization and diseaseQ35111115
Exfoliative toxins of Staphylococcus aureusQ35155819
ω-Hydroxyemodin limits staphylococcus aureus quorum sensing-mediated pathogenesis and inflammation.Q35169008
Small molecule disruption of quorum sensing cross-regulation in pseudomonas aeruginosa causes major and unexpected alterations to virulence phenotypesQ35215393
Inhibition of Salmonella enterica biofilm formation using small-molecule adenosine mimeticsQ35329761
Five birds, one stone: neutralization of α-hemolysin and 4 bi-component leukocidins of Staphylococcus aureus with a single human monoclonal antibodyQ35530119
Small molecule inhibitors of Clostridium difficile toxin B-induced cellular damageQ35548934
Exploring the existence of lipid rafts in bacteriaQ35555348
The role of innate immunity in promoting SaeR/S-mediated virulence in Staphylococcus aureus.Q35619910
Quorum quenching quandary: resistance to antivirulence compoundsQ35758927
The Small Molecule DAM Inhibitor, Pyrimidinedione, Disrupts Streptococcus pneumoniae Biofilm Growth In VitroQ35797408
Potent and Selective Modulation of the RhlR Quorum Sensing Receptor by Using Non-native Ligands: An Emerging Target for Virulence Control in Pseudomonas aeruginosaQ35804360
Campylobacter jejuni biofilms contain extracellular DNA and are sensitive to DNase I treatmentQ35837269
Ultrashort Antimicrobial Peptides with Antiendotoxin PropertiesQ35860048
Fine-Tuning Covalent Inhibition of Bacterial Quorum Sensing.Q35913305
Engineered nanoparticles mimicking cell membranes for toxin neutralizationQ35991625
Evaluation of ethyl N-(2-phenethyl) carbamate analogues as biofilm inhibitors of methicillin resistant Staphylococcus aureusQ36061148
Strain-specific transfer of antibiotic resistance from an environmental plasmid to foodborne pathogensQ36082888
Context matters: The importance of dimerization-induced conformation of the LukGH leukocidin of Staphylococcus aureus for the generation of neutralizing antibodies.Q36088381
Biofilms: an emergent form of bacterial lifeQ36100732
Designed Small-Molecule Inhibitors of the Anthranilyl-CoA Synthetase PqsA Block Quinolone Biosynthesis in Pseudomonas aeruginosaQ36141081
Infection control by antibody disruption of bacterial quorum sensing signalingQ36162145
A new small molecule inhibits Streptococcus mutans biofilms in vitro and in vivoQ36249980
Synergistic Action of Staphylococcus aureus α-Toxin on Platelets and Myeloid Lineage Cells Contributes to Lethal SepsisQ36274821
Dual coenzyme specificity of Archaeoglobus fulgidus HMG-CoA reductaseQ36282074
Exploring functional membrane microdomains in bacteria: an overviewQ36290863
Reducing Virulence and Biofilm of Pseudomonas aeruginosa by Potential Quorum Sensing Inhibitor Carotenoid: Zeaxanthin.Q36296165
Mechanistic analysis of a synthetic inhibitor of the Pseudomonas aeruginosa LasI quorum-sensing signal synthase.Q36305679
Quorum sensing network in clinical strains of A. baumannii: AidA is a new quorum quenching enzymeQ36318434
Targeting of Streptococcus mutans Biofilms by a Novel Small Molecule Prevents Dental Caries and Preserves the Oral Microbiome.Q36389955
A quorum sensing small volatile molecule promotes antibiotic tolerance in bacteriaQ28537801
Selective chemical inhibition of agr quorum sensing in Staphylococcus aureus promotes host defense with minimal impact on resistanceQ28539668
Unravelling the Structural and Molecular Basis Responsible for the Anti-Biofilm Activity of Zosteric AcidQ28545999
The agr Inhibitors Solonamide B and Analogues Alter Immune Responses to Staphylococccus aureus but Do Not Exhibit Adverse Effects on Immune Cell FunctionsQ28552024
