The Pre-clinical Toolbox of Pharmacokinetics and Pharmacodynamics: in vitro and ex vivo Models.

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The Pre-clinical Toolbox of Pharmacokinetics and Pharmacodynamics: in vitro and ex vivo Models. is …
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scholarly articleQ13442814
review articleQ7318358

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P356DOI10.3389/FPHAR.2019.00578
P932PMC publication ID6543330
P698PubMed publication ID31178736

P50authorCarolina HerreraQ116679881
P2860cites workFirst phase 1 double-blind, placebo-controlled, randomized rectal microbicide trial using UC781 gel with a novel index of ex vivo efficacyQ21135264
Hormonal contraception and the risk of HIV acquisition: an individual participant data meta-analysisQ21144588
Identification of gammaretroviruses constitutively released from cell lines used for human immunodeficiency virus researchQ24651042
HIV Drug Resistance: Problems and PerspectivesQ26864534
μOrgano: A Lego®-Like Plug & Play System for Modular Multi-Organ-ChipsQ27315172
New candidate biomarkers in the female genital tract to evaluate microbicide toxicityQ27334382
Drug transporters in tissues and cells relevant to sexual transmission of HIV: Implications for drug deliveryQ28081272
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal nicheQ28239639
HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapyQ28339571
In vitro and ex vivo testing of tenofovir shows it is effective as an HIV-1 microbicideQ28472968
Prevention of SIV rectal transmission and priming of T cell responses in macaques after local pre-exposure application of tenofovir gelQ28473376
Global expression of molecular transporters in the human vaginal tract: implications for HIV chemoprophylaxisQ28534412
Correlation between compartmental tenofovir concentrations and an ex vivo rectal biopsy model of tissue infectibility in the RMP-02/MTN-006 phase 1 studyQ28544439
Expression of Genes for Drug Transporters in the Human Female Genital Tract and Modulatory Effect of Antiretroviral DrugsQ28548592
Coreceptor usage of primary human immunodeficiency virus type 1 isolates varies according to biological phenotypeQ28646874
Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy.Q29619254
Infection of HTLV-III/LAV in HTLV-I-carrying cells MT-2 and MT-4 and application in a plaque assayQ29619255
Effects of CCR5 and CD4 cell surface concentrations on infections by macrophagetropic isolates of human immunodeficiency virus type 1.Q29622903
Formulation, pharmacokinetics and pharmacodynamics of topical microbicidesQ30412592
Primary genotypic and phenotypic HIV-1 drug resistance in recent seroconverters in MadridQ32165620
Restricted expression of human T-cell leukemia--lymphoma virus (HTLV) in transformed human umbilical cord blood lymphocytesQ42822749
Microbicide trial screeches to a haltQ42841576
Enhanced levels of functional HIV-1 co-receptors on human mucosal T cells demonstrated using intestinal biopsy tissueQ43565951
Interim guidance for clinicians considering the use of preexposure prophylaxis for the prevention of HIV infection in heterosexually active adultsQ44109830
Interleukin (IL)-1, IL-6, and IL-8 predict mucosal toxicity of vaginal microbicidal contraceptivesQ44884891
Formulation and transport properties of tenofovir loaded liposomes through Caco-2 cell modelQ45366387
Antigens Encoded by the 3′-Terminal Region of Human T-Cell Leukemia Virus: Evidence for a Functional GeneQ45807592
Antiretroviral-drug resistance among patients recently infected with HIV.Q46277555
Prospects for passive immunity to prevent HIV infectionQ46621371
A human colorectal explant culture to evaluate topical microbicides for the prevention of HIV infectionQ46736849
In vitro enteroid-derived three-dimensional tissue model of human small intestinal epithelium with innate immune responsesQ47109988
Microphysiologic systems in female reproductive biologyQ47600086
In Silico and in Vitro Screening for P-Glycoprotein Interaction with Tenofovir, Darunavir, and Dapivirine: An Antiretroviral Drug Combination for Topical Prevention of Colorectal HIV TransmissionQ48059033
MDR1 and BCRP Transporter-Mediated Drug-Drug Interaction between Rilpivirine and Abacavir and Effect on Intestinal Absorption.Q48145638
Vascularized and functional human liver from an iPSC-derived organ bud transplant.Q48453997
Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids.Q49504268
Use of frozen-thawed cervical tissues in the organ culture system to measure anti-HIV activities of candidate microbicides.Q50110975
