Beneficial Effects of Citrus Flavonoids on Cardiovascular and Metabolic Health

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Beneficial Effects of Citrus Flavonoids on Cardiovascular and Metabolic Health is …
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scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1155/2019/5484138
P932PMC publication ID6431442
P698PubMed publication ID30962863

P50authorAyman Moawad MahmoudQ46889225
P2093author name stringOmnia E Hussein
Mansur A Sandhu
Rene J Hernández Bautista
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Anti-atherogenic effect of citrus flavonoids, naringin and naringenin, associated with hepatic ACAT and aortic VCAM-1 and MCP-1 in high cholesterol-fed rabbitsQ43633005
Naringin has an antiatherogenic effect with the inhibition of intercellular adhesion molecule-1 in hypercholesterolemic rabbitsQ43798821
Comparison of antioxidant effects of naringin and probucol in cholesterol-fed rabbitsQ43868658
Hepatocyte apoB-containing lipoprotein secretion is decreased by the grapefruit flavonoid, naringenin, via inhibition of MTP-mediated microsomal triglyceride accumulationQ44301183
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Effects of glucosyl hesperidin on serum lipids in hyperlipidemic subjects: preferential reduction in elevated serum triglyceride level.Q45074072
Flavonoids inhibit platelet function through binding to the thromboxane A2 receptorQ45237834
Naringenin reduces oxidative stress and improves mitochondrial dysfunction via activation of the Nrf2/ARE signaling pathway in neuronsQ46300500
Hesperidin protects against cyclophosphamide-induced hepatotoxicity by upregulation of PPARγ and abrogation of oxidative stress and inflammationQ46390723
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Flavonoid Naringenin Attenuates Oxidative Stress, Apoptosis and Improves Neurotrophic Effects in the Diabetic Rat RetinaQ46500518
Naringenin ameliorates renal and platelet purinergic signalling alterations in high-cholesterol fed rats through the suppression of ROS and NF-κB signaling pathways.Q46639895
Short-term effects of glucosyl hesperidin and hesperetin on blood pressure and vascular endothelial function in spontaneously hypertensive rats.Q46664537
Carnitine palmitoyltransferase-1 up-regulation by PPAR-β/δ prevents lipid-induced endothelial dysfunction.Q46687600
Combined treatment with naringin and vitamin C ameliorates streptozotocin-induced diabetes in male Wistar ratsQ46698985
Glucosyl hesperidin prevents endothelial dysfunction and oxidative stress in spontaneously hypertensive ratsQ46711058
Hesperidin protects against chemically induced hepatocarcinogenesis via modulation of Nrf2/ARE/HO-1, PPARγ and TGF-β1/Smad3 signaling, and amelioration of oxidative stress and inflammationQ46755279
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Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic miceQ46904894
Effect of citrus flavonoids and tocotrienols on serum cholesterol levels in hypercholesterolemic subjects.Q46912549
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Tangeretin regulates platelet function through inhibition of phosphoinositide 3-kinase and cyclic nucleotide signalingQ86546460
Nobiletin protects human retinal pigment epithelial cells from hydrogen peroxide-induced oxidative damageQ88451961
Hesperidin Suppresses Renin-Angiotensin System Mediated NOX2 Over-Expression and Sympathoexcitation in 2K-1C Hypertensive RatsQ88652418
Naringenin exhibits the protective effect on cardiac hypertrophy via EETs-PPARs activation in streptozocin-induced diabetic miceQ88736859
Intervention with citrus flavonoids reverses obesity and improves metabolic syndrome and atherosclerosis in obese Ldlr-/- miceQ90217787
Combating oxidative stress disorders with citrus flavonoid: NaringeninQ90316345
Pathophysiological mechanisms of diabetic cardiomyopathy and the therapeutic potential of epigallocatechin-3-gallateQ90513104
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Naringenin, a common flavanone, inhibits the formation of AGEs in bread and attenuates AGEs-induced oxidative stress and inflammation in RAW264.7 cellsQ90904849
Hesperetin, a citrus flavonoid, attenuates testicular damage in diabetic rats via inhibition of oxidative stress, inflammation, and apoptosisQ91282554
Potential protective effects of naringenin against vancomycin-induced nephrotoxicity via reduction on apoptotic and oxidative stress markers in ratsQ91780144
Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesionsQ33916802
Biochemical alterations during the obese-aging process in female and male monosodium glutamate (MSG)-treated mice.Q34072214
