Histogenesis of Merkel Cell Carcinoma: A Comprehensive Review.

scientific article published on 10 June 2019

Histogenesis of Merkel Cell Carcinoma: A Comprehensive Review. is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.3389/FONC.2019.00451
P932PMC publication ID6579919
P698PubMed publication ID31245285

P2093author name stringMahtab Samimi
Roland Houben
Emmanuelle Blanchard
David Schrama
Patricia Berthon
Antoine Touzé
Serge Guyétant
Thibault Kervarrec
Jérémy Chéret
Bhavishya Sarma
P2860cites workMerkel cell carcinoma and multiple primary cancersQ48452116
Aberrant expression of miR-21, miR-376c and miR-145 and their target host genes in Merkel cell polyomavirus-positive non-small cell lung cancerQ49306989
Merkel cell carcinomas infiltrated with CD33+ myeloid cells and CD8+ T cells are associated with improved outcomeQ49608349
B-cell specific activation protein encoded by the PAX-5 gene is commonly expressed in merkel cell carcinoma and small cell carcinomas.Q50485212
Merkel cell carcinoma and melanoma: etiological similarities and differences.Q50638833
Estrogen receptor β in Merkel cell carcinoma: its possible roles in pathogenesis.Q51681837
SATB2 is expressed in Merkel cell carcinoma.Q51719947
Comparative transcriptional profiling of human Merkel cells and Merkel cell carcinoma.Q51813785
Usefulness of significant morphologic characteristics in distinguishing between Merkel cell polyomavirus-positive and Merkel cell polyomavirus-negative Merkel cell carcinomas.Q51874961
Detection of the Merkel cell polyomavirus in the neuroendocrine component of combined Merkel cell carcinoma.Q52623982
Efficacy and Safety of First-line Avelumab Treatment in Patients With Stage IV Metastatic Merkel Cell Carcinoma: A Preplanned Interim Analysis of a Clinical Trial.Q52642670
Pulmonary Carcinoids and Low-Grade Gastrointestinal Neuroendocrine Tumors Show Common MicroRNA Expression Profiles, Different from Adenocarcinomas and Small Cell Carcinomas.Q52789604
Association of Merkel cell polyomavirus infection with morphologic differences in Merkel cell carcinoma.Q53271484
Immunohistochemical demonstration of the expression of neurofilament proteins in Merkel cells.Q53469295
Spontaneous losses of control of cytokeratin gene expression in transformed, non-epithelial human cells occurring at different levels of regulation.Q53512940
Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulatorQ24609227
Merkel cell polyomavirus expression in merkel cell carcinomas and its absence in combined tumors and pulmonary neuroendocrine carcinomasQ24619452
T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirusQ24645091
Mammalian Merkel cells are descended from the epidermal lineageQ24650452
Epidermal progenitors give rise to Merkel cells during embryonic development and adult homeostasisQ24652945
Clonal integration of a polyomavirus in human Merkel cell carcinomaQ24657675
Benign follicular tumorsQ26770472
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factorsQ27860937
Friedrich Sigmund Merkel and his "Merkel cell", morphology, development, and physiology: review and new resultsQ28205409
UV-Associated Mutations Underlie the Etiology of MCV-Negative Merkel Cell CarcinomasQ28270523
Atoh1, an essential transcription factor in neurogenesis and intestinal and inner ear development: function, regulation, and context dependency.Q30454062
A transgenic mouse model of metastatic carcinoma involving transdifferentiation of a gastric epithelial lineage progenitor to a neuroendocrine phenotypeQ33201186
Current considerations about Merkel cellsQ33276780
Immunoglobulin G expression in carcinomas and cancer cell linesQ33283502
Merkel cells as putative regulatory cells in skin disorders: an in vitro studyQ33492355
Nasopharyngeal tonsils (adenoids) contain extrathymic corticothymocytesQ33655149
Immunoglobulin G locus events in soft tissue sarcoma cell linesQ33952273
Effect of host, tumor, diagnostic, and treatment variables on outcomes in a large cohort with Merkel cell carcinoma.Q34076523
Neural crest origin of mammalian Merkel cells.Q34184663
Pathologic nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: analysis of 5823 cases as the basis of the first consensus staging systemQ34208807
Trabecular Carcinoma of the SkinQ34226403
