Distinct gene expression profiles of viral- and nonviral-associated merkel cell carcinoma revealed by transcriptome analysis

scientific article published on 6 December 2012

Distinct gene expression profiles of viral- and nonviral-associated merkel cell carcinoma revealed by transcriptome analysis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/JID.2012.445
P932PMC publication ID3597750
P698PubMed publication ID23223137
P5875ResearchGate publication ID233881091

P50authorThomas GiordanoQ37621567
Paul W. HarmsQ41662914
Rajiv M PatelQ56439080
P2093author name stringJames T Elder
Dafydd G Thomas
Johann E Gudjonsson
Douglas R Fullen
Timothy M Johnson
Kevin T Nash
Stephanie Daignault
Christopher K Bichakjian
Andrzej A Dlugosz
Monique E Verhaegen
Craig N Johnson
P2860cites workQuantitation of human seroresponsiveness to Merkel cell polyomavirusQ21559417
A new member of the ETS family fused to EWS in Ewing tumorsQ24317176
Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulatorQ24609227
Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation ChannelsQ24633274
Association of Merkel cell polyomavirus-specific antibodies with Merkel cell carcinomaQ24644897
T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirusQ24645091
Human Merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassaysQ24650632
Epidermal progenitors give rise to Merkel cells during embryonic development and adult homeostasisQ24652945
Clonal integration of a polyomavirus in human Merkel cell carcinomaQ24657675
Basal cell carcinoma - molecular biology and potential new therapiesQ27006913
Fyn: a novel molecular target in cancerQ28273098
TRPC1 contributes to light-touch sensation and mechanical responses in low-threshold cutaneous sensory neuronsQ30505980
Expression of the embryonic stem cell transcription factor SOX2 in human skin: relevance to melanocyte and merkel cell biologyQ33597213
Array-CGH reveals recurrent genomic changes in Merkel cell carcinoma including amplification of L-MycQ33696336
Immunological detection of viral large T antigen identifies a subset of Merkel cell carcinoma tumors with higher viral abundance and better clinical outcomeQ33949606
Merkel cell carcinoma subgroups by Merkel cell polyomavirus DNA relative abundance and oncogene expressionQ34012538
Proneural and proneuroendocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinomaQ34147557
Merkel cell carcinoma: critical review with guidelines for multidisciplinary managementQ34631014
Frequent detection of Merkel cell polyomavirus in human Merkel cell carcinomas and identification of a unique deletion in the VP1 geneQ34791033
Frequent expression of glypican-3 in Merkel cell carcinoma: an immunohistochemical study of 55 casesQ34835574
Transcriptome-wide studies of merkel cell carcinoma and validation of intratumoral CD8+ lymphocyte invasion as an independent predictor of survival.Q34866209
Huntingtin-interacting protein 1: a Merkel cell carcinoma marker that interacts with c-Kit.Q35216141
Merkel cell polyomavirus-specific CD8⁺ and CD4⁺ T-cell responses identified in Merkel cell carcinomas and blood.Q35510910
Integration of regulatory networks by NKX3-1 promotes androgen-dependent prostate cancer survivalQ35665662
The Toker tumor: spectrum of morphologic features in primary neuroendocrine carcinomas of the skin (Merkel cell carcinoma).Q36663302
MYB function in normal and cancer cellsQ37198576
Neurosensory mechanotransductionQ37386621
Global gene expression analysis reveals evidence for decreased lipid biosynthesis and increased innate immunity in uninvolved psoriatic skinQ37441334
Molecular profiling reveals synaptic release machinery in Merkel cells.Q37569634
Akt signalling in health and disease.Q37881228
Immunobiology of Merkel cell carcinoma: implications for immunotherapy of a polyomavirus-associated cancer.Q37939726
An intact retinoblastoma protein-binding site in Merkel cell polyomavirus large T antigen is required for promoting growth of Merkel cell carcinoma cellsQ39574886
Gene-expression profiling reveals distinct expression patterns for Classic versus Variant Merkel cell phenotypes and new classifier genes to distinguish Merkel cell from small-cell lung carcinomaQ40593745
Merkel cells and Merkel cell carcinoma express the BCL-2 proto-oncogeneQ40937231
Merkel's cell carcinoma in organ recipients: report of 41 casesQ41710517
Merkel cell polyomavirus is more frequently present in North American than Australian Merkel cell carcinoma tumors.Q41991356
Gli proteins up-regulate the expression of basonuclin in Basal cell carcinomaQ42466272
Antibodies to Merkel cell polyomavirus correlate to presence of viral DNA in the skinQ42486059
Merkel cell polyomavirus and Merkel cell carcinoma, FranceQ43227669
Detection of Merkel cell polyomavirus in Merkel cell carcinoma and Kaposi's sarcomaQ43664743
Expression and function of FRA2/JUND in cutaneous T-cell lymphomas.Q43710388
CD117 (KIT receptor) expression in Merkel cell carcinomaQ44079778
Comparable expression and phosphorylation of the retinoblastoma protein in Merkel cell polyoma virus-positive and negative Merkel cell carcinomaQ45382483
Expression of VEGF-A/C, VEGF-R2, PDGF-alpha/beta, c-kit, EGFR, Her-2/Neu, Mcl-1 and Bmi-1 in Merkel cell carcinomaQ46647666
Characteristic pattern of chromosomal gains and losses in Merkel cell carcinoma detected by comparative genomic hybridization.Q49091108
Merkel cell polyomavirus infection, large T antigen, retinoblastoma protein and outcome in Merkel cell carcinoma.Q51454638
Functional conservation of atonal and Math1 in the CNS and PNS.Q52171174
Merkel cell polyomavirus status is not associated with clinical course of Merkel cell carcinoma.Q53248708
Association of Merkel cell polyomavirus infection with tumor p53, KIT, stem cell factor, PDGFR-alpha and survival in Merkel cell carcinoma.Q54642656
Merkel cell carcinoma and HIV infection.Q55035696
MC polyomavirus is frequently present in Merkel cell carcinoma of European patients.Q55050206
Merkel cell carcinomaQ56681295
Tumor Infiltrating Immune Cells and Outcome of Merkel Cell Carcinoma: A Population-Based StudyQ62268141
Recurrent DNA copy number changes revealed by comparative genomic hybridization in primary Merkel cell carcinomasQ62268317
Merkel cell (small cell) carcinoma of the skin: immunohistochemical and ultrastructural demonstration of distinctive perinuclear cytokeratin aggregates and a possible association with B cell neoplasmsQ68971272
Differences of bcl-2 protein expression between Merkel cells and Merkel cell carcinomasQ71296513
Expression of bcl-2 and p53 in Merkel cell carcinoma. An immunohistochemical studyQ71531368
Loss of heterozygosity of chromosome 13 in Merkel cell carcinomaQ73683278
Expression profiles associated with aggressive behavior in Merkel cell carcinomaQ79370590
Chronic lymphocytic leukemia is associated with decreased survival of patients with malignant melanoma and Merkel cell carcinoma in a SEER population-based studyQ83441078
Immunohistochemistry for Merkel cell polyomavirus is highly specific but not sensitive for the diagnosis of Merkel cell carcinoma in the Australian populationQ83757291
Expression of the embryonic morphogen Nodal in cutaneous melanocytic lesionsQ84285533
P433issue4
P407language of work or nameEnglishQ1860
P921main subjecttranscriptomeQ252857
Merkel cell carcinomaQ1711744
P304page(s)936-945
P577publication date2012-12-06
P1433published inJournal of Investigative DermatologyQ3186921
P1476titleDistinct gene expression profiles of viral- and nonviral-associated merkel cell carcinoma revealed by transcriptome analysis
P478volume133

