KMT2C mediates the estrogen dependence of breast cancer through regulation of ERα enhancer function.

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KMT2C mediates the estrogen dependence of breast cancer through regulation of ERα enhancer function. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1103956827
P356DOI10.1038/S41388-018-0273-5
P932PMC publication ID6107480
P698PubMed publication ID29755131

P50authorPedram RazaviQ63869181
James J HsiehQ88029561
Sarat ChandarlapatyQ88608703
Qing LiQ88654166
P2093author name stringOmar Abdel-Wahab
Nikolaus Schultz
Alessandro Pastore
Michael Berger
Amit Sinha
Young Rock Chung
Francisco Sanchez-Vega
Ronald Hendrickson
Kinisha Gala
Madeline Dorso
P2860cites workOxidative stress and AP-1 activity in tamoxifen-resistant breast tumors in vivoQ73270417
Model-based analysis of ChIP-Seq (MACS)Q21183902
Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteinsQ24336785
Multiplex genome engineering using CRISPR/Cas systemsQ24609428
Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identitiesQ24617969
Histone H3K27ac separates active from poised enhancers and predicts developmental stateQ24628758
FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcriptionQ24645118
Progesterone receptor modulates ERα action in breast cancerQ27316268
ESR1 ligand-binding domain mutations in hormone-resistant breast cancerQ27852637
Fast gapped-read alignment with Bowtie 2Q27860699
Comprehensive Molecular Portraits of Invasive Lobular Breast CancerQ28268284
Whole-genome analysis informs breast cancer response to aromatase inhibitionQ28269291
Mutational landscape and significance across 12 major cancer typesQ28300353
A Myc network accounts for similarities between embryonic stem and cancer cell transcription programsQ28507017
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2Q29547403
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroupsQ29614700
Genome-wide analysis of estrogen receptor binding sitesQ29614765
STAR: ultrafast universal RNA-seq alignerQ29615052
DNA targeting specificity of RNA-guided Cas9 nucleasesQ29615793
Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sitesQ29620551
Estrogen receptor expression and function in long-term estrogen-deprived human breast cancer cellsQ30472602
In-depth genomic data analyses revealed complex transcriptional and epigenetic dysregulations of BRAFV600E in melanomaQ30936571
Enhanced NF kappa B and AP-1 transcriptional activity associated with antiestrogen resistant breast cancerQ33281087
Oncogenic BRAF regulates melanoma proliferation through the lineage specific factor MITF.Q33352015
HOXC10 is overexpressed in breast cancer and transcriptionally regulated by estrogen via involvement of histone methylases MLL3 and MLL4.Q34238519
Modification of enhancer chromatin: what, how, and why?Q34331930
featureCounts: an efficient general purpose program for assigning sequence reads to genomic featuresQ34384848
MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemiaQ34386922
H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiationQ34394362
Crucial roles of mixed-lineage leukemia 3 and 4 as epigenetic switches of the hepatic circadian clock controlling bile acid homeostasis in miceQ34444945
FOXA1 is a key determinant of estrogen receptor function and endocrine responseQ34508204
Histone methylases MLL1 and MLL3 coordinate with estrogen receptors in estrogen-mediated HOXB9 expressionQ34861446
Histone H3K4 trimethylation by MLL3 as part of ASCOM complex is critical for NR activation of bile acid transporter genes and is downregulated in cholestasisQ34979974
A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4Q34980453
Detecting somatic genetic alterations in tumor specimens by exon capture and massively parallel sequencing.Q35032007
An optimized microRNA backbone for effective single-copy RNAiQ35065928
HOXC6 Is transcriptionally regulated via coordination of MLL histone methylase and estrogen receptor in an estrogen environmentQ35127065
Estrogen induces c-myc gene expression via an upstream enhancer activated by the estrogen receptor and the AP-1 transcription factorQ35193155