Structure-Function Analyses of a Staphylococcus epidermidis Autoinducing Peptide Reveals Motifs Critical for AgrC-type Receptor ModulationQ28830075
Quorum sensing: cell-to-cell communication in bacteriaQ29547325
Solution structure of polymyxins B and E and effect of binding to lipopolysaccharide: an NMR and molecular modeling study.Q30584946
Validation of PqsD as an anti-biofilm target in Pseudomonas aeruginosa by development of small-molecule inhibitorsQ31093948
Inhibitors of pathogen intercellular signals as selective anti-infective compoundsQ33302936
Engineered probiotic Escherichia coli can eliminate and prevent Pseudomonas aeruginosa gut infection in animal modelsQ33571968
Identification, evolution, and essentiality of the mevalonate pathway for isopentenyl diphosphate biosynthesis in gram-positive cocciQ33603097
Can bacteria evolve resistance to quorum sensing disruption?Q33632154
Plasmid transfer in biofilms: a perspective on limitations and opportunitiesQ33636216
VLP-based vaccine induces immune control of Staphylococcus aureus virulence regulationQ33677615
Passive control of quorum sensing: prevention of Pseudomonas aeruginosa biofilm formation by imprinted polymers.Q33832737
Approaches to Dispersing Medical BiofilmsQ33845349
Simplified AIP-II Peptidomimetics Are Potent Inhibitors of Staphylococcus aureus AgrC Quorum Sensing Receptors.Q33894378
Pseudomonas aeruginosa Alters Staphylococcus aureus Sensitivity to Vancomycin in a Biofilm Model of Cystic Fibrosis InfectionQ33916479
Interference with Pseudomonas quinolone signal synthesis inhibits virulence factor expression by Pseudomonas aeruginosaQ33944784
Essentiality, expression, and characterization of the class II 3-hydroxy-3-methylglutaryl coenzyme A reductase of Staphylococcus aureusQ33994610
Functional microdomains in bacterial membranesQ34102247
Lovastatin and beyond: the history of the HMG-CoA reductase inhibitorsQ34207135
Growth dependence of conjugation explains limited plasmid invasion in biofilms: an individual-based modelling studyQ34215024
Bacterial osmosensing: roles of membrane structure and electrostatics in lipid-protein and protein-protein interactionsQ34363946
A quorum-sensing inhibitor blocks Pseudomonas aeruginosa virulence and biofilm formationQ34379079
Inhaled lactonase reduces Pseudomonas aeruginosa quorum sensing and mortality in rat pneumoniaQ34414546
Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases.Q34439737
MomL, a novel marine-derived N-acyl homoserine lactonase from Muricauda oleariaQ34448019
Development of a mimotope vaccine targeting the Staphylococcus aureus quorum sensing pathwayQ34472793
Structural and functional analysis of Bacillus subtilis YisP reveals a role of its product in biofilm productionQ34615108
The hierarchy quorum sensing network in Pseudomonas aeruginosaQ34864770
Transfer of carbapenem-resistant plasmid from Klebsiella pneumoniae ST258 to Escherichia coli in patient.Q34908110
Targeting virulence not viability in the search for future antibacterials.Q35023691
High-sensitivity monoclonal antibodies specific for homoserine lactones protect mice from lethal Pseudomonas aeruginosa infectionsQ35031087
Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobialsQ35050042
Pitfalls associated with evaluating enzymatic quorum quenching activity: the case of MomL and its effect on Pseudomonas aeruginosa and Acinetobacter baumannii biofilmsQ38809973
Considerations and caveats in anti-virulence drug developmentQ38810589
Polypharmacology Approaches against the Pseudomonas aeruginosa MvfR Regulon and Their Application in Blocking Virulence and Antibiotic ToleranceQ38852941
