scholarly article | Q13442814 |
P50 | author | Richard Pestell | Q7328381 |
Ubaldo E Martinez-Outschoorn | Q37828916 | ||
Anthony Howell | Q37828919 | ||
Carmela Guido | Q51755234 | ||
Saveria Aquila | Q56826478 | ||
Michael P. Lisanti | Q77913186 | ||
Renee M Balliet | Q114778646 | ||
Claudia Capparelli | Q114778670 | ||
P2093 | author name string | Diana Whitaker-Menezes | |
Federica Sotgia | |||
Zhao Lin | |||
Sebastiano Andò | |||
P2860 | cites work | p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest | Q24319021 |
HIF1-alpha functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: Autophagy drives compartment-specific oncogenesis | Q24611063 | ||
Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment | Q24611183 | ||
The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism | Q24611412 | ||
Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells | Q24619475 | ||
Stromal cell expression of caveolin-1 predicts outcome in breast cancer | Q24658345 | ||
An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers | Q24658358 | ||
Host microenvironment in breast cancer development: extracellular matrix-stromal cell contribution to neoplastic phenotype of epithelial cells in the breast | Q24803379 | ||
Understanding the Warburg effect and the prognostic value of stromal caveolin-1 as a marker of a lethal tumor microenvironment | Q26852398 | ||
Mechanisms of TGF-beta signaling from cell membrane to the nucleus | Q27860785 | ||
Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptor | Q28139202 | ||
Smad-dependent and Smad-independent pathways in TGF-beta family signalling | Q28208250 | ||
TGFbeta in Cancer | Q28288866 | ||
Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia | Q28586744 | ||
Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice | Q28594495 | ||
TGF- Biology in Mammary Development and Breast Cancer | Q33681686 | ||
Transforming growth factor beta (TGF-beta) and inflammation in cancer | Q33712568 | ||
Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth | Q34124481 | ||
Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism | Q34235866 | ||
TGF-β1 Protects against Mesangial Cell Apoptosis via Induction of Autophagy | Q34333868 | ||
Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts | Q34358613 | ||
Stromal-epithelial metabolic coupling in cancer: integrating autophagy and metabolism in the tumor microenvironment | Q35009567 | ||
The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma | Q35013613 | ||
Warburg meets autophagy: cancer-associated fibroblasts accelerate tumor growth and metastasis via oxidative stress, mitophagy, and aerobic glycolysis | Q35884610 | ||
Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts | Q36232642 | ||
TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors | Q36235100 | ||
Alterations in components of the TGF-beta superfamily signaling pathways in human cancer | Q36323395 | ||
A delicate balance: TGF-beta and the tumor microenvironment | Q36814529 | ||
Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts | Q37150735 | ||
Caveolin-1, transforming growth factor-beta receptor internalization, and the pathogenesis of systemic sclerosis | Q37307795 | ||
Roles of TGFbeta in metastasis | Q37339711 | ||
Gain or loss of TGFbeta signaling in mammary carcinoma cells can promote metastasis | Q37608885 | ||
Caveolin-1 and cancer metabolism in the tumor microenvironment: markers, models, and mechanisms | Q37955237 | ||
Spatial coupling of mTOR and autophagy augments secretory phenotypes. | Q39554934 | ||
Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: implications for breast cancer and DCIS therapy with autophagy inhibitors | Q39690774 | ||
Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expression | Q40788311 | ||
Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction | Q40964604 | ||
Induction of alpha-smooth muscle actin by transforming growth factor-beta 1 in quiescent human breast gland fibroblasts. Implications for myofibroblast generation in breast neoplasia | Q41548309 | ||
Cell biology. The TASCC of secretion | Q41953731 | ||
Transforming growth factor-beta1 downregulates caveolin-1 expression and enhances sphingosine 1-phosphate signaling in cultured vascular endothelial cells | Q43285292 | ||