Merkel cells and touch domes: more than mechanosensory functions?Q34270418
Primary neuroendocrine (Merkel cell) carcinoma of the skin: morphologic diversity and implications thereofQ34326308
Entry tropism of BK and Merkel cell polyomaviruses in cell cultureQ34364604
Merkel cell polyomavirus small T antigen controls viral replication and oncoprotein expression by targeting the cellular ubiquitin ligase SCFFbw7.Q34364753
Merkel cell polyomavirus small T antigen is oncogenic in transgenic mice.Q34443490
Imaging of Merkel cell carcinomaQ34564908
Embryonic maturation of epidermal Merkel cells is controlled by a redundant transcription factor networkQ34985761
Tumorigenic activity of merkel cell polyomavirus T antigens expressed in the stratified epithelium of miceQ35178392
Histogenesis of pure and combined Merkel cell carcinomas: An immunohistochemical study of 14 cases.Q53602595
The related retinoblastoma (pRb) and p130 proteins cooperate to regulate homeostasis in the intestinal epithelium.Q53651300
Immunohistochemical analyses point to epidermal origin of human Merkel cells.Q54508851
Neurofilament is Superior to Cytokeratin 20 in Supporting Cutaneous Origin for Neuroendocrine CarcinomaQ56915047
The biology and treatment of Merkel cell carcinoma: current understanding and research prioritiesQ57030149
ISL1 expression is not restricted to pancreatic well-differentiated neuroendocrine neoplasms, but is also commonly found in well and poorly differentiated neuroendocrine neoplasms of extrapancreatic originQ57289794
The expression of terminal deoxynucleotidyl transferase and paired box gene 5 in Merkel cell carcinomas and its relation to the presence of Merkel cell polyomavirus DNAQ57471468
Diagnostic accuracy of a panel of immunohistochemical and molecular markers to distinguish Merkel cell carcinoma from other neuroendocrine carcinomasQ57804570
Intraepidermal Formation of Merkel Cells in Xenografts of Human Fetal SkinQ58438803
Neuroendocrine Key Regulator Gene Expression in Merkel Cell CarcinomaQ58600005
A case of combined Merkel cell carcinoma and squamous cell carcinoma: Molecular insights and diagnostic pitfallsQ58700375
Advillin Is Expressed in All Adult Neural Crest-Derived NeuronsQ58744570
Differential Outcomes Among Immunosuppressed Patients With Merkel Cell Carcinoma: Impact of Immunosuppression Type on Cancer-specific and Overall SurvivalQ59352725
Peripherin, a neuronal intermediate protein, is stably expressed by neuroendocrine carcinomas of the skin, their xenograft on nude mice, and the corresponding primary culturesQ61894140
Neuroendocrine differentiation in primary Merkel cell carcinoma--possible prognostic significanceQ62268299
Trabecular carcinoma of the skin: an ultrastructural studyQ67415556
Origin of spinal cord meninges, sheaths of peripheral nerves, and cutaneous receptors including Merkel cells. An experimental and ultrastructural study with avian chimerasQ70242806
New immunocytochemical observations with diagnostic significance in cutaneous neuroendocrine carcinomaQ72380897
Differentiation between merkel cell carcinoma and malignant melanoma: An immunohistochemical studyQ73129337
Developmental origin of avian Merkel cellsQ73219487
Immunostaining for thyroid transcription factor 1 and cytokeratin 20 aids the distinction of small cell carcinoma from Merkel cell carcinoma, but not pulmonary from extrapulmonary small cell carcinomasQ73435051
Adhesion molecules CD171 (L1CAM) and CD24 are expressed by primary neuroendocrine carcinomas of the skin (Merkel cell carcinomas)Q73592496
Merkel cell carcinoma of palatal mucosa in a young adult: immunohistochemical and ultrastructural featuresQ73724281
Expression profiles associated with aggressive behavior in Merkel cell carcinomaQ79370590
Merkel cell carcinoma within follicular cysts: report of two casesQ79801631
An immunohistochemical study of cervical neuroendocrine carcinomas: Neoplasms that are commonly TTF1 positive and which may express CK20 and P63Q83024632
Chronic lymphocytic leukemia is associated with decreased survival of patients with malignant melanoma and Merkel cell carcinoma in a SEER population-based studyQ83441078
Fluorescence in situ hybridization confirms the presence of Merkel cell polyomavirus in chronic lymphocytic leukemia cellsQ84204781
