Long-term safety and efficacy of the sodium glucose cotransporter 2 inhibitor tofogliflozin added on glucagon-like peptide-1 receptor agonist in Japanese patients with type 2 diabetes mellitus (J-STEP/GLP): a 52-week open-label, multicenter, post-mar

scientific article published on 28 May 2019

Long-term safety and efficacy of the sodium glucose cotransporter 2 inhibitor tofogliflozin added on glucagon-like peptide-1 receptor agonist in Japanese patients with type 2 diabetes mellitus (J-STEP/GLP): a 52-week open-label, multicenter, post-mar is …
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scholarly articleQ13442814

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P356DOI10.1111/JDI.13066
P932PMC publication ID6825952
P698PubMed publication ID31033218

P50authorKohei KakuQ47419459
Yasuo TerauchiQ88294909
Masayuki SendaQ89606169
Yuji KuriharaQ89606173
Hisataka FujiwaraQ91288050
P2093author name stringHideki Suganami
Masahiro Tamura
Ryoji Gunji
P2860cites workSGLT2 inhibitors or GLP-1 receptor agonists as second-line therapy in type 2 diabetes: patient selection and perspectivesQ26746901
A clinical review of GLP-1 receptor agonists: efficacy and safety in diabetes and beyondQ26799389
The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetesQ28273497
Efficacy and safety of monotherapy with the novel sodium/glucose cotransporter-2 inhibitor tofogliflozin in Japanese patients with type 2 diabetes mellitus: a combined Phase 2 and 3 randomized, placebo-controlled, double-blind, parallel-group comparQ33612741
Discovery of tofogliflozin, a novel C-arylglucoside with an O-spiroketal ring system, as a highly selective sodium glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetesQ34293786
Tofogliflozin: first global approvalQ34420901
Renal sodium-glucose cotransporter inhibition in the management of type 2 diabetes mellitusQ36345951
Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitusQ37141727
Liraglutide for weight management: a critical review of the evidenceQ37711170
The Effect of Tofogliflozin Treatment on Postprandial Glucose and Lipid Metabolism in Japanese Men With Type 2 Diabetes: A Pilot StudyQ37737187
Glucose dynamics and mechanistic implications of SGLT2 inhibitors in animals and humansQ37848043
The role of the kidneys in glucose homeostasis: a new path towards normalizing glycaemia.Q37940036
Early Combination Therapy with Oral Glucose-Lowering Agents in Type 2 Diabetes.Q38762377
Sodium Glucose Cotransporter 2 Inhibitors in the Treatment of Diabetes Mellitus: Cardiovascular and Kidney Effects, Potential Mechanisms, and Clinical Applications.Q38912082
Exenatide once weekly plus dapagliflozin once daily versus exenatide or dapagliflozin alone in patients with type 2 diabetes inadequately controlled with metformin monotherapy (DURATION-8): a 28 week, multicentre, double-blind, phase 3, randomised cQ39368551
Glycated albumin: a potential biomarker in diabetes.Q39430493
Safety and Effectiveness of Tofogliflozin in Elderly Japanese Patients with Type 2 Diabetes Mellitus: a Post-Marketing Study (J-STEP/EL Study).Q40363925
Overview of Glucagon-Like Peptide-1 Receptor Agonists for the Treatment of Patients with Type 2 DiabetesQ41184651
Combination therapy with GLP-1 analogues and SGLT-2 inhibitors in the management of diabesity: the real world experience.Q42082791
Tofogliflozin: the road goes ever on.Q42658161
Efficacy of antihyperglycemic therapies and the influence of baseline hemoglobin A(1C): a meta-analysis of the liraglutide development programQ46110493
A novel and selective sodium-glucose cotransporter-2 inhibitor, tofogliflozin, improves glycaemic control and lowers body weight in patients with type 2 diabetes mellitus.Q47374718
Real-world effectiveness and safety of dapagliflozin therapy added to a GLP1 receptor agonist in patients with type 2 diabetes.Q50957907
Tofogliflozin: a highly selective SGLT2 inhibitor for the treatment of type 2 diabetes.Q53094851
Short-term impacts of sodium/glucose co-transporter 2 inhibitors in Japanese clinical practice: considerations for their appropriate use to avoid serious adverse events.Q53551539
Tofogliflozin, a potent and highly specific sodium/glucose cotransporter 2 inhibitor, improves glycemic control in diabetic rats and miceQ83629703
SGLT-2 INHIBITOR THERAPY ADDED TO GLP-1 AGONIST THERAPY IN THE MANAGEMENT OF T2DMQ85985011
Long-term safety and efficacy of tofogliflozin, a selective inhibitor of sodium-glucose cotransporter 2, as monotherapy or in combination with other oral antidiabetic agents in Japanese patients with type 2 diabetes mellitus: multicenter, open-labelQ87261695
P433issue6
P407language of work or nameEnglishQ1860
P921main subjecttype 2 diabetesQ3025883
P304page(s)1518-1526
P577publication date2019-05-28
P1433published inJournal of Diabetes InvestigationQ28207066
P1476titleLong-term safety and efficacy of the sodium-glucose cotransporter 2 inhibitor, tofogliflozin, added on glucagon-like peptide-1 receptor agonist in Japanese patients with type 2 diabetes mellitus: A 52-week open-label, multicenter, post-marketing clinical study
P478volume10

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