| review article | Q7318358 |
| scholarly article | Q13442814 |
| P50 | author | Cesar de la Fuente-Nunez | Q87607358 |
| Octávio Luiz Franco | Q55807541 | ||
| P2093 | author name string | Osmar Nascimento Silva | |
| William Farias Porto | |||
| Állan da Silva Pires | |||
| Osmel Fleitas Martínez | |||
| Pietra Orlandi Rigueiras | |||
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| LuxS-independent formation of AI-2 from ribulose-5-phosphate. | Q39668354 | ||
| HHQ and PQS, two Pseudomonas aeruginosa quorum-sensing molecules, down-regulate the innate immune responses through the nuclear factor-kappaB pathway. | Q39747759 | ||
| From deep-sea volcanoes to human pathogens: a conserved quorum-sensing signal in Epsilonproteobacteria | Q39942673 | ||
| Signal Biosynthesis Inhibition with Ambuic Acid as a Strategy To Target Antibiotic-Resistant Infections. | Q40175211 | ||
| CRISPR Interference (CRISPRi) Inhibition of luxS Gene Expression in E. coli: An Approach to Inhibit Biofilm | Q40176863 | ||
| In-depth Profiling of MvfR-Regulated Small Molecules in Pseudomonas aeruginosa after Quorum Sensing Inhibitor Treatment | Q40179538 | ||
| AI-2 quorum sensing negatively regulates rbf expression and biofilm formation in Staphylococcus aureus. | Q40248210 | ||
| CRISPR-based genome editing of clinically important Escherichia coli SE15 isolated from indwelling urinary catheters of patients | Q40411788 | ||
| Plant phenolic volatiles inhibit quorum sensing in pectobacteria and reduce their virulence by potential binding to ExpI and ExpR proteins | Q40428232 | ||
| Antisense locked nucleic acids targeting agrA inhibit quorum sensing and pathogenesis of community-associated methicillin-resistant Staphylococcus aureus | Q40513076 | ||
| Truncated Autoinducing Peptides as Antagonists of Staphylococcus lugdunensis Quorum Sensing | Q40554825 | ||
| Discovery of new diketopiperazines inhibiting Burkholderia cenocepacia quorum sensing in vitro and in vivo | Q40556314 | ||
| Hybrid Quadrupole-Orbitrap mass spectrometry for quantitative measurement of quorum sensing inhibition | Q40654671 | ||
| Application of Dual Inhibition Concept within Looped Autoregulatory Systems toward Antivirulence Agents against Pseudomonas aeruginosa Infections | Q40789654 | ||
| Analysis of the antibacterial effect of an Edwardsiella tarda LuxS inhibitor | Q40803820 | ||
| High variability in quorum quenching and growth inhibition by furanone C-30 in Pseudomonas aeruginosa clinical isolates from cystic fibrosis patients | Q41181052 | ||
| Transition State Structure and Inhibition of Rv0091, a 5'-Deoxyadenosine/5'-methylthioadenosine Nucleosidase from Mycobacterium tuberculosis | Q41228530 | ||
| Exploring the chemical space of ureidothiophene-2-carboxylic acids as inhibitors of the quorum sensing enzyme PqsD from Pseudomonas aeruginosa | Q41334326 | ||
| Apparent role for Borrelia burgdorferi LuxS during mammalian infection. | Q41531292 | ||
| Catechol-based substrates of chalcone synthase as a scaffold for novel inhibitors of PqsD. | Q41641534 | ||
| Pfs promotes autolysis-dependent release of eDNA and biofilm formation in Staphylococcus aureus. | Q41754774 | ||
| S-Ribosylhomocysteine Analogues Modified at the Ribosyl C-4 Position | Q41833897 | ||
| Identification of four new agr quorum sensing-interfering cyclodepsipeptides from a marine Photobacterium | Q41845339 | ||
| A naturally occurring brominated furanone covalently modifies and inactivates LuxS. | Q42049118 | ||
| LuxS promotes biofilm maturation and persistence of nontypeable haemophilus influenzae in vivo via modulation of lipooligosaccharides on the bacterial surface | Q42089994 | ||