CCR5- and CXCR4-tropic subtype C human immunodeficiency virus type 1 isolates have a lower level of pathogenic fitness than other dominant group M subtypes: implications for the epidemicQ37191866
Pharmacokinetics and pharmacodynamics in HIV prevention; current status and future directions: a summary of the DAIDS and BMGF sponsored think tank on pharmacokinetics (PK)/pharmacodynamics (PD) in HIV preventionQ37258271
Single dose pharmacokinetics of oral tenofovir in plasma, peripheral blood mononuclear cells, colonic tissue, and vaginal tissueQ37258298
Short communication: expression of transporters and metabolizing enzymes in the female lower genital tract: implications for microbicide researchQ37258318
Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infectionQ37273158
Evidence that ecotropic murine leukemia virus contamination in TZM-bl cells does not affect the outcome of neutralizing antibody assays with human immunodeficiency virus type 1.Q37275060
Maraviroc concentrates in the cervicovaginal fluid and vaginal tissue of HIV-negative womenQ37362444
HIV infection of the genital mucosa in women.Q37370910
Multisite comparison of anti-human immunodeficiency virus microbicide activity in explant assays using a novel endpoint analysisQ37410434
A quantitative affinity-profiling system that reveals distinct CD4/CCR5 usage patterns among human immunodeficiency virus type 1 and simian immunodeficiency virus strainsQ37410812
Cell-mediated immunity to HIV in the female reproductive tractQ37456785
In vitro comparison of topical microbicides for prevention of human immunodeficiency virus type 1 transmissionQ37568492
Pharmacokinetics and drug-drug interactions of antiretrovirals: an updateQ37576490
The complexities of antiretroviral drug-drug interactions: role of ABC and SLC transportersQ37651953
Vaginal microbicides to prevent human immunodeficiency virus infection in women: perspectives on the female genital tract, sexual maturity and mucosal inflammationQ37994918
Candidate microbicides and their mechanisms of actionQ38101262
Inflammation and HIV Transmission in Sub-Saharan AfricaQ38422546
Sensing of HIV-1 Infection in Tzm-bl Cells with Reconstituted Expression of STING.Q38812549
Drug transporter gene expression in human colorectal tissue and cell lines: modulation with antiretrovirals for microbicide optimization.Q38823939
Vaginal expression of efflux transporters and the potential impact on the disposition of microbicides in vitro and in rabbits.Q38946716
Development of an in vitro dual-chamber model of the female genital tract as a screening tool for epithelial toxicityQ39015851
Optimization and validation of a neutralizing antibody assay for HIV-1 in A3R5 cellsQ39017459
HIV-1 pathogenesis differs in rectosigmoid and tonsillar tissues infected ex vivo with CCR5- and CXCR4-tropic HIV-1.Q39033850
Human intestinal lamina propria lymphocytes are naturally permissive to HIV-1 infection.Q39160304
Prevention of vaginal SHIV transmission in rhesus macaques through inhibition of CCR5.Q39165804
Role of drug efflux and uptake transporters in atazanavir intestinal permeability and drug-drug interactionsQ39229674
The Effect of Commonly Used Excipients on the Epithelial Integrity of Human Cervicovaginal TissueQ39407355
A dual chamber model of female cervical mucosa for the study of HIV transmission and for the evaluation of candidate HIV microbicidesQ39550855
Primary human immunodeficiency virus type 2 (HIV-2) isolates, like HIV-1 isolates, frequently use CCR5 but show promiscuity in coreceptor usage.Q39551934
Sensitivity of human immunodeficiency virus type 1 to the fusion inhibitor T-20 is modulated by coreceptor specificity defined by the V3 loop of gp120Q39612212
The impact of pregnancy on anti-HIV activity of cervicovaginal secretionsQ39619969
Impact of drug transporters on cellular resistance towards saquinavir and darunavirQ39659414
The epidemiology of antiretroviral drug resistance among drug-naive HIV-1-infected persons in 10 US citiesQ39686664
Preventing HIV infection without targeting the virus: how reducing HIV target cells at the genital tract is a new approach to HIV preventionQ40047164
Vaginal bacteria modify HIV tenofovir microbicide efficacy in African womenQ40176907
The future of HIV prevention: prospects for an effective anti-HIV microbicide.Q40213117
Comparison of Mucosal Markers of Human Immunodeficiency Virus Susceptibility in Healthy Premenopausal Versus Postmenopausal WomenQ40248406