Activin/TGF-beta induce apoptosis through Smad-dependent expression of the lipid phosphatase SHIP. | Q44226377 | ||
TGF-β signaling in development and disease. | Q50804223 | ||
Transforming growth factor-beta1 induces desmoplasia in an experimental model of human pancreatic carcinoma | Q60609781 | ||
Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancer | Q71601446 | ||
Autocrine production and TGF-beta 1-mediated effects on metabolism and viability in renal cells | Q71645980 | ||
TGF-beta induces apoptosis through Smad-mediated expression of DAP-kinase | Q77342591 | ||
Cancer associated fibroblasts stimulated by transforming growth factor beta1 (TGF-beta 1) increase invasion rate of tumor cells: a population study | Q80732647 | ||
Human breast cancer-associated fibroblasts (CAFs) show caveolin-1 downregulation and RB tumor suppressor functional inactivation: Implications for the response to hormonal therapy | Q81220604 | ||
Power surge: supporting cells "fuel" cancer cell mitochondria | Q83191232 | ||
P433 | issue | 16 | |
P921 | main subject | cancer-associated fibroblast | Q42417562 |
P1104 | number of pages | 17 | |
P304 | page(s) | 3019-3035 | |
P577 | publication date | 2012-08-09 | |
P1433 | published in | Cell Cycle | Q1254166 |
P1476 | title | Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: connecting TGF-β signaling with "Warburg-like" cancer metabolism and L-lactate production | |
P478 | volume | 11 |
Q30356080 | A microfluidic chip for screening individual cancer cells via eavesdropping on autophagy-inducing crosstalk in the stroma niche. |
Q88186503 | Absence of caveolin-1 expression in carcinoma-associated fibroblasts of invasive micropapillary carcinoma of the breast predicts poor patient outcome |
Q91857825 | Activated Fibroblast Program Orchestrates Tumor Initiation and Progression; Molecular Mechanisms and the Associated Therapeutic Strategies |
Q38795278 | Activating autophagy to potentiate immunogenic chemotherapy and radiation therapy |
Q37610799 | Altered gene products involved in the malignant reprogramming of cancer stem/progenitor cells and multitargeted therapies |
Q64245159 | An Integrative Systems Biology and Experimental Approach Identifies Convergence of Epithelial Plasticity, Metabolism, and Autophagy to Promote Chemoresistance |
Q47117430 | Angiopoietin-like protein 2 facilitates non-small cell lung cancer progression by promoting the polarization of M2 tumor-associated macrophages |
Q38200130 | Autophagy: detection, regulation and its role in cancer and therapy response |
Q36556331 | BRCA1 mutations drive oxidative stress and glycolysis in the tumor microenvironment: implications for breast cancer prevention with antioxidant therapies |
Q91997750 | Biological heterogeneity and versatility of cancer-associated fibroblasts in the tumor microenvironment |
Q26772925 | Breast Cancer-Associated Fibroblasts: Where We Are and Where We Need to Go |
Q91310930 | CAF Subpopulations: A New Reservoir of Stromal Targets in Pancreatic Cancer |
Q36839044 | CAF-like state in primary skin fibroblasts with constitutional BRCA1 epimutation sheds new light on tumor suppressor deficiency-related changes in healthy tissue |
Q91656807 | Cancer Metabolism Drives a Stromal Regenerative Response |
Q42962693 | Cancer metabolism: new validated targets for drug discovery |
Q26746123 | Cancer stem cell metabolism |
Q55254924 | Cancer stem cells (CSCs): metabolic strategies for their identification and eradication. |
Q38627888 | Cancer-Associated Fibroblasts Autophagy Enhances Progression of Triple-Negative Breast Cancer Cells. |
Q64233813 | Cancer-associated fibroblast regulation of tumor neo-angiogenesis as a therapeutic target in cancer |
Q39144790 | Cancer-associated fibroblasts and M2-polarized macrophages synergize during prostate carcinoma progression |
Q28078990 | Cancer: An Oxidative Crosstalk between Solid Tumor Cells and Cancer Associated Fibroblasts |
Q38215035 | Canonical and non-canonical Hedgehog signalling and the control of metabolism |
Q38388286 | Caveolae and signalling in cancer |
Q38096319 | Caveolin and TGF-β entanglements |
