Homozygous germ line mutation in exon 27 of murine Brca2 disrupts the Fancd2-Brca2 pathway in the homologous recombination-mediated DNA interstrand cross-links' repair but does not affect meiosis

scientific article published on 01 December 2005

Homozygous germ line mutation in exon 27 of murine Brca2 disrupts the Fancd2-Brca2 pathway in the homologous recombination-mediated DNA interstrand cross-links' repair but does not affect meiosis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/GCC.20255
P698PubMed publication ID16127665

P50authorBoyko S AtanassovQ53940121
P2093author name stringJ Carl Barrett
Barbara J Davis
P2860cites workBRCA2 deficiency in mice leads to meiotic impairment and infertilityQ28588378
Biallelic inactivation of BRCA2 in Fanconi anemiaQ29616130
BRCA2 is required for homology-directed repair of chromosomal breaksQ29618799
Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequencesQ34081887
Heterogeneity in Fanconi anemia: evidence for 2 new genetic subtypesQ34278200
Tracing the network connecting BRCA and Fanconi anaemia proteinsQ35730286
Truncated BRCA2 is cytoplasmic: implications for cancer-linked mutationsQ36703641
Repair kinetics of genomic interstrand DNA cross-links: evidence for DNA double-strand break-dependent activation of the Fanconi anemia/BRCA pathwayQ40376906
Deletion of Brca2 exon 27 causes hypersensitivity to DNA crosslinks, chromosomal instability, and reduced life span in mice.Q40666357
Cell cycle analysis and synchronization of the Xenopus cell line XL2.Q41025045
Regulated interaction of the Fanconi anemia protein, FANCD2, with chromatinQ45083320
BRCA2-dependent and independent formation of RAD51 nuclear foci.Q53939630
Modification of the alkaline Comet assay to allow simultaneous evaluation of mitomycin C-induced DNA cross-link damage and repair of specific DNA sequences in RT4 cellsQ73739195
BRCA1 and BRCA2 in breast cancer predisposition and recombination controlQ81042311
The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCGQ24290486
BRCA2 and homologous recombinationQ24291786
CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repairQ24299313
Direct interaction of FANCD2 with BRCA2 in DNA damage response pathwaysQ24338293
Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatinQ24563629
A Multiprotein Nuclear Complex Connects Fanconi Anemia and Bloom SyndromeQ24669612
Evidence for at least eight Fanconi anemia genesQ24678164
DNA damage response pathway uses histone modification to assemble a double-strand break-specific cohesin domainQ27937364
Genome maintenance mechanisms for preventing cancerQ28131737
Molecular views of recombination proteins and their controlQ28207872
Analysis of murine Brca2 reveals conservation of protein-protein interactions but differences in nuclear localization signalsQ28209536
Impaired DNA damage-induced nuclear Rad51 foci formation uniquely characterizes Fanconi anemia group D1Q28214715
Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2Q28236543
Association of BRCA1 with Rad51 in mitotic and meiotic cellsQ28302118
P433issue4
P407language of work or nameEnglishQ1860
P921main subjecthomozygosityQ114049690
P304page(s)429-437
P577publication date2005-12-01
P1433published inGenes, Chromosomes and CancerQ5532697
P1476titleHomozygous germ line mutation in exon 27 of murine Brca2 disrupts the Fancd2-Brca2 pathway in the homologous recombination-mediated DNA interstrand cross-links' repair but does not affect meiosis
P478volume44

Reverse relations

cites work (P2860)
Q37002955BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers
Q34655484BRCA2: a universal recombinase regulator.
Q37311285Degradation of BRCA2 in alkyltransferase-mediated DNA repair and its clinical implications
Q36267818Expression Quantitative Trait loci (QTL) in tumor adjacent normal breast tissue and breast tumor tissue
Q47870583Germline BRCA2 mutations and the risk of esophageal squamous cell carcinoma
Q24306511Interaction with the BRCA2 C terminus protects RAD51-DNA filaments from disassembly by BRC repeats
Q24307601Interactions between human BRCA2 protein and the meiosis-specific recombinase DMC1
Q37092814Mouse embryonic stem cell-based functional assay to evaluate mutations in BRCA2
Q28244296Mouse models of Fanconi anemia
Q26823605Oxidative stress, bone marrow failure, and genome instability in hematopoietic stem cells
Q64123909Rare Variants in Known Susceptibility Loci and Their Contribution to Risk of Lung Cancer
Q40020039Upregulated ATM gene expression and activated DNA crosslink-induced damage response checkpoint in Fanconi anemia: implications for carcinogenesis

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