Current and future pharmacological therapies for managing cirrhosis and its complications

scientific article published on 01 February 2019

Current and future pharmacological therapies for managing cirrhosis and its complications is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.3748/WJG.V25.I8.888
P932PMC publication ID6397723
P698PubMed publication ID30833797

P50authorPinelopi ManousouQ88955142
Roberta ForlanoQ90967036
Benjamin MullishQ42838708
P2093author name stringRooshi Nathwani
Ameet Dhar
David Kockerling
P2860cites workNon-absorbable disaccharides versus placebo/no intervention and lactulose versus lactitol for the prevention and treatment of hepatic encephalopathy in people with cirrhosisQ24185895
Guidelines on the management of ascites in cirrhosisQ24676541
Human albumin in the management of complications of liver cirrhosisQ26852608
Systematic review with meta-analysis: the haemodynamic effects of carvedilol compared with propranolol for portal hypertension in cirrhosisQ27013775
Rifaximin treatment in hepatic encephalopathyQ28277660
Statin Use and Risk of Cirrhosis and Related Complications in Patients with Chronic Liver Diseases: a Systematic Review and Meta-analysisQ30234533
Anticoagulation in cirrhosis: a new paradigm?Q30235307
The burden of liver disease in Europe: a review of available epidemiological dataQ30590517
Beta-adrenergic-antagonist drugs in the prevention of gastrointestinal bleeding in patients with cirrhosis and esophageal varices. An analysis of data and prognostic factors in 589 patients from four randomized clinical trials. Franco-Italian MulticQ31043168
Non-absorbable disaccharides for hepatic encephalopathy: systematic review of randomised trialsQ33200604
The management of ascites in cirrhosis: report on the consensus conference of the International Ascites ClubQ33966809
Management of cirrhosis and ascitesQ33977520
Albumin infusion in patients undergoing large-volume paracentesis: a meta-analysis of randomized trialsQ34077523
Comparison of lactulose and neomycin in the treatment of chronic portal-systemic encephalopathy. A double blind controlled trialQ34255207
Propranolol for prevention of recurrent gastrointestinal bleeding in patients with cirrhosis: a controlled studyQ34276429
Beta-blockers to prevent gastroesophageal varices in patients with cirrhosis.Q34469981
Albumin infusion improves outcomes of patients with spontaneous bacterial peritonitis: a meta-analysis of randomized trialsQ34487499
Can Non-Selective Beta-Blockers (NSBBs) Prevent Enlargement of Small Esophageal Varices in Patients with Cirrhosis? A Meta-analysisQ47194571
Statins in cirrhosis-Ready for prime timeQ48097930
Review article: the gut microbiome as a therapeutic target in the pathogenesis and treatment of chronic liver disease.Q48105576
Non-selective beta-blockers are not associated with increased mortality in cirrhotic patients with ascites.Q48122792
Rifaximin treatment is associated with reduced risk of cirrhotic complications and prolonged overall survival in patients experiencing hepatic encephalopathy.Q48182745
Prevention of progression from small to large varices: are we there yet? An updated meta-analysisQ48326607
Rifaximin has no effect on hemodynamics in decompensated cirrhosis: A randomized, double-blind, placebo-controlled trial.Q48462438
A randomized controlled trial comparing lactulose, probiotics, and L-ornithine L-aspartate in treatment of minimal hepatic encephalopathyQ48655913
Coffee Consumption and Prevention of Cirrhosis - In Support of the Caffeine HypothesisQ50148162
Beta-blockers in patients with advanced cirrhosis: Red light, green light, yellow light….Q50202878
Beta-blockers in 2016: Still the safest and most useful drugs for portal hypertension?Q50255140
Nonselective β blockers increase risk for hepatorenal syndrome and death in patients with cirrhosis and spontaneous bacterial peritonitis.Q50709932
Carvedilol use is associated with improved survival in patients with liver cirrhosis and ascites.Q50885984
l-ornithine-l-aspartate for hepatic encephalopathy in patients with cirrhosis: a meta-analysis of randomized controlled trials.Q51344453
Prospective evaluation of anticoagulation and transjugular intrahepatic portosystemic shunt for the management of portal vein thrombosis in cirrhosis.Q51397672
Coagulopathy does not protect against venous thromboembolism in hospitalized patients with chronic liver disease.Q51792687
Proton Pump Inhibitor Administration Triggers Encephalopathy in Cirrhotic Patients by Modulating Blood-Brain Barrier Drug Transport.Q52096132
Beneficial and harmful effects of nonselective beta blockade on acute kidney injury in liver transplant candidates.Q52909369
