Down regulation of prothrombinase by activated protein C during prothrombin activation

scientific article published on 13 April 2010

Down regulation of prothrombinase by activated protein C during prothrombin activation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1160/TH09-09-0650
P932PMC publication ID3152479
P698PubMed publication ID20390226

P2093author name stringPaul Y Kim
Michael E Nesheim
P2860cites workThe functional significance of vitamin K action. Difference in phospholipid binding between normal and abnormal prothrombinQ66923212
Phospholipid-binding properties of bovine factor V and factor VaQ66938908
The effect of phospholipids, calcium ions and protein S on rate constants of human factor Va inactivation by activated human protein CQ67546959
Human factor VIIIa subunit structure. Reconstruction of factor VIIIa from the isolated A1/A3-C1-C2 dimer and A2 subunitQ67987635
Activated protein C-catalyzed inactivation of human factor VIII and factor VIIIa. Identification of cleavage sites and correlation of proteolysis with cofactor activityQ68041007
The activated protein C-mediated enhancement of tissue-type plasminogen activator-induced fibrinolysis in a cell-free systemQ68358930
Kinetics of inactivation of membrane-bound factor Va by activated protein C. Protein S modulates factor Xa protectionQ70061814
Factor VQ70233554
Regulation of bovine activated protein C by protein S: the role of the cofactor protein in species specificityQ70559191
Comparison of activated protein C/protein S-mediated inactivation of human factor VIII and factor VQ71099927
Functional properties of human factor Va lacking the Asp683-Arg709 domain of the heavy chainQ72108255
Contribution of the heavy and light chains of factor Va to the interaction with factor XaQ72520628
Role of the membrane in the inactivation of factor Va by activated protein CQ72661630
Activated protein C cleavage of factor Va leads to dissociation of the A2 domainQ73575454
Thrombin-mediated proteolysis of factor V resulting in gradual B-domain release and exposure of the factor Xa-binding siteQ74578461
The interaction of fragment 1 of prothrombin with the membrane surface is a prerequisite for optimum expression of factor Va cofactor activity within prothrombinaseQ80838396
Factor V: a combination of Dr Jekyll and Mr HydeQ28209649
The mechanism of inactivation of human factor V and human factor Va by activated protein CQ28242588
The contribution of bovine Factor V and Factor Va to the activity of prothrombinaseQ28249212
Studies of the capacity of factor Xa to protect factor Va from inactivation by activated protein CQ28275580
The molecular basis of blood coagulationQ28294854
The binding of activated protein C to factors V and VaQ28304170
Activation of human prothrombin by human prothrombinase. Influence of factor Va on the reaction mechanismQ28305220
Endothelial cell protein C receptor plays an important role in protein C activation in vivoQ28628837
Effects of protein S and factor Xa on peptide bond cleavages during inactivation of factor Va and factor VaR506Q by activated protein CQ28631087
The molecular weights, mass distribution, chain composition, and structure of soluble fibrin degradation products released from a fibrin clot perfused with plasminQ31905183
Factor V and thrombotic disease: description of a janus-faced proteinQ34123469
Anticoagulant properties of bovine plasma protein C following activation by thrombinQ34241254
Binding of protein S to factor Va associated with inhibition of prothrombinase that is independent of activated protein C.Q34360006
Binding sites for blood coagulation factor Xa and protein S involving residues 493-506 in factor Va.Q36280112
Exosites in the substrate specificity of blood coagulation reactionsQ36884329
Surface-dependent reactions in the propagation phase of blood coagulationQ37711773
Proexosite-1 on Prothrombin Is a Factor Va-dependent Recognition Site for the Prothrombinase ComplexQ40647381
Interactions of a fluorescent active-site-directed inhibitor of thrombin: dansylarginine N-(3-ethyl-1,5-pentanediyl)amideQ41482286
Importance of protein S and phospholipid for activated protein C-mediated cleavages in factor Va.Q44411439
Structural requirements for expression of factor Va activityQ44467155
Binding site for blood coagulation factor Xa involving residues 311-325 in factor Va.Q44798012
Prothrombin residues 473-487 contribute to factor Va binding in the prothrombinase complexQ45032492
Factor Va residues 311-325 represent an activated protein C binding regionQ46162373
Effects of prothrombin on the individual activated protein C-mediated cleavages of coagulation factor Va.Q46806167
Differences in prethrombin-1 activation with human or bovine factor Va can be attributed to the heavy chain.Q53367354
Prothrombin amino terminal region helps protect coagulation factor Va from proteolytic inactivation by activated protein C.Q53425306
Identification of surface epitopes of human coagulation factor Va that are important for interaction with activated protein C and heparin.Q53473754
A control switch for prothrombinase: characterization of a hirudin-like pentapeptide from the COOH terminus of factor Va heavy chain that regulates the rate and pathway for prothrombin activation.Q53595426
Effects of factor Xa and protein S on the individual activated protein C-mediated cleavages of coagulation factor Va.Q53602924
P433issue1
P921main subjectdrotrecogin alfaQ412888
P304page(s)61-70
P577publication date2010-04-13
P1433published inThrombosis and HaemostasisQ15724413
P1476titleDown regulation of prothrombinase by activated protein C during prothrombin activation
P478volume104

Reverse relations

cites work (P2860)
Q33748551Comparative response of platelet fV and plasma fV to activated protein C and relevance to a model of acute traumatic coagulopathy
Q64121883Identification and characterization of a factor Va-binding site on human prothrombin fragment 2
Q34274796Modeling of human factor Va inactivation by activated protein C.

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