Glycosylation steps during spiramycin biosynthesis in Streptomyces ambofaciens: involvement of three glycosyltransferases and their interplay with two auxiliary proteins

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Glycosylation steps during spiramycin biosynthesis in Streptomyces ambofaciens: involvement of three glycosyltransferases and their interplay with two auxiliary proteins is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/AAC.01602-09
P953full work available at URLhttps://europepmc.org/articles/pmc2897285?pdf=render
P932PMC publication ID2897285
P698PubMed publication ID20439613

P7228access restriction statusopen accessQ232932
P2093author name stringFatma Karray
Hoang Chuong Nguyen
Jean-Luc Pernodet
Josette Gagnat
Ahmed Lebrihi
Thuy Duong Ho Huynh
Sylvie Lautru
P2860cites workIn vitro reconstitution of EryCIII activity for the preparation of unnatural macrolidesQ24657200
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The structures of four macrolide antibiotics bound to the large ribosomal subunitQ27639442
An efficient recombination system for chromosome engineering in Escherichia coliQ29615038
A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxRQ29615324
PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosminQ30764407
Analysis of genes involved in 6-deoxyhexose biosynthesis and transfer in Saccharopolyspora erythraeaQ33181530
Organization of the biosynthetic gene cluster for the macrolide antibiotic spiramycin in Streptomyces ambofaciensQ33307918
In vitro characterization of the enzymes involved in TDP-D-forosamine biosynthesis in the spinosyn pathway of Saccharopolyspora spinosa.Q33618888
Nomenclature for macrolide and macrolide-lincosamide-streptogramin B resistance determinantsQ33785512
Macrolide resistance conferred by base substitutions in 23S rRNA.Q34106180
Resistance to spiramycin in Streptomyces ambofaciens, the producer organism, involves at least two different mechanisms.Q34306427
Resistance to the macrolide antibiotic tylosin is conferred by single methylations at 23S rRNA nucleotides G748 and A2058 acting in synergyQ34378672
Altering the glycosylation pattern of bioactive compoundsQ34402040
Functional analysis of desVIII homologues involved in glycosylation of macrolide antibiotics by interspecies complementationQ34574869
Modification of post-PKS tailoring steps through combinatorial biosynthesisQ34996044
The macrolide-lincosamide-streptogramin B resistance phenotypes characterized by using a specifically deleted, antibiotic-sensitive strain of Streptomyces lividansQ35122875
Translation and protein synthesis: macrolidesQ36034620
Engineering the glycosylation of natural products in actinomycetesQ36782462
AknT is an activating protein for the glycosyltransferase AknS in L-aminodeoxysugar transfer to the aglycone of aclacinomycin A.Q38325948
Characterization of a glycosyl transferase inactivating macrolides, encoded by gimA from Streptomyces ambofaciens.Q39559140
A rapid method for efficient gene replacement in the filamentous fungus Aspergillus nidulansQ39601017
Excisable cassettes: new tools for functional analysis of Streptomyces genomes.Q41487200
Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosaQ42649630
Two glycosyltransferases and a glycosidase are involved in oleandomycin modification during its biosynthesis by Streptomyces antibioticusQ42681734
Chapter 11. Sugar biosynthesis and modificationQ43168676
Feedback control of polyketide metabolism during tylosin productionQ43562808
Characterization of the glycosyltransferase activity of desVII: analysis of and implications for the biosynthesis of macrolide antibiotics.Q44909083
New olivosyl derivatives of methymycin/pikromycin from an engineered strain of Streptomyces venezuelaeQ45052530
Characterization of tylM3/tylM2 and mydC/mycB pairs required for efficient glycosyltransfer in macrolide antibiotic biosynthesisQ45196753
Antibiotic resistance gene cassettes derived from the omega interposon for use in E. coli and StreptomycesQ48049898
Characterization of a novel regulatory gene governing the expression of a polyketide synthase gene in Streptomyces ambofaciensQ48167415
In vitro insertional mutagenesis with a selectable DNA fragmentQ48387759
Stimulation of polyketide metabolism in Streptomyces fradiae by tylosin and its glycosylated precursors.Q52528621
Production of a novel polyketide through the construction of a hybrid polyketide synthase.Q53978015
Structure activity relationships of spiramycinsQ69913518
Biosynthesis of the anti-parasitic agent megalomicin: transformation of erythromycin to megalomicin in Saccharopolyspora erythraeaQ74266942
Substrate specificity of the macrolide-glycosylating enzyme pair DesVII/DesVIII: opportunities, limitations, and mechanistic hypothesesQ82832707
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectglycosylationQ898365
Streptomyces ambofaciensQ22286894
spiramycin IQ104909302
P6954online access statusopen accessQ232932
P304page(s)2830-2839
P577publication date2010-05-03
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titleGlycosylation steps during spiramycin biosynthesis in Streptomyces ambofaciens: involvement of three glycosyltransferases and their interplay with two auxiliary proteins
P478volume54

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cites work (P2860)
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Q33665576Time-Resolved Transcriptomics and Constraint-Based Modeling Identify System-Level Metabolic Features and Overexpression Targets to Increase Spiramycin Production in Streptomyces ambofaciens

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