Carvedilol delays the progression of small oesophageal varices in patients with cirrhosis: a randomised placebo-controlled trial.Q53081546
Dose-dependency of clonidine's effects in ascitic cirrhotic rats: comparison with α1-adrenergic agonist midodrine.Q53449356
Nonselective Beta-Blockers Do Not Affect Survival in Cirrhotic Patients with Ascites.Q53686281
EASL-EASD-EASO Clinical Practice Guidelines for the Management of Non-Alcoholic Fatty Liver Disease.Q55497819
Long-term albumin administration in decompensated cirrhosis (ANSWER): an open-label randomised trialQ56379261
L-ornithine L-aspartate for prevention and treatment of hepatic encephalopathy in people with cirrhosisQ56456331
Coffee and tea breaks for liver healthQ56958980
Carvedilol for primary prophylaxis of variceal bleeding in cirrhotic patients with haemodynamic non-response to propranololQ57168135
Expanding consensus in portal hypertensionQ58034372
Comparison of rifaximin and lactitol in the treatment of acute hepatic encephalopathy: results of a randomized, double-blind, double-dummy, controlled clinical trialQ34529788
Lactulose improves cognitive functions and health-related quality of life in patients with cirrhosis who have minimal hepatic encephalopathyQ34576485
Clinical trial: a randomized controlled study on prevention of variceal rebleeding comparing nadolol + ligation vs. hepatic venous pressure gradient-guided pharmacological therapy.Q34600223
Statin use in patients with cirrhosis: a retrospective cohort studyQ34661975
Secondary prophylaxis of hepatic encephalopathy: an open-label randomized controlled trial of lactulose versus placeboQ34985317
The chronic use of beta-blockers and proton pump inhibitors may affect the rate of bacterial infections in cirrhosisQ35170336
The treatment of vasopressin V2-receptor antagonists in cirrhosis patients with ascites: a meta-analysis of randomized controlled trialsQ35657152
Effects of midodrine in patients with ascites due to cirrhosis: Systematic review and meta-analysisQ35859138
Carvedilol Improves Inflammatory Response, Oxidative Stress and Fibrosis in the Alcohol-Induced Liver Injury in Rats by Regulating Kuppfer Cells and Hepatic Stellate CellsQ35927446
Improving survival in decompensated cirrhosisQ36090423
Beneficial Effects of Statins on the Rates of Hepatic Fibrosis, Hepatic Decompensation, and Mortality in Chronic Liver Disease: A Systematic Review and Meta-AnalysisQ36393781
Statins Are Associated With a Decreased Risk of Decompensation and Death in Veterans With Hepatitis C-Related Compensated Cirrhosis.Q36505496
Rifaximin versus Nonabsorbable Disaccharides for the Treatment of Hepatic Encephalopathy: A Meta-AnalysisQ36802060
Cost-effectiveness analysis of rifaximin-α administration for the reduction of episodes of overt hepatic encephalopathy in recurrence compared with standard treatment in France.Q37019499
A randomized, prospective, double-blind, placebo-controlled trial of terlipressin for type 1 hepatorenal syndromeQ37061659
Evaluation and management of patients with refractory ascitesQ37122130
Proton pump inhibitors in cirrhosis: tradition or evidence based practice?Q37169345
Rifaximin in the treatment of hepatic encephalopathyQ37355818
Coffee intake is associated with lower rates of liver disease progression in chronic hepatitis C.Q37440725
An updated dose-response meta-analysis of coffee consumption and liver cancer riskQ37464692
Molecular Bases Underlying the Hepatoprotective Effects of Coffee.Q37628490
EASL clinical practice guidelines on the management of ascites, spontaneous bacterial peritonitis, and hepatorenal syndrome in cirrhosisQ37773059
Association between proton pump inhibitors and spontaneous bacterial peritonitis in cirrhotic patients - a systematic review and meta-analysisQ37874694
Proton pump inhibitor therapy use does not predispose to small intestinal bacterial overgrowth.Q37983998
Statins are associated with a reduced risk of hepatocellular cancer: a systematic review and meta-analysisQ38051955
Albumin: pathophysiologic basis of its role in the treatment of cirrhosis and its complicationsQ38083035
Human serum albumin, systemic inflammation, and cirrhosis.Q38206059
Addressing liver disease in the UK: a blueprint for attaining excellence in health care and reducing premature mortality from lifestyle issues of excess consumption of alcohol, obesity, and viral hepatitisQ38272635
Non-selective beta-blockers may reduce risk of hepatocellular carcinoma: a meta-analysis of randomized trialsQ38315552
Non-selective betablocker therapy decreases intestinal permeability and serum levels of LBP and IL-6 in patients with cirrhosisQ38319073
Use of Statins in Patients with Chronic Liver Disease and Cirrhosis: Current Views and ProspectsQ38656007
