In-depth genomic data analyses revealed complex transcriptional and epigenetic dysregulations of BRAFV600E in melanoma

scientific article

In-depth genomic data analyses revealed complex transcriptional and epigenetic dysregulations of BRAFV600E in melanoma is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1050278072
P356DOI10.1186/S12943-015-0328-Y
P932PMC publication ID4373107
P698PubMed publication ID25890285
P5875ResearchGate publication ID273702824

P50authorYaomin XuQ90344508
P2093author name stringZhongming Zhao
Xingyi Guo
P2860cites workA landscape of driver mutations in melanomaQ24603357
Melanoma genome sequencing reveals frequent PREX2 mutationsQ24610463
Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulationQ24629474
Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutationsQ24632064
Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trialQ27851856
Integrated genomic analyses of ovarian carcinomaQ27860518
Linear models and empirical bayes methods for assessing differential expression in microarray experimentsQ27860758
Mutations of the BRAF gene in human cancerQ27860760
edgeR: a Bioconductor package for differential expression analysis of digital gene expression dataQ27860819
The epigenomics of cancerQ28289975
TGF-β regulates DNA methyltransferase expression in prostate cancer, correlates with aggressive capabilities, and predicts disease recurrenceQ28477306
Oncogenic BRAF(V600E) promotes stromal cell-mediated immunosuppression via induction of interleukin-1 in melanomaQ39304634
Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma.Q39604101
Cross-talk between aryl hydrocarbon receptor and mitogen-activated protein kinase signaling pathway in liver cancer through c-raf transcriptional regulationQ39949896
Evidence for an aryl hydrocarbon receptor-mediated cytochrome p450 autoregulatory pathwayQ40089340
Elevated expression of MITF counteracts B-RAF-stimulated melanocyte and melanoma cell proliferationQ40380155
Gene expression signature associated with BRAF mutations in human primary cutaneous melanomasQ41251515
Antitumor effects of liposomal IL1? and TNF? against the pulmonary metastases of the B16F10 murine melanoma in syngeneic miceQ54169077
Poems syndrome with high interleukin (IL)6 and IL1β serum levels, in a patient with thyroid carcinoma and melanomaQ56967004
IL-1β Upregulates IL-8 Production in Human Müller Cells Through Activation of the p38 MAPK and ERK1/2 Signaling PathwaysQ63407236
Routine multiplex mutational profiling of melanomas enables enrollment in genotype-driven therapeutic trialsQ28730438
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanomaQ29614282
Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3KQ29614757
Cancer epigenetics: from mechanism to therapyQ29614799
Distinct sets of genetic alterations in melanomaQ29614965
COT drives resistance to RAF inhibition through MAP kinase pathway reactivationQ29615032
Improved survival with MEK inhibition in BRAF-mutated melanomaQ29620663
Oncogenic BRAF regulates melanoma proliferation through the lineage specific factor MITF.Q33352015
Oncogenic BRAFV600E induces expression of neuronal differentiation marker MAP2 in melanoma cells by promoter demethylation and down-regulation of transcription repressor HES1.Q33581231
Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarraysQ33593399
A meta-analysis of somatic mutations from next generation sequencing of 241 melanomas: a road map for the study of genes with potential clinical relevanceQ33875566
Response of BRAF-mutant melanoma to BRAF inhibition is mediated by a network of transcriptional regulators of glycolysisQ33946905
Incidence of the V600K mutation among melanoma patients with BRAF mutations, and potential therapeutic response to the specific BRAF inhibitor PLX4032.Q34049618
The aryl hydrocarbon receptor functions as a tumor suppressor of liver carcinogenesisQ34128053
A melanoma cell state distinction influences sensitivity to MAPK pathway inhibitorsQ34132936
Seminal plasma induces the expression of IL-1α in normal and neoplastic cervical cells via EP2/EGFR/PI3K/AKT pathwayQ34199061
Directed phenotype switching as an effective antimelanoma strategy.Q34352683
Somatic activation of KIT in distinct subtypes of melanomaQ34569987
Snowball: resampling combined with distance-based regression to discover transcriptional consequences of a driver mutationQ34737289
Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancerQ35134003
The INK4a/ARF locus and melanomaQ35146563
New Perspectives of "omics" Applications in Melanoma ResearchQ35670683
The BRAF(V600E) causes widespread alterations in gene methylation in the genome of melanoma cellsQ35801395
BRAFV600E remodels the melanocyte transcriptome and induces BANCR to regulate melanoma cell migrationQ36021702
Role of transforming growth factor Beta in human cancerQ36073421
Epidermal growth factor (EGF) and interleukin (IL)-1β synergistically promote ERK1/2-mediated invasive breast ductal cancer cell migration and invasionQ36510571
Down-regulation of TGF-beta receptors in human colorectal cancer: implications for cancer developmentQ36620077
BCL2A1 is a lineage-specific antiapoptotic melanoma oncogene that confers resistance to BRAF inhibition.Q36692818
Whole-genome sequencing identifies a recurrent functional synonymous mutation in melanomaQ37104104
The genetic landscape of clinical resistance to RAF inhibition in metastatic melanomaQ37626102
Resistance to transforming growth factor β-mediated tumor suppression in melanoma: are multiple mechanisms in place?Q37775417
Cancer epigenomics: beyond genomicsQ37991917
Genetics and epigenetics of cutaneous malignant melanoma: a concert out of tune.Q38002668
Role of aryl hydrocarbon receptor in cancer.Q38109748
A melanocyte lineage program confers resistance to MAP kinase pathway inhibitionQ39067618
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that useslimmaQ112236343
P304page(s)60
P577publication date2015-03-14
P1433published inMolecular CancerQ15724585
P1476titleIn-depth genomic data analyses revealed complex transcriptional and epigenetic dysregulations of BRAFV600E in melanoma
P478volume14

Reverse relations

cites work (P2860)
Q41911805ALDH1A1 and HLTF modulate the activity of lysosomal autophagy inhibitors in cancer cells
Q36111466An integrative genomics approach for identifying novel functional consequences of PBRM1 truncated mutations in clear cell renal cell carcinoma (ccRCC).
Q38994275Comparison of Five Different Assays for the Detection of BRAF Mutations in Formalin-Fixed Paraffin Embedded Tissues of Patients with Metastatic Melanoma
Q26778761Epigenetic mechanisms involved in melanoma pathogenesis and chemoresistance
Q42516254Epigenetics of Skin Cancer: Interventions by selected bioactive Phytochemicals.
Q64884689KMT2C mediates the estrogen dependence of breast cancer through regulation of ERα enhancer function.
Q39257898Transcriptome- and proteome-oriented identification of dysregulated eIF4G, STAT3, and Hippo pathways altered by PIK3CA H1047R in HER2/ER-positive breast cancer