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Cardioprotective effects of hesperetin against doxorubicin-induced oxidative stress and DNA damage in rat.Q34629050
Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome.Q34894220
The flavonoid, naringenin, decreases adipose tissue mass and attenuates ovariectomy-associated metabolic disturbances in miceQ35149393
Standards of medical care in diabetes-2015 abridged for primary care providersQ35428940
From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I.Q35552554
Anti-inflammatory plant flavonoids and cellular action mechanismsQ35946561
Pharmacological actions of nobiletin in the modulation of platelet function.Q35978127
Vascular endothelium, hemodynamics, and the pathobiology of atherosclerosisQ36041802
Liraglutide and Cardiovascular Outcomes in Type 2 DiabetesQ36050559
Role of hesperetin in LDL-receptor expression in hepatoma HepG2 cells.Q36062697
Type 2 diabetes mellitus: a review of current trendsQ36299039
Hyperlipidemia as a risk factor for cardiovascular diseaseQ36609968
Hematological alterations in diabetic rats - Role of adipocytokines and effect of citrus flavonoidsQ36651887
Inhibition of apoB secretion from HepG2 cells by insulin is amplified by naringenin, independent of the insulin receptorQ36870580
Polyphenols, dietary sources and bioavailabilityQ37061773
Sitagliptin attenuates cardiomyopathy by modulating the JAK/STAT signaling pathway in experimental diabetic rats.Q37066737
Long-term orange juice consumption is associated with low LDL-cholesterol and apolipoprotein B in normal and moderately hypercholesterolemic subjectsQ37113680
Antioxidative effects of hesperetin against lead acetate-induced oxidative stress in ratsQ37133320
Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitusQ37141727
High density lipoprotein biogenesis, cholesterol efflux, and immune cell functionQ37221779
Frequency of citrus fruit intake is associated with the incidence of cardiovascular disease: the Jichi Medical School cohort study.Q37506195
The citrus flavonoid naringenin confers protection in a murine endotoxaemia model through AMPK-ATF3-dependent negative regulation of the TLR4 signalling pathwayQ37526079
Molecular mechanisms of diabetic cardiomyopathy.Q37672583
Free radicals, antioxidants and functional foods: Impact on human healthQ37974201
Emerging biomarkers and intervention targets for immune-modulation of atherosclerosis - a review of the experimental evidenceQ38062226
Citrus flavonoids and lipid metabolismQ38068733
Metabolism of dietary flavonoids in liver microsomes.Q38075032
Anti-inflammatory properties of orange juice: possible favorable molecular and metabolic effects.Q38082460
Hyperglycemia-induced oxidative stress and its role in diabetes mellitus related cardiovascular diseasesQ38085394
Antioxidants and human diseasesQ38220589
Hesperidin potentiates ghrelin signalingQ38245167
The Health Potential of Fruits and Vegetables Phytochemicals: Notable ExamplesQ38250068
Antioxidant and anti-inflammatory properties of the citrus flavonoids hesperidin and hesperetin: an updated review of their molecular mechanisms and experimental models.Q38267943
Diabetic cardiomyopathy and its mechanisms: Role of oxidative stress and damageQ38271210
Nobiletin improves hyperglycemia and insulin resistance in obese diabetic ob/ob miceQ38346573
Health-promoting effects of the citrus flavanone hesperidinQ38352905
Association Between Coronary Artery Disease Genetic Variants and Subclinical Atherosclerosis: An Association Study and Meta-analysis.Q38389219
Dietary flavonoid aglycones and their glycosides: Which show better biological significance?Q38547479
Advance on the Flavonoid C-glycosides and Health Benefits.Q38606218
Endothelial microparticles prevent lipid-induced endothelial damage via Akt/eNOS signaling and reduced oxidative stress.Q38688884
Naringin protects cardiomyocytes against hyperglycemia-induced injuries in vitro and in vivo.Q38766128
Nobiletin, a citrus flavonoid, activates vasodilator-stimulated phosphoprotein in human platelets through non-cyclic nucleotide-related mechanismsQ38783535
IDF Diabetes Atlas: Global estimates for the prevalence of diabetes for 2015 and 2040.Q38822669
Citrus Flavonoids as Regulators of Lipoprotein Metabolism and AtherosclerosisQ38825735
Flavonoids and platelet aggregation: A brief reviewQ38835561
Naringenin suppresses macrophage infiltration into adipose tissue in an early phase of high-fat diet-induced obesity.Q38934838
MicroRNAs in the Pathobiology and Therapy of AtherosclerosisQ39148384
Effects of Dietary Flavonoids on Reverse Cholesterol Transport, HDL Metabolism, and HDL FunctionQ39180588
