Cancer-associated fibroblast regulation of tumor neo-angiogenesis as a therapeutic target in cancer

Cancer-associated fibroblast regulation of tumor neo-angiogenesis as a therapeutic target in cancer is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3892/OL.2019.9973
P932PMC publication ID6396119
P698PubMed publication ID30867734

P2093author name stringWei Sun
Jing-Tao Zhang
Yue-Zu Fan
Fang-Tao Wang
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Angiomodulin is a specific marker of vasculature and regulates vascular endothelial growth factor-A-dependent neoangiogenesis.Q34113868
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Cancer-associated fibroblasts from hepatocellular carcinoma promote malignant cell proliferation by HGF secretionQ34718091
Endoglin regulates cancer-stromal cell interactions in prostate tumorsQ34988080
Adverse effects of anticancer agents that target the VEGF pathwayQ34990961
A pilot histomorphology and hemodynamic of vasculogenic mimicry in gallbladder carcinomas in vivo and in vitroQ34995053
Matrix metalloproteinase (MMP)-9 in cancer-associated fibroblasts (CAFs) is suppressed by omega-3 polyunsaturated fatty acids in vitro and in vivoQ35107715
Norcantharidin inhibits tumor growth and vasculogenic mimicry of human gallbladder carcinomas by suppression of the PI3-K/MMPs/Ln-5γ2 signaling pathwayQ35120530
Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapyQ35127584
Induction of Vasculogenic Mimicry Overrides VEGF-A Silencing and Enriches Stem-like Cancer Cells in MelanomaQ35463820
Fibroblast activation protein and its prognostic significance in correlation with vascular endothelial growth factor in pancreatic adenocarcinomaQ35549869
Targeting the expression of platelet-derived growth factor receptor by reactive stroma inhibits growth and metastasis of human colon carcinoma.Q35569799
Fibroblast activation protein-α, a stromal cell surface protease, shapes key features of cancer associated fibroblasts through proteome and degradome alterationsQ35754294
PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stromaQ35811104
Short-term anti-vascular endothelial growth factor treatment elicits vasculogenic mimicry formation of tumors to accelerate metastasisQ35848075
Targeting the cancer stroma with a fibroblast activation protein-activated promelittin protoxinQ35947656
NOTCH3 Is Induced in Cancer-Associated Fibroblasts and Promotes Angiogenesis in Oral Squamous Cell CarcinomaQ36001853
Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblastsQ36028740
Angiogenesis inhibitors in the treatment of cancerQ36222054
Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: connecting TGF-β signaling with "Warburg-like" cancer metabolism and L-lactate production.Q36235529
FGF-1/-3/FGFR4 signaling in cancer-associated fibroblasts promotes tumor progression in colon cancer through Erk and MMP-7Q36262850
Cdc42EP3/BORG2 and Septin Network Enables Mechano-transduction and the Emergence of Cancer-Associated FibroblastsQ36426917
Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression.Q36426956
p16INK4A represses breast stromal fibroblasts migration/invasion and their VEGF-A-dependent promotion of angiogenesis through Akt inhibition.Q36520748
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Stromal fibroblasts in cancer: a novel tumor-promoting cell typeQ36553020
Targeting of cancer‑associated fibroblasts enhances the efficacy of cancer chemotherapy by regulating the tumor microenvironmentQ36624058
Antiangiogenesis and vascular endothelial growth factor/vascular endothelial growth factor receptor targeting as part of a combined-modality approach to the treatment of cancerQ36937491
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The interplay of matrix metalloproteinases, morphogens and growth factors is necessary for branching of mammary epithelial cells.Q37448181
Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in miceQ37452281
Biological mechanisms of bevacizumab-associated adverse eventsQ37546065
Combining radiation, immunotherapy, and antiangiogenesis agents in the management of cancer: the Three Musketeers or just another quixotic combination?Q37613493
Molecular biology of cancer-associated fibroblasts: can these cells be targeted in anti-cancer therapy?Q37617724
Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity.Q37651981
HIF-1α/GPER signaling mediates the expression of VEGF induced by hypoxia in breast cancer associated fibroblasts (CAFs)Q37690722