Immunohistochemical profiles of different subsets of Merkel cell carcinomaQ90691438
INSM1 Is More Sensitive and Interpretable than Conventional Immunohistochemical Stains Used to Diagnose Merkel Cell CarcinomaQ90773786
Characterization of the human ridged and non-ridged skin: a comprehensive histological, histochemical and immunohistochemical analysisQ90899916
Identification of high-risk human papillomavirus and Rb/E2F pathway genomic alterations in mutually exclusive subsets of colorectal neuroendocrine carcinomaQ91599039
Morphologic and immunophenotypical features distinguishing Merkel cell polyomavirus-positive and negative Merkel cell carcinomaQ92761524
Evidence of proliferative activity in human Merkel cells: implications in the histogenesis of Merkel cell carcinomaQ93258884
Basal cell carcinoma preferentially arises from stem cells within hair follicle and mechanosensory niches.Q35290089
Neural Hedgehog signaling maintains stem cell renewal in the sensory touch dome epitheliumQ35740378
Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skinQ35752935
Identification of Drugs that Regulate Dermal Stem Cells and Enhance Skin Repair.Q35883449
Asymptomatic primary Merkel cell polyomavirus infection among adults.Q36053618
The Distinctive Mutational Spectra of Polyomavirus-Negative Merkel Cell Carcinoma.Q36070575
Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin DevelopmentQ36077325
Merkel Cell Polyomavirus Small T Antigen Induces Cancer and Embryonic Merkel Cell Proliferation in a Transgenic Mouse ModelQ36257844
The evolving classification of soft tissue tumours: an update based on the new WHO classificationQ36344264
Next generation sequencing of Cytokeratin 20-negative Merkel cell carcinoma reveals ultraviolet-signature mutations and recurrent TP53 and RB1 inactivationQ36625997
Characterization of hair follicle bulge in human fetal skin: the human fetal bulge is a pool of undifferentiated keratinocytesQ36671485
Distinct gene expression profiles of viral- and nonviral-associated merkel cell carcinoma revealed by transcriptome analysisQ36684979
Cytokeratin 20 is a general marker of cutaneous Merkel cells while certain neuronal proteins are absentQ36706110
Identifying the Target Cells and Mechanisms of Merkel Cell Polyomavirus InfectionQ36989398
Cutaneous squamous and neuroendocrine carcinoma: genetically and immunohistochemically different from Merkel cell carcinomaQ37037117
Merkel disc is a serotonergic synapse in the epidermis for transmitting tactile signals in mammalsQ37264205
SV40: Cell transformation and tumorigenesisQ37345587
An epigenetic switch induced by Shh signalling regulates gene activation during development and medulloblastoma growth.Q37583341
Merkel cell carcinoma, chronic lymphocytic leukemia and other lymphoproliferative disorders: an old bond with possible new viral tiesQ37768576
Collision tumor of primary merkel cell carcinoma and chronic lymphocytic leukemia/small lymphocytic lymphoma, diagnosed on ultrasound-guided fine-needle aspiration biopsy: a unique case report and review of literatureQ38194540
Recent advances in histogenesis research of lung neuroendocrine cancers: Evidence obtained from functional analyses of primitive neural/neuroendocrine cell-specific transcription factorsQ38364517
Avelumab in patients with chemotherapy-refractory metastatic Merkel cell carcinoma: a multicentre, single-group, open-label, phase 2 trialQ38378516
Rare cancers: a sea of opportunityQ38730141
Enhanced Neurogenic Biomarker Expression and Reinnervation in Human Acute Skin Wounds Treated by Electrical StimulationQ38730619
Systematic literature review of efficacy, safety and tolerability outcomes of chemotherapy regimens in patients with metastatic Merkel cell carcinomaQ38738614
Prognostic relevance of high atonal homolog-1 expression in Merkel cell carcinomaQ38746468
Merkel cells transduce and encode tactile stimuli to drive Aβ-afferent impulsesQ39031272
Reviewing the current evidence supporting early B-cells as the cellular origin of Merkel cell carcinomaQ39426361
The Merkel cell system and a comparison between it and the neurosecretory or APUD cell systemQ39441652
Which are the cells of origin in merkel cell carcinoma?Q39488379