| Establishing bacterial communities by 'word of mouth': LuxS and autoinducer 2 in biofilm development | Q81415382 | ||
| Benzamidobenzoic acids as potent PqsD inhibitors for the treatment of Pseudomonas aeruginosa infections | Q87398209 | ||
| From in vitro to in cellulo: structure-activity relationship of (2-nitrophenyl)methanol derivatives as inhibitors of PqsD in Pseudomonas aeruginosa | Q88039396 | ||
| Autoinducer 2 (AI-2) Production by Nontypeable Haemophilus influenzae 86-028NP Promotes Expression of a Predicted Glycosyltransferase That Is a Determinant of Biofilm Maturation, Prevention of Dispersal, and Persistence In Vivo | Q91700942 | ||
| Analysis of Pseudomonas aeruginosa 4-hydroxy-2-alkylquinolines (HAQs) reveals a role for 4-hydroxy-2-heptylquinoline in cell-to-cell communication | Q24608407 | ||
| Beyond killing: Can we find new ways to manage infection? | Q26750724 | ||
| Targeting Staphylococcus aureus Toxins: A Potential form of Anti-Virulence Therapy | Q26752975 | ||
| Inhibiting N-acyl-homoserine lactone synthesis and quenching Pseudomonas quinolone quorum sensing to attenuate virulence | Q26779425 | ||
| Quorum-sensing regulation in staphylococci-an overview | Q26823976 | ||
| PqsBC, a Condensing Enzyme in the Biosynthesis of thePseudomonas aeruginosaQuinolone Signal | Q27312117 | ||
| Structure of Escherichia coli 5'-methylthioadenosine/ S-adenosylhomocysteine nucleosidase inhibitor complexes provide insight into the conformational changes required for substrate binding and catalysis | Q27640206 | ||
| Structure ofStaphylococcus aureus5′-methylthioadenosine/S-adenosylhomocysteine nucleosidase | Q27650516 | ||
| Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing | Q27654037 | ||
| Structure of PqsD, a Pseudomonas Quinolone Signal Biosynthetic Enzyme, in Complex with Anthranilate | Q27657088 | ||
| Enzyme-ligand interactions that drive active site rearrangements in the Helicobacter pylori 5′-methylthioadenosine/S-adenosylhomocysteine nucleosidase | Q27665126 | ||
| Small-molecule inhibitor binding to an N-acyl-homoserine lactone synthase | Q27670682 | ||
| Identification of a Hydrophobic Cleft in the LytTR Domain of AgrA as a Locus for Small Molecule Interactions That Inhibit DNA Binding | Q27675241 | ||
| Salmonella enterica MTAN at 1.36 Å Resolution: A Structure-Based Design of Tailored Transition State Analogs | Q27678174 | ||
| Crystal structure and biochemical studies of Brucella melitensis 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | Q27689593 | ||
| Flipping the switch: tools for detecting small molecule inhibitors of staphylococcal virulence | Q27692092 | ||
| Picomolar inhibitors as transition-state probes of 5'-methylthioadenosine nucleosidases | Q28258295 | ||
| Transition state structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli and its similarity to transition state analogues | Q28269510 | ||
| Norlichexanthone Reduces Virulence Gene Expression and Biofilm Formation in Staphylococcus aureus | Q28354141 | ||
| Characterization of Pseudomonas aeruginosa enoyl-acyl carrier protein reductase (FabI): a target for the antimicrobial triclosan and its role in acylated homoserine lactone synthesis | Q28492770 | ||
| Triclosan resistance of Pseudomonas aeruginosa PAO1 is due to FabV, a triclosan-resistant enoyl-acyl carrier protein reductase | Q28492833 | ||
| The contribution of MvfR to Pseudomonas aeruginosa pathogenesis and quorum sensing circuitry regulation: multiple quorum sensing-regulated genes are modulated without affecting lasRI, rhlRI or the production of N-acyl-L-homoserine lactones | Q28493075 | ||
