Engineering of leucine-responsive regulatory protein improves spiramycin and bitespiramycin biosynthesis

scientific article published on 19 February 2019

Engineering of leucine-responsive regulatory protein improves spiramycin and bitespiramycin biosynthesis is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1112225101
P356DOI10.1186/S12934-019-1086-0
P932PMC publication ID6379999
P698PubMed publication ID30782164

P50authorWeiqing HeQ91720248
P2093author name stringXiaoting Zhang
Yiguang Wang
Zhili Lu
Jianlu Dai
P2860cites workEngineering of an Lrp family regulator SACE_Lrp improves erythromycin production in Saccharopolyspora erythraea.Q51117156
Expression of the alaE gene is positively regulated by the global regulator Lrp in response to intracellular accumulation of l-alanine in Escherichia coli.Q51214180
Identification of two regulatory genes involved in carbomycin biosynthesis in Streptomyces thermotolerans.Q53736108
Enhanced production of branched-chain amino acids by Gluconacetobacter europaeus with a specific regional deletion in a leucine responsive regulatorQ88198613
Structure of the Escherichia coli leucine-responsive regulatory protein Lrp reveals a novel octameric assemblyQ24684156
Regulation and characterization of the dadRAX locus for D-amino acid catabolism in Pseudomonas aeruginosa PAO1Q28492480
The Lrp family of transcription regulators in archaeaQ28744496
Cloning and expression of midecamycin 4"-acylase gene in spiramycin producing strains.Q31016940
Organization of the biosynthetic gene cluster for the macrolide antibiotic spiramycin in Streptomyces ambofaciensQ33307918
Glycosylation steps during spiramycin biosynthesis in Streptomyces ambofaciens: involvement of three glycosyltransferases and their interplay with two auxiliary proteinsQ33962799
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Regulation of the Biosynthesis of the Macrolide Antibiotic Spiramycin in Streptomyces ambofaciensQ34192714
Genomic and transcriptomic insights into the thermo-regulated biosynthesis of validamycin in Streptomyces hygroscopicus 5008.Q34349891
A consensus sequence for binding of Lrp to DNAQ35593078
Evolution of a global regulator: Lrp in four orders of γ-ProteobacteriaQ36024525
Lrp, a leucine-responsive protein, regulates branched-chain amino acid transport genes in Escherichia coliQ36109382
Leucine-responsive regulatory protein controls the expression of both the pap and fan pili operons in Escherichia coliQ36999517
Post-PKS tailoring steps of the spiramycin macrolactone ring in Streptomyces ambofaciensQ37036600
Leucine-responsive regulatory protein (Lrp) acts as a virulence repressor in Salmonella enterica serovar TyphimuriumQ37075381
Differential proteomic profiling reveals regulatory proteins and novel links between primary metabolism and spinosad production in Saccharopolyspora spinosaQ37606863
Global gene expression profiling in Escherichia coli K12. The effects of leucine-responsive regulatory proteinQ38364098
Specialised metabolites regulating antibiotic biosynthesis in Streptomyces spp.Q38861928
Leucine-responsive regulatory protein: a global regulator of gene expression in E. coliQ40945234
One-step high-efficiency CRISPR/Cas9-mediated genome editing in StreptomycesQ41296754
Cloning and nucleotide sequences of two genes involved in the 4''-O-acylation of macrolide antibiotics from Streptomyces thermotoleransQ42685119
Construction and physiological studies on a stable bioengineered strain of shengjimycinQ43554341
Leucine-regulated self-association of leucine-responsive regulatory protein (Lrp) from Escherichia coliQ43749956
Tissue distribution of bitespiramycin and spiramycin in ratsQ45138392
Leucine improves the component of isovalerylspiramycins for the production of bitespiramycinQ46179903
The local repressor AcrR plays a modulating role in the regulation of acrAB genes of Escherichia coli by global stress signalsQ46280464
Structural identification of bitespiramycin metabolites in rat: a single oral dose studyQ46601134
In vivo functions of the gamma-butyrolactone autoregulator receptor in Streptomyces ambofaciens producing spiramycinQ46867227
Methanol assimilation in Escherichia coli is improved by co-utilization of threonine and deletion of leucine-responsive regulatory proteinQ47285724
Leucine responsive regulatory protein is involved in methionine metabolism and polyamine homeostasis in acetic acid bacterium Komagataeibacter europaeusQ47862412
Characterization of an Lrp/AsnC family regulator SCO3361, controlling actinorhodin production and morphological development in Streptomyces coelicolorQ48030170
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectspiramycinQ422265
biotechnologyQ7108
bioengineeringQ580689
P304page(s)38
P577publication date2019-02-19
P1433published inMicrobial Cell FactoriesQ15766995
P1476titleEngineering of leucine-responsive regulatory protein improves spiramycin and bitespiramycin biosynthesis
P478volume18