Mast Cells in Cardiac Fibrosis: New Insights Suggest Opportunities for Intervention

scientific article published on 28 March 2019

Mast Cells in Cardiac Fibrosis: New Insights Suggest Opportunities for Intervention is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3389/FIMMU.2019.00580
P932PMC publication ID6455071
P698PubMed publication ID31001246

P50authorJean S MarshallQ60329463
P2093author name stringIan D Haidl
Jean-François Légaré
Stephanie A Legere
P2860cites workMast cell tryptase stimulates the synthesis of type I collagen in human lung fibroblastsQ24561756
The role of IL-33 and mast cells in allergy and inflammationQ26783420
Mast cells as effectors in atherosclerosisQ26995160
The role of mast cells in allergic inflammationQ27003571
The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndromeQ28288581
Chymase mediates injury and mitochondrial damage in cardiomyocytes during acute ischemia/reperfusion in the dogQ28537860
Angiotensin II generation by mast cell alpha- and beta-chymasesQ28610117
Morphometrical and stereological analysis of myocardial mast cells in myocarditis and dilated cardiomyopathy.Q33180037
Tryptase activates TGFbeta in human airway smooth muscle cells via direct proteolysis.Q46688270
Chymase induces profibrotic response via transforming growth factor-beta 1/Smad activation in rat cardiac fibroblastsQ46867288
Inhibition of pulmonary fibrosis by the chemokine IP-10/CXCL10.Q47324915
Interleukin-10 Inhibits Bone Marrow Fibroblast Progenitor Cell-Mediated Cardiac Fibrosis in Pressure-Overloaded MyocardiumQ47969185
Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitorsQ48425484
The controversial role of mast cells in fibrosisQ50068930
Mast cells as sources of cytokines, chemokines, and growth factors.Q50068970
Non-IgE mediated mast cell activation.Q50069011
Changing the threshold-Signals and mechanisms of mast cell primingQ50069023
Mast cell degranulation promotes ischemia-reperfusion injury in rat liverQ50228623
Correlation between mast cell density and myocardial fibrosis in congestive heart failure patients.Q50675712
The human cardiac mast cell: localization, isolation, phenotype, and functional characterizationQ50767564
Quantitative changes in mast cell populations after left ventricular assist device implantation.Q51428172
Evidence for tissue angiotensin-converting enzyme in explanted hearts of ischemic cardiomyopathy using targeted radiotracer technique.Q53573892
VEGF-A promotes cardiac stem cell engraftment and myocardial repair in the infarcted heart.Q53617599
Novel mechanism of angiotensin II-induced cardiac injury in hypertensive rats: the critical role of ASK1 and VEGF.Q54338960
IL-33 attenuates cardiac remodeling following myocardial infarction via inhibition of the p38 MAPK and NF-κB pathways.Q54368873
The novel role of mast cells in the microenvironment of acute myocardial infarction.Q54389254
Reduction in IL-33 expression exaggerates ischaemia/reperfusion-induced myocardial injury in mice with diabetes mellitus.Q54535403
Comparison between the collagen intensity and mast cell density in the lingual muscles and myocardium of autopsied chronic chagasic and nonchagasic patientsQ58843476
Inhibition of mast cell PGD2release protects against mannitol-induced airway narrowingQ60168438
Inhibition profiles of sodium cromoglycate and nedocromil sodium on mediator release from mast cells of human skin, lung, tonsil, adenoid and intestineQ67535901
Mast cell tryptase stimulates human lung fibroblast proliferation via protease-activated receptor-2Q73382005
Differential regulation of mast cell function by IL-10 and stem cell factorQ73900176
Production of fibrogenic cytokines by cord blood-derived cultured human mast cellsQ73972452
Mast cell tryptase stimulates both human dermal fibroblast proliferation and type I collagen productionQ74452712
Tumor necrosis factor-alpha mediates cardiac remodeling and ventricular dysfunction after pressure overload stateQ79923829
CD117-positive cells of the heart: progenitor cells or mast cells?Q33742772
Mast cell chymase limits the cardiac efficacy of Ang I-converting enzyme inhibitor therapy in rodentsQ33755314
ADAM10 is required for SCF-induced mast cell migrationQ34026123
CXCR3-independent actions of the CXC chemokine CXCL10 in the infarcted myocardium and in isolated cardiac fibroblasts are mediated through proteoglycansQ34106221
Activation of human interstitial procollagenase through direct cleavage of the Leu83-Thr84 bond by mast cell chymase.Q34329991
Progressive replacement of embryo-derived cardiac macrophages with ageQ34375144
Central domain of IL-33 is cleaved by mast cell proteases for potent activation of group-2 innate lymphoid cellsQ34442444
Myocardial remodeling in diabetic cardiomyopathy associated with cardiac mast cell activationQ34654120
Stem cell factor gene transfer improves cardiac function after myocardial infarction in swineQ35002029
Interferon-gamma protects against chronic viral myocarditis by reducing mast cell degranulation, fibrosis, and the profibrotic cytokines transforming growth factor-beta 1, interleukin-1 beta, and interleukin-4 in the heartQ35103548