| Pseudomonas aeruginosa PqsA is an anthranilate-coenzyme A ligase | Q28493103 | ||
| Functions required for extracellular quinolone signaling by Pseudomonas aeruginosa | Q28493106 | ||
| Selective chemical inhibition of agr quorum sensing in Staphylococcus aureus promotes host defense with minimal impact on resistance | Q28539668 | ||
| Structure-Function Analyses of a Staphylococcus epidermidis Autoinducing Peptide Reveals Motifs Critical for AgrC-type Receptor Modulation | Q28830075 | ||
| Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression | Q29615784 | ||
| Active site and remote contributions to catalysis in methylthioadenosine nucleosidases. | Q30373000 | ||
| Chemotaxis towards autoinducer 2 mediates autoaggregation in Escherichia coli | Q30820001 | ||
| Catalytic mechanism of S-ribosylhomocysteinase: ionization state of active-site residues | Q31063791 | ||
| Validation of PqsD as an anti-biofilm target in Pseudomonas aeruginosa by development of small-molecule inhibitors | Q31093948 | ||
| Inhibitors of pathogen intercellular signals as selective anti-infective compounds | Q33302936 | ||
| The end of an old hypothesis: the pseudomonas signaling molecules 4-hydroxy-2-alkylquinolines derive from fatty acids, not 3-ketofatty acids | Q37424462 | ||
| New Insights into Autoinducer-2 Signaling as a Virulence Regulator in a Mouse Model of Pneumonic Plague | Q37503760 | ||
| AI-2-mediated signalling in bacteria | Q38019983 | ||
| Quorum sensing inhibitors: a patent review | Q38090644 | ||
| Targeting agr- and agr-Like quorum sensing systems for development of common therapeutics to treat multiple gram-positive bacterial infections. | Q38100055 | ||
| Small molecule inhibitors of AI-2 signaling in bacteria: state-of-the-art and future perspectives for anti-quorum sensing agents | Q38133222 | ||
| Evolution of resistance to quorum-sensing inhibitors. | Q38160197 | ||
| Quorum quenching enzymes. | Q38249028 | ||
| Quorum sensing in group A Streptococcus | Q38259588 | ||
| Inhibition of LuxS by S-ribosylhomocysteine analogues containing a [4-aza]ribose ring | Q38382554 | ||
| Femtomolar transition state analogue inhibitors of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli | Q38474904 | ||
| Can resistance against quorum-sensing interference be selected? | Q38507310 | ||
| LuxS/AI-2 in Streptococcus agalactiae reveals a key role in acid tolerance and virulence | Q38693689 | ||
| Interfering with Bacterial Quorum Sensing | Q38714614 | ||
| Regulation of Virulence in Staphylococcus aureus: Molecular Mechanisms and Remaining Puzzles | Q38772517 | ||
| Quorum Quenching Strategy Targeting Gram-Positive Pathogenic Bacteria | Q38831839 | ||
| Polypharmacology Approaches against the Pseudomonas aeruginosa MvfR Regulon and Their Application in Blocking Virulence and Antibiotic Tolerance | Q38852941 | ||
| Cyclodepsipeptides produced by actinomycetes inhibit cyclic-peptide-mediated quorum sensing in Gram-positive bacteria | Q38856105 | ||
| Riemerella anatipestifer lacks luxS, but can uptake exogenous autoinducer-2 to regulate biofilm formation | Q38990793 | ||
| Autoinducer 2 Signaling via the Phosphotransferase FruA Drives Galactose Utilization by Streptococcus pneumoniae, Resulting in Hypervirulence | Q39001121 | ||
| Pharmacological Targeting of the Host-Pathogen Interaction: Alternatives to Classical Antibiotics to Combat Drug-Resistant Superbugs | Q39173330 | ||
| Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance | Q39197564 | ||
