Interaction between galectin-3 and cystinosin uncovers a pathogenic role of inflammation in kidney involvement of cystinosis.

scientific article published on 6 March 2019

Interaction between galectin-3 and cystinosin uncovers a pathogenic role of inflammation in kidney involvement of cystinosis. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.KINT.2019.01.029
P932PMC publication ID7269416
P698PubMed publication ID30928021

P50authorDaniel PoulyQ59704868
Celine J RoccaQ64505813
Stephanie CherquiQ46181476
P2093author name stringRoy Miller
Marie-Claire Gubler
Corinne Antignac
Nathalie Nevo
Tristan Montier
Ida Chiara Guerrera
Robert H Mak
Wai W Cheung
Sergio D Catz
Lucie Thomas
Anne Bailleux
Jinzhong Zhang
Fiona Moore
Tatiana Lobry
P2860cites workHuman galectin-3 is a novel chemoattractant for monocytes and macrophagesQ22254736
CystinosisQ24262959
The targeting of cystinosin to the lysosomal membrane requires a tyrosine-based signal and a novel sorting motifQ24290722
Chaperone-mediated autophagy prevents apoptosis by degrading BBC3/PUMAQ24338571
Galectin-3 expression and secretion links macrophages to the promotion of renal fibrosisQ24649584
A Role for galectin-3 in renal tissue damage triggered by ischemia and reperfusion injuryQ46461255
Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A.Q46864655
Monocyte chemoattractant protein-1 promotes the development of diabetic renal injury in streptozotocin-treated miceQ46865455
Galectin-3: One Molecule for an Alphabet of Diseases, from A to Z.Q48159180
Triggered recruitment of ESCRT machinery promotes endolysosomal repair.Q52330605
The Ocular Anomalies in a Cystinosis Animal Model Mimic Disease PathogenesisQ56788181
Cysteamine therapy delays the progression of nephropathic cystinosis in late adolescents and adultsQ63979931
Nephropathic cystinosis in adults: natural history and effects of oral cysteamine therapyQ64045497
Cystinosin, the protein defective in cystinosis, is a H(+)-driven lysosomal cystine transporterQ27937730
Mechanisms of chaperone-mediated autophagyQ28278324
Intralysosomal cystine accumulation in mice lacking cystinosin, the protein defective in cystinosisQ28591791
Origin and physiological roles of inflammationQ29614298
A third-generation lentivirus vector with a conditional packaging systemQ29616120
Upregulation of the Rab27a-dependent trafficking and secretory mechanisms improves lysosomal transport, alleviates endoplasmic reticulum stress, and reduces lysosome overload in cystinosisQ30541728
Modified citrus pectin reduces galectin-3 expression and disease severity in experimental acute kidney injuryQ33873592
Galectin-3: an open-ended storyQ34494555
The regulation of inflammation by galectin-3.Q34991925
Impairment of chaperone-mediated autophagy leads to selective lysosomal degradation defects in the lysosomal storage disease cystinosisQ35084396
Effect of indomethacin on clinical progress and renal function in cystinosisQ35116910
A mouse model suggests two mechanisms for thyroid alterations in infantile cystinosis: decreased thyroglobulin synthesis due to endoplasmic reticulum stress/unfolded protein response and impaired lysosomal processing.Q35603385
Much More than M1 and M2 Macrophages, There are also CD169(+) and TCR(+) MacrophagesQ35646486
Cysteamine therapy: a treatment for cystinosis, not a cureQ36068161
Galectin-3 Blockade Reduces Renal Fibrosis in Two Normotensive Experimental Models of Renal DamageQ36187612
Cystinosin is a Component of the Vacuolar H+-ATPase-Ragulator-Rag Complex Controlling Mammalian Target of Rapamycin Complex 1 SignalingQ36944628
Nephropathic cystinosis: late complications of a multisystemic diseaseQ37002855
Elevated galectin-3 precedes the development of CKDQ37119904
Monocyte chemoattractant protein-1 (MCP-1): an overviewQ37481208
Human monocyte chemoattractant protein-1 (MCP-1).Q37922199
Cytokines in the systemic inflammatory response syndrome: a reviewQ38084633
Targeting inflammation in the treatment of type 2 diabetesQ38134116
The renal Fanconi syndrome in cystinosis: pathogenic insights and therapeutic perspectivesQ38781097
Activation of the transcription factor EB rescues lysosomal abnormalities in cystinotic kidney cellsQ38784895
c-Abl and Arg tyrosine kinases regulate lysosomal degradation of the oncoprotein Galectin-3.Q39740457
Regulation of alternative macrophage activation by galectin-3.Q40016366
Proteolytic activation of monocyte chemoattractant protein-1 by plasmin underlies excitotoxic neurodegeneration in mice.Q40170899
Isolation of rat liver lysosomes by isopycnic centrifugation in a metrizamide gradientQ40171644
Predominance of M2-polarized macrophages in bladder cancer affects angiogenesis, tumor grade and invasivenessQ40497512
Pharmacological inhibition of galectin-3 protects against hypertensive nephropathyQ41695164
The impact of galectin-3 inhibition on aldosterone-induced cardiac and renal injuries.Q41744993
Galectin-3 captures interferon-gamma in the tumor matrix reducing chemokine gradient production and T-cell tumor infiltrationQ41911091
Role of leptin and melanocortin signaling in uremia-associated cachexiaQ41966819
Impact of Cystinosin Glycosylation on Protein Stability by Differential Dynamic Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC).Q42803803
Renal phenotype of the cystinosis mouse model is dependent upon genetic backgroundQ43257283
Associations between circulating inflammatory markers and residual renal function in CRF patientsQ44459462
Blockade of CCL2/CCR2 signalling ameliorates diabetic nephropathy in db/db miceQ45232179
Peripheral administration of the melanocortin-4 receptor antagonist NBI-12i ameliorates uremia-associated cachexia in mice.Q45936147
Kidney preservation by bone marrow cell transplantation in hereditary nephropathy.Q46023359
P4510describes a project that usesImageJQ1659584
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)350-362
P577publication date2019-03-06
P1433published inKidney InternationalQ6404823
P1476titleInteraction between galectin-3 and cystinosin uncovers a pathogenic role of inflammation in kidney involvement of cystinosis
P478volume96

Reverse relations

cites work (P2860)
Q90640438Macrophage polarization impacts tunneling nanotube formation and intercellular organelle trafficking
Q91843135Microvesicle delivery of a lysosomal transport protein to ex vivo rabbit cornea
Q90239959Protection of Cystinotic Mice by Kidney-Specific Megalin Ablation Supports an Endocytosis-Based Mechanism for Nephropathic Cystinosis Progression

Search more.