Lipopolysaccharide (LPS) Aggravates High Glucose- and Hypoxia/Reoxygenation-Induced Injury through Activating ROS-Dependent NLRP3 Inflammasome-Mediated Pyroptosis in H9C2 Cardiomyocytes

scientific article published on 17 February 2019

Lipopolysaccharide (LPS) Aggravates High Glucose- and Hypoxia/Reoxygenation-Induced Injury through Activating ROS-Dependent NLRP3 Inflammasome-Mediated Pyroptosis in H9C2 Cardiomyocytes is …
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scholarly articleQ13442814

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P356DOI10.1155/2019/8151836
P932PMC publication ID6398034
P698PubMed publication ID30911553

P50authorZhong-Yuan XiaQ87315645
Shaoqing LeiQ88929369
Zhen QiuQ89715393
Yan LengQ90477913
P2093author name stringYuhong He
Hao Ming
P2860cites workThe Role of Oxidative Stress in Myocardial Ischemia and Reperfusion Injury and Remodeling: RevisitedQ26744642
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Innate cell communication kick-starts pathogen-specific immunityQ26752790
Calcium signaling and mitochondrial destabilization in the triggering of the NLRP3 inflammasomeQ28387113
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane poresQ28511994
K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matterQ29620146
The immunopathology of sepsis and potential therapeutic targetsQ30234689
The Emerging Role of Thioredoxin-Interacting Protein in Myocardial Ischemia/Reperfusion InjuryQ33559046
Triptolide reduces ischemia/reperfusion injury in rats and H9C2 cells via inhibition of NF‑κB, ROS and the ERK1/2 pathway.Q52670104
Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 InflammasomeQ58606016
Geniposide Attenuates LPS-Induced Injury via Up-Regulation of miR-145 in H9c2 CellsQ88250752
Inhibition of NLRP9b attenuates acute lung injury through suppressing inflammation, apoptosis and oxidative stress in murine and cell modelsQ88360583
Protective effect of ginsenoside metabolite compound K against diabetic nephropathy by inhibiting NLRP3 inflammasome activation and NF-κB/p38 signaling pathway in high-fat diet/streptozotocin-induced diabetic miceQ90942744
Fmr1 protects cardiomyocytes against lipopolysaccharide-induced myocardial injuryQ91306414
LPS from P. gingivalis and hypoxia increases oxidative stress in periodontal ligament fibroblasts and contributes to periodontitisQ34412657
MicroRNA-30d regulates cardiomyocyte pyroptosis by directly targeting foxo3a in diabetic cardiomyopathyQ34541619
Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria.Q34678595
Lipopolysaccharide pretreatment protects against ischemia/reperfusion injury via increase of HSP70 and inhibition of NF-κBQ34797253
NLRP3 gene silencing ameliorates diabetic cardiomyopathy in a type 2 diabetes rat modelQ35227844
Trimetazidine prevents macrophage-mediated septic myocardial dysfunction via activation of the histone deacetylase sirtuin 1Q36506880
NF-κB Restricts Inflammasome Activation via Elimination of Damaged MitochondriaQ36625160
LPS induces cardiomyocyte injury through calcium-sensing receptorQ36882431
The inflammasomes in health and disease: from genetics to molecular mechanisms of autoinflammation and beyondQ37729538
Diabetes and acute coronary syndrome.Q37751843
Activation of NLRP3 inflammasomes contributes to hyperhomocysteinemia-aggravated inflammation and atherosclerosis in apoE-deficient miceQ38708257
DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosisQ38732531
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell deathQ38835009
Melatonin alleviates inflammasome-induced pyroptosis through inhibiting NF-κB/GSDMD signal in mice adipose tissue.Q38842534
Mechanism and Regulation of NLRP3 Inflammasome ActivationQ38964695
Inflammasomes and its importance in viral infections.Q38971599