Novel linear polymers able to inhibit bacterial quorum sensing.Q38915890
Presence of Biofilms on Polyurethane-Coated Breast Implants: Preliminary ResultsQ38992333
Implementation of Rapid Molecular Infectious Disease Diagnostics: the Role of Diagnostic and Antimicrobial StewardshipQ39061539
Pharmacological Targeting of the Host-Pathogen Interaction: Alternatives to Classical Antibiotics to Combat Drug-Resistant SuperbugsQ39173330
Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistanceQ39197564
Bacterial Membranes: Structure, Domains, and FunctionQ39429007
Structure-based design and screen of novel inhibitors for class II 3-hydroxy-3-methylglutaryl coenzyme A reductase from Streptococcus pneumoniaeQ39598025
TLR 2 and CD14 mediate innate immunity and lung inflammation to staphylococcal Panton-Valentine leukocidin in vivoQ39617084
The role of multispecies social interactions in shaping Pseudomonas aeruginosa pathogenicity in the cystic fibrosis lung.Q40062783
Lysionotin attenuates Staphylococcus aureus pathogenicity by inhibiting α-toxin expressionQ40133970
Attenuating Staphylococcus aureus Virulence by Targeting Flotillin Protein Scaffold ActivityQ40150336
In Situ Capture of Bacterial Toxins for Antivirulence VaccinationQ40155457
Signal Biosynthesis Inhibition with Ambuic Acid as a Strategy To Target Antibiotic-Resistant Infections.Q40175211
CRISPR Interference (CRISPRi) Inhibition of luxS Gene Expression in E. coli: An Approach to Inhibit BiofilmQ40176863
In-depth Profiling of MvfR-Regulated Small Molecules in Pseudomonas aeruginosa after Quorum Sensing Inhibitor TreatmentQ40179538
Glyceryl trinitrate is a novel inhibitor of quorum sensing in Pseudomonas aeruginosa.Q40223046
Immunization with 3-oxododecanoyl-L-homoserine lactone-protein conjugate protects mice from lethal Pseudomonas aeruginosa lung infectionQ40226804
Mycobacterium abscessus subsp. abscessus Is Capable of Degrading Pseudomonas aeruginosa Quinolone SignalsQ40288402
Staphylococcus aureus Survives in Cystic Fibrosis Macrophages, Forming a Reservoir for Chronic PneumoniaQ40295903
Biofilm formation of Achromobacter xylosoxidans on contact lens.Q40325689
CRISPR-based genome editing of clinically important Escherichia coli SE15 isolated from indwelling urinary catheters of patientsQ40411788
Penicillin V acylases from gram-negative bacteria degrade N-acylhomoserine lactones and attenuate virulence in Pseudomonas aeruginosaQ40417008
Development of a novel series of non-natural triaryl agonists and antagonists of the Pseudomonas aeruginosa LasR quorum sensing receptor.Q40459509
Antisense locked nucleic acids targeting agrA inhibit quorum sensing and pathogenesis of community-associated methicillin-resistant Staphylococcus aureusQ40513076
Sclareol protects Staphylococcus aureus-induced lung cell injury via inhibiting alpha-hemolysin expressionQ40528066
IVIG-mediated protection against necrotizing pneumonia caused by MRSA.Q40531502
1,2,3-Triazole-based inhibitors of Porphyromonas gingivalis adherence to oral streptococci and biofilm formationQ40534514
Truncated Autoinducing Peptides as Antagonists of Staphylococcus lugdunensis Quorum SensingQ40554825
Discovery of new diketopiperazines inhibiting Burkholderia cenocepacia quorum sensing in vitro and in vivoQ40556314
Host Responses to Biofilm.Q40559785
Staphylococcus aureus α toxin potentiates opportunistic bacterial lung infectionsQ40761003
Application of Dual Inhibition Concept within Looped Autoregulatory Systems toward Antivirulence Agents against Pseudomonas aeruginosa InfectionsQ40789654