| Biochemical and biophysical analysis of a chiral PqsD inhibitor revealing tight-binding behavior and enantiomers with contrary thermodynamic signatures | Q39338322 | ||
| Edwardsiella ictaluri LuxS: activity, expression, and involvement in pathogenicity. | Q39420329 | ||
| Biological activity and identification of a peptide inhibitor of LuxS from Streptococcus suis serotype 2. | Q33459427 | ||
| Can bacteria evolve resistance to quorum sensing disruption? | Q33632154 | ||
| VLP-based vaccine induces immune control of Staphylococcus aureus virulence regulation | Q33677615 | ||
| Molecular Mechanism of Quorum-Sensing in Enterococcus faecalis: Its Role in Virulence and Therapeutic Approaches | Q33754949 | ||
| Autoinducer-2 Quorum Sensing Influences Viability of Escherichia coli O157:H7 under Osmotic and In Vitro Gastrointestinal Stress Conditions | Q33790209 | ||
| Acyl homoserine-lactone quorum-sensing signal generation | Q33858545 | ||
| Simplified AIP-II Peptidomimetics Are Potent Inhibitors of Staphylococcus aureus AgrC Quorum Sensing Receptors. | Q33894378 | ||
| Interference with Pseudomonas quinolone signal synthesis inhibits virulence factor expression by Pseudomonas aeruginosa | Q33944784 | ||
| Inhibition of virulence gene expression in Staphylococcus aureus by novel depsipeptides from a marine photobacterium | Q34169738 | ||
| Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases. | Q34439737 | ||
| Non-antibiotic quorum sensing inhibitors acting against N-acyl homoserine lactone synthase as druggable target | Q34580774 | ||
| Methylthioadenosine/S-adenosylhomocysteine nucleosidase, a critical enzyme for bacterial metabolism | Q34672769 | ||
| Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials | Q35050042 | ||
| Novel quorum-quenching agents promote methicillin-resistant Staphylococcus aureus (MRSA) wound healing and sensitize MRSA to β-lactam antibiotics | Q35076859 | ||
| ω-Hydroxyemodin limits staphylococcus aureus quorum sensing-mediated pathogenesis and inflammation. | Q35169008 | ||
| Evolution of acyl-substrate recognition by a family of acyl-homoserine lactone synthases. | Q35424287 | ||
| Role of methylthioadenosine/S-adenosylhomocysteine nucleosidase in Vibrio cholerae cellular communication and biofilm development. | Q35588921 | ||
| Quorum quenching quandary: resistance to antivirulence compounds | Q35758927 | ||
| Autoinducer-2 regulates Pseudomonas aeruginosa PAO1 biofilm formation and virulence production in a dose-dependent manner | Q35792742 | ||
| Mechanism of action of S-ribosylhomocysteinase (LuxS). | Q35902752 | ||
| Recent Advances in Ligand and Structure Based Screening of Potent Quorum Sensing Inhibitors Against Antibiotic Resistance Induced Bacterial Virulence | Q36088996 | ||
| Designed Small-Molecule Inhibitors of the Anthranilyl-CoA Synthetase PqsA Block Quinolone Biosynthesis in Pseudomonas aeruginosa | Q36141081 | ||
| Mechanistic analysis of a synthetic inhibitor of the Pseudomonas aeruginosa LasI quorum-sensing signal synthase. | Q36305679 | ||
| Exploiting quorum sensing to confuse bacterial pathogens | Q36667376 | ||
| S-Ribosylhomocysteine analogues with the carbon-5 and sulfur atoms replaced by a vinyl or (fluoro)vinyl unit | Q36744732 | ||
| Structure and inhibition of a quorum sensing target from Streptococcus pneumoniae | Q36840500 | ||
| Discovery of antivirulence agents against methicillin-resistant Staphylococcus aureus | Q37036588 | ||
| The Crp-activated small noncoding regulatory RNA CyaR (RyeE) links nutritional status to group behavior | Q37051352 | ||