Phase 2 Study of the Safety and Tolerability of Maraviroc-Containing Regimens to Prevent HIV Infection in Men Who Have Sex With Men (HPTN 069/ACTG A5305).Q40464768
Brief Report: Pharmacokinetic/Pharmacodynamic Investigation of Single-Dose Oral Maraviroc in the Context of HIV-1 Pre-exposure ProphylaxisQ40510608
Transporters for Antiretroviral Drugs in Colorectal CD4+ T Cells and Circulating α4β7 Integrin CD4+ T Cells: Implications for HIV Microbicides.Q40596923
Specific Antibody Responses to Vaccination with Bivalent CM235/SF2 gp120: Detection of Homologous and Heterologous Neutralizing Antibody to Subtype E (CRF01.AE) HIV Type 1Q40621694
Reduced levels of genital tract immune biomarkers in postmenopausal women: implications for HIV acquisitionQ40736441
Maraviroc and reverse transcriptase inhibitors combinations as potential preexposure prophylaxis candidates.Q40800869
Classification of human colorectal adenocarcinoma cell linesQ41062939
Confocal fluorescence microscopy: An ultra-sensitive tool used to evaluate intracellular antiretroviral nano-drug delivery in HeLa cellsQ41084513
Absence of HeLa cell contamination in 169 cell lines derived from human tumorsQ41761715
Directed differentiation of human pluripotent stem cells into intestinal tissue in vitroQ41770080
Metabolism and anti-human immunodeficiency virus-1 activity of 2-halo-2',3'-dideoxyadenosine derivativesQ42211960
Correction: Seminal plasma induces inflammation and enhances HIV-1 replication in human cervical tissue explantsQ42333108
Fluorescence and electron microscopy to visualize the intracellular fate of nanoparticles for drug deliveryQ42431249
Absorption of poorly water soluble drugs subject to apical efflux using phospholipids as solubilizers in the Caco-2 cell modelQ42503397
Cationic polypeptides are required for anti-HIV-1 activity of human vaginal fluidQ33227608
Role of seminal plasma in the anti-HIV-1 activity of candidate microbicidesQ33260514
Protein abundance of clinically relevant multidrug transporters along the entire length of the human intestineQ33358999
Seminal plasma induces inflammation and enhances HIV-1 replication in human cervical tissue explantsQ33390855
Anti-HIV activity in cervical-vaginal secretions from HIV-positive and -negative women correlate with innate antimicrobial levels and IgG antibodiesQ33627673
A vaginal fluid simulantQ33653706
Optimization and validation of the TZM-bl assay for standardized assessments of neutralizing antibodies against HIV-1.Q33693391
Expression of six drug transporters in vaginal, cervical, and colorectal tissues: Implications for drug disposition in HIV preventionQ33769971
Parameters of human immunodeficiency virus infection of human cervical tissue and inhibition by vaginal virucidesQ33805787
A randomized trial to assess anti-HIV activity in female genital tract secretions and soluble mucosal immunity following application of 1% tenofovir gel.Q33808638
Antiretroviral drug exposure in the female genital tract: implications for oral pre- and post-exposure prophylaxisQ33821257
A comparative proteomic analysis of the soluble immune factor environment of rectal and oral mucosaQ33825756
Differential inhibition of human immunodeficiency virus type 1 in peripheral blood mononuclear cells and TZM-bl cells by endotoxin-mediated chemokine and gamma interferon productionQ33827798
A preponderance of CCR5(+) CXCR4(+) mononuclear cells enhances gastrointestinal mucosal susceptibility to human immunodeficiency virus type 1 infection.Q33853988
Pharmacokinetics of antiretrovirals in genital secretions and anatomic sites of HIV transmission: implications for HIV preventionQ33888718
Burden of nonnucleoside reverse transcriptase inhibitor resistance in HIV-1-infected patients: a systematic review and meta-analysisQ33988153
Tenofovir diphosphate concentrations and prophylactic effect in a macaque model of rectal simian HIV transmissionQ34034418
Productive HIV-1 infection of human cervical tissue ex vivo is associated with the secretory phase of the menstrual cycle.Q34127684
In vitro preclinical testing of nonoxynol-9 as potential anti-human immunodeficiency virus microbicide: a retrospective analysis of results from five laboratoriesQ34352144
A multi-compartment single and multiple dose pharmacokinetic comparison of rectally applied tenofovir 1% gel and oral tenofovir disoproxil fumarateQ34414539
Expression and localization of p-glycoprotein, multidrug resistance protein 4, and breast cancer resistance protein in the female lower genital tract of human and pigtailed macaqueQ34420654