An intact retinoblastoma protein-binding site in Merkel cell polyomavirus large T antigen is required for promoting growth of Merkel cell carcinoma cellsQ39574886
Immunoglobulin kappa and immunoglobulin lambda are required for expression of the anti-apoptotic molecule Bcl-xL in human colorectal cancer tissueQ39780361
Mutational landscape of MCPyV-positive and MCPyV-negative Merkel cell carcinomas with implications for immunotherapy.Q39926027
Proteasomal degradation of Atoh1 by aberrant Wnt signaling maintains the undifferentiated state of colon cancerQ40013068
NOTCH, ASCL1, p53 and RB alterations define an alternative pathway driving neuroendocrine and small cell lung carcinomasQ40198629
Upregulated expression of kappa light chain by Epstein-Barr virus encoded latent membrane protein 1 in nasopharyngeal carcinoma cells via NF-kappaB and AP-1 pathwaysQ40230950
Shared Oncogenic Pathways Implicated in Both Virus-Positive and UV-Induced Merkel Cell Carcinomas.Q40491492
Joint occurrence of Merkel cell carcinoma and non-Hodgkin lymphomas in four Nordic countries.Q41033057
Immature and Transitional B Cells Are Latency Reservoirs for a GammaherpesvirusQ41232435
Immunoglobulin expressions are only associated with MCPyV-positive Merkel cell carcinomas but not with MCPyV-negative ones: comparison of prognosisQ41664748
Characterization of functional domains in the Merkel cell polyoma virus Large T antigenQ41744694
Differential diagnosis of eccrine spiradenoma: A case reportQ42145803
Merkel cell polyomavirus infection occurs during early childhood and is transmitted between siblingsQ42285726
Pax-5 immunoexpression in various types of benign and malignant tumours: a high-throughput tissue microarray analysisQ42409927
Merkel cells in hyperplastic and neoplastic lesions of the skin. An immunohistochemical study using an antibody to keratin 20.Q42454492
Special Program of Differentiation Expressed in Keratinocytes of Human Haarscheiben: An Analysis of Individual Cytokeratin PolypeptidesQ42482726
TTF-1 and PAX5 Are Frequently Expressed in Combined Merkel Cell CarcinomaQ42495019
Merkel cells and Meissner's corpuscles in human digital skin display Piezo2 immunoreactivity.Q42515042
KIT expression reveals a population of precursor melanocytes in human skinQ42516934
Localization of Merkel cells at hairless and hairy human skin sites using keratin 18.Q42520188
Merkel cell polyomavirus in cutaneous swabsQ42553271
Merkel cell polyomavirus-positive Merkel cell carcinoma cells do not require expression of the viral small T antigen.Q42825145
Merkel cell carcinoma with divergent differentiation: histopathological and immunohistochemical study of 15 cases with PCR analysis for Merkel cell polyomavirus.Q43777103
Detection of a novel truncating Merkel cell polyomavirus large T antigen deletion in chronic lymphocytic leukemia cellsQ43980810
CD117 (KIT receptor) expression in Merkel cell carcinomaQ44079778
Developmental expression pattern of monoamine oxidases in sensory organs and neural crest derivativesQ44538538
The role of NT-3 signaling in Merkel cell developmentQ44709774
Early B-cell differentiation in Merkel cell carcinomas: clues to cellular ancestryQ45333097
[Merkel cell carcinoma--immunohistochemical study in a group of 11 patients].Q46032433
Potential use of skin-derived precursors (SKPs) in establishing a cell-based treatment model for Hirschsprung's disease.Q46348278
Merkel cell carcinoma in the age of immunotherapy: Facts and hopesQ47348356
Are there multiple cells of origin of Merkel cell carcinoma?Q47555708
Genetic profiles of different subsets of Merkel cell carcinoma show links between combined and pure MCPyV-negative tumorsQ47597524
Merkel cell carcinoma: Current US incidence and projected increases based on changing demographicsQ47658993
Plasticity of neuropeptidergic neoplasm cells in the primary and metastatic Merkel cell carcinoma.Q47878167
Expression of immunoglobulin kappa light chain constant region in abnormal human cervical epithelial cellsQ48177368
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P921main subjectMerkel cell carcinomaQ1711744
P304page(s)451
P577publication date2019-06-10
P1433published inFrontiers in OncologyQ26839986
P1476titleHistogenesis of Merkel Cell Carcinoma: A Comprehensive Review.
P478volume9

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