Deinococcus radiodurans HD-Pnk, a Nucleic Acid End-Healing Enzyme, Abets Resistance to Killing by Ionizing Radiation and Mitomycin C

article published in 2018

Deinococcus radiodurans HD-Pnk, a Nucleic Acid End-Healing Enzyme, Abets Resistance to Killing by Ionizing Radiation and Mitomycin C is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JB.00151-18
P932PMC publication ID6088165
P698PubMed publication ID29891641

P50authorStewart ShumanQ66411198
P2093author name stringBrad J Schmier
P2860cites workA kinetic framework for tRNA ligase and enforcement of a 2'-phosphate requirement for ligation highlights the design logic of an RNA repair machineQ41864188
An end-healing enzyme from Clostridium thermocellum with 5' kinase, 2',3' phosphatase, and adenylyltransferase activitiesQ42010105
ATP-type DNA ligase requires other proteins for its activity in vitro and its operon components for radiation resistance in Deinococcus radiodurans in vivoQ42870047
Characterization of a 5'-polynucleotide kinase/3'-phosphatase from bacteriophage RM378.Q43016837
Pnk1, a DNA kinase/phosphatase required for normal response to DNA damage by gamma-radiation or camptothecin in Schizosaccharomyces pombeQ43812775
Characterization of a baculovirus enzyme with RNA ligase, polynucleotide 5'-kinase, and polynucleotide 3'-phosphatase activitiesQ44745282
Structural basis for the GTP specificity of the RNA kinase domain of fungal tRNA ligaseQ47171475
Oxidative stress damages rRNA inside the ribosome and differentially affects the catalytic centerQ47197769
Characterization and role of a 2',3'-cyclic phosphodiesterase from Deinococcus radiodurans.Q48154608
Crystal structure of the RNA 2',3'-cyclic phosphodiesterase from Deinococcus radiodurans.Q51020850
RNA under attack: cellular handling of RNA damageQ83002527
???Q27680429
Genome of the extremely radiation-resistant bacterium Deinococcus radiodurans viewed from the perspective of comparative genomicsQ24548476
Preserving genome integrity: the DdrA protein of Deinococcus radiodurans R1Q24804675
Structure-function analysis of the kinase-CPD domain of yeast tRNA ligase (Trl1) and requirements for complementation of tRNA splicing by a plant Trl1 homologQ25257339
The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolaseQ27673075
The Structural Basis for Substrate Recognition by Mammalian Polynucleotide Kinase 3′ PhosphataseQ27675396
Mitomycin C: small, fast and deadly (but very selective)Q28255522
Reassembly of shattered chromosomes in Deinococcus radioduransQ28265761
Analysis of Deinococcus radiodurans's transcriptional response to ionizing radiation and desiccation reveals novel proteins that contribute to extreme radioresistanceQ28485657
RNA cleavage and inhibition of protein synthesis by bleomycinQ30310489
Site-specific cleavage of RNA by Fe(II).bleomycinQ30441762
Oxidative stress resistance in Deinococcus radioduransQ30499016
The HD domain defines a new superfamily of metal-dependent phosphohydrolasesQ31944351
Enzymes involved in DNA ligation and end-healing in the radioresistant bacterium Deinococcus radioduransQ33294477
Deletion of the rnl gene encoding a nick-sealing RNA ligase sensitizes Deinococcus radiodurans to ionizing radiationQ33580464
Stable down-regulation of human polynucleotide kinase enhances spontaneous mutation frequency and sensitizes cells to genotoxic agentsQ33781435
Mitomycin C inhibits ribosomal RNA: a novel cytotoxic mechanism for bioreductive drugsQ33911220
An RNA ligase from Deinococcus radioduransQ33980934
Deinococcus radiodurans - the consummate survivorQ33991135
Deinococcus radiodurans RNA ligase exemplifies a novel ligase clade with a distinctive N-terminal module that is important for 5'-PO4 nick sealing and ligase adenylylation but dispensable for phosphodiester formation at an adenylylated nickQ34001771
gamma Ray induced deoxyribonucleic acid strand breaks. 3' Glycolate terminiQ34270825
Structure and mechanism of E. coli RNA 2',3'-cyclic phosphodiesteraseQ34363871
Structures of CRISPR Cas3 offer mechanistic insights into Cascade-activated DNA unwinding and degradationQ34433997
Transcriptome dynamics of Deinococcus radiodurans recovering from ionizing radiationQ34922870
An HD-domain phosphodiesterase mediates cooperative hydrolysis of c-di-AMP to affect bacterial growth and virulenceQ35128803
Reconstitution and structure of a bacterial Pnkp1-Rnl-Hen1 RNA repair complexQ35543262
Structure and two-metal mechanism of a eukaryal nick-sealing RNA ligaseQ36300386
Bacterial DNA repair by non-homologous end joiningQ36972411
Effects of 3'-OH and 5'-PO4 base mispairs and damaged base lesions on the fidelity of nick sealing by Deinococcus radiodurans RNA ligaseQ37713148
Characterization of Runella slithyformis HD-Pnk, a bifunctional DNA/RNA end-healing enzyme composed of an N-terminal 2',3' -phosphoesterase HD domain and a C-terminal 5' -OH polynucleotide kinase domainQ39147497
Mutational analysis defines the 5'-kinase and 3'-phosphatase active sites of T4 polynucleotide kinaseQ39530891
P433issue17
P407language of work or nameEnglishQ1860
P921main subjectDeinococcus radioduransQ386827
P577publication date2018-09-01
P1433published inJournal of BacteriologyQ478419
P1476titleDeinococcus radiodurans HD-Pnk, a Nucleic Acid End-Healing Enzyme, Abets Resistance to Killing by Ionizing Radiation and Mitomycin C
P478volume200

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cites work (P2860)
Q58595875Conservation and diversity of radiation and oxidative stress resistance mechanisms in Deinococcus species
Q92500817Structure-Function Analysis of the Phosphoesterase Component of the Nucleic Acid End-Healing Enzyme Runella slithyformis HD-Pnk

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