Beta-blockers in patients with advanced liver disease: Has the dust settled?Q38673738
The Diagnosis and Management of Nonalcoholic Fatty Liver Disease: Practice Guidance from the American Association for the Study of Liver Diseases.Q38676257
Proton pump inhibitor therapy and its association with spontaneous bacterial peritonitis incidence and mortality: A meta-analysisQ38706114
Fecal Microbiota Transplant from a Rational Stool Donor Improves Hepatic Encephalopathy: A Randomized Clinical TrialQ38740977
Enoxaparin Prevents Portal Vein Thrombosis and Liver Decompensation in Patients With Advanced CirrhosisQ58034394
Carvedilol versus traditional, non-selective beta-blockers for adults with cirrhosis and gastroesophageal varicesQ58102151
Are proton pump inhibitors a threat for spontaneous bacterial peritonitis and hepatic encephalopathy in cirrhosis? Not so fastQ58833167
The use of faecal microbiota transplant as treatment for recurrent or refractory Clostridium difficile infection and other potential indications: joint British Society of Gastroenterology (BSG) and Healthcare Infection Society (HIS) guidelinesQ60174336
Non-selective β-blockers are associated with improved survival in patients with ascites listed for liver transplantationQ61796520
Proton Pump Inhibitor Initiation and Withdrawal affects Gut Microbiota and Readmission Risk in Cirrhosis.Q64970387
Relation between portal pressure response to pharmacotherapy and risk of recurrent variceal haemorrhage in patients with cirrhosisQ71756341
Effect of propranolol on the factors promoting bacterial translocation in cirrhotic rats with ascitesQ73308039
Effects of clonidine on diuretic response in ascitic patients with cirrhosis and activation of sympathetic nervous systemQ79152275
Efficacy and safety of high-dose pravastatin in hypercholesterolemic patients with well-compensated chronic liver disease: Results of a prospective, randomized, double-blind, placebo-controlled, multicenter trialQ80720162
The window hypothesis: haemodynamic and non-haemodynamic effects of β-blockers improve survival of patients with cirrhosis during a window in the diseaseQ83207473
Rifaximin improves systemic hemodynamics and renal function in patients with alcohol-related cirrhosis and ascitesQ83574872
Management of adult patients with ascites due to cirrhosis: an updateQ83932911
Primary prophylaxis of overt hepatic encephalopathy in patients with cirrhosis: an open labeled randomized controlled trial of lactulose versus no lactuloseQ84164852
Secondary prophylaxis of hepatic encephalopathy in cirrhosis: an open-label, randomized controlled trial of lactulose, probiotics, and no therapyQ84403028
Midodrine in patients with cirrhosis and refractory or recurrent ascites: a randomized pilot studyQ84546778
Satavaptan for the management of ascites in cirrhosis: efficacy and safety across the spectrum of ascites severityQ84749771
The role of rifaximin in the primary prophylaxis of spontaneous bacterial peritonitis in patients with liver cirrhosisQ84762999
Long-term administration of rifaximin improves the prognosis of patients with decompensated alcoholic cirrhosisQ85631083
α1 and α2-adrenergic agonists on cirrhotic patients with refractory ascitesQ85924133
Midodrine and clonidine in patients with cirrhosis and refractory or recurrent ascites: a randomized pilot studyQ86152266
Liver cirrhosisQ87200165
Hepatic encephalopathy in chronic liver disease: 2014 Practice Guideline by the American Association for the Study of Liver Diseases and the European Association for the Study of the LiverQ87416507
Proton Pump Inhibitors and the Possible Development of Hepatic Encephalopathy in Cirrhotic Patients: True Association or Residual Confounding?Q88009336
The Use of Statins in Patients With Chronic Liver Disease and CirrhosisQ88153292
EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosisQ88353946
Portal hypertensive bleeding in cirrhosis: Risk stratification, diagnosis, and management: 2016 practice guidance by the American Association for the study of liver diseasesQ88636602
Treatment with non-selective beta-blockers affects the systemic inflammatory response to bacterial DNA in patients with cirrhosisQ88869445
Beta-blockers in patients with cirrhosis and ascites: type of beta-blocker mattersQ89252223
Diagnosis and treatment of ascitesQ89894406
Coffee and herbal tea consumption is associated with lower liver stiffness in the general population: The Rotterdam studyQ38746130
Anticoagulation in chronic liver diseaseQ38770377
Translating Our Current Understanding of Ascites Management into New Therapies for Patients with Cirrhosis and Fluid Retention.Q38806797
Treatment of Cirrhosis-Associated Hyponatremia with Midodrine and OctreotideQ38869934
Treatment of Patients with CirrhosisQ38936166