Ischemia/ReperfusionQ39109413
Recent advances in the pathophysiology and molecular basis of sepsis-associated organ dysfunction: Novel therapeutic implications and challengesQ39148522
Adherence to Healthy Lifestyle and Cardiovascular Diseases in the Chinese Population.Q39195677
Sevoflurane combined with ATP activates caspase-1 and triggers caspase-1-dependent pyroptosis in murine J774 macrophagesQ39271570
Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases.Q39277467
Molecular mechanisms in the pathogenesis of sepsisQ39444607
Synthetic high-density lipoprotein-like nanoparticles potently inhibit cell signaling and production of inflammatory mediators induced by lipopolysaccharide binding Toll-like receptor 4.Q39722614
Heart in sepsis : Molecular mechanisms, diagnosis and therapy of septic cardiomyopathyQ40147443
HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1β production via suppressing the NF-κB pathway and ROS productionQ40393747
Sulforaphane attenuates activation of NLRP3 and NLRC4 inflammasomes but not AIM2 inflammasome.Q40611372
Angiotensin-(1-7) Improves Liver Fibrosis by Regulating the NLRP3 Inflammasome via Redox Balance ModulationQ40846418
Hydroxysafflor yellow A alleviates myocardial ischemia/reperfusion in hyperlipidemic animals through the suppression of TLR4 signalingQ41431093
Myocardial depression during sepsisQ41993640
NLRP3 Inflammasome Activation-Mediated Pyroptosis Aggravates Myocardial Ischemia/Reperfusion Injury in Diabetic Rats.Q43372985
Lipopolysaccharide/adenosine triphosphate-mediated signal transduction in the regulation of NLRP3 protein expression and caspase-1-mediated interleukin-1β secretionQ45399633
Bisphenol AF negatively affects oocyte maturation of mouse in vitro through increasing oxidative stress and DNA damage.Q46268891
Salidroside suppressing LPS-induced myocardial injury by inhibiting ROS-mediated PI3K/Akt/mTOR pathway in vitro and in vivoQ46307231
microRNA-99a Reduces Lipopolysaccharide-Induced Oxidative Injury by Activating Notch Pathway in H9c2 CellsQ46369415
Edaravone attenuates lipopolysaccharide-induced acute respiratory distress syndrome associated early pulmonary fibrosis via amelioration of oxidative stress and transforming growth factor-β1/Smad3 signalingQ47441751
Klotho protects the heart from hyperglycemia-induced injury by inactivating ROS and NF-κB-mediated inflammation both in vitro and in vivoQ47690852
Lipopolysaccharide pretreatment promotes cardiac stem cell migration through heat shock protein 90-dependent β-catenin activationQ47875586
Astragalus polysaccharide alleviates LPS-induced inflammation injury by regulating miR-127 in H9c2 cardiomyoblastsQ49935322
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P407language of work or nameEnglishQ1860
P921main subjecthypoxiaQ105688
inflammasome complexQ412405
lipopolysaccharideQ421804
P304page(s)8151836
P577publication date2019-02-17
P1433published inJournal of Diabetes ResearchQ26841822
P1476titleLipopolysaccharide (LPS) Aggravates High Glucose- and Hypoxia/Reoxygenation-Induced Injury through Activating ROS-Dependent NLRP3 Inflammasome-Mediated Pyroptosis in H9C2 Cardiomyocytes
P478volume2019

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cites work (P2860)
Q99237953Baicalein Attenuates Pyroptosis and Endoplasmic Reticulum Stress Following Spinal Cord Ischemia-Reperfusion Injury via Autophagy Enhancement
Q89964178Clemastine Fumarate Protects Against Myocardial Ischemia Reperfusion Injury by Activating the TLR4/PI3K/Akt Signaling Pathway
Q98771724Nucleotide-Binding Oligomerization Domain-Like Receptor 3 Deficiency Attenuated Isoproterenol-Induced Cardiac Fibrosis via Reactive Oxygen Species/High Mobility Group Box 1 Protein Axis

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