| Design and synthesis of potent "sulfur-free" transition state analogue inhibitors of 5'-methylthioadenosine nucleosidase and 5'-methylthioadenosine phosphorylase | Q37091234 | ||
| A high-throughput screen for quorum-sensing inhibitors that target acyl-homoserine lactone synthases | Q37117945 | ||
| Probing the catalytic mechanism of S-ribosylhomocysteinase (LuxS) with catalytic intermediates and substrate analogues | Q37124553 | ||
| Highly Stable, Amide-Bridged Autoinducing Peptide Analogues that Strongly Inhibit the AgrC Quorum Sensing Receptor in Staphylococcus aureus | Q37149488 | ||
| Attenuation of Edwardsiella tarda virulence by small peptides that interfere with LuxS/autoinducer type 2 quorum sensing | Q37232414 | ||
| Quorum sensing signal-response systems in Gram-negative bacteria | Q37324474 | ||
| Ambuic acid inhibits the biosynthesis of cyclic peptide quormones in gram-positive bacteria | Q42111795 | ||
| Functional analysis of luxS in the probiotic strain Lactobacillus rhamnosus GG reveals a central metabolic role important for growth and biofilm formation | Q42125989 | ||
| Methylthioadenosine/S-adenosylhomocysteine nucleosidase (Pfs) of Staphylococcus aureus is essential for the virulence independent of LuxS/AI-2 system. | Q42265583 | ||
| Functional Characterization of Triclosan-Resistant Enoyl-acyl-carrier Protein Reductase (FabV) in Pseudomonas aeruginosa | Q42362561 | ||
| Inhibition of S-ribosylhomocysteinase (LuxS) by substrate analogues modified at the ribosyl C-3 position | Q42588530 | ||
| The LuxS Based Quorum Sensing Governs Lactose Induced Biofilm Formation by Bacillus subtilis | Q43100378 | ||
| Growth deficiencies of Neisseria meningitidis pfs and luxS mutants are not due to inactivation of quorum sensing | Q43192633 | ||
| S-Ribosylhomocysteine analogs containing a [4-thio]ribose ring | Q43223907 | ||
| Regulation of autoinducer 2 production and luxS expression in a pathogenic Edwardsiella tarda strain | Q43590505 | ||
| Resistance to the quorum-quenching compounds brominated furanone C-30 and 5-fluorouracil in Pseudomonas aeruginosa clinical isolates. | Q43682863 | ||
| LuxS influences Escherichia coli biofilm formation through autoinducer-2-dependent and autoinducer-2-independent modalities | Q44214601 | ||
| Structure optimization of 2-benzamidobenzoic acids as PqsD inhibitors for Pseudomonas aeruginosa infections and elucidation of binding mode by SPR, STD NMR, and molecular docking | Q44250810 | ||
| High-level triclosan resistance in Pseudomonas aeruginosa is solely a result of efflux | Q44383185 | ||
| Catalytic mechanism of S-ribosylhomocysteinase (LuxS): direct observation of ketone intermediates by 13C NMR spectroscopy | Q44635056 | ||
| Structural comparison of MTA phosphorylase and MTA/AdoHcy nucleosidase explains substrate preferences and identifies regions exploitable for inhibitor design | Q44880352 | ||
| Combining in silico and biophysical methods for the development of Pseudomonas aeruginosa quorum sensing inhibitors: an alternative approach for structure-based drug design | Q46137425 | ||
| Immucillins in Infectious Diseases | Q46259033 | ||
| Characterization of S-adenosylhomocysteine/Methylthioadenosine nucleosidase on secretion of AI-2 and biofilm formation of Escherichia coli | Q46368826 | ||
| Autoinducer-2 Facilitates Pseudomonas aeruginosa PAO1 Pathogenicity in Vitro and in Vivo | Q46515252 | ||
| Structural and Functional Analyses of Periplasmic 5'-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase from Aeromonas hydrophila. | Q47870481 | ||
| Transition State Analogue Inhibitors of 5'-Deoxyadenosine/5'-Methylthioadenosine Nucleosidase from Mycobacterium tuberculosis | Q47912078 | ||
