Characterizing the Therapeutic Potential of a Potent BET Degrader in Merkel Cell Carcinoma

Characterizing the Therapeutic Potential of a Potent BET Degrader in Merkel Cell Carcinoma is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.NEO.2019.01.003
P932PMC publication ID6384317
P698PubMed publication ID30797188

P2093author name stringRui Wang
Bing Zhou
Arul M Chinnaiyan
Xuhong Cao
Yuping Wang
Shaomeng Wang
Rohit Malik
Andrzej A Dlugosz
Jae Eun Choi
Doris Mangelberger
Fengyun Su
Monique E Verhaegen
Paul W Harms
Xiaojun Jing
Ingrid J Apel
Marcin Cieślik
Jean Tien
Jonathan Gurkan
Kristin Juckette
Mishaal Yazdani
Sahr Yazdani
P2860cites workSelective inhibition of BET bromodomainsQ24301009
Response to Idelalisib in a Patient with Stage IV Merkel-Cell CarcinomaQ27853225
PD-1 Blockade with Pembrolizumab in Advanced Merkel-Cell Carcinoma.Q27853379
edgeR: a Bioconductor package for differential expression analysis of digital gene expression dataQ27860819
BET bromodomain inhibition as a therapeutic strategy to target c-MycQ28247024
limma powers differential expression analyses for RNA-sequencing and microarray studiesQ29617988
voom: Precision weights unlock linear model analysis tools for RNA-seq read countsQ33741687
A phase II trial of imatinib mesylate in merkel cell carcinoma (neuroendocrine carcinoma of the skin): A Southwest Oncology Group study (S0331)Q34088836
Pathologic nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: analysis of 5823 cases as the basis of the first consensus staging systemQ34208807
Merkel cell carcinoma dependence on bcl-2 family members for survival.Q34273863
Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancerQ34416771
Merkel cell polyomavirus small T antigen is oncogenic in transgenic mice.Q34443490
Separate-channel analysis of two-channel microarrays: recovering inter-spot informationQ34739043
Embryonic maturation of epidermal Merkel cells is controlled by a redundant transcription factor networkQ34985761
Unipotent, Atoh1+ progenitors maintain the Merkel cell population in embryonic and adult miceQ35042887
BET protein inhibitor JQ1 attenuates Myc-amplified MCC tumor growth in vivoQ35066871
BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cellsQ35574955
Ectopic Atoh1 expression drives Merkel cell production in embryonic, postnatal and adult mouse epidermisQ35878136
Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteinsQ36436791
Distinct gene expression profiles of viral- and nonviral-associated merkel cell carcinoma revealed by transcriptome analysisQ36684979
PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancerQ37065079
Epigenetic reader BRD4 inhibition as a therapeutic strategy to suppress E2F2-cell cycle regulation circuit in liver cancerQ37362732
Avelumab in patients with chemotherapy-refractory metastatic Merkel cell carcinoma: a multicentre, single-group, open-label, phase 2 trialQ38378516
Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression.Q38710711
Analysis of Prognostic Factors from 9387 Merkel Cell Carcinoma Cases Forms the Basis for the New 8th Edition AJCC Staging SystemQ38838916
Sensitivity of Small Cell Lung Cancer to BET Inhibition Is Mediated by Regulation of ASCL1 Gene ExpressionQ38845398
Merkel Cell Polyomavirus Small T Antigen Initiates Merkel Cell Carcinoma-like Tumor Development in MiceQ40198756
Targeted Degradation of BET Proteins in Triple-Negative Breast Cancer.Q42775768
Response to a novel multitargeted tyrosine kinase inhibitor pazopanib in metastatic Merkel cell carcinoma.Q45947378
BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment.Q50547887
Clinical remission of Merkel cell carcinoma after treatment with imatinibQ85766984
P4510describes a project that useslimmaQ112236343
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectMerkel cell carcinomaQ1711744
P304page(s)322-330
P577publication date2019-03-01
P1433published inNeoplasiaQ2962042
P1476titleCharacterizing the Therapeutic Potential of a Potent BET Degrader in Merkel Cell Carcinoma
P478volume21

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Q93016452Targeting BET Proteins With a PROTAC Molecule Elicits Potent Anticancer Activity in HCC Cellscites workP2860

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