Mast cell secretory granules: armed for battleQ35182662
Dengue vascular leakage is augmented by mast cell degranulation mediated by immunoglobulin Fcγ receptorsQ35183803
Cross-talk between human mast cells and bronchial epithelial cells in plasminogen activator inhibitor-1 production via transforming growth factor-β1.Q35207676
Involvement of chymase-mediated angiotensin II generation in blood pressure regulationQ35233098
Corin-deficient W-sh mice poorly tolerate increased cardiac afterloadQ35381245
The development of myocardial fibrosis in transgenic mice with targeted overexpression of tumor necrosis factor requires mast cell-fibroblast interactionsQ35552846
Evidence for an active inflammatory process in the hibernating human myocardiumQ35788998
The Protective Role of Interleukin-33 in Myocardial Ischemia and Reperfusion Is Associated with Decreased HMGB1 Expression and Up-Regulation of the P38 MAPK Signaling PathwayQ35841956
Substance P signaling controls mast cell activation, degranulation, and nociceptive sensitization in a rat fracture model of complex regional pain syndromeQ35850819
Inhibition of IgE-dependent histamine release from human dispersed lung mast cells by anti-allergic drugs and salbutamolQ35887104
Testosterone and interleukin-1β increase cardiac remodeling during coxsackievirus B3 myocarditis via serpin A 3n.Q35900980
Stem cell factor programs the mast cell activation phenotypeQ35981165
Cromoglycate, not ketotifen, ameliorated the injured effect of warm ischemia/reperfusion in rat liver: role of mast cell degranulation, oxidative stress, proinflammatory cytokine, and inducible nitric oxide synthaseQ36079408
Prevention of salt induced hypertension and fibrosis by angiotensin converting enzyme inhibitors in Dahl S ratsQ36144638
Interleukin-10 treatment attenuates pressure overload-induced hypertrophic remodeling and improves heart function via signal transducers and activators of transcription 3-dependent inhibition of nuclear factor-κBQ36174897
Stem cell factor is responsible for the rapid response in mature mast cell density in the acutely stressed heartQ36225609
Signal transduction and chemotaxis in mast cellsQ36240848
IP-10 inhibits epidermal growth factor-induced motility by decreasing epidermal growth factor receptor-mediated calpain activityQ36382107
The cardiac repair benefits of inflammation do not persist: evidence from mast cell implantationQ36394723
Mast cell tryptase may modulate endothelial cell phenotype in healing myocardial infarctsQ36509613
Pathological roles of angiotensin II produced by mast cell chymase and the effects of chymase inhibition in animal modelsQ36534366
Mast cell progenitor trafficking and maturationQ36560191
New models for analyzing mast cell functions in vivoQ36610811
A novel chymase inhibitor, 4-[1-([bis-(4-methyl-phenyl)-methyl]-carbamoyl)3-(2-ethoxy-benzyl)-4-oxo-azetidine-2-yloxy]-benzoic acid (BCEAB), suppressed cardiac fibrosis in cardiomyopathic hamstersQ44370359
Chymase Inhibition Prevents Cardiac Fibrosis and Improves Diastolic Dysfunction in the Progression of Heart FailureQ44438460
Norepinephrine-induced cardiac hypertrophy and fibrosis are not due to mast cell degranulationQ44631192
Pirfenidone attenuates cardiac fibrosis in a mouse model of TAC-induced left ventricular remodeling by suppressing NLRP3 inflammasome formation.Q44853398
A single treatment with a specific chymase inhibitor, TY-51184, prevents vascular proliferation in canine grafted veinsQ44859380
Protective role of mast cells in homocysteine-induced cardiac remodelingQ45182725
Cardiac mast cells mediate left ventricular fibrosis in the hypertensive rat heart.Q46034399
Erythropoietin combined with ACE inhibitor prevents heart remodeling in 5/6 nephrectomized rats independently of blood pressure and kidney function.Q46192933
Cutting edge: The ST2 ligand IL-33 potently activates and drives maturation of human mast cellsQ80736011
Interleukin-33 prevents apoptosis and improves survival after experimental myocardial infarction through ST2 signalingQ84916626
Eotaxin/CCL11 Levels Correlate With Myocardial Fibrosis and Mast Cell Density in Native and Transplanted Rat HeartsQ85014745
Myocardial inflammatory infiltrate in human chronic chagasic cardiomyopathy: Immunohistochemical findingsQ87072610
Mast cells contribute to bleomycin-induced lung inflammation and injury in mice through a chymase/mast cell protease 4-dependent mechanismQ87147961
Correction for Lavine et al., Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heartQ87397419
Distribution of mast cells within the mouse heart and its dependency on MitfQ93341378
Chronic chymase inhibition preserves cardiac function after left ventricular repair in ratsQ94608691
Evidence questioning cromolyn's effectiveness and selectivity as a 'mast cell stabilizer' in mice.Q36632214
Activated mast cells synthesize and release soluble ST2-a decoy receptor for IL-33.Q36744984