| Survival of an Aggregatibacter actinomycetemcomitans quorum sensing luxS mutant in the mouths of Rhesus monkeys: insights into ecological adaptation | Q48312289 | ||
| Quorum-Sensing Systems as Targets for Antivirulence Therapy | Q49046920 | ||
| Therapeutic Targeting of the Staphylococcus aureus Accessory Gene Regulator (agr) System | Q49188630 | ||
| Autoinducer 2-dependent Escherichia coli biofilm formation is enhanced in a dual-species co-culture | Q50230766 | ||
| Synthesis of isomeric analogues of S-ribosylhomocysteine analogues with homocysteine unit attached to C2 of ribose. | Q51096151 | ||
| CRISPR-Based Antibacterials: Transforming Bacterial Defense into Offense. | Q52429399 | ||
| Linear peptidomimetics as potent antagonists of Staphylococcus aureus agr quorum sensing. | Q52687686 | ||
| The Impairment of Methyl Metabolism From luxS Mutation of Streptococcus mutans. | Q52691266 | ||
| Design and synthesis of substrate and intermediate analogue inhibitors of S-ribosylhomocysteinase. | Q53623563 | ||
| Development of molecularly imprinted polymers to block quorum sensing and inhibit bacterial biofilm formation. | Q53681307 | ||
| Avellanin C, an inhibitor of quorum-sensing signaling in Staphylococcus aureus, from Hamigera ingelheimensis. | Q54173212 | ||
| The LuxS/AI-2 Quorum-Sensing System of Streptococcus pneumoniae Is Required to Cause Disease, and to Regulate Virulence- and Metabolism-Related Genes in a Rat Model of Middle Ear Infection. | Q54204920 | ||
| Terrein is an inhibitor of quorum sensing and c-di-GMP in Pseudomonas aeruginosa: a connection between quorum sensing and c-di-GMP. | Q55265092 | ||
| Quorum sensing in thermophiles: prevalence of autoinducer-2 system. | Q55514021 | ||
| Small-molecule AgrA inhibitors F12 and F19 act as antivirulence agents against Gram-positive pathogens | Q57062562 | ||
| Investigating the Mechanism of Action of Diketopiperazines Inhibitors of the Quorum Sensing Synthase CepI: A Site-Directed Mutagenesis Study | Q57173956 | ||
| Biofilm formation by Pseudomonas aeruginosa in solid murine tumors – a novel model system | Q57542537 | ||
| Methylthioadenosine Suppresses Salmonella Virulence | Q58721434 | ||
| Biosynthesis of 2-Alkyl-4(1H)-Quinolones in Pseudomonas aeruginosa: Potential for Therapeutic Interference with Pathogenicity | Q61859113 | ||
| Application of an agr-Specific Antivirulence Compound as Therapy for Staphylococcus aureus-Induced Inflammatory Skin Disease | Q62368248 | ||
| Developments in strategies for Quorum Sensing virulence factor inhibition to combat bacterial drug resistance | Q62631260 | ||
| Anti-Quorum Sensing Natural Compounds. | Q64986706 | ||
| Synthesis of LuxS inhibitors targeting bacterial cell-cell communication | Q80494628 | ||
| A role for type I signal peptidase in Staphylococcus aureus quorum sensing | Q80562862 | ||
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | multiple drug resistance | Q643839 |
| quorum sensing | Q905754 | ||
| virulence | Q1460232 | ||
| bacteria | Q10876 | ||
| antibiotic | Q12187 | ||
| physiological adaptation | Q67080983 | ||
| biological adaptation | Q67504163 | ||
| P304 | page(s) | 444 | |
| P577 | publication date | 2018-01-01 | |
| 2019-02-05 | |||
| P1433 | published in | Frontiers in Cellular and Infection Microbiology | Q27724376 |
| P1476 | title | Interference With Quorum-Sensing Signal Biosynthesis as a Promising Therapeutic Strategy Against Multidrug-Resistant Pathogens | |
| P478 | volume | 8 |
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