Q37205669 | Cell-extrinsic consequences of epithelial stress: activation of protumorigenic tissue phenotypes |
Q35793591 | Chemotherapy induces the cancer-associated fibroblast phenotype, activating paracrine Hedgehog-GLI signalling in breast cancer cells |
Q64968387 | Combined Inhibition of TGF-β Signaling and the PD-L1 Immune Checkpoint Is Differentially Effective in Tumor Models. |
Q92670843 | Discovery of Novel Small Molecules that Block Myofibroblast Formation: Implications for Capsular Contracture Treatment |
Q47685050 | Dual effects of hyperglycemia on endothelial cells and cardiomyocytes to enhance coronary LPL activity |
Q49552882 | Dynamic and Diverse Changes in the Functional Properties of Vascular Smooth Muscle Cells in Pulmonary Hypertension |
Q44300041 | Effects of targeted CD97 immune epitopes small interference RNA on cellular biological behaviors in MDA-MB231 malignant breast cancer cell line |
Q91452491 | Evolution of placental invasion and cancer metastasis are causally linked |
Q26745566 | Evolving Insights on Metabolism, Autophagy, and Epigenetics in Liver Myofibroblasts |
Q38225316 | Extracellular acidity, a "reappreciated" trait of tumor environment driving malignancy: perspectives in diagnosis and therapy. |
Q33964324 | Fibroblast heterogeneity in the cancer wound |
Q64981236 | Fibroblasts as Modulators of Local and Systemic Cancer Metabolism. |
Q89631276 | Fibroblasts in the Tumor Microenvironment |
Q91329598 | HIC-5 in cancer-associated fibroblasts contributes to esophageal squamous cell carcinoma progression |
Q38605077 | Heat Shock Protein 27, a Novel Regulator of Transforming Growth Factor β Induced Resistance to Cisplatin in A549 Cell |
Q40097296 | Herpesviral microRNAs in Cellular Metabolism and Immune Responses. |
Q39013710 | Identifying progression predictors of breast ductal carcinoma in situ. |
Q92255756 | Inflammation Associated Pancreatic Tumorigenesis: Upregulation of Succinate Dehydrogenase (Subunit B) Reduces Cell Growth of Pancreatic Ductal Epithelial Cells |
Q26745577 | Interactions between Autophagy and Inhibitory Cytokines |
Q92827591 | Knockdown of vascular cell adhesion molecule 1 impedes transforming growth factor beta 1-mediated proliferation, migration, and invasion of endometriotic cyst stromal cells |
Q58796872 | LY2157299 Monohydrate, a TGF-βR1 Inhibitor, Suppresses Tumor Growth and Ascites Development in Ovarian Cancer |
Q41787058 | MPL W515L expression induces TGFβ secretion and leads to an increase in chemokinesis via phosphorylation of THOC5. |
Q88973517 | Mechanisms and context underlying the role of autophagy in cancer metastasis |
Q34482050 | Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression. |
Q39265746 | Metabolic Cooperation and Competition in the Tumor Microenvironment: Implications for Therapy. |
Q55412562 | Metabolic Reprogramming of Cancer Associated Fibroblasts: The Slavery of Stromal Fibroblasts. |
Q92757099 | Metabolic landscape of the tumor microenvironment at single cell resolution |
Q64257472 | Metabolism in Human Mesenchymal Stromal Cells: A Missing Link Between hMSC Biomanufacturing and Therapy? |
Q64972879 | MicroRNA-181a/b-1 over-expression enhances osteogenesis by modulating PTEN/PI3K/AKT signaling and mitochondrial metabolism. |
Q36556326 | Mitochondria "fuel" breast cancer metabolism: fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cells |
Q92794916 | Natural Killer Cells as Key Players of Tumor Progression and Angiogenesis: Old and Novel Tools to Divert Their Pro-Tumor Activities into Potent Anti-Tumor Effects |
Q37690547 | Next generation sequencing-based expression profiling identifies signatures from benign stromal proliferations that define stromal components of breast cancer |
Q37187702 | Nodal regulates energy metabolism in glioma cells by inducing expression of hypoxia-inducible factor 1α. |
Q39456875 | Nutrient Exploitation within the Tumor-Stroma Metabolic Crosstalk |
Q28072798 | On metabolic reprogramming and tumor biology: A comprehensive survey of metabolism in breast cancer |
Q37396904 | Oncogenes and inflammation rewire host energy metabolism in the tumor microenvironment: RAS and NFκB target stromal MCT4. |