Nobiletin suppresses adipocyte differentiation of 3T3-L1 cells by an insulin and IBMX mixture inductionQ39427724
Hyperglycemia-mediated activation of the hexosamine biosynthetic pathway results in myocardial apoptosisQ39712126
The citrus flavonoids hesperetin and nobiletin differentially regulate low density lipoprotein receptor gene transcription in HepG2 liver cellsQ39970114
Persistent impairment of endothelial vasomotor function has a negative impact on outcome in patients with coronary artery diseaseQ40008474
Flavonoid glucosides are hydrolyzed and thus activated in the oral cavity in humans.Q40458132
Complications of Diabetes 2016Q40485268
Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP.Q40806146
Western-type diets induce insulin resistance and hyperinsulinemia in LDL receptor-deficient mice but do not increase aortic atherosclerosis compared with normoinsulinemic mice in which similar plasma cholesterol levels are achieved by a fructose-ricQ41664275
Rutin administration attenuates myocardial dysfunction in diabetic ratsQ41713255
Oxidative stress as a common mediator for apoptosis induced-cardiac damage in diabetic ratsQ41912037
Advanced Glycation End Products: A Molecular Target for Vascular Complications in DiabetesQ42115221
Inhibition of hepatocyte apoB secretion by naringenin: enhanced rapid intracellular degradation independent of reduced microsomal cholesteryl esters.Q42526033
Prelesional events in atherogenesis. Accumulation of extracellular cholesterol-rich liposomes in the arterial intima and cardiac valves of the hyperlipidemic rabbitQ42528560
Naringin, the major grapefruit flavonoid, specifically affects atherosclerosis development in diet-induced hypercholesterolemia in miceQ42732172
Citrus flavonoid naringenin inhibits TLR2 expression in adipocytesQ42826572
The citrus flavonoids hesperetin and naringenin block the lipolytic actions of TNF-alpha in mouse adipocytesQ42828521
Effect of eriodictyol on glucose uptake and insulin resistance in vitro.Q42832621
Antioxidant properties, radical scavenging activity and biomolecule protection capacity of flavonoid naringenin and its glycoside naringin: a comparative studyQ43098762
Antihyperglycemic effect of diosmin on hepatic key enzymes of carbohydrate metabolism in streptozotocin-nicotinamide-induced diabetic rats.Q43110824
Naringenin decreases progression of atherosclerosis by improving dyslipidemia in high-fat-fed low-density lipoprotein receptor-null miceQ43181464
Lemon Polyphenols Suppress Diet-induced Obesity by Up-Regulation of mRNA Levels of the Enzymes Involved in beta-Oxidation in Mouse White Adipose TissueQ43244167
The C-glycosyl flavonoid, aspalathin, is absorbed, methylated and glucuronidated intact in humansQ43298933
The Role of Nrf2 in Cardiovascular Function and DiseaseQ43372995
Glucosyl hesperidin lowers serum triglyceride level in hypertriglyceridemic subjects through the improvement of very low-density lipoprotein metabolic abnormalityQ46978908
Hesperidin inhibits ovarian cancer cell viability through endoplasmic reticulum stress signaling pathwaysQ47118003
Nobiletin induces brown adipocyte-like phenotype and ameliorates stress in 3T3-L1 adipocytesQ47318478
Naringenin-induced enhanced antioxidant defence system meliorates cholinergic neurotransmission and consolidates memory in male ratsQ47737236
Anti-inflammatory effects of flavonoids in neurodegenerative disorders.Q47965744
Oxidative Stress in Metabolic Disorders and Drug-Induced Injury: The Potential Role of Nrf2 and PPARs ActivatorsQ48214408
Exercise Amaliorates Metabolic Disturbances and Oxidative Stress in Diabetic Cardiomyopathy: Possible Underlying Mechanisms.Q48634281
Nobiletin prevents cadmium-induced neuronal apoptosis by inhibiting reactive oxygen species and modulating JNK/ERK1/2 and Akt/mTOR networks in ratsQ50044447
Inhibition of Fat Accumulation by Hesperidin in Caenorhabditis elegansQ50238261
Effects of pure total flavonoids from Citrus changshan-huyou on blood lipid metabolism in hyperlipidemic ratsQ50243681
Definition, classification and diagnosis of diabetes mellitus.Q51068406
Citrus flavonoid naringenin reduces mammary tumor cell viability, adipose mass, and adipose inflammation in obese ovariectomized mice.Q51074606
Radioprotective effects of hesperidin on oxidative damages and histopathological changes induced by X-irradiation in rats heart tissue.Q51157774
Trends in Type 1 diabetes incidence in the UK in 0- to 14-year-olds and in 15- to 34-year-olds, 1991-2008.Q51160334
[Effect of naringin on oxidative stress and endoplasmic reticulum stress in diabetic cardiomyopathy].Q51243816
Antiplatelet Effects of Flavonoids Mediated by Inhibition of Arachidonic Acid Based Pathway.Q51332889
