Tuning the properties of tris(hydroxypyridinone) ligands: efficient Ga chelators for PET imaging

scientific article published on 01 March 2019

Tuning the properties of tris(hydroxypyridinone) ligands: efficient Ga chelators for PET imaging is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1039/C8DT04454F
P932PMC publication ID6469224
P698PubMed publication ID30860215

P50authorBrett M PatersonQ56855593
Cinzia ImbertiQ58522338
Philip J BlowerQ60617592
P2093author name stringMichelle T Ma
Robert C Hider
Calum A Foley
Jennifer D Young
Yifu Wang
Yu-Lin Chen
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Systematic comparison of the mono-, dimethyl- and trimethyl 3-hydroxy-4(1H)-pyridones - Attempted optimization of the orally active iron chelator, deferiproneQ89062664
Determination of the intrinsic site pK(a) value and cooperativity of the symmetrical hexadentate chelator N,N',N''-tris[2-(3-hydroxy-2-oxo-1,2-dihydropyridin-1-yl)acetamido]ethylamine.Q52338740
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PET imaging with a [68Ga]gallium-labelled PSMA ligand for the diagnosis of prostate cancer: biodistribution in humans and first evaluation of tumour lesions.Q53131398
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Technetium and gallium derived radiopharmaceuticals: comparing and contrasting the chemistry of two important radiometals for the molecular imaging era.Q34111790
Underscoring the influence of inorganic chemistry on nuclear imaging with radiometalsQ34119201
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Tripodal tris(hydroxypyridinone) ligands for immunoconjugate PET imaging with (89)Zr(4+): comparison with desferrioxamine-B.Q35170338
Rapid kit-based (68)Ga-labelling and PET imaging with THP-Tyr(3)-octreotate: a preliminary comparison with DOTA-Tyr(3)-octreotateQ36143456
New Tris(hydroxypyridinone) Bifunctional Chelators Containing Isothiocyanate Groups Provide a Versatile Platform for Rapid One-Step Labeling and PET Imaging with (68)Ga(3.).Q36595679
Comparison of PET imaging with a (68)Ga-labelled PSMA ligand and (18)F-choline-based PET/CT for the diagnosis of recurrent prostate cancerQ37350456
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Efficient bifunctional gallium-68 chelators for positron emission tomography: tris(hydroxypyridinone) ligandsQ37594420
Enhancing PET Signal at Target Tissue in Vivo: Dendritic and Multimeric Tris(hydroxypyridinone) Conjugates for Molecular Imaging of αvβ3 Integrin Expression with Gallium-68.Q37648915
Positron emitting [68Ga]Ga-based imaging agents: chemistry and diversityQ37895281
Matching chelators to radiometals for radiopharmaceuticalsQ38156660
A nuclear chocolate box: the periodic table of nuclear medicine.Q38269216
Continued rapid growth in (68) Ga applications: update 2013 to June 2014.Q38358666
68Ga-THP-PSMA: A PET Imaging Agent for Prostate Cancer Offering Rapid, Room-Temperature, 1-Step Kit-Based RadiolabelingQ38707752
Equilibrium, Kinetic and Structural Properties of Gallium(III) and Some Divalent Metal Complexes Formed with the New DATAm and DATA5m Ligands.Q38786041
68Ga-complex lipophilicity and the targeting property of a urea-based PSMA inhibitor for PET imagingQ39389586
National Electrical Manufacturers Association NU-4 performance evaluation of the PET component of the NanoPET/CT preclinical PET/CT scannerQ40001502
A triazacyclononane-based bifunctional phosphinate ligand for the preparation of multimeric 68Ga tracers for positron emission tomography.Q42167262
Acyclic chelate with ideal properties for (68)Ga PET imaging agent elaborationQ42854505
Amido-3-hydroxypyridin-4-ones as iron(III) ligandsQ43097060
Fusarinine C, a novel siderophore-based bifunctional chelator for radiolabeling with Gallium-68.Q43125421
Design, synthesis, and evaluation of novel 2-substituted 3-hydroxypyridin-4-ones: structure-activity investigation of metalloenzyme inhibition by iron chelatorsQ43863758
Emerging understanding of the advantage of small molecules such as hydroxypyridinones in the treatment of iron overloadQ44392273
Simple, mild, one-step labelling of proteins with gallium-68 using a tris(hydroxypyridinone) bifunctional chelator: a 68Ga-THP-scFv targeting the prostate-specific membrane antigen.Q47105948
Comparison of macrocyclic and acyclic chelators for gallium-68 radiolabellingQ47195725
Imaging Characteristics and First Experience of [68Ga]THP-PSMA, a Novel Probe for Rapid Kit-Based Ga-68 Labeling and PET Imaging: Comparative Analysis with [68Ga]PSMA I&T.Q48221776
PSA-stratified detection rates for [68Ga]THP-PSMA, a novel probe for rapid kit-based 68Ga-labeling and PET imaging, in patients with biochemical recurrence after primary therapy for prostate cancerQ48297324
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P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P433issue13
P407language of work or nameEnglishQ1860
P304page(s)4299-4313
P577publication date2019-03-01
P1433published inDalton TransactionsQ282900
P1476titleTuning the properties of tris(hydroxypyridinone) ligands: efficient 68Ga chelators for PET imaging
P478volume48

Reverse relations

Q89879563Manipulating the In Vivo Behaviour of 68Ga with Tris(Hydroxypyridinone) Chelators: Pretargeting and Blood Clearancecites workP2860

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