Reverse relations

described by source (P1343)
Q98134052UM-MCC13
Q98134054UM-MCC19
Q98134056UM-MCC21
Q98134072UM-MCC565

cites work (P2860)
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Q58761272Cellular sheddases are induced by Merkel cell polyomavirus small tumour antigen to mediate cell dissociation and invasiveness
Q64120735Characterizing the Therapeutic Potential of a Potent BET Degrader in Merkel Cell Carcinoma
Q36213758Disruption of BRD4 at H3K27Ac-enriched enhancer region correlates with decreased c-Myc expression in Merkel cell carcinoma.
Q50968904Distinct gene expression profiles in two cases of Merkel cell polyomavirus-negative Merkel cell carcinoma: shedding light on an esoteric entity.
Q38217106Diversification and specialization of touch receptors in skin
Q36916277Dual mTOR inhibitor MLN0128 suppresses Merkel cell carcinoma (MCC) xenograft tumor growth
Q36252579Expression of pRb and p16INK4 in human thymic epithelial tumors in relation to the presence of human polyomavirus 7.
Q42221952Fluorescence in situ hybridization and qPCR to detect Merkel cell polyomavirus physical status and load in Merkel cell carcinomas
Q35122235Gene expression differences predict treatment outcome of merkel cell carcinoma patients
Q98283428Gene expression profile identifies distinct molecular subtypes and potential therapeutic genes in Merkel cell carcinoma
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Q39098039History of chronic inflammatory disorders increases the risk of Merkel cell carcinoma, but does not correlate with Merkel cell polyomavirus infection
Q64235215Low prevalence of Merkel cell polyomavirus in human epithelial thymic tumors
Q37556614Merkel Cell Polyomavirus Exhibits Dominant Control of the Tumor Genome and Transcriptome in Virus-Associated Merkel Cell Carcinoma
Q34273863Merkel cell carcinoma dependence on bcl-2 family members for survival.
Q38231446Merkel cell carcinoma: is this a true carcinoma?
Q36721063Merkel cell polyomavirus T antigens promote cell proliferation and inflammatory cytokine gene expression
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Q34443490Merkel cell polyomavirus small T antigen is oncogenic in transgenic mice.
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Q55078045Multiclass classification for skin cancer profiling based on the integration of heterogeneous gene expression series.
Q27021034Mutational analysis of merkel cell carcinoma
Q40463395Polyomavirus-Negative Merkel Cell Carcinoma: A More Aggressive Subtype Based on Analysis of 282 Cases Using Multimodal Tumor Virus Detection.
Q42224405RB1 gene in Merkel cell carcinoma: hypermethylation in all tumors and concurrent heterozygous deletions in the polyomavirus-negative subgroup
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Q35049080Response of Merkel cell polyomavirus-positive merkel cell carcinoma xenografts to a survivin inhibitor
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Q41607962miRNA-34a underexpressed in Merkel cell polyomavirus-negative Merkel cell carcinoma.

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