Rutin improves glucose homeostasis in streptozotocin diabetic tissues by altering glycolytic and gluconeogenic enzymes.Q51499950
Antiplatelet activity of flavonoid and coumarin drugs.Q51519824
Antioxidant Protection of Nobiletin, 5-Demethylnobiletin, Tangeretin, and 5-Demethyltangeretin from Citrus Peel in Saccharomyces cerevisiae.Q51764268
Taurine and pioglitazone attenuate diabetes-induced testicular damage by abrogation of oxidative stress and up-regulation of the pituitary-gonadal axis.Q52139481
IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045.Q52678531
Apigetrin inhibits adipogenesis in 3T3-L1 cells by downregulating PPARγ and CEBP-α.Q52716700
Nobiletin attenuates cardiac dysfunction, oxidative stress, and inflammatory in streptozotocin: induced diabetic cardiomyopathy.Q53105082
Prevention of arterial thrombosis by nobiletin: in vitro and in vivo studies.Q53176648
Flavonoids and platelet-derived thrombotic disorders.Q53691991
Consumption of polyphenol-rich Morus alba leaves extract attenuates early diabetic retinopathy: the underlying mechanism.Q53766666
Naringenin reduces cholesterol-induced hepatic inflammation in rats by modulating matrix metalloproteinases-2, 9 via inhibition of nuclear factor κB pathway.Q53815987
Beneficial effects of naringenin in liver diseases: Molecular mechanisms.Q54113356
Hesperidin, a flavanoglycone attenuates experimental diabetic neuropathy via modulation of cellular and biochemical marker to improve nerve functions.Q54486210
Antioxidant and antiplatelet activities of flavonoid-rich fractions of three citrus fruits from Korea.Q55117060
Impact of specific functional groups in flavonoids on the modulation of platelet activation.Q55445847
Naringenin and its Nano-formulations for Fatty Liver: Cellular Modes of Action and Clinical PerspectiveQ56671157
The Role of Nrf2 Signaling in PPAR/-Mediated Vascular Protection against Hyperglycemia-Induced Oxidative StressQ56967583
Hesperidin and naringin attenuate hyperglycemia-mediated oxidative stress and proinflammatory cytokine production in high fat fed/streptozotocin-induced type 2 diabetic ratsQ56983743
Role of intestinal hydrolase in the absorption of prenylated flavonoids present in YinyanghuoQ57122747
Extracranial Thrombotically Active Carotid Plaque as a Risk Factor for Ischemic StrokeQ58492208
Daily Consumption of Chocolate Rich in Flavonoids Decreases Cellular Genotoxicity and Improves Biochemical Parameters of Lipid and Glucose MetabolismQ58696120
Bioflavonoids as antiradicals, antioxidants and DNA cleavage protectorsQ60503395
Vascular endothelium: nature's blood-compatible containerQ68679637
Quercetin metabolites in plasma of rats fed diets containing rutin or quercetinQ71895206
Absorption, metabolism and health effects of dietary flavonoids in manQ74069002
Dietary patterns and adenocarcinoma of the esophagus and distal stomachQ77386781
The chemistry and biological effects of flavonoids and phenolic acidsQ77936102
Regulation of HepG2 cell apolipoprotein B metabolism by the citrus flavanones hesperetin and naringeninQ78000736
Molecular structures of citrus flavonoids determine their effects on lipid metabolism in HepG2 cells by primarily suppressing apoB secretionQ83678762
Citrus unshiu peel extract ameliorates hyperglycemia and hepatic steatosis by altering inflammation and hepatic glucose- and lipid-regulating enzymes in db/db miceQ84370332
The citrus flavonoids hesperidin and naringin do not affect serum cholesterol in moderately hypercholesterolemic men and womenQ84595643
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P407language of work or nameEnglishQ1860
P921main subjectCitrusQ81513
2-phenylchromane flavonoidQ222174
lipid metabolismQ2792936
P304page(s)5484138
P577publication date2019-03-10
P1433published inOxidative medicine and cellular longevityQ26840015
P1476titleBeneficial Effects of Citrus Flavonoids on Cardiovascular and Metabolic Health
P478volume2019

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cites work (P2860)
Q99725314Citrus Flavonoids as Promising Phytochemicals Targeting Diabetes and Related Complications: A Systematic Review of In Vitro and In Vivo Studies
Q90446794Construction and Chemical Profile on "Activity Fingerprint" of Citri Reticulatae Pericarpium from Different Cultivars Based on HPLC-UV, LC/MS-IT-TOF, and Principal Component Analysis
Q92504487New Insights for Cellular and Molecular Mechanisms of Aging and Aging-Related Diseases: Herbal Medicine as Potential Therapeutic Approach
Q64898745Rutin ameliorates carbon tetrachloride (CCl4)-induced hepatorenal toxicity and hypogonadism in male rats.
Q99614766The Effects of Flavonoids in Cardiovascular Diseases

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