Stem cell factor gene transfer promotes cardiac repair after myocardial infarction via in situ recruitment and expansion of c-kit+ cells.Q36837256
Mast cells regulate myofilament calcium sensitization and heart function after myocardial infarctionQ37047339
Mast Cell Inhibition Attenuates Cardiac Remodeling and Diastolic Dysfunction in Middle-aged, Ovariectomized Fischer 344 × Brown Norway RatsQ37079737
Lives of a heart cell: tracing the origins of cardiac progenitorsQ37132482
Mast cells and epsilonPKC: a role in cardiac remodeling in hypertension-induced heart failureQ37133226
The pathogenesis of cardiac fibrosis.Q37161329
IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1Q37246528
Cardiogenic differentiation and transdifferentiation of progenitor cellsQ37319214
IL-10 inhibits inflammation and attenuates left ventricular remodeling after myocardial infarction via activation of STAT3 and suppression of HuR.Q37415365
Mouse mast cell proteases 4 and 5 mediate epidermal injury through disruption of tight junctionsQ37674001
Vascular endothelial growth factor promotes fibrosis resolution and repair in miceQ37726957
TNFα in myocardial ischemia/reperfusion, remodeling and heart failureQ37767172
Are mast cells instrumental for fibrotic diseases?Q38183377
Hematopoietic Kit Deficiency, rather than Lack of Mast Cells, Protects Mice from Obesity and Insulin ResistanceQ38299158
IL-33 and Thymic Stromal Lymphopoietin in mast cell functionsQ38519638
Interleukin-1 in cardiac injury, repair, and remodeling: pathophysiologic and translational conceptsQ38566665
The Biological Basis for Cardiac Repair After Myocardial Infarction: From Inflammation to Fibrosis.Q38875774
Pressure overload leads to an increased accumulation and activity of mast cells in the right ventricleQ38885347
Persistent change in cardiac fibroblast physiology after transient ACE inhibitionQ38963920
Redefinition of the human mast cell transcriptome by deep-CAGE sequencingQ38967503
5TNF-α and IL-1β neutralization ameliorates angiotensin II-induced cardiac damage in male miceQ38990137
A critical role for mast cells and mast cell-derived IL-6 in TLR2-mediated inhibition of tumor growth.Q39637223
Short-term ACE inhibition confers long-term protection against target organ damageQ39654678
Mast cell degranulation is induced by A549 airway epithelial cell infected with respiratory syncytial virusQ39887208
Mast cells promote proliferation and migration and inhibit differentiation of mesenchymal stem cells through PDGF.Q39903739
Local injection of stem cell factor (SCF) improves myocardial homing of systemically delivered c-kit + bone marrow-derived stem cellsQ40153856
Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells.Q40216222
Human mast cells stimulate fibroblast proliferation, collagen synthesis and lattice contraction: a direct role for mast cells in skin fibrosisQ40740841
The differentiation and function of myofibroblasts is regulated by mast cell mediatorsQ40768319
Cord blood-derived human cultured mast cells produce transforming growth factor beta1.Q40969668
Human mast cells activate fibroblasts: tryptase is a fibrogenic factor stimulating collagen messenger ribonucleic acid synthesis and fibroblast chemotaxis.Q41125883
Nonclassical resident macrophages are important determinants in the development of myocardial fibrosisQ41186913
TNF receptor 1 signaling is critically involved in mediating angiotensin-II-induced cardiac fibrosisQ41324289
Formalin sensitivity and differential staining of mast cells in human dermisQ42091758
Induction of the CXC chemokine interferon-gamma-inducible protein 10 regulates the reparative response following myocardial infarction.Q42278450
Cardiac mast cells cause atrial fibrillation through PDGF-A-mediated fibrosis in pressure-overloaded mouse heartsQ42946844
Activation of paracrine TGF-beta1 signaling upon stimulation and degranulation of rat serosal mast cells: a novel function for chymaseQ43626582
Mast cells in acute and chronic rejection of rat cardiac allografts--a major source of basic fibroblast growth factorQ43675872
Comparison of the modulatory effect of ketotifen, sodium cromoglycate, procaterol and salbutamol in human skin, lung and tonsil mast cellsQ43720282
Mast cells and macrophages in normal C57/BL/6 miceQ44067220
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P407language of work or nameEnglishQ1860
P921main subjectimmunologyQ101929
inflammationQ101991
mast cellQ191989
neovascularizationQ1281049
myocardial ischemiaQ6947906
P304page(s)580
P577publication date2019-03-28
P1433published inFrontiers in ImmunologyQ27723748
P1476titleMast Cells in Cardiac Fibrosis: New Insights Suggest Opportunities for Intervention
P478volume10

Reverse relations

cites work (P2860)
Q89994640Future Needs in Mast Cell Biology
Q99547055Increased mast cell density is associated with decreased fibrosis in human atrial tissue
Q93165013Leukocyte-Dependent Regulation of Cardiac Fibrosis
Q98224256The Roles of Noncardiomyocytes in Cardiac Remodeling

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