A Randomized, Double-Blind, Placebo-Controlled, Phase II Study Assessing Safety, Tolerability, and Efficacy of Bryostatin in the Treatment of Moderately Severe to Severe Alzheimer's Disease

scholarly article by Martin R Farlow et al published 2019 in Journal of Alzheimer's Disease

A Randomized, Double-Blind, Placebo-Controlled, Phase II Study Assessing Safety, Tolerability, and Efficacy of Bryostatin in the Treatment of Moderately Severe to Severe Alzheimer's Disease is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3233/JAD-180759
P932PMC publication ID6398557
P698PubMed publication ID30530975

P2093author name stringDaniel L Alkon
Martin R Farlow
Lee-Jen Wei
Richard E Thompson
David Crockford
Susanne Wilke
Alan J Tuchman
Elaine Grenier
Jeffrey Benison
P2860cites workPostischemic PKC activation rescues retrograde and anterograde long-term memoryQ24646400
“Mini-mental state”Q25938989
Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairmentQ29547294
Bryostatin Effects on Cognitive Function and PKCɛ in Alzheimer's Disease Phase IIa and Expanded Access TrialsQ33708951
Safety and tolerability of donepezil 23 mg in moderate to severe Alzheimer's diseaseQ33911859
An inventory to assess activities of daily living for clinical trials in Alzheimer's disease. The Alzheimer's Disease Cooperative Study.Q34433716
Loss in PKC Epsilon Causes Downregulation of MnSOD and BDNF Expression in Neurons of Alzheimer's Disease Hippocampus.Q54979994
Phase II study of bryostatin 1 in patients with relapsed multiple myelomaQ74524894
The severe impairment battery: concurrent validity and the assessment of longitudinal change in Alzheimer's disease. The Alzheimer's Disease Cooperative Study.Q34433720
Poststroke neuronal rescue and synaptogenesis mediated in vivo by protein kinase C in adult brainsQ34596733
Effectiveness and tolerability of high-dose (23 mg/d) versus standard-dose (10 mg/d) donepezil in moderate to severe Alzheimer's disease: A 24-week, randomized, double-blind studyQ34746698
A focus on the synapse for neuroprotection in Alzheimer disease and other dementiasQ35914866
Immunology and immunotherapy of Alzheimer's diseaseQ36460445
Alzheimer's disease-related alterations in synaptic density: neocortex and hippocampus.Q36568086
PKC signaling deficits: a mechanistic hypothesis for the origins of Alzheimer's diseaseQ36705548
Randomized phase II designs.Q37173942
Towards universal therapeutics for memory disordersQ38470188
Reduction of beta-amyloid levels by novel protein kinase C(epsilon) activatorsQ39784350
Apolipoprotein E3 (ApoE3) but not ApoE4 protects against synaptic loss through increased expression of protein kinase C epsilonQ42084058
Memantine in moderate-to-severe Alzheimer's diseaseQ44388745
PKC ε activation prevents synaptic loss, Aβ elevation, and cognitive deficits in Alzheimer's disease transgenic miceQ44962410
Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairmentQ48694961
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectAlzheimer's diseaseQ11081
bryostatinQ4981136
placeboQ269829
memantineQ412189
P304page(s)555-570
P577publication date2019-01-01
P1433published inJournal of Alzheimer's DiseaseQ6294755
P1476titleA Randomized, Double-Blind, Placebo-Controlled, Phase II Study Assessing Safety, Tolerability, and Efficacy of Bryostatin in the Treatment of Moderately Severe to Severe Alzheimer's Disease
P478volume67

Reverse relations

cites work (P2860)
Q89690206Born to Protect: Leveraging BDNF Against Cognitive Deficit in Alzheimer's Disease
Q100945954Chronic bryostatin-1 rescues autistic and cognitive phenotypes in the fragile X mice
Q93057430Munc13 Is a Molecular Target of Bryostatin 1
Q64880531Natural Compounds for Alzheimer's Disease Therapy: A Systematic Review of Preclinical and Clinical Studies.
Q91710367Pharmacotherapy of Alzheimer's Disease: Seeking Clarity in a Time of Uncertainty

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