Inhibitory effects of antibiofilm compound 1 against Staphylococcus aureus biofilms.Q40826464
Hybrids of acylated homoserine lactone and nitric oxide donors as inhibitors of quorum sensing and virulence factors in Pseudomonas aeruginosa.Q41047554
Bacterial endotoxin: Chemical constitution, biological recognition, host response, and immunological detoxificationQ41100882
Design, synthesis and biological evaluation of 4-(alkyloxy)-6-methyl-2H-pyran-2-one derivatives as quorum sensing inhibitorsQ41180969
High variability in quorum quenching and growth inhibition by furanone C-30 in Pseudomonas aeruginosa clinical isolates from cystic fibrosis patientsQ41181052
Exploring the chemical space of ureidothiophene-2-carboxylic acids as inhibitors of the quorum sensing enzyme PqsD from Pseudomonas aeruginosaQ41334326
Chalcone Attenuates Staphylococcus aureus Virulence by Targeting Sortase A and Alpha-Hemolysin.Q41400482
Zingerone silences quorum sensing and attenuates virulence of Pseudomonas aeruginosaQ41470499
Catechol-based substrates of chalcone synthase as a scaffold for novel inhibitors of PqsD.Q41641534
Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in miceQ41681261
Regulation of bacteria population behaviors by AI-2 "consumer cells" and "supplier cells".Q41712005
Inhibition of the class II HMG-CoA reductase of Pseudomonas mevaloniiQ41771875
Biosynthesis of Squalene from Farnesyl Diphosphate in Bacteria: Three Steps Catalyzed by Three EnzymesQ41871541
Rhodococcus erythropolis BG43 Genes Mediating Pseudomonas aeruginosa Quinolone Signal Degradation and Virulence Factor AttenuationQ41908511
Activity of Bacteriophages in Removing Biofilms of Pseudomonas aeruginosa Isolates from Chronic Rhinosinusitis PatientsQ41919523
Bacterial toxins: Offensive, defensive, or something else altogether?Q41995627
Quorum-quenching acylase reduces the virulence of Pseudomonas aeruginosa in a Caenorhabditis elegans infection modelQ42111522
Tuning of the Lethal Response to Multiple Stressors with a Single-Site Mutation during Clinical Infection by Staphylococcus aureus.Q42638883
Aii810, a Novel Cold-Adapted N-Acylhomoserine Lactonase Discovered in a Metagenome, Can Strongly Attenuate Pseudomonas aeruginosa Virulence Factors and Biofilm FormationQ42654254
Neutralization of Clostridium difficile Toxin B Mediated by Engineered Lactobacilli That Produce Single-Domain AntibodiesQ42697422
Attenuation of Vibrio fischeri quorum sensing using rationally designed polymersQ43129549
Dioxygenase-mediated quenching of quinolone-dependent quorum sensing in Pseudomonas aeruginosa.Q43197650
Cross species quorum quenching using a native AI-2 processing enzymeQ43213175
Resistance to the quorum-quenching compounds brominated furanone C-30 and 5-fluorouracil in Pseudomonas aeruginosa clinical isolates.Q43682863
Synthesis and stability of small molecule probes for Pseudomonas aeruginosa quorum sensing modulationQ45144916
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P407language of work or nameEnglishQ1860
P921main subjectimmunologyQ101929
infectious diseaseQ18123741
antibioticQ12187
biofilmQ467410
quorum sensingQ905754
virulenceQ1460232
membrane microdomainQ22327677
P304page(s)74
P577publication date2019-04-02
P1433published inFrontiers in Cellular and Infection MicrobiologyQ27724376
P1476titleRecent Advances in Anti-virulence Therapeutic Strategies With a Focus on Dismantling Bacterial Membrane Microdomains, Toxin Neutralization, Quorum-Sensing Interference and Biofilm Inhibition
P478volume9

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