A phase 1 randomized, double blind, placebo controlled rectal safety and acceptability study of tenofovir 1% gel (MTN-007).Q34661892
Anti-HIV-1 activity of flavonoid myricetin on HIV-1 infection in a dual-chamber in vitro model.Q34784838
Single and multiple dose pharmacokinetics of maraviroc in saliva, semen, and rectal tissue of healthy HIV-negative men.Q34834065
Glycerol monolaurate prevents mucosal SIV transmissionQ34957016
Selective transmission of R5 HIV-1 variants: where is the gatekeeper?Q35018140
Analysis of prevalence of HIV-1 drug resistance in primary infections in the United KingdomQ35075694
Natural substrate concentrations can modulate the prophylactic efficacy of nucleotide HIV reverse transcriptase inhibitors.Q35077568
Innate immunity in the vagina (Part II): Anti-HIV activity and antiviral content of human vaginal secretionsQ35078336
Cultivated vaginal microbiomes alter HIV-1 infection and antiretroviral efficacy in colonized epithelial multilayer culturesQ35133798
HIV-1 infection of human penile explant tissue and protection by candidate microbicidesQ35148241
Raltegravir permeability across blood-tissue barriers and the potential role of drug efflux transportersQ35385630
A Phase 1 Randomized, Open Label, Rectal Safety, Acceptability, Pharmacokinetic, and Pharmacodynamic Study of Three Formulations of Tenofovir 1% Gel (the CHARM-01 Study).Q35571216
Monoclonal and Single Domain Antibodies Targeting β-Integrin Subunits Block Sexual Transmission of HIV-1 in In Vitro and In Vivo Model SystemsQ35591504
Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies.Q51417311
Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow.Q51541144
Genital inflammation undermines the effectiveness of tenofovir gel in preventing HIV acquisition in women.Q52685409
CONTINUOUS CULTURE OF HUMAN LYMPHOBLASTS FROM PERIPHERAL BLOOD OF A CHILD WITH ACUTE LEUKEMIA.Q52828546
Studies of the growth and cytogenetic properties of human endometrial adenocarcinoma in culture and its development into an established lineQ52831160
Some properties of a new epithelial cell line of human origin.Q52832927
Frequency of genotypic and phenotypic drug-resistant HIV-1 among therapy-naive patients of the German Seroconverter Study.Q52965935
French national sentinel survey of antiretroviral drug resistance in patients with HIV-1 primary infection and in antiretroviral-naive chronically infected patients in 2001-2002.Q53276114
MRP2 Inhibition by HIV Protease Inhibitors in Rat and Human Hepatocytes: A Quantitative Confocal Microscopy Study.Q53703256
Evidence for differences in the sexual transmission efficiency of HIV strains with distinct drug resistance genotypes.Q53882650
Prevalence of HIV-1 resistant to antiretroviral drugs in 81 individuals newly infected by sexual contact or injecting drug use. Investigators of the Quebec Primary Infection Study.Q54059737
Comparative Assessment of Small and Large Intestine Biopsies for Ex Vivo HIV-1 Pathogenesis Studies.Q54239255
Detection, quantification, and characterisation of HIV/SIV.Q54399618
Synthetic cervical mucus formulationQ56765936
Brief summary of the current protocols for generating intestinal organoidsQ57171935
Development of an in vitro organ culture model to study transmissionof HIV-1 in the female genital tractQ57369522
Diversity of vaginal microbiota in sub-Saharan Africa and its effects on HIV transmission and preventionQ57469974
Characterization of the Genital Mucosa Immune Profile to Distinguish Phases of the Menstrual Cycle: Implications for HIV SusceptibilityQ58088897
Ex vivo culture of human colorectal tissue for the evaluation of candidate microbicidesQ61312701
Epithelial Cells and Fibroblasts from the Human Female Reproductive Tract Accumulate and Release TFV and TAF to Sustain Inhibition of HIV Infection of CD4+ T cellsQ61796692
Vaginal microbiome modulates topical antiretroviral drug pharmacokineticsQ63361759
STUDIES ON SUCCINATE-TETRAZOLIUM REDUCTASE SYSTEMS. III. POINTS OF COUPLING OF FOUR DIFFERENT TETRAZOLIUM SALTSQ76640750
Regional levels of drug transporters along the human intestinal tract: co-expression of ABC and SLC transporters and comparison with Caco-2 cellsQ79844072
The pharmacokinetics, pharmacodynamics, and mucosal responses to maraviroc-containing pre-exposure prophylaxis regimens in MSMQ90583050
Organ-on-chip models: Implications in drug discovery and clinical applicationsQ93167893
Durable protection from vaginal simian-human immunodeficiency virus infection in macaques by tenofovir gel and its relationship to drug levels in tissueQ35665851