Beta blockers and cirrhosis, 2016.Q38975429
Beta adrenergic blockade and decompensated cirrhosis.Q39013562
Proton Pump Inhibitors Increase Risk for Hepatic Encephalopathy in Patients With Cirrhosis in A Population StudyQ39378097
Proton pump inhibitors as a risk factor for hepatic encephalopathy and spontaneous bacterial peritonitis in patients with cirrhosis with ascites.Q39542998
The use of β-blockers is associated with a lower risk of developing hepatocellular carcinoma in patients with cirrhosis.Q39688617
Effect of propranolol on survival in patients with decompensated cirrhosis: a nationwide study based Danish patient registersQ39908375
LactuloseQ39997360
Management of ascites and hepatorenal syndrome.Q40081708
Addition of Simvastatin to Standard Therapy for the Prevention of Variceal Rebleeding Does Not Reduce Rebleeding but Increases Survival in Patients With CirrhosisQ40100867
Nonselective β-blockers do not affect mortality in cirrhosis patients with ascites: Post Hoc analysis of three randomized controlled trials with 1198 patients.Q40282684
Statins decrease the risk of decompensation in hepatitis B virus- and hepatitis C virus-related cirrhosis: A population-based study.Q40285529
Treatment with non-selective beta blockers is associated with reduced severity of systemic inflammation and improved survival of patients with acute-on-chronic liver failureQ40372534
Efficacy and safety of anticoagulation in more advanced portal vein thrombosis in patients with liver cirrhosisQ40379898
Loop diuretic therapy in liver cirrhosis with ascitesQ40385335
Proton pump inhibitor treatment is associated with the severity of liver disease and increased mortality in patients with cirrhosisQ41591557
Proton pump inhibitor therapy does not increase the incidence of spontaneous bacterial peritonitis in cirrhosis: a multicenter prospective studyQ41613676
Rifaximin versus norfloxacin for prevention of spontaneous bacterial peritonitis: a systematic reviewQ41698366
Can non-selective beta-blockers prevent hepatocellular carcinoma in patients with cirrhosis?Q42267541
Rifaximin therapy and hepatic encephalopathy: Pros and consQ42324150
Rifaximin is safe and well tolerated for long-term maintenance of remission from overt hepatic encephalopathy.Q42634652
Deleterious effects of beta-blockers on survival in patients with cirrhosis and refractory ascitesQ43003630
Safety and efficacy of anticoagulation therapy with low molecular weight heparin for portal vein thrombosis in patients with liver cirrhosisQ43281073
Hemodynamic events in a prospective randomized trial of propranolol versus placebo in the prevention of a first variceal hemorrhageQ43560935
Coffee, caffeine, and the risk of liver cirrhosisQ43737586
The use of beta-blockers is associated with the occurrence of acute kidney injury in severe alcoholic hepatitisQ44239223
The complications of diuretic therapy in patients with cirrhosisQ44322569
Efficacy and safety of anticoagulation on patients with cirrhosis and portal vein thrombosis.Q44439466
Simvastatin enhances hepatic nitric oxide production and decreases the hepatic vascular tone in patients with cirrhosis.Q44779682
Patients with elevated liver enzymes are not at higher risk for statin hepatotoxicityQ44887140
A randomized controlled trial of acarbose in hepatic encephalopathyQ45259881
beta-Blockers protect against spontaneous bacterial peritonitis in cirrhotic patients: a meta-analysis.Q45976511
Simvastatin lowers portal pressure in patients with cirrhosis and portal hypertension: a randomized controlled trialQ46126097
Is acarbose an effective drug for treating patients with cirrhosis and hepatic encephalopathy?Q46787163
P275copyright licenseCreative Commons Attribution-NonCommercial 4.0 InternationalQ34179348
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectliver cirrhosisQ147778
cirrosisQ12569389
gastroenterologyQ120569
rifaximinQ416073
gastrointestinal bleedingQ1495657
esophageal and gastric varicesQ54911777
P304page(s)888-908
P577publication date2019-02-01
2019-02-28
P1433published inWorld Journal of GastroenterologyQ15708885
P1476titleCurrent and future pharmacological therapies for managing cirrhosis and its complications
P478volume25

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cites work (P2860)
Q91867520Editorial: Systems Biology and Bioinformatics in Gastroenterology and Hepatology
Q99239921Laparoscopic splenectomy via the spleen bed in combination with selective esophagogastric devascularization for patients with cirrhotic portal hypertension: a single-institution experience
Q64940894Proton pump inhibitor use increases hepatic encephalopathy risk: A systematic review and meta-analysis.

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