Identification and characterization of a factor Va-binding site on human prothrombin fragment 2

scientific article published on 21 February 2019

Identification and characterization of a factor Va-binding site on human prothrombin fragment 2 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41598-019-38857-4
P932PMC publication ID6385242
P698PubMed publication ID30792421

P50authorJeffrey I. WeitzQ29561411
James C FredenburghQ88164289
Paul Y. KimQ89313405
P2093author name stringPing Xu
Feng Ni
Peter L Gross
Chengliang Wu
Alexander P Friedmann
Anatoli Koutychenko
P2860cites workFurther evidence for two functional forms of prothrombinase each specific for either of the two prothrombin activation cleavagesQ40088315
Proexosite-1 on Prothrombin Is a Factor Va-dependent Recognition Site for the Prothrombinase ComplexQ40647381
Interactions of a fluorescent active-site-directed inhibitor of thrombin: dansylarginine N-(3-ethyl-1,5-pentanediyl)amideQ41482286
Importance of factor VIIa Gla-domain residue Arg-36 for recognition of the macromolecular substrate factor X Gla-domainQ41608315
Role of the acidic hirudin-like COOH-terminal amino acid region of factor Va heavy chain in the enhanced function of prothrombinaseQ41922890
Long range communication between exosites 1 and 2 modulates thrombin functionQ42030991
Prothrombin kringle 1 domain interacts with factor Va during the assembly of prothrombinase complex.Q42159858
Formation of meizothrombin as intermediate in factor Xa-catalyzed prothrombin activationQ43804213
Structural requirements for expression of factor Va activityQ44467155
Characteristics of the association between prothrombin fragment 2 and alpha-thrombinQ45047422
The wisdom of crowds: regulating cell function through condensed states of living matter.Q47952877
The activation of prothrombin. II. Partial reactions, physical and chemical characterization of the intermediates of activation.Q47956980
Prothrombin activation by prothrombinase in a tubular flow reactor.Q52352846
Improved three-dimensional1H−13C−1H correlation spectroscopy of a13C-labeled protein using constant-time evolutionQ52443061
Studies of the role of factor Va in the factor Xa-catalyzed activation of prothrombin, fragment 1.2-prethrombin-2, and dansyl-L-glutamyl-glycyl-L-arginine-meizothrombin in the absence of phospholipid.Q52480915
Differences in prethrombin-1 activation with human or bovine factor Va can be attributed to the heavy chain.Q53367354
A control switch for prothrombinase: characterization of a hirudin-like pentapeptide from the COOH terminus of factor Va heavy chain that regulates the rate and pathway for prothrombin activation.Q53595426
Crystal structure of prethrombin-1Q27665368
Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human PPACK-thrombinQ27732031
The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factorQ27732597
New insights into the regulation of the blood clotting cascade derived from the X-ray crystal structure of bovine meizothrombin des F1 in complex with PPACKQ27748810
Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutionsQ27860828
NMRPipe: a multidimensional spectral processing system based on UNIX pipesQ27860859
The program XEASY for computer-supported NMR spectral analysis of biological macromoleculesQ27860993
An efficient 3D NMR technique for correlating the proton and 15N backbone amide resonances with the alpha-carbon of the preceding residue in uniformly 15N/13C enriched proteinsQ28239344
Processive post-translational modification. Vitamin K-dependent carboxylation of a peptide substrateQ28271279
Cofactor proteins in the assembly and expression of blood clotting enzyme complexesQ28289123
Kinetics of coagulation factor X activation by platelet-bound factor IXaQ28630360
Improved sensitivity of HSQC spectra of exchanging protons at short interscan delays using a new fast HSQC (FHSQC) detection scheme that avoids water saturationQ29619727
A peptide derived from human prothrombin fragment 2 inhibits prothrombinase and angiogenesisQ30841356
Ratcheting of the substrate from the zymogen to proteinase conformations directs the sequential cleavage of prothrombin by prothrombinaseQ33895760
Pathophysiology of coronary artery diseaseQ34429470
Zymogenic and enzymatic properties of the 70-80 loop mutants of factor X/XaQ36526481
Exosites in the substrate specificity of blood coagulation reactionsQ36884329
Membrane binding by prothrombin mediates its constrained presentation to prothrombinase for cleavageQ37201181
Structural transitions during prothrombin activation: On the importance of fragment 2Q38530486
Coagulation and non-coagulation effects of thrombinQ38924721
Biomolecular condensates: organizers of cellular biochemistryQ39146409
The roles of selected arginine and lysine residues of TAFI (Pro-CPU) in its activation to TAFIa by the thrombin-thrombomodulin complexQ39906372
Contribution of the NH2-terminal EGF-domain of factor IXa to the specificity of intrinsic tenase.Q64960028
Prothrombin fragments. Ca2+ binding and activation kineticsQ66913473
The conversion of prothrombin to thrombin. IV. The function of the fragment 2 region during activation in the presence of factor VQ68927171
Interaction of clotting factor V heavy chain with prothrombin and prethrombin 1 and role of activated protein C in regulating this interaction: analysis by analytical ultracentrifugationQ69608549
Modulation of human prothrombin activation on phospholipid vesicles and platelets using monoclonal antibodies to prothrombin fragment 2Q70144049
Factor VQ70511914
Increased sensitivity in HNCA and HN(CO)CA experiments by selective C beta decouplingQ71720249
Prothrombin contributes to the assembly of the factor Va-factor Xa complex at phosphatidylserine-containing phospholipid membranesQ71824146
Structure of the non-covalent complex of prothrombin kringle 2 with PPACK-thrombinQ72428922
Blood coagulation factor Xa interacts with a linear sequence of the kringle 2 domain of prothrombinQ72536247
The second kringle domain of prothrombin promotes factor Va-mediated prothrombin activation by prothrombinaseQ72591926
Factor IX activation by factor XIa proceeds without release of a free intermediateQ73215791
Contribution of the prothrombin fragment 2 domain to the function of factor Va in the prothrombinase complexQ73259491
Role of proexosite I in factor Va-dependent substrate interactions of prothrombin activationQ73626480
Channeling during prothrombin activationQ73953674
The Gla domain of human prothrombin has a binding site for factor VaQ74270327
Chemical shift as a probe of molecular interfaces: NMR studies of DNA binding by the three amino-terminal zinc finger domains from transcription factor IIIAQ77210975
The interaction of fragment 1 of prothrombin with the membrane surface is a prerequisite for optimum expression of factor Va cofactor activity within prothrombinaseQ80838396
Role of Hirudin-like factor Va heavy chain sequences in prothrombinase functionQ82348193
Models of blood coagulationQ82656664
Down regulation of prothrombinase by activated protein C during prothrombin activationQ84059905
Histidine-rich glycoprotein binds DNA and RNA and attenuates their capacity to activate the intrinsic coagulation pathwayQ86101059
Polyvalent Interactions in Biological Systems: Implications for Design and Use of Multivalent Ligands and InhibitorsQ88519588
Why Do Disordered and Structured Proteins Behave Differently in Phase Separation?Q88536612
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)2436
P577publication date2019-02-21
P1433published inScientific ReportsQ2261792
P1476titleIdentification and characterization of a factor Va-binding site on human prothrombin fragment 2
P478volume9

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cites work (P2860)
Q90480263A Novel Heterozygous Variant in F2 Gene in a Chinese Patient With Coronary Thrombosis and Acute Myocardial Infarction Leads to Antithrombin Resistance
Q90053141Disruption of the kringle 1 domain of prothrombin leads to late onset mortality in zebrafish