Q26851813 | Oncogenes induce the cancer-associated fibroblast phenotype: metabolic symbiosis and "fibroblast addiction" are new therapeutic targets for drug discovery |
Q38731165 | Oxidative stress induced autophagy in cancer associated fibroblast enhances proliferation and metabolism of colorectal cancer cells |
Q49323466 | Paracrine and epigenetic control of CAF-induced metastasis: the role of HOTAIR stimulated by TGF-ß1 secretion |
Q39185439 | Perillyl alcohol, a pleiotropic natural compound suitable for brain tumor therapy, targets free radicals. |
Q55382820 | Periostin attenuates tumor growth by inducing apoptosis in colitis-related colorectal cancer. |
Q35955331 | Peritoneal expression of Matrilysin helps identify early post-operative recurrence of colorectal cancer. |
Q91529202 | Pharmacologic treatment with CPI-613 and PS48 decreases mitochondrial membrane potential and increases quantity of autolysosomes in porcine fibroblasts |
Q35832431 | Podoplanin-expressing cancer-associated fibroblasts inhibit small cell lung cancer growth |
Q41535142 | Prostate stromal cell proteomics analysis discriminates normal from tumour reactive stromal phenotypes. |
Q38148991 | Regulation and function of mitophagy in development and cancer. |
Q93195637 | Reprogramming of lipid metabolism in cancer-associated fibroblasts potentiates migration of colorectal cancer cells |
Q37628179 | Stromal Modulators of TGF-β in Cancer |
Q38567353 | Stromal barriers and strategies for the delivery of nanomedicine to desmoplastic tumors |
Q37711961 | Systemic Activin signaling independently regulates sugar homeostasis, cellular metabolism, and pH balance in Drosophila melanogaster |
Q52559212 | TGF-β and the Tissue Microenvironment: Relevance in Fibrosis and Cancer. |
Q37100262 | TGF-β modulates ovarian cancer invasion by upregulating CAF-derived versican in the tumor microenvironment. |
Q47915386 | TGF-β1 targets Smad, p38 MAPK, and PI3K/Akt signaling pathways to induce PFKFB3 gene expression and glycolysis in glioblastoma cells |
Q37637112 | TGFβ/Activin signalling is required for ribosome biogenesis and cell growth in Drosophila salivary glands |
Q38713056 | TGFβ1-induced leucine limitation uncovered by differential ribosome codon reading. |
Q52594771 | The Influence of Breast Tumour-Derived Factors and Wnt Antagonism on the Transformation of Adipose-Derived Mesenchymal Stem Cells into Tumour-Associated Fibroblasts. |
Q52687668 | The autophagic network and cancer. |
Q38828825 | The biology and function of fibroblasts in cancer |
Q98946913 | The fuel and engine: The roles of reprogrammed metabolism in metastasis of primary liver cancer |
Q46304569 | The metabolic cross-talk between epithelial cancer cells and stromal fibroblasts in ovarian cancer progression: Autophagy plays a role. |
Q34100815 | The nutritional phenome of EMT-induced cancer stem-like cells |
Q41339597 | The reverse Warburg effect is likely to be an Achilles' heel of cancer that can be exploited for cancer therapy. |
Q50116077 | The role of TGF-β in the pathophysiology of peritoneal endometriosis |
Q38922999 | The roles of tumor- and metastasis-promoting carcinoma-associated fibroblasts in human carcinomas. |
Q47128288 | The small vesicular culprits: the investigation of extracellular vesicles as new targets for cancer treatment |
Q28077319 | Transforming growth factor β as regulator of cancer stemness and metastasis |
Q34396502 | Transforming growth factor-β induced Warburg-like metabolic reprogramming may underpin the development of peritoneal endometriosis. |
Q36556290 | Transforming growth factor-β: guardian of catabolic metabolism in carcinoma-associated fibroblasts |
Q38757103 | Transitions from mono- to co- to tri-culture uniquely affect gene expression in breast cancer, stromal, and immune compartments |
Q37106988 | Triggering the landslide: The tumor-promotional effects of myofibroblasts |
Q93336606 | Turning foes to friends: targeting cancer-associated fibroblasts |
Q37224595 | Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma. |
Q28395443 | Xenohormetic and anti-aging activity of secoiridoid polyphenols present in extra virgin olive oil: a new family of gerosuppressant agents |
Search more.