Dengue virus nonstructural protein 1 activates platelets via Toll-like receptor 4, leading to thrombocytopenia and hemorrhage

scientific article published on 22 April 2019

Dengue virus nonstructural protein 1 activates platelets via Toll-like receptor 4, leading to thrombocytopenia and hemorrhage is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PPAT.1007625
P932PMC publication ID6497319
P698PubMed publication ID31009511

P50authorTrai-Ming YehQ35703871
P2093author name stringPei-Jane Tsai
Yee-Shin Lin
Guey-Chuen Perng
Yen-Chung Lai
Chiao-Hsuan Chao
Wei-Chueh Wu
P2860cites workZika virus NS1 structure reveals diversity of electrostatic surfaces among flavivirusesQ24048197
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Flavivirus NS1 protein in infected host sera enhances viral acquisition by mosquitoesQ24705181
Dengue Virus Nonstructural Protein 1 Induces Vascular Leakage through Macrophage Migration Inhibitory Factor and AutophagyQ26700117
Biomarkers of severe dengue disease - a reviewQ26783659
Enzyme-linked immunosorbent assay specific to Dengue virus type 1 nonstructural protein NS1 reveals circulation of the antigen in the blood during the acute phase of disease in patients experiencing primary or secondary infectionsQ27473433
Both Virus and Tumor Necrosis Factor Alpha Are Critical for Endothelium Damage in a Mouse Model of Dengue Virus-Induced HemorrhageQ27480369
Dengue: a continuing global threatQ28298464
Platelet proteome reveals novel pathways of platelet activation and platelet-mediated immunoregulation in dengueQ30250939
Platelet activation determines the severity of thrombocytopenia in dengue infectionQ30836939
Dengue virus NS1 enhances viral replication and pro-inflammatory cytokine production in human dendritic cellsQ31110897
NS1: A corner piece in the dengue pathogenesis puzzle?Q33361468
Platelets express functional Toll-like receptor-4.Q33366814
Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-alpha production in vivoQ33368585
Antiplatelet autoantibodies elicited by dengue virus non-structural protein 1 cause thrombocytopenia and mortality in mice.Q33377137
Increased values of mean platelet volume and platelet size deviation width may provide a safe positive diagnosis of idiopathic thrombocytopenic purpuraQ33379782
Lipopolysaccharide stimulates platelet secretion and potentiates platelet aggregation via TLR4/MyD88 and the cGMP-dependent protein kinase pathwayQ33384817
Dengue induces platelet activation, mitochondrial dysfunction and cell death through mechanisms that involve DC-SIGN and caspasesQ33406043
Inhibition of megakaryocyte development in the bone marrow underlies dengue virus-induced thrombocytopenia in humanized miceQ33409934
Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome activationQ33410191
Dengue virus and antiplatelet autoantibodies synergistically induce haemorrhage through Nlrp3-inflammasome and FcγRIII.Q51051739
Optimized THP-1 differentiation is required for the detection of responses to weak stimuli.Q53576670
Prophylactic platelet transfusion does not reduce risk of clinical bleeding in adults with dengue and thrombocytopaenia.Q54323645
Dengue virus non-structural protein 1: a pathogenic factor, therapeutic target, and vaccine candidateQ56396121
Macrophage migration inhibitory factor is critical for dengue NS1-induced endothelial glycocalyx degradation and hyperpermeabilityQ56481034
The Good, the Bad, and the Shocking: The Multiple Roles of Dengue Virus Nonstructural Protein 1 in Protection and PathogenesisQ59356038
Circulating activated platelets assist THP-1 monocytoid/endothelial cell interaction under shear stressQ73070242
Fc receptor-mediated platelet activation is dependent on phosphatidylinositol 3-kinase activation and involves p120(Cbl)Q77800933
Platelet activation and apoptosis modulate monocyte inflammatory responses in dengueQ33416386
Thrombocytopenia in Dengue: Interrelationship between Virus and the Imbalance between Coagulation and Fibrinolysis and Inflammatory MediatorsQ33423030
Anti-dengue virus nonstructural protein 1 antibodies contribute to platelet phagocytosis by macrophagesQ33428119
Association of Mean Platelet Volume with Severity, Serology & Treatment Outcome in Dengue Fever: Prognostic UtilityQ33428430
The value of daily platelet counts for predicting dengue shock syndrome: Results from a prospective observational study of 2301 Vietnamese children with dengueQ33441421
Dengue NS1 antigen as a marker of severe clinical diseaseQ34463249
Dengue in travelers: kinetics of viremia and NS1 antigenemia and their associations with clinical parametersQ34766802
A three-component biomarker panel for prediction of dengue hemorrhagic fever.Q35716620
Activation of TLR2 and TLR6 by Dengue NS1 Protein and Its Implications in the Immunopathogenesis of Dengue Virus InfectionQ35727211
HMGB1 Is a Potential Biomarker for Severe Viral Hemorrhagic FeversQ36062318
Molecular and functional interactions among monocytes, platelets, and endothelial cells and their relevance for cardiovascular diseasesQ37307308
The flavivirus NS1 protein: molecular and structural biology, immunology, role in pathogenesis and application as a diagnostic biomarkerQ38092510
Dengue virus induces thrombomodulin expression in human endothelial cells and monocytes in vitroQ39869387
Progress and Challenges Towards Point-of-Care Diagnostic Development for Dengue.Q40037516
Antibodies Against Modified NS1 Wing Domain Peptide Protect Against Dengue Virus Infection.Q40045064
Dengue virus NS1 protein activates immune cells via TLR4 but not TLR2 or TLR6.Q40068149
Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrityQ40140011
Dengue virus NS1 triggers endothelial permeability and vascular leak that is prevented by NS1 vaccinationQ40140017
Dengue virus NS1 cytokine-independent vascular leak is dependent on endothelial glycocalyx componentsQ44081256
Neutrophils phagocytose activated platelets in vivo: a phosphatidylserine, P-selectin, and {beta}2 integrin-dependent cell clearance programQ46098869
Platelet Toll-like receptor (TLR) expression and TLR-mediated platelet activation in acute myocardial infarctionQ47265950
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectimmunologyQ101929
thrombocytopeniaQ585285
modulation by virus of host processQ14818042
Dengue virusQ476209
dengue virus protein NS1Q114697989
P304page(s)e1007625
P577publication date2019-04-22
P1433published inPLOS PathogensQ283209
P1476titleDengue virus nonstructural protein 1 activates platelets via Toll-like receptor 4, leading to thrombocytopenia and hemorrhage
P478volume15

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cites work (P2860)
Q97521483Challenges in Dengue Vaccines Development: Pre-existing Infections and Cross-Reactivity
Q66678806Endocytosis of flavivirus NS1 is required for NS1-mediated endothelial hyperpermeability and is abolished by a single N-glycosylation site mutation
Q94587197Inflammatory signaling in dengue-infected platelets requires translation and secretion of nonstructural protein 1
Q115250761Molecular Determinants of Tissue Specificity of Flavivirus Nonstructural Protein 1 Interaction with Endothelial Cells
Q96645360Platelet Gene Expression and Function in COVID-19 Patients
Q92859173Recent advances in understanding dengue
Q66679100The Dual Role of the Antibody Response Against the Flavivirus Non-structural Protein 1 (NS1) in Protection and Immuno-Pathogenesis
Q90401541The Era of Thromboinflammation: Platelets Are Dynamic Sensors and Effector Cells During Infectious Diseases
Q115216088microRNAs, the Link Between Dengue Virus and the Host Genome

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