Preclinical testing of candidate topical microbicides for anti-human immunodeficiency virus type 1 activity and tissue toxicity in a human cervical explant culture.Q35759112
Growth of macrophage-tropic and primary human immunodeficiency virus type 1 (HIV-1) isolates in a unique CD4+ T-cell clone (PM1): failure to downregulate CD4 and to interfere with cell-line-tropic HIV-1.Q35839936
Transmembrane domain membrane proximal external region but not surface unit-directed broadly neutralizing HIV-1 antibodies can restrict dendritic cell-mediated HIV-1 trans-infectionQ35842299
Molecular Signatures of Immune Activation and Epithelial Barrier Remodeling Are Enhanced during the Luteal Phase of the Menstrual Cycle: Implications for HIV SusceptibilityQ35913894
Preclinical evaluation of the HIV-1 fusion inhibitor L'644 as a potential candidate microbicideQ35941336
Expression Profile of Human Fc Receptors in Mucosal Tissue: Implications for Antibody-Dependent Cellular Effector Functions Targeting HIV-1 Transmission.Q36013396
Magnitude and breadth of the neutralizing antibody response in the RV144 and Vax003 HIV-1 vaccine efficacy trialsQ36083337
Reformulated tenofovir gel for use as a dual compartment microbicide.Q36159765
Saquinavir inhibits early events associated with establishment of HIV-1 infection: potential role for protease inhibitors in preventionQ36171647
Use of human tissue explants to study human infectious agentsQ36189818
Three-dimensional analysis of budding sites and released virus suggests a revised model for HIV-1 morphogenesisQ36266587
Sensitive and rapid assay on MT-4 cells for detection of antiviral compounds against the AIDS virusQ36283746
Penetration of tenofovir and emtricitabine in mucosal tissues: implications for prevention of HIV-1 transmissionQ36353342
Dose-response relationship between tissue concentrations of UC781 and explant infectibility with HIV type 1 in the RMP-01 rectal safety studyQ36358774
Genital tract viral load in HIV Type 1-positive women correlates with specific cytokine levels in cervical-vaginal secretions but is not a determinant of infectious virus or anti-HIV activityQ36358905
Nonreproducibility of "snap-frozen" rectal biopsies for later use in ex vivo explant infectibility studiesQ36359000
RMP-02/MTN-006: A phase 1 rectal safety, acceptability, pharmacokinetic, and pharmacodynamic study of tenofovir 1% gel compared with oral tenofovir disoproxil fumarateQ36359092
Blockade of attachment and fusion receptors inhibits HIV-1 infection of human cervical tissueQ36399466
Safety and efficacy of tenofovir/IQP-0528 combination gels - a dual compartment microbicide for HIV-1 preventionQ36409617
Impact of Sex on the Pharmacokinetics and Pharmacodynamics of 1% Tenofovir GelQ36446138
Development of a comprehensive human immunodeficiency virus type 1 screening algorithm for discovery and preclinical testing of topical microbicides.Q36593791
Innate and adaptive anti-HIV immune responses in the female reproductive tractQ36637034
Differential Mechanisms of Tenofovir and Tenofovir Disoproxil Fumarate Cellular Transport and Implications for Topical Preexposure Prophylaxis.Q36644606
Short Communication: Limited Anti-HIV-1 Activity of Maraviroc in Mucosal TissuesQ36756170
Narrative review: antiretroviral therapy to prevent the sexual transmission of HIV-1.Q36793483
Distinct Pharmacodynamic Activity of Rilpivirine in Ectocervical and Colonic Explant TissueQ36888077
Comparison of Follicular and Luteal Phase Mucosal Markers of HIV Susceptibility in Healthy WomenQ36966645
Inhibition of human immunodeficiency virus type 1 infection by the candidate microbicide dapivirine, a nonnucleoside reverse transcriptase inhibitorQ37072072
Recent advances in the characterization of HIV-1 neutralization assays for standardized evaluation of the antibody response to infection and vaccinationQ37119451
Lack of prophylactic efficacy of oral maraviroc in macaques despite high drug concentrations in rectal tissuesQ37123335
Apples and oranges? Interpreting success in HIV prevention trialsQ37178472
Reverse transcriptase inhibitors as potential colorectal microbicidesQ37190754
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P921main subjectpharmacodynamicsQ725307
P304page(s)578
P577publication date2019-05-24
P1433published inFrontiers in PharmacologyQ2681208
P1476titleThe Pre-clinical Toolbox of Pharmacokinetics and Pharmacodynamics: in vitro and ex vivo Models.
P478volume10

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