KEOPS complex promotes homologous recombination via DNA resection.

scientific article published in June 2019

KEOPS complex promotes homologous recombination via DNA resection. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/NAR/GKZ228
P932PMC publication ID6582355
P698PubMed publication ID30937455

P50authorJin-Qiu ZhouQ88234052
P2093author name stringJing Peng
Ying-Ying Liu
Jia-Cheng Liu
Zhenfang Wu
Ming-Hong He
Yi-Si Lu
Zhi-Jing Wu
P2860cites workCell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiaeQ24649768
Mechanisms and regulation of mitotic recombination in Saccharomyces cerevisiaeQ26864428
Repair of strand breaks by homologous recombinationQ27012688
Atomic Structure of the KEOPS Complex: An Ancient Protein Kinase-Containing Molecular MachineQ27652648
Structure of the archaeal Kae1/Bud32 fusion protein MJ1130: a model for the eukaryotic EKC/KEOPS subcomplexQ27653522
Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme systemQ27677604
Functional profiling of the Saccharomyces cerevisiae genomeQ27860544
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexesQ27860662
Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiaeQ27861085
Inhibition of telomere recombination by inactivation of KEOPS subunit Cgi121 promotes cell longevityQ27929502
Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processingQ27929897
Sua5p is required for telomere recombination in Saccharomyces cerevisiae.Q54685135
The MRX complex regulates Exo1 resection activity by altering DNA end structureQ60603429
A familial case of Galloway-Mowat syndrome due to a novel TP53RK mutation: a case reportQ64044040
Exonuclease activity is required for sequence addition and Cdc13p loading at a de novo telomereQ64388053
Use of cdc13-1-induced DNA damage to study effects of checkpoint genes on DNA damage processingQ73572486
Yeast Ku as a regulator of chromosomal DNA end structureQ74490854
Physical monitoring of HO-induced homologous recombinationQ78114425
Yeast KEOPS complex regulates telomere length independently of its t6A modification functionQ88875682
Repair of double-strand breaks by end joiningQ38103528
Modernizing the nonhomologous end-joining repertoire: alternative and classical NHEJ share the stage.Q38139497
Exo1 and Rad24 differentially regulate generation of ssDNA at telomeres of Saccharomyces cerevisiae cdc13-1 mutantsQ38335994
Break dosage, cell cycle stage and DNA replication influence DNA double strand break responseQ38847818
Differential chromatin proteomics of the MMS-induced DNA damage response in yeastQ39019272
Minimal, encapsulated proteomic-sample processing applied to copy-number estimation in eukaryotic cellsQ39028018
Differential regulation of the cellular response to DNA double-strand breaks in G1.Q39601534
EXO1-dependent single-stranded DNA at telomeres activates subsets of DNA damage and spindle checkpoint pathways in budding yeast yku70Delta mutantsQ39860143
Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly.Q40094779
tRNA N6-adenosine threonylcarbamoyltransferase defect due to KAE1/TCS3 (OSGEP) mutation manifest by neurodegeneration and renal tubulopathyQ40303611
The tail-module of yeast Mediator complex is required for telomere heterochromatin maintenanceQ40395489
Crystal structures of the Gon7/Pcc1 and Bud32/Cgi121 complexes provide a model for the complete yeast KEOPS complexQ41308269
Plasmid-mediated induction of recombination in yeast.Q41837609
A genomewide suppressor and enhancer analysis of cdc13-1 reveals varied cellular processes influencing telomere capping in Saccharomyces cerevisiae.Q41892175
A novel role of the Dna2 translocase function in DNA break resectionQ41948259
The motor activity of DNA2 functions as an ssDNA translocase to promote DNA end resectionQ42291337
Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaksQ42408271
DNA helicases Sgs1 and BLM promote DNA double-strand break resectionQ42750184
Strategies for the structural analysis of multi-protein complexes: lessons from the 3D-Repertoire projectQ44435501
Chromatin remodeler CHD1 promotes XPC-to-TFIIH handover of nucleosomal UV lesions in nucleotide excision repair.Q47669368
Telomere maintenance is dependent on activities required for end repair of double-strand breaksQ47946099
Rif1 maintains telomeres and mediates DNA repair by encasing DNA ends.Q48293384
Physiological protein blocks direct the Mre11-Rad50-Xrs2 and Sae2 nuclease complex to initiate DNA end resectionQ50102216
Plasticity of the Mre11-Rad50-Xrs2-Sae2 nuclease ensemble in the processing of DNA-bound obstaclesQ50102221
Telomerase-null survivor screening identifies novel telomere recombination regulators.Q27930545
The universal YrdC/Sua5 family is required for the formation of threonylcarbamoyladenosine in tRNA.Q27931264
The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A.Q27932308
Histone deacetylase Rpd3 antagonizes Sir2-dependent silent chromatin propagationQ27932909
Yeast homolog of a cancer-testis antigen defines a new transcription complexQ27933400
Functional assignment of KEOPS/EKC complex subunits in the biosynthesis of the universal t6A tRNA modificationQ27933516
Gcn4 misregulation reveals a direct role for the evolutionary conserved EKC/KEOPS in the t6A modification of tRNAsQ27934109
A short C-terminal domain of Yku70p is essential for telomere maintenanceQ27935969
Sua5p a single-stranded telomeric DNA-binding protein facilitates telomere replicationQ27936111
Xbp1-mediated histone H4 deacetylation contributes to DNA double-strand break repair in yeastQ27936119
The Saccharomyces CDC13 protein is a single-strand TG1-3 telomeric DNA-binding protein in vitro that affects telomere behavior in vivoQ27937905
A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulatorQ27938839
Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpointQ27939822
Proteomic analysis of the human KEOPS complex identifies C14ORF142 as a core subunit homologous to yeast Gon7Q29147565
Sae2 promotes dsDNA endonuclease activity within Mre11-Rad50-Xrs2 to resect DNA breaksQ29346869
Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damageQ29614221
Double-strand break end resection and repair pathway choiceQ29614422
Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break endsQ29615269
Srs2 and Sgs1-Top3 suppress crossovers during double-strand break repair in yeastQ29618612
Mutually exclusive binding of telomerase RNA and DNA by Ku alters telomerase recruitment modelQ30455151
Rad6-Bre1-mediated H2B ubiquitination regulates telomere replication by promoting telomere-end resection.Q33557995
Ku must load directly onto the chromosome end in order to mediate its telomeric functionsQ33996667
In vitro biosynthesis of a universal t6A tRNA modification in Archaea and EukaryaQ34034860
Cdc13 prevents telomere uncapping and Rad50-dependent homologous recombinationQ34083558
Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2Q34211299
A role for the universal Kae1/Qri7/YgjD (COG0533) family in tRNA modificationQ34626470
RPA coordinates DNA end resection and prevents formation of DNA hairpinsQ34740136
Telomere recombination preferentially occurs at short telomeres in telomerase-null type II survivorsQ35110580
DNA damage response at functional and dysfunctional telomeresQ37058277
The role of the DNA damage response pathways in brain development and microcephaly: insight from human disordersQ37155150
P275copyright licenseCreative Commons Attribution-NonCommercial 4.0 InternationalQ34179348
P6216copyright statuscopyrightedQ50423863
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)5684-5697
P577publication date2019-06-01
P1433published inNucleic Acids ResearchQ135122
P1476titleKEOPS complex promotes homologous recombination via DNA resection
P478volume47

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Q89669020Molecular basis for t6A modification in human mitochondriacites workP2860

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