Estrogen receptor-alpha expression in the mammary epithelium is required for ductal and alveolar morphogenesis in miceQ35990241
BRAFV600E remodels the melanocyte transcriptome and induces BANCR to regulate melanoma cell migrationQ36021702
BPTF is required for c-MYC transcriptional activity and in vivo tumorigenesis.Q36506766
Histone methyltransferase MLL3 contributes to genome-scale circadian transcriptionQ36567973
Activating signal cointegrator-2 is an essential adaptor to recruit histone H3 lysine 4 methyltransferases MLL3 and MLL4 to the liver X receptorsQ36710181
Blockade of AP-1 Potentiates Endocrine Therapy and Overcomes Resistance.Q36902056
Antisense transcript long noncoding RNA (lncRNA) HOTAIR is transcriptionally induced by estradiolQ36920160
c-MYC partners with BPTF in human cancer.Q37008590
Crucial roles for interactions between MLL3/4 and INI1 in nuclear receptor transactivationQ37176269
Mammary-Stem-Cell-Based Somatic Mouse Models Reveal Breast Cancer Drivers Causing Cell Fate DysregulationQ37349731
ASCOM controls farnesoid X receptor transactivation through its associated histone H3 lysine 4 methyltransferase activityQ37369784
Increased activator protein-1 DNA binding and c-Jun NH2-terminal kinase activity in human breast tumors with acquired tamoxifen resistanceQ38327743
Expression Levels of KMT2C and SLC20A1 Identified by Information-theoretical Analysis Are Powerful Prognostic Biomarkers in Estrogen Receptor-positive Breast CancerQ39093822
Endogenous purification reveals GREB1 as a key estrogen receptor regulatory factorQ39195669
Integrative model of genomic factors for determining binding site selection by estrogen receptor-αQ39616908
Progression of MCF-7 breast cancer cells to antiestrogen-resistant phenotype is accompanied by elevated levels of AP-1 DNA-binding activity.Q41220529
Gene expression signature associated with BRAF mutations in human primary cutaneous melanomasQ41251515
Estrogen deprivation causes estradiol hypersensitivity in human breast cancer cellsQ41291278
Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription.Q42972194
Molecular changes in tamoxifen-resistant breast cancer: relationship between estrogen receptor, HER-2, and p38 mitogen-activated protein kinaseQ45309214
Rapid immunoprecipitation mass spectrometry of endogenous proteins (RIME) for analysis of chromatin complexes.Q48256635
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesDESeq2Q113018293
GSVAQ113334751
P433issue34
P407language of work or nameEnglishQ1860
P304page(s)4692-4710
P577publication date2018-05-14
P1433published inOncogeneQ1568657
P1476titleKMT2C mediates the estrogen dependence of breast cancer through regulation of ERα enhancer function
P478volume37

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cites work (P2860)
Q92564167Effect of the key histone modifications on the expression of genes related to breast cancer
Q92227242Genomic characterization of metastatic breast cancers
Q92853921Germline Variants in Driver Genes of Breast Cancer and Their Association with Familial and Early-Onset Breast Cancer Risk in a Chilean Population
Q92387567Histone methyltransferases regulate the transcriptional expression of ERα and the proliferation of tamoxifen-resistant breast cancer cells
Q58718563Mechanisms for estrogen receptor expression in human cancer
Q90539392MutEx: a multifaceted gateway for exploring integrative pan-cancer genomic data
Q58699733TET2 coactivates gene expression through demethylation of enhancers
Q101476170Targeted sequencing reveals the somatic mutation landscape in a Swedish breast cancer cohort
Q94465327Whole-Genome Sequencing and Target Validation Analysis of Müllerian Adenosarcoma: A Tumor With Complex but Specific Genetic Alterations
Q99565341XIST lost induces ovarian cancer stem cells to acquire taxol resistance via a KMT2C-dependent way
Q61806992deepDriver: Predicting Cancer Driver Genes Based on Somatic Mutations Using Deep Convolutional Neural Networks

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