Switching on Endogenous Metal Binding Proteins in Parkinson's Disease

scientific article published on 19 February 2019

Switching on Endogenous Metal Binding Proteins in Parkinson's Disease is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3390/CELLS8020179
P932PMC publication ID6406413
P698PubMed publication ID30791479

P50authorRoger ChungQ53110401
Fleur McLearyQ63365244
Rowan RadfordQ63890163
Peter FallerQ50036921
P2093author name stringDean L Pountney
Michael Goulding
Alexandre N Rcom-H'cheo-Gauthier
Yuho Okita
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Raised calcium and oxidative stress cooperatively promote alpha-synuclein aggregate formationQ38060447
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Calcipotriol inhibits α-synuclein aggregation in SH-SY5Y neuroblastoma cells by a Calbindin-D28k-dependent mechanismQ38717826
Copper dyshomoeostasis in Parkinson's disease: implications for pathogenesis and indications for novel therapeuticsQ38766440
Amyotrophic lateral sclerosis-like superoxide dismutase 1 proteinopathy is associated with neuronal loss in Parkinson's disease brainQ38773599
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Non-ceruloplasmin bound copper and ATP7B gene variants in Alzheimer's disease.Q51587028
Alpha-synuclein aggregates activate calcium pump SERCA leading to calcium dysregulation.Q51732455
Brain iron and ferritin in Parkinson's and Alzheimer's diseases.Q53184175
Up-regulation of metallothionein gene expression in parkinsonian astrocytes.Q54356779
Striking while the iron is hot: Iron metabolism and ferroptosis in neurodegenerationQ57666825
Model Senescent Microglia Induce Disease Related Changes in α-Synuclein Expression and ActivityQ58804178
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Accumulation of copper and other metal ions, and metallothionein I/II expression in the bovine brain as a function of agingQ60955728
Neurite Collapse and Altered ER Ca Control in Human Parkinson Disease Patient iPSC-Derived Neurons with LRRK2 G2019S MutationQ61454783
Recruitment of calbindin into nigral dopamine neurons protects against MPTP-Induced parkinsonismQ64376686
Parkinson's disease: a short story of 200 yearsQ64791337
A Proposed Mechanism for Neurodegeneration in Movement Disorders Characterized by Metal Dyshomeostasis and Oxidative StressQ64868269
Raised cerebrospinal-fluid copper concentration in Parkinson's diseaseQ69903302
Ceruloplasmin oxidation, a feature of Parkinson's disease CSF, inhibits ferroxidase activity and promotes cellular iron retentionQ82968961
Calcium: Alpha-Synuclein Interactions in Alpha-SynucleinopathiesQ39075636
Potential Modes of Intercellular α-Synuclein TransmissionQ39152836
Alpha-synuclein aggregates are excluded from calbindin-D28k-positive neurons in dementia with Lewy bodies and a unilateral rotenone mouse modelQ39286106
Iron transport proteins: Gateways of cellular and systemic iron homeostasisQ39374086
alpha-Synuclein modulation of Ca2+ signaling in human neuroblastoma (SH-SY5Y) cellsQ39782960
Human metallothionein gene expression is upregulated by beta-thujaplicin: possible involvement of protein kinase C and reactive oxygen speciesQ40333665
Meis1 promotes poly (rC)-binding protein 2 expression and inhibits angiotensin II-induced cardiomyocyte hypertrophyQ41103735
Midbrain dopaminergic cell loss in Parkinson's disease and MPTP-induced parkinsonism: sparing of calbindin-D28k-containing cellsQ41843416
The involvement of dityrosine crosslinking in α-synuclein assembly and deposition in Lewy Bodies in Parkinson's diseaseQ42351555
α-Synuclein impairs ferritinophagy in the retinal pigment epithelium: Implications for retinal iron dyshomeostasis in Parkinson's diseaseQ42373959
Age-related changes in calbindin-D28k, calretinin, and parvalbumin-immunoreactive neurons in the human cerebral cortexQ42443528
Reduced ferroxidase activity in the cerebrospinal fluid from patients with Parkinson's diseaseQ42472074
Adrenergic nerves compensate for a decline in calcium buffering during ageing.Q42495049
Three functional facets of calbindin D-28kQ42581477
Metallothioneins I/II are involved in the neuroprotective effect of sildenafil in focal brain injury.Q44008754
Copper pathology in vulnerable brain regions in Parkinson's diseaseQ44278519
The neuroprotective effect of overexpression of calbindin-D(28k) in an animal model of Parkinson's diseaseQ44563974
Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease.Q46009075
Chemistry of mammalian metallothioneins and their interaction with amyloidogenic peptides and proteinsQ46266209
α-Synuclein-Dependent Calcium Entry Underlies Differential Sensitivity of Cultured SN and VTA Dopaminergic Neurons to a Parkinsonian Neurotoxin.Q47135899
A low blood copper concentration is a co-morbidity burden factor in Parkinson's disease developmentQ47333037
Accumulation of dysfunctional SOD1 protein in Parkinson's disease is not associated with mutations in the SOD1 gene.Q47593429
Dexamethasone Inhibits Copper-Induced Alpha-Synuclein Aggregation by a Metallothionein-Dependent MechanismQ47611418
Subcellular compartmentalisation of copper, iron, manganese, and zinc in the Parkinson's disease brain.Q47614352
Iron promotes α-synuclein aggregation and transmission by inhibiting TFEB-mediated autophagosome-lysosome fusionQ47648956
Astroglial and microglial contributions to iron metabolism disturbance in Parkinson's diseaseQ47873659
Alpha-synuclein ferrireductase activity is detectible in vivo, is altered in Parkinson's disease and increases the neurotoxicity of DOPAL.Q47948873
Neurodegeneration with inflammation is accompanied by accumulation of iron and ferritin in microglia and neurons.Q48266120
Clinical utility of copper, ceruloplasmin, and metallothionein plasma determinations in human neurodegenerative patients and their first-degree relativesQ48372462
Degeneration in different parkinsonian syndromes relates to astrocyte type and astrocyte protein expressionQ48405912
Rare Disease Mechanisms Identified by Genealogical Proteomics of Copper Homeostasis Mutant PedigreesQ48514121
A novel glycosylphosphatidylinositol-anchored form of ceruloplasmin is expressed by mammalian astrocytesQ48638438
Relative sparing in Parkinson's disease of substantia nigra dopamine neurons containing calbindin-D28K.Q48899006
C-terminal calcium binding of α-synuclein modulates synaptic vesicle interactionQ49829897
Genetics of Parkinson diseaseQ50081370
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectParkinson's diseaseQ11085
alpha-synucleinQ24725459
metalQ11426
Parkinson’s DiseaseQ39074077
P304page(s)179
P577publication date2019-02-19
P1433published inCellsQ27724621
P1476titleSwitching on Endogenous Metal Binding Proteins in Parkinson's Disease
P478volume8

Reverse relations

cites work (P2860)
Q90319955Differential effects of Cu2+ and Fe3+ ions on in vitro amyloid formation of biologically-relevant α-synuclein variants
Q91962671Genetic Disorders Associated with Metal Metabolism
Q92028537Metal Chelation Therapy and Parkinson's Disease: A Critical Review on the Thermodynamics of Complex Formation between Relevant Metal Ions and Promising or Established Drugs
Q99635876The relationships of vitamin D, vitamin D receptor gene polymorphisms, and vitamin D supplementation with Parkinson's disease

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