Stromal fibroblasts present in breast carcinomas promote tumor growth and angiogenesis through adrenomedullin secretionQ37716611
The dynamic roles of TGF-β in cancerQ37801347
Angiogenesis-related factors are molecular targets for diagnosis and treatment of patients with esophageal carcinomaQ37832115
The tumor microenvironment: a target for combination therapy of breast cancerQ38067162
'Cancer associated fibroblasts'--more than meets the eye.Q38114651
Podoplanin expression in cancer-associated fibroblasts correlates with VEGF-C expression in cancer cells of invasive ductal breast carcinomaQ38395964
Transcriptional over-expression of chloride intracellular channels 3 and 4 in malignant pleural mesotheliomaQ38456660
Luteolin suppresses angiogenesis and vasculogenic mimicry formation through inhibiting Notch1-VEGF signaling in gastric cancerQ38698840
Vascular mimicry formation is promoted by paracrine TGF-β and SDF1 of cancer-associated fibroblasts and inhibited by miR-101 in hepatocellular carcinoma.Q38735975
p53 functional deficiency in human colon cancer cells promotes fibroblast-mediated angiogenesis and tumor growth.Q38752162
Role of the tumor stroma in resistance to anti-angiogenic therapy.Q38828196
Tumor necrosis factor α induces myofibroblast differentiation in human tongue cancer and promotes invasiveness and angiogenesis via secretion of stromal cell-derived factor-1.Q38828968
Cancer-associated fibroblasts promote angiogenesis in gastric cancer through galectin-1 expressionQ38839374
GPER in CAFs regulates hypoxia-driven breast cancer invasion in a CTGF-dependent mannerQ38913417
Co-migration of colon cancer cells and CAFs induced by TGFβ₁ enhances liver metastasisQ38923300
Norcantharidin enhances TIMP‑2 anti‑vasculogenic mimicry activity for human gallbladder cancers through downregulating MMP‑2 and MT1‑MMP.Q38939660
Importance of the interaction between immune cells and tumor vasculature mediated by thalidomide in cancer treatment (Review).Q38947481
CLIC3 controls recycling of late endosomal MT1-MMP and dictates invasion and metastasis in breast cancerQ38976198
The role of endoglin in post-ischemic revascularization.Q39036151
CD44 expressed on cancer-associated fibroblasts is a functional molecule supporting the stemness and drug resistance of malignant cancer cells in the tumor microenvironmentQ39036931
Tumor-associated fibroblast-conditioned medium promotes tumor cell proliferation and angiogenesisQ39049745
Hepatocyte growth factor activates tumor stromal fibroblasts to promote tumorigenesis in gastric cancerQ39195929
Cancer-associated fibroblasts do not respond to combined irradiation and kinase inhibitor treatmentQ39227644
Vinorelbine inhibits angiogenesis and 95D migration via reducing hypoxic fibroblast stromal cell-derived factor 1 secretionQ39285839
Cancer-associated fibroblasts induce matrix metalloproteinase-mediated cetuximab resistance in head and neck squamous cell carcinoma cellsQ39312271
Elevated expression of angiomodulin (AGM/IGFBP-rP1) in tumor stroma and its roles in fibroblast activationQ39399018
Zinc finger E-box binding homeobox 1 promotes vasculogenic mimicry in colorectal cancer through induction of epithelial-to-mesenchymal transitionQ39418945
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectangiogenesisQ539568
neoplasmQ1216998
signaling pathwayQ28864300
P304page(s)3055-3065
P577publication date2019-03-01
P1433published inOncology LettersQ20640514
P1476titleCancer-associated fibroblast regulation of tumor neo-angiogenesis as a therapeutic target in cancer
P478volume17

Reverse relations

cites work (P2860)
Q90705823Cancer-associated fibroblast stimulates cancer cell invasion in an interleukin-1 receptor (IL-1R)-dependent manner
Q96128259Design and validation of fibroblast activation protein alpha targeted imaging and therapeutic agents
Q92996743Endothelial-to-Mesenchymal Transition (EndoMT): Roles in Tumorigenesis, Metastatic Extravasation and Therapy Resistance
Q91994824Exosomal miRNAs in tumor microenvironment
Q98291421Resistance to Anti-angiogenic Therapies: A Mechanism Depending on the Time of Exposure to the Drugs
Q99591486The Role of Cancer-Associated Fibroblasts and Extracellular Vesicles in Tumorigenesis
Q91704928Tumor microenvironment complexity and therapeutic implications at a glance

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