Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: connecting TGF-β signaling with "Warburg-like" cancer metabolism and L-lactate production.

scientific article

Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: connecting TGF-β signaling with "Warburg-like" cancer metabolism and L-lactate production. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4161/CC.21384
P932PMC publication ID3442913
P698PubMed publication ID22874531
P5875ResearchGate publication ID230637713

P50authorRichard PestellQ7328381
Ubaldo E Martinez-OutschoornQ37828916
Anthony HowellQ37828919
Carmela GuidoQ51755234
Saveria AquilaQ56826478
Michael P. LisantiQ77913186
Renee M BallietQ114778646
Claudia CapparelliQ114778670
P2093author name stringDiana Whitaker-Menezes
Federica Sotgia
Zhao Lin
Sebastiano Andò
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Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cellsQ24619475
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An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancersQ24658358
Host microenvironment in breast cancer development: extracellular matrix-stromal cell contribution to neoplastic phenotype of epithelial cells in the breastQ24803379
Understanding the Warburg effect and the prognostic value of stromal caveolin-1 as a marker of a lethal tumor microenvironmentQ26852398
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Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growthQ34124481
Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanismQ34235866
TGF-β1 Protects against Mesangial Cell Apoptosis via Induction of AutophagyQ34333868
Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblastsQ34358613
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Warburg meets autophagy: cancer-associated fibroblasts accelerate tumor growth and metastasis via oxidative stress, mitophagy, and aerobic glycolysisQ35884610
Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblastsQ36232642
TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptorsQ36235100
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Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblastsQ37150735
Caveolin-1, transforming growth factor-beta receptor internalization, and the pathogenesis of systemic sclerosisQ37307795
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Gain or loss of TGFbeta signaling in mammary carcinoma cells can promote metastasisQ37608885
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Spatial coupling of mTOR and autophagy augments secretory phenotypes.Q39554934
Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: implications for breast cancer and DCIS therapy with autophagy inhibitorsQ39690774
Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expressionQ40788311
Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reactionQ40964604
Induction of alpha-smooth muscle actin by transforming growth factor-beta 1 in quiescent human breast gland fibroblasts. Implications for myofibroblast generation in breast neoplasiaQ41548309
Cell biology. The TASCC of secretionQ41953731
Transforming growth factor-beta1 downregulates caveolin-1 expression and enhances sphingosine 1-phosphate signaling in cultured vascular endothelial cellsQ43285292
Activin/TGF-beta induce apoptosis through Smad-dependent expression of the lipid phosphatase SHIP.Q44226377
TGF-β signaling in development and disease.Q50804223
Transforming growth factor-beta1 induces desmoplasia in an experimental model of human pancreatic carcinomaQ60609781
Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancerQ71601446
Autocrine production and TGF-beta 1-mediated effects on metabolism and viability in renal cellsQ71645980
TGF-beta induces apoptosis through Smad-mediated expression of DAP-kinaseQ77342591
Cancer associated fibroblasts stimulated by transforming growth factor beta1 (TGF-beta 1) increase invasion rate of tumor cells: a population studyQ80732647
Human breast cancer-associated fibroblasts (CAFs) show caveolin-1 downregulation and RB tumor suppressor functional inactivation: Implications for the response to hormonal therapyQ81220604
Power surge: supporting cells "fuel" cancer cell mitochondriaQ83191232
P433issue16
P921main subjectcancer-associated fibroblastQ42417562
P1104number of pages17
P304page(s)3019-3035
P577publication date2012-08-09
P1433published inCell CycleQ1254166
P1476titleMetabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: connecting TGF-β signaling with "Warburg-like" cancer metabolism